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Ludger Grote
Professor/ Chief Physician
Department of Internal Medicine and Clinical NutritionAbout Ludger Grote
Ludger Groteis currently the medical director of the Sleep Disorders Center at the Sahlgrenska University Hospital in Gothenburg, Sweden.
After training in sleep medicine at the Zeitreihenlabor, University of Marburg, Germany, (headed by Jörg Herman Peter) he joined the sleep research group at Sahlgrenska University in Gothenburg, Sweden (group leader Jan Hedner) since 1998. Today he is an Adjunct Professor at the Institute of Medicine (area respiratory medicine, sleep related disorders), Sahlgrenska Academy, Gothenburg University, and supervisor for PhD students in respiratory and sleep research on topics related to sleep in COPD patients, traffic safety in sleep apnea, cardio-metabolic risk assessment during sleep, and the interaction between pain, restless legs syndrome, and sleep. From 2015 to 2016 he joined the Research Group for Sleep and Respiratory Medicine at Johns Hopkins University, Baltimore, USA,as a guest researcher.
Ludger Grote has published more than 200 original papers, book chapters, and monographs. He is active in national and international networks like the European Sleep Apnea Database (ESADA), the Swedish Sleep Apnea Registry (SESAR), the Swedish Oxygen and home ventilation registry SWEDEVOX, and the SLEEP SCAPIS group.
In the European Sleep Research Society, he servedas the chair of the Executive Committee of the Assembly of National Sleep Societies (2010-14) and as a currentmember of the Sleep Education Committee. He was the former president of the Swedish Sleep Society (2007-2011),where he is responsible today for educational programs.In addition, Ludger is scientific secretary of the Swedish Respiratory Society (SLMF, 2017 and ongoing) and chair of the national working group (NAG) on sleep apnea within the national program area “Respiratory Medicine” (NPO) (2019 and ongoing)
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Moderate to Severe Obstructive Sleep Apnea Is a Risk Factor for Severe COVID-19-A Nationwide Cohort
Study
Mirjam Ljunggren, Andreas Palm, Magnus Ekstroem, Josefin Sundh, Ludger Grote, Huiqi Li, Fredrik Nyberg, Ossur Ingi Emilsson
JOURNAL OF SLEEP RESEARCH - 2025 -
Factors influencing the PAP adherence of elderly European sleep apnea patients in the ESADA
cohort
Aino Lammintausta, Ulla Anttalainen, Izolde Bouloukaki, Sophia E. Schiza, Athanasia Pataka, Francesco Fanfulla, Stefan A. Mihaicuta, Sebastien Bailly, Ludger Grote, Jan A Hedner, Tarja Saaresranta
SLEEP - 2025 -
Arousal burden is highest in supine sleeping position and during light
sleep
Minna Pitkanen, Juho Huovinen, Marika Rissanen, Henna Pitkanen, Samu Kainulainen, Thomas Penzel, Francesco Fanfulla, Ulla Anttalainen, Tarja Saaresranta, Ludger Grote, Jan A Hedner, Richard Staats, Brett Duce, Juha Toyras, Arie Oksenberg, Timo Leppanen
JOURNAL OF CLINICAL SLEEP MEDICINE - 2025 -
Overnight stiffness index from finger photoplethysmography in relation to markers of cardiovascular risk and vascular
ageing
Henrik Hellqvist, Hermine Rietz, Ludger Grote, Jan A Hedner, Dirk Sommermeyer, Thomas Kahan, Jonas Spaak
HEART AND VESSELS - 2025 -
The future of education in sleep science and medicine in Europe: Report of an ESRS
workshop
W. T. Mcnicholas, E. S. Arnardottir, V. V. Vyazovskiy, D. Pevernagie, T. Penzel, P. Peigneux, Ludger Grote, Y. van der Werf, F. de Jongh, M. Schmidt, M. Adamantidis, S. Sekaran, A. M. Biller, B. Knobl, P. -h. Luppi, C. L. Bassetti, T. Paunio
JOURNAL OF SLEEP RESEARCH - 2025 -
What are the important risk factors for excessive daytime sleepiness in a population-based
cohort?
Jenny Theorell-Haglow, Martin Ulander, John Brandberg, Martin Claesson, Karl A. Franklin, Jan A Hedner, Magnus Hultin, Fredrik Iredahl, Eva Lindberg, Mirjam Ljunggren, Andrei Malinovschi, Maria Mannila, Ida Pesonen, Anthony Prakash, Carin Sahlin, Magnus Skold, Jonas Spaak, Hanan Tanash, Ding Zou, Ludger Grote
JOURNAL OF SLEEP RESEARCH - 2025 -
Feasibility and usability of three consecutive nights with self-applied, home
polysomnography
Dimitri Ferretti, Anna S. Islind, Kristin A. Olafsdottir, Sigridur Sigurdardottir, Kamilla R. Johannsdottir, Jan A Hedner, Ludger Grote, Erna Sif Arnardottir
JOURNAL OF SLEEP RESEARCH - 2024 -
Control of hypercapnia and mortality in home mechanicalventilation: the population-based DISCOVERY
study
Andreas Palm, Magnus Ekstrom, Ossur Emilsson, Karin Ersson, Mirjam Ljunggren, Josefin Sundh, Ludger Grote
ERJ OPEN RESEARCH - 2024 -
The modified Baveno classification for obstructive sleep apnoea: development and evaluation based on the ESADA
database
Sandhya Matthes, Marcel Treml, Ludger Grote, Jan A Hedner, Ding Zou, Maria R. Bonsignore, Jean Louis Pépin, Sébastien Bailly, Silke Ryan, Walter T. McNicholas, Sofia E. Schiza, Johan Verbraecken, Athanasia Pataka, Paweł Śliwiński, Özen K. Basoglu, Carolina Lombardi, Gianfranco Parati, Winfried J. Randerath
The European respiratory journal - 2024 -
The effect of sulthiame on potential biomarkers in moderate to severe obstructive sleep
apnoea
Erik Hoff, Musovic Saliha, Ali Komai, Ding Zou, Christian Strassberger, Kaj Stenlöf, Ludger Grote, Jan A Hedner
ERJ Open Research - 2024 -
Sleep apnoea phenotypes in women: A cluster analysis from the ESADA
cohort
A. Pataka, J. L. Pepin, M. R. Bonsignore, S. Schiza, T. Saaresranta, I. Bouloukaki, P. Steiropoulos, G. Trakada, R. Riha, Z. Dogas, D. Testelmans, O. K. Basoglu, S. Mihaicuta, F. Fanfulla, Ludger Grote, S. Bailly, J. Verbraecken, E. Petiet, I. Fietze, T. Penzel, O. Ludka, W. T. McNicholas, S. Ryan, R. L. Riha, J. A. Kvamme, J. Hedner, D. Zou, K. Hertegonne, D. Pevernagie, J. L. Pépin, R. Tamisier, H. Hein, M. S. Tasbakan, J. Buskova, P. Joppa, R. Staats, A. Kalkanis, H. Gouveris, K. Ludwig, C. Lombardi, G. Parati, Fanfulla Francesco, M. Drummond, M. van Zeller, W. Randerath, M. Treml, R. Pecotic, U. Anttalainen, P. Sliwinski
Sleep Medicine - 2024 -
Evolution of Home Mechanical Ventilation in Sweden Over 27 Years: Changing Trends in Incidence, Prevalence, and Patient Characteristics - The Population-Based the Course of Disease in Patients Reported to the Swedish CPAP Oxygen and Ventilator Registry (DISCOVERY)
Study
Andreas Palm, Ludger Grote, Jonas Einarsson, Daniel Hansson, Mirjam Ljunggren, Josefin Sundh, Magnus Ekström
CHEST Pulmonary - 2024 -
Obstructive sleep apnoea and lung function, and their association with nocturnal hypoxemia: results from the Swedish CArdioPulmonary bioimage Study (SCAPIS) - a cross-sectional
study
Baz Delshad, Mirjam Ljunggren, Xing Wu Zhou, J. Theorell-Haglow, Christer Janson, Ding Zou, Jan A Hedner, Ludger Grote, Anders Blomberg, Karl Franklin, Carlin Sahlin, Andrei Malinovschi, Eva Lindberg
BMJ OPEN - 2024 -
Temporal and sleep stage-dependent agreement in manual scoring of respiratory
events
Minna Pitkanen, Henna Pitkanen, Rajdeep Kumar Nath, Sami Nikkonen, Samu Kainulainen, Henri Korkalainen, Kristin Anna Olafsdottir, Erna Sif Arnardottir, Sigridur Sigurdardottir, Thomas Penzel, Francesco Fanfulla, Ulla Anttalainen, Tarja Saaresranta, Ludger Grote, Jan A Hedner, Richard Staats, Juha Toyras, Timo Leppanen
JOURNAL OF SLEEP RESEARCH - 2024 -
The Swedish sleep apnea registry (SESAR) cohort - " Real world data" on a national
level
Ludger Grote, Yvonne Asp Jonzon, Peter Barta, Tarmo Murto, Zarita Nilsson, Anna Nygren, Jenny Theorell-Haglow, Ola Sunnergren, Martin Ulander, Magnus Ekstrom, Andreas Palm, Jan A Hedner
SLEEP MEDICINE - 2024 -
The influence of diabetes on sleep-derived cardiorespiratory features of the finger pulse wave signal - The population-based SCAPIS
study
Christian Strassberger, Jan A Hedner, Dirk Sommermeyer, Ding Zou, Ludger Grote
SLEEP MEDICINE - 2024 -
Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea
patients
Serajeddin Ebrahimian, Saara Sillanmaki, Salla Hietakoste, Antti Kulkas, Juha Toyras, Raquel Bailón, David Hernando, Carolina Lombardi, Ludger Grote, Maria R. Bonsignore, Tarja Saaresranta, Jean Louis Pépin, Timo Leppanen, Samu Kainulainen
American Journal of Physiology - Heart and Circulatory Physiology - 2024 -
Interhemispheric differences of electroencephalography signal characteristics in different sleep
stages
Masoumeh Tashakori, Matias Rusanen, Tuomas Karhu, Ludger Grote, Rajdeep Kumar Nath, Timo Leppanen, Sami Nikkonen
SLEEP MEDICINE - 2024 -
Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and
women.
Magnus Ekström, Josefin Sundh, Anders Andersson, Oskar Angerås, Anders Blomberg, Mats Börjesson, Kenneth Caidahl, Össur Ingi Emilsson, Jan Engvall, Erik Frykholm, Ludger Grote, Kristofer Hedman, Tomas Jernberg, Eva Lindberg, Andrei Malinovschi, André Nyberg, Eric Rullman, Jacob Sandberg, Magnus Sköld, Nikolai Stenfors, Johan Sundström, Hanan Tanash, Suneela Zaigham, Carl-Johan Carlhäll
Respiratory research - 2024 -
Modification of Endotypic Traits in OSA by the Carbonic Anhydrase Inhibitor
Sulthiame
Erik Hoff, Christian Strassberger, Ding Zou, Ludger Grote, Kaj Stenlöf, Jan A Hedner
CHEST - 2024 -
The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep
apnea
A. Bikov, S. Bailly, D. Testelmans, F. Fanfulla, A. Pataka, I. Bouloukaki, H. Hein, Z. Dogas, O. K. Basoglu, R. Staats, G. Parati, C. Lombardi, Ludger Grote, S. Mihaicuta, Esada Study Grp Esada Study Grp
Journal of Sleep Research - 2024 -
Review and perspective on sleep-disordered breathing research and translation to
clinics
Henri Korkalainen, Samu Kainulainen, Anna Sigridur Islind, Maria Oskarsdottir, Christian Strassberger, Sami Nikkonen, Juha Toyras, Antti Kulkas, Ludger Grote, Jan A Hedner, Reijo Sund, Harald Hrubos-Strom, Jose M. Saavedra, Kristin Anna Olafsdottir, Jon S. Agustsson, Philip I. Terrill, Walter T. McNicholas, Erna Sif Arnardottir, Timo Leppanen
SLEEP MEDICINE REVIEWS - 2024 -
Breathlessness and exercise performance to predict mortality in long-term oxygen therapy – The population-based DISCOVERY
study
Filip Björklund, Andreas Palm, Jwan Abdulrazak Gorani, Zainab Ahmadi, Josefin Sundh, Jenny Theorell-Haglöw, Mirjam Ljunggren, Ludger Grote, Karin Wadell, Magnus Ekström
Respiratory Medicine - 2023 -
The placebo effect in pharmacological treatment of obstructive sleep apnea, a systematic review and
meta-analysis
Erik Hoff, Ding Zou, Ludger Grote, Kaj Stenlöf, Jan A Hedner
Sleep Medicine - 2023 -
Beneficial Effects of Early Intervention Telemedicine-based Follow-Up in Sleep Apnea A Randomized Controlled Multicenter
Trial
Benedikt Fridriksson, M. Berndtson, H. Hamnered, E. Faeder, Ding Zou, J. Hedner, Ludger Grote
Annals of the American Thoracic Society - 2023 -
Sleep and cardiometabolic comorbidities in the obstructive sleep apnoea-COPD overlap syndrome: data from the European Sleep Apnoea
Database
M. van Zeller, O. K. Basoglu, J. Verbraecken, C. Lombardi, W. T. McNicholas, J. L. Pepin, P. Steiropoulos, P. Sliwinski, D. Correia, M. R. Bonsignore, S. E. Schiza, Jan A Hedner, Ludger Grote, M. Drummond
European Respiratory Journal Open Research (ERJ Open Research) - 2023 -
Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure- a national cohort
study.
Josefin Sundh, Andreas Palm, Mirjam Ljunggren, Össur Ingi Emilsson, Ludger Grote, Sara Cajander, Huiqi Li, Fredrik Nyberg, Magnus Ekström
Respiratory medicine - 2023 -
Changes in cognitive function and daytime sleepiness in patients with chronic heart failure and Cheyne-Stokes respiration with adaptive servo ventilation
treatment
Mahssa Karimi, Jan A Hedner, Ludger Grote
Sleep Medicine - 2023 -
Arterial bicarbonate is associated with hypoxic burden and uncontrolled hypertension in obstructive sleep apnea- The ESADA
cohort
Ding Zou, Ludger Grote, O. K. Basoglu, J. Verbraecken, S. Schiza, P. Sliwinski, P. Steiropoulos, C. Lombardi, H. Hein, J. L. Pepin, G. Parati, W. T. McNicholas, Jan A Hedner
Sleep Medicine - 2023 -
Nasal polyposis is a risk factor for nonadherence to CPAP treatment in sleep apnea: the population-based DISCOVERY
study
C. Bengtsson, Ludger Grote, M. Ljunggren, M. Ekstrom, A. Palm
JOURNAL OF CLINICAL SLEEP MEDICINE - 2023 -
Adherence to CPAP therapy in Down syndrome: the population-based DISCOVERY
study
M. Svensson, M. Ekstrom, J. Sundh, M. Ljunggren, Ludger Grote, A. Palm
JOURNAL OF CLINICAL SLEEP MEDICINE - 2023 -
Blood pressure control in hypertensive sleep apnoea patients of the European Sleep Apnea Database cohort - effects of positive airway pressure and antihypertensive
medication
Sven Svedmyr, Jan A Hedner, Sebastien Bailly, Francesco Fanfulla, Holger Hein, Carolina Lombardi, Ondrej Ludka, Stefan Mihaicuta, Gianfranco Parati, Athanasia Pataka, Sophia Schiza, Sezai Tasbakan, Dries Testelmans, Ding Zou, Ludger Grote
European Heart Journal Open - 2023 -
Clinical characteristics and positive airway pressure adherence among elderly European sleep apnoea patients from the ESADA
cohort
A. Lammintausta, U. Anttalainen, O. K. Basoglu, M. R. Bonsignore, H. Gouveris, Ludger Grote, Jan A Hedner, O. Ludka, S. Mihaicuta, A. Pataka, G. Trakada, M. van Zeller, T. Saaresranta, Grp Esada Study
ERJ Open Research - 2023 -
Clinical impact of routine sleep assessment by peripheral arterial tonometry in patients with
COPD
D. Hansson, Anders Andersson, Lowie E G W Vanfleteren, Kristina Andelid, Ding Zou, Jan A Hedner, Ludger Grote
ERJ Open Research - 2023 -
Night-to-Night Variability of Polysomnography-Derived Physiologic Endotypic Traits in Patients With Moderate to Severe
OSA
C. Strassberger, Jan A Hedner, S. A. Sands, T. M. Tolbert, L. Taranto-Montemurro, Albert Marciniak, Ding Zou, Ludger Grote
Chest - 2023 -
National Knowledge-Driven Management of Obstructive Sleep Apnea-The Swedish
Approach
Ludger Grote, C. P. Anderberg, D. Friberg, G. Grundstrom, K. Hinz, G. Isaksson, T. Murto, Z. Nilsson, J. Spaak, G. Stillberg, K. Soderberg, A. Tegelberg, J. Theorell-Haglow, M. Ulander, Jan A Hedner
Diagnostics - 2023 -
Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY
cohort
A. Palm, J. Theorell-Haglow, J. Isakson, M. Ljunggren, J. Sundh, M. P. Ekstrom, Ludger Grote
Bmj Open - 2023 -
A Randomized Controlled Clinical Trial Exploring Safety and Tolerability of Sulthiame in Sleep
Apnea
Jan A Hedner, Kaj Stenlöf, Ding Zou, Erik Hoff, C. Hansen, K. Kuhn, P. Lennartz, Ludger Grote
American Journal of Respiratory and Critical Care Medicine - 2022 -
10-year anniversary of the European Somnologist examination - A historic overview and critical
appraisal
Ludger Grote, D. Pevernagie, O. Bruni, T. Deboer, D. Garcia-Borreguero, E. A. Hill, T. Penzel, F. J. Puertas, A. Wiechmann, M. Verspaandonk, T. Paunio
Journal of Sleep Research - 2022 -
Lessons for sleep medicine learned from the COVID-19
pandemic
Ludger Grote
Breathe - 2022 -
COVID-19 and Risk of Oxygen-Dependent Chronic Respiratory Failure: A National Cohort
Study.
Josefin Sundh, Magnus Ekström, Andreas Palm, Mirjam Ljunggren, Össur Ingi Emilsson, Ludger Grote, Sara Cajander, Huiqi Li, Fredrik Nyberg
American journal of respiratory and critical care medicine - 2022 -
Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision
medicine
Sven Svedmyr, Jan A Hedner, M. R. Bonsignore, C. Lombardi, G. Parati, O. Ludka, Ding Zou, Ludger Grote
Journal of Sleep Research - 2022 -
Correlates of excessive daytime sleepiness in obstructive sleep apnea: Results from the nationwide SESAR cohort including 34,684
patients
M. Ulander, Jan A Hedner, G. Stillberg, O. Sunnergren, Ludger Grote
Journal of sleep research - 2022 -
The Sleep Revolution project: the concept and
objectives
E. S. Arnardottir, A. S. Islind, M. Oskarsdottir, K. A. Olafsdottir, E. August, L. Jonasdottir, H. Hrubos-Strom, J. M. Saavedra, Ludger Grote, Jan A Hedner, S. Hoskuldsson, J. S. Agustsson, K. R. Johannsdottir, W. T. McNicholas, D. Pevernagie, R. Sund, J. Toyras, T. Leppanen, Revolution Sleep
Journal of Sleep Research - 2022 -
Eveningness is associated with sedentary behavior and increased 10-year risk of cardiovascular disease: the SCAPIS pilot
cohort
Mio Kobayashi Frisk, Jan A Hedner, Ludger Grote, O. Ekblom, Daniel Arvidsson, Göran Bergström, Mats Börjesson, Ding Zou
Scientific Reports - 2022 -
Baseline clusters and the response to positive airway pressure treatment in obstructive sleep apnoea patients: longitudinal data from the European Sleep Apnea Database
cohort
A. Yassen, K. Coboeken, S. Bailly, R. Burghaus, J. Buskova, Z. Dogas, M. Drummond, H. Gouveris, P. Joppa, J. Lippert, C. Lombardi, S. Mihaicuta, J. L. Pepin, Ding Zou, Jan A Hedner, Ludger Grote
European Respiratory Journal Open Research (ERJ Open Research) - 2022 -
Management of obstructive sleep apnea in Europe-A 10-year
follow-up
I. Fietze, N. Laharnar, P. Bargiotas, O. K. Basoglu, Z. Dogas, M. Drummond, F. Fanfulla, T. Gislason, H. Gouveris, Ludger Grote, H. Hein, P. Jennum, P. Joppa, K. van Kralingen, J. A. Kvamme, C. Lombardi, O. Ludka, W. Mallin, O. Marrone, W. T. McNicholas, S. Mihaicuta, J. Montserrat, G. Pillar, A. Pataka, W. Randerath, R. L. Riha, G. Roisman, T. Saaresranta, S. E. Schiza, P. Sliwinski, J. Svaza, P. Steiropoulos, R. Tamisier, D. Testelmans, G. Trakada, J. Verbraecken, R. Zablockis, T. Penzel
Sleep Medicine - 2022 -
Excessive Daytime Sleepiness in Obstructive Sleep Apnea Patients Treated With Continuous Positive Airway Pressure: Data From the European Sleep Apnea
Database
M. R. Bonsignore, J. L. Pepin, F. Cibella, C. D. Barbera, O. Marrone, J. Verbraecken, T. Saaresranta, O. K. Basoglu, G. Trakada, I. Bouloukaki, W. T. McNicholas, S. Bailly, A. Pataka, J. A. Kvamme, H. Hein, S. Mihaicuta, Ludger Grote, F. Fanfulla
Frontiers in Neurology - 2021 -
Beyond the AHI-pulse wave analysis during sleep for recognition of cardiovascular risk in sleep apnea
patients
Christian Strassberger, Ding Zou, T. Penzel, I. Fietze, Jan A Hedner, J. H. Ficker, W. Randerath, B. Sanner, Dirk Sommermeyer, Ludger Grote
Journal of Sleep Research - 2021 -
Superior hypertension control with betablockade in the European Sleep Apnea
Database
Sven Svedmyr, Jan A Hedner, Ding Zou, G. Parati, S. Ryan, H. Hein, J. L. Pepin, R. Tkacova, O. Marrone, S. Schiza, B. Ozen, Ludger Grote
Journal of Hypertension - 2021
More publications
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