Our primary research interest is the neurobiology of appetite with particular emphasis on understanding how food intake and feeding behavior is controlled. We are interested in disease mechanisms that lead to obesity and eating disorders.
One major focus is to determine the effects of endocrine and metabolic signals, such as ghrelin, on brain networks that control food intake. These brain networks include pathways involved in energy balance, reward and emotion.
We have active research programs that pursue the physiological brain targets for the circulating hormone, ghrelin, and to understand how the brain ghrelin signalling system may be developed as a therapeutic target. We combine classical behavioural studies with neurocircuit mapping (e.g. chemogenetics), neuroanatomy and molecular techniques with a view to better understand biological events at the level of the organism.