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Martin Dalin i ett laboratorium.
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Group Martin Dalin

Research group
Pågående forskning
Project owner
Martin Dalin

Short description

Research on liquid biopsies for evaluation of treatment response in childhood cancer.

Research summary

Circulating tumor DNA (ctDNA) is fragmented genetic material originating from dead tumor cells, that can be detected in the plasma and other body fluids of cancer patients. Analysis of ctDNA has emerged as a highly specific method to monitor tumor burden during and after oncologic treatment. The concentration of ctDNA is generally low, but recent development of genetic analysis methods has enabled measurements with increased sensitivity. In many cases, ctDNA has been found in patients with tumors too small to be detected with standard imaging modalities.

The aim of our research is to test the potential of ctDNA as a marker for treatment response and disease recurrence in pediatric oncology. This biomarker could potentially be used to optimize the treatment for each patient, and may thereby reduce the mortality and morbidity of cancer in children.

Research tools and resources

We run a translational study enrolling children treated for different typed of cancer at Sahlgrenska University Hospital. We have consecutive plasma, white blood cell and urine samples, collected before, during and after treatment, from a large number of patients. We use a range of DNA analysis techniques, including whole genome and exome sequencing as well as novel ultra-sensitive targeted mutation analysis methods.

Selected publications

  1. Circulating cell-free tumor DNA analysis in pediatric cancers. Andersson D, Fagman H, Dalin MG, Ståhlberg A. (2019) Mol Aspects Med. Sep 25. pii: S0098-2997(19)30091-3. doi: 10.1016/j.mam.2019.09.003.
     
  2. Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.
    Dalin MG, Katabi N, Persson M, Lee KW, Makarov V, Desrichard A, Walsh LA, West L, Nadeem Z, Ramaswami D, Havel JJ, Kuo F, Chadalavada K, Nanjangud GJ, Ganly I, Riaz N, Ho AL, Antonescu CR, Ghossein R, Stenman G, Chan TA, Morris LGT. (2017) Nat Commun. Oct 30;8(1):1197. doi: 10.1038/s41467-017-01178-z.
     
  3. Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer.
    Dalin MG, Desrichard A, Katabi N, Makarov V, Walsh LA, Lee KW, Wang Q, Armenia J, West L, Dogan S, Wang L, Ramaswami D, Ho AL, Ganly I, Solit DB, Berger MF, Schultz ND, Reis-Filho JS, Chan TA, Morris LG. (2016) Clin Cancer Res. Sep 15;22(18):4623-33. doi: 10.1158/1078-0432.CCR-16-0637.

More group Martin Dalin publications on PubMed

Martin Dalin
Photo: Emelie Asplund

Contact information

Martin Dalin

E-mail: Martin Dalin

Visiting address:
Sahlgrenska Center
for Cancer Research,
Medicinaregatan 1F
413 90 Gothenburg

Group Members

Mohamed Ibrahim, Senior researcher

After graduating from the pharmacy program, Mohamed received his PhD at University of Gothenburg in 2014, with the thesis “Hutchinson Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis”. After that, he has worked as a researcher in lab Martin Bergö, and is since 2015 a medical student at University of Gothenburg. As of 2019, Mohamed is a part-time senior researcher in the group.

Christin Karlsson, Senior researcher

Christin is a licensed Biomedical Analyst with a bachelor in Biomedicine, Chemistry and Data and a master in Biology and Chemistry at the University of Gothenburg. She received her PhD at the University of Gothenburg in 1997, with the thesis “Studies on mechanisms of biocompatibility elicited at blood-material interfaces.” She has several years of experience as a postdoc/researcher at the University of Gothenburg. She is now an Associate Professor at the department of Laboratory Medicine, University of Gothenburg. Since 2019, she is a part-time lab manager in the group.

Fani Pujol Calderón, Postdoc

Fani has a bachelor in Biotechnology at the Rovira i Virgili University in Tarragona, and a master in Basic and translational research in human pathologies at University of Barcelona. She received her PhD at the University of Gothenburg in 2019, with the thesis “Neurofilaments as biomarkers of neuronal damage”. As of 2020, she is a postdoc in the group, focusing mainly on experimental method development.

Ida Rahmqvist, PhD student

Ida has a bachelor in Molecular Biology and a master in Genomics and Systems Biology at University of Gothenburg. Since 2019, she is a PhD student in the group, focusing on both bioinformatics and experimental biology.

Elisabeth Mellström, PhD student

Elisabeth received her MD at the University of Perugia, Italy. She has around 14 years of experience as a pediatrician, working in Croydon University Hospital, King’s College Hospital and West Middlesex University Hospital in London, and in Centralsjukhuset, Karlstad. She is now a resident physician in pediatric oncology and hematology at Sahlgrenska University Hospital. As of 2019, Elisabeth is a part-time PhD student in the group, focusing mainly on clinical aspects of the project.

Raghda Ibrahim, Associate Researcher

Raghda has a bachelor in Dental medicine and surgery and a master in Biotechnology from the University of Alexandria, Egypt. She started in the group as a student in 2019, and in June 2020 she received a master in Molecular Genetics and Biotechnology at Lund University. Since then, she is a full-time associate researcher, focusing her work on method development and experimental research.