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- Karin Manhem
Karin Manhem
Professor Emerita
Department of Molecular and Clinical MedicineAbout Karin Manhem
Main Research
Cardivascular prevention with focus on hypertension. Registry- and cohortstudies on hypertension and related diseases.
High blood pressure (hypertension), the most significant risk factor for death worldwide according to WHO is the main focus for our research. Despite cost-effective drugs, the majority of individuals with hypertension are still not well-treated. At present we study hypertension and its complications via two large registers created within the framework of primary health care in Sweden. In the Swedish Primary Care Cardiovascular Database (SPCCD) (n = 74751, mean age 69 +/- 13 years, 56% women) individual clinical patient data from 48 medical centers in patients with high blood pressure (collected from 2001 to 2008 with follow-up to 2013) are linked to the Medical register, National Board of the patient - and the cause of death records and Statistics Sweden's population register. Another large register, QRegPV , (Primary Care in the region of Västra Götaland) has a similar structure with linkage to national registers. Our scientific questions at present include how cardiovascular morbidity in men and women with hypertension is affected by the type of treatment and achieved blood pressure. In particular we focus on the effect of hypertension and its treatment on fractures, stroke, atrial fibrillation, diabetes and metabolic disturbances. Finally we study patients with severe hypertension (resistant hypertension).
Group Members
- Kristina Bengtsson Boström, Associated professor, specialist in general practise Närhälsan Billingen vårdcentral och Närhälsan FoU primärvård FoU-centrum Skaraborg
- Per Hjerpe, PhD, specialist in general practise, Närhälsan Norrmalm Vårdcentral och Närhälsan FoU primärvård FoU-centrum Skaraborg
- Andersson Björn, Associated professor, specialist in internal medicine, chief physician Omr 6, Medklin, SU/Sahlgrenska
- Clara Hjalmarsson, PhD, specialist in internal medicine and cardiology, chief physician, Sahlgrenska Universitetssjukhuset/ VO Kardiologi
- Anna-Clara Collén, PhD, specialist in internal medicine, chief physician Med Klin SU/Östra
- Charlotta Ljungman, PhD,specialist in internal medicine and cardiology, chief physician, Kardiologen Sahlgrenska universitetssjukhuset
- Lina Holmqvist, PhD, specialist in internal medicine, Sahlgrenska Universitetssjukhuset/Sahlgrenska, Medicinkliniken
- Georgios Mourtzinis, PhD student, specialist in internal medicine and cardiology, chief physician, Sahlgrenska Universitetssjukhuset/Medicin- och akutverksamhet Mölndal
- Tove Bokrantz, PhD student, resident in general practise, Carlanderska Sjukhuset
Key Publications
- Ljungman C, Kahan T, Schiöler L, Wettermark B, Boström KB, Hasselström J, Hjerpe P, Manhem K. Non-steroidal anti-inflammatory drugs and blood pressure control in patients treated for hypertension: results from the Swedish primary care cardiovascular database. Blood Press. 13:1-9. doi: 10.1080/08037051.2017.1290503. [Epub ahead of print] (2017)
- Qvarnström M, Kahan T, Kieler H, Brandt L, Hasselström J, Boström KB, Manhem K, Hjerpe P, Wettermark B. Persistence to antihypertensive drug classes: A cohort study using the Swedish Primary Care Cardiovascular Database (SPCCD). Medicine (Baltimore). 95(40):e4908. (2016)
- Bokrantz T, Ljungman C, Kahan T, Boström KB, Hasselström J, Hjerpe P, Mellström D, Schiöler L, Manhem K. Thiazide diuretics and the risk of osteoporotic fractures in hypertensive patients. Results from the Swedish Primary Care Cardiovascular Database. J Hypertens. 35(1):188-197. (2017)
- Holmqvist L, Boström KB, Kahan T, Schiöler L, Hasselström J, Hjerpe P, Wettermark B, Manhem K. Prevalence of treatment-resistant hypertension and important associated factors-results from the Swedish Primary Care Cardiovascular Database. J Am Soc Hypertens. 10(11):838-846. doi: 10.1016/j.jash.2016.08.008. (2016)
- Thunström E, Manhem K, Yucel-Lindberg T, Rosengren A, Lindberg C, Peker Y. Neuroendocrine and Inflammatory Responses to Losartan and Continuous Positive Airway Pressure in Patients with Hypertension and Obstructive Sleep Apnea. A Randomized Controlled Trial. Ann Am Thorac Soc. 13(11):2002-2011. (2016)
- Adamsson Eryd S, Gudbjörnsdottir S, Manhem K, Rosengren A, Svensson AM, Miftaraj M, Franzén S, Björck S. Blood pressure and complications in individuals with type 2 diabetes and no previous cardiovascular disease: national population based cohort study. BMJ. 4;354:i4070. doi: 10.1136/bmj.i4070. (2016)
- Thunström E, Manhem K, Rosengren A, Peker Y. Blood Pressure Response to Losartan and Continuous Positive Airway Pressure in Hypertension and Obstructive Sleep Apnea. Am J Respir Crit Care Med. 1;193(3):310-20. doi: 10.1164/rccm.201505-0998OC. (2016)
- Collén AC, Johansson MC, Guron CW, Gustafsson H, Manhem K. Cardiac structure and function is related to current blood pressure rather than to previous hypertensive pregnancy. J Hum Hypertens. 29(11):702-4. doi: 10.1038/jhh.2015.68. (2015)
- Jansson S, Fredén Lindqvist J, Manhem K, Nilsson O, Rosén T, Herlitz H. Quiz page June 2015: a young woman with hypertension. Am J Kidney Dis. 65(6):A17-9. doi: 10.1053/j.ajkd.2015.01.027. (2015)
- Collén AC, Gustafsson H, Hellgren M, Schiöler L, Bexander L, Manhem K. Cardiovascular response to stress and perceived stress is not altered 40 years after hypertensive pregnancies. Hypertens Pregnancy. 34(1):116-24. doi: 10.3109/10641955.2014.988348. (2015)
- Ljungman C, Kahan T, Schiöler L, Hjerpe P, Hasselström J, Wettermark B, Boström KB, Manhem K. Gender differences in antihypertensive drug treatment: results from the Swedish Primary Care Cardiovascular Database (SPCCD). J Am Soc Hypertens. 8(12):882-90. doi: 10.1016/j.jash.2014.08.015. (2014)
- Ljungman C, Kahan T, Schiöler L, Hjerpe P, Wettermark B, Boström KB, Manhem K. Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database (SPCCD). J Hum Hypertens. 29(6):385-93. doi: 10.1038/jhh.2014.100. (2015)
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High blood pressure in the emergency department as an opportunistic screening tool for detection of
hypertension.
Sara Bentzel, Karin Manhem, Ottilia Öhman, Karzan Abdulla, Georgios Mourtzinis
Journal of Human Hypertension - 2025 -
Long-term secondary prevention and outcome following acute coronary syndrome: Real-world results from the Swedish Primary Care Cardiovascular Database
(SPCCD)
Sara Bentzel, Charlotta Ljungman, Per Hjerpe, Linus Schiöler, Karin Manhem, Kristina Bengtsson Boström, Thomas Kahan, Georgios Mourtzinis
European journal of preventive cardiology - 2024 -
Improving cardiovascular control in a hypertensive population in primary care. Results from a staff training
intervention
Rebecka Quester, Staffan Bjorck, Karin Manhem, Jonatan Natman, Susanne Andersson, Per Hjerpe
SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE - 2024 -
Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary
care.
Johan-Emil Bager, Karin Manhem, Tobias Andersson, Per Hjerpe, Kristina Bengtsson Boström, Charlotta Ljungman, Georgios Mourtzinis
Journal of human hypertension - 2023 -
The association between peripheral arterial disease and risk for hip fractures in elderly men is not explained by low hip bone mineral density. Results from the MrOS Sweden
study
Tove Bokrantz, Karin Manhem, Mattias Lorentzon, M. Karlsson, O. Ljunggren, Claes Ohlsson, Dan Mellström
Osteoporosis International - 2022 -
Obesity, overweight and risk for cardiovascular disease and mortality in young
women
Pigi Dikaiou, Lena Björck, Martin Adiels, Christina Lundberg, Zacharias Mandalenakis, Karin Manhem, Annika Rosengren
European Journal of Preventive Cardiology - 2021 -
Blood pressure levels and risk of haemorrhagic stroke in patients with atrial fibrillation and oral anticoagulants: results from The Swedish Primary Care Cardiovascular Database of
Skaraborg.
Johan-Emil Bager, Per Hjerpe, Linus Schiöler, Kristina Bengtsson Boström, Thomas Kahan, Helena Ödesjö, Katarina Jood, Jan Hasselström, Charlotta Ljungman, Karin Manhem, Georgios Mourtzinis
Journal of hypertension - 2021 -
Country of birth and mortality risk in hypertension with and without diabetes: the Swedish primary care cardiovascular
database.
Tobias Andersson, Miriam Pikkemaat, Linus Schiöler, Per Hjerpe, Axel C Carlsson, Per Wändell, Karin Manhem, Thomas Kahan, Kristina Bengtsson Boström
Journal of hypertension - 2021 -
Socioeconomic status affects achievement of blood pressure target in hypertension: contemporary results from the Swedish primary care cardiovascular
database.
Georgios Mourtzinis, Karin Manhem, Thomas Kahan, Linus Schiöler, Jetish Isufi, Charlotta Ljungman, Tobias Andersson, Per Hjerpe
Scandinavian journal of primary health care - 2021 -
Adherence to lipid-lowering guidelines for secondary prevention and potential reduction in CVD events in Swedish primary care: a cross-sectional
study
Helena Ödesjö, S. Bjorck, S. Franzen, Per Hjerpe, Karin Manhem, Annika Rosengren, Jörgen Thorn, Samuel Adamsson Eryd
Bmj Open - 2020 -
Antihypertensive drug classes and the risk of hip fracture: results from the Swedish primary care cardiovascular
database.
Tove Bokrantz, Linus Schiöler, Kristina Bengtsson Boström, Thomas Kahan, Dan Mellström, Charlotta Ljungman, Per Hjerpe, Jan Hasselström, Karin Manhem
Journal of hypertension - 2020 -
The impact of diabetes, education and income on mortality and cardiovascular events in hypertensive patients: A cohort study from the Swedish Primary Care Cardiovascular Database
(SPCCD).
Tobias Andersson, Miriam Pikkemaat, Linus Schiöler, Per Hjerpe, Axel C Carlsson, Per Wändell, Karin Manhem, Thomas Kahan, Jan Hasselström, Kristina Bengtsson Boström
PloS one - 2020 -
Visit patterns at primary care centres and individual blood pressure level - a cross-sectional
study
Helena Ödesjö, Samuel Adamsson Eryd, S. Franzen, Per Hjerpe, Karin Manhem, Annika Rosengren, Jörgen Thorn, S. Bjorck
Scandinavian Journal of Primary Health Care - 2019 -
Treatment of hypertension in old patients without previous cardiovascular
disease.
Johan-Emil Bager, Per Hjerpe, Karin Manhem, Staffan Björck, Stefan Franzén, Annika Rosengren, Samuel Adamsson Eryd
Journal of hypertension - 2019 -
Meta-analyses and blood pressure
goals
Karin Manhem, Annika Rosengren, Samuel Adamsson Eryd
The Journal of Clinical Hypertension - 2018 -
Links between blood pressure and medication intake, well-being, stress, physical activity and symptoms reported via a mobile phone-based self-management support system: a cohort study in primary
care
Charles Taft, Inger Hallberg, Ulrika Bengtsson, Karin Manhem, Karin I Kjellgren
BMJ Open - 2018 -
Primary aldosteronism and thyroid disorders in atrial fibrillation: A Swedish nationwide case-control
study
Georgios Mourtzinis, Samuel Adamsson Eryd, Annika Rosengren, Lena Björck, Martin Adiels, Gudmundur Johannsson, Karin Manhem
European Journal of Preventive Cardiology - 2018 -
Mortality trends and cause of death in patients with new-onset type 2 diabetes and controls: A 24-year follow-up prospective cohort
study.
Tobias Andersson, Per Hjerpe, Axel C Carlsson, Aldina Pivodic, Per Wändell, Karin Manhem, Kristina Bengtsson Boström
Diabetes research and clinical practice - 2018 -
Cardiovascular outcome in treatment-resistant hypertension: results from the Swedish Primary Care Cardiovascular Database
(SPCCD).
Lina Holmqvist, Kristina B Boström, Thomas Kahan, Linus Schiöler, Jan Hasselström, Per Hjerpe, Björn Wettermark, Karin Manhem
Journal of hypertension - 2018 -
Acute blood pressure levels and long-term outcome in ischemic
stroke.
Johan-Emil Bager, Clara Hjalmarsson, Karin Manhem, Björn Andersson
Brain and behavior - 2018 -
Relation Between Lipid Profile and New-Onset Atrial Fibrillation in Patients With Systemic Hypertension (From the Swedish Primary Care Cardiovascular Database SPCCD
)
Georgios Mourtzinis, T. Kahan, K. B. Bostrom, Linus Schiöler, L. C. Wallin, P. Hjerpe, J. Hasselstrom, Karin Manhem
American Journal of Cardiology - 2018 -
Drug adherence in treatment resistant and in controlled hypertension - Results from the Swedish Primary Care Cardiovascular Database
(SPCCD)
Lina Holmqvist, K. B. Bostrom, T. Kahan, Linus Schiöler, M. Qvarnstrom, B. Wettermark, P. Hjerpe, J. Hasselstrom, Karin Manhem
Pharmacoepidemiology and Drug Safety - 2018 -
Improved treatment and control of hypertension in Swedish primary care: results from the Swedish primary care cardiovascular
database
C. Holmquist, J. Hasselstrom, K. B. Bostrom, Karin Manhem, B. Wettermark, P. Hjerpe, T. Kahan
Journal of Hypertension - 2017 -
Aldosterone to Renin Ratio as a Screening Instrument for Primary Aldosteronism in a Middle-Aged Population with Atrial
Fibrillation.
Georgios Mourtzinis, Ahmad Ebrahimi, Helena Gustafsson, Gudmundur Johannsson, Karin Manhem
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 2017 -
Antihypertensive Control and Control and new-onset atrial fibrillation: Results from the Swedish Primary Care Cardiovascular Database
(SPCCD)
Georgios Mourtzinis, Linus Schiöler, T Kahan, Kristina Bengtsson Boström, P Hjerpe, J Hasselström, Karin Manhem
European Journal of Preventive Cardiology - 2017 -
Non-steroidal anti-inflammatory drugs and blood pressure control in patients treated for hypertension: results from the Swedish primary care cardiovascular
database.
Charlotta Ljungman, Thomas Kahan, Linus Schiöler, Björn Wettermark, Kristina B Boström, Jan Hasselström, Per Hjerpe, Karin Manhem
Blood pressure - 2017 -
Thiazide diuretics and the risk of osteoporotic fractures in hypertensive patients. Results from the Swedish Primary Care Cardiovascular
Database.
Tove Bokrantz, Charlotta Ljungman, Thomas Kahan, Kristina B Boström, Jan Hasselström, Per Hjerpe, Dan Mellström, Linus Schiöler, Karin Manhem
Journal of hypertension - 2017 -
Reply.
Tove Bokrantz, Charlotta Ljungman, Dan Mellström, Kristina Bengtsson Boström, Karin Manhem
Journal of hypertension - 2017 -
Hypertoni
Karin Manhem
Kvinnohjärtan Red: K Schenk-Gustafsson & N Johnston-Holmström - 2017 -
Persistence to antihypertensive drug classes: A cohort study using the Swedish Primary Care Cardiovascular Database
(SPCCD)
M. Qvarnstrom, T. Kahan, H. Kieler, L. Brandt, J. Hasselstrom, K. B. Bostrom, Karin Manhem, P. Hjerpe, B. Wettermark
Medicine - 2016 -
Blood Pressure Response to Losartan and CPAP in Hypertension and Obstructive Sleep
Apnea
Erik Thunström, Karin Manhem, Annika Rosengren, Yüksel Peker
American journal of respiratory and critical care medicine - 2016 -
Blood pressure and complications in individuals with type 2 diabetes and no previous cardiovascular disease: national population based cohort
study
Samuel Adamsson Eryd, Soffia Gudbjörnsdottir, Karin Manhem, Annika Rosengren, A. M. Svensson, Mervete Miftaraj, S. Franzen, S. Bjorck
Bmj-British Medical Journal - 2016 -
Neuroendocrine and Inflammatory Responses to Losartan and Continuous Positive Airway Pressure in Patients with Hypertension and Obstructive Sleep Apnea A Randomized Controlled
Trial
Erik Thunström, Karin Manhem, T. Yucel-Lindberg, Annika Rosengren, C. Lindberg, Yüksel Peker
Annals of the American Thoracic Society - 2016 -
Prevalence of treatment-resistant hypertension and important associated factors—results from the Swedish Primary Care Cardiovascular
Database
Lina Holmqvist, Kristina Bengtsson Boström, Thomas Kahan, Linus Schiöler, Jan Hasselström, Per Hjerpe, Björn Wettermark, Karin Manhem
Journal of the American Society of Hypertension - 2016 -
Cardiovascular response to stress and perceived stress is not altered 40 years after hypertensive
pregnancies
Anna-Clara Collen, Helena Gustafsson, Margareta Hellgren, Linus Schiöler, Louise Bexander, Karin Manhem
Hypertension in Pregnancy - 2015 -
7b.10: Thiazide Diuretics and Fracture-Risk among Hypertensive Patients. Results from the Swedish Primary Care Cardiovascular Database
(Spccd)
Tove Bokrantz, Charlotta Ljungman, T. Kahan, Linus Schiöler, P. Hjerpe, J. Hasselstrom, B. Wettermark, K. Bostrom, Karin Manhem
Journal of hypertension - 2015 -
7b.02: The Association between Non-Steroidal Anti-Inflammatory Drugs and Blood Pressure Control in Hypertensive Patients and the Relation to
Gender
Charlotta Ljungman, T. Kahan, Linus Schiöler, B. Wettermark, K. B. Bostrom, J. Hasselstrom, Karin Manhem
Journal of hypertension - 2015 -
Epidemiology and standard risk factors in relation to psychosocial risk factors for coronary heart
disease
Annika Rosengren, Karin Manhem
Psychosocial Stress and Cardiovascular Disease in Women: Concepts, Findings, Future Perspectives - 2015 -
Quiz page June 2015: a young woman with
hypertension.
Svante Jansson, Johan Fredén Lindqvist, Karin Manhem, Ola Nilsson, Thord Rosén, Hans Herlitz
American journal of kidney diseases : the official journal of the National Kidney Foundation - 2015 -
Cardiac structure and function is related to current blood pressure rather than to previous hypertensive
pregnancy
Anna-Clara Collen, Magnus C Johansson, Cecilia Wallentin Guron, Helena Gustafsson, Karin Manhem
Journal of Human Hypertension - 2015 -
Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database
(SPCCD)
Charlotta Ljungman, T. Kahan, Linus Schiöler, P. Hjerpe, B. Wettermark, K. B. Bostrom, Karin Manhem
Journal of Human Hypertension - 2015 -
Effect of catheter-based renal sympathetic denervation on 24-h ambulatory blood pressure in patients with resistant
hypertension.
Sebastian Völz, Bert Andersson, Karin Manhem, Inger Haraldsson, Bengt Rundqvist
Blood pressure - 2014 -
The Swedish Primary Care Cardiovascular Database (SPCCD): 74 751 hypertensive primary care
patients
J. Hasselstrom, R. Zarrinkoub, C. Holmquist, P. Hjerpe, Charlotta Ljungman, M. Qvarnstrom, B. Wettermark, Karin Manhem, T. Kahan, Kristina Bengtsson Boström
Blood Pressure - 2014 -
The role of prestroke glycemic control on severity and outcome of acute ischemic
stroke.
Clara Hjalmarsson, Karin Manhem, Lena Bokemark, Björn Andersson
Stroke Research and Treatment - 2014 -
Gender differences in antihypertensive drug treatment: results from the Swedish Primary Care Cardiovascular Database
(SPCCD).
Charlotta Ljungman, Thomas Kahan, Linus Schiöler, Per Hjerpe, Jan Hasselström, Björn Wettermark, Kristina Bengtsson Boström, Karin Manhem
Journal of the American Society of Hypertension : JASH - 2014 -
[Catheter-based renal denervation: a new method for resistant hypertension. Initial experiences of the procedure shows significant decrease in blood
pressure]
Bengt Rundqvist, S. Volz, Karin Manhem, Hans Herlitz, Inger Haraldsson, B. Andersson
Läkartidningen - 2013 -
Cardiovascular and metabolic characteristics 40 years after hypertensive pregnancies: a long-term follow-up study of
mothers.
Anna-Clara Collen, Margareta Hellgren, Helena Gustafsson, Magnus C Johansson, Karin Manhem
Journal of hypertension - 2013 -
Electrocardiographic Abnormalities and Elevated cTNT at Admission for Intracerebral Hemorrhage: Predictors for
Survival?
Clara Hjalmarsson, Lennart Bergfeldt, Lena Bokemark, Karin Manhem, Björn Andersson
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc - 2013 -
Gender differences in the prevalence of metabolic syndrome in 50-year-old Swedish men and women with hypertension born in
1953
Masuma Novak, Lena Björck, Lennart Welin, Catharina Welin, Karin Manhem, Annika Rosengren
Journal of human hypertension - 2013 -
Persistence to antihypertensive drug treatment in Swedish primary
healthcare
M. Qvarnstrom, T. Kahan, H. Kieler, L. Brandt, J. Hasselstrom, K. B. Bostrom, Karin Manhem, P. Hjerpe, B. Wettermark
European Journal of Clinical Pharmacology - 2013
More publications
We have limited the number of publications on this page. Visit GUP (The Publication Database for Gothenburg University) to find more publications.