The Wallenberg Laboratory comprises several basic and clinical research groups that focus on elucidating the mechanisms underlying obesity, cardiovascular disease and associated metabolic disorders, kidney diseases and cancer. Through extensive collaboration both within the laboratory and externally, our research teams aim to identify new strategies for the treatment and prevention of these diseases.
Our laboratory has established a number of genetically modified mice and disease models, which are used to delineate the molecular mechanisms of metabolic diseases, kidney diseases and cancer. Fredrik Bäckhed’s group has established a gnotobiotic unit housing germ-free mice, which allows us to investigate the role of the gut microbiota in obesity and related diseases. We have extensive experience working with population-based cohorts in both cross-sectional and longitudinal studies of cardiovascular and associated diseases. In addition, Annika Rosengren is renowned for her expertise in epidemiological research. Lena Carlsson’s group leads the Swedish Obese Subjects (SOS) study, which investigates the long-term effects of bariatric surgery and aims at defining criteria to identify who would benefit most from surgery. The SOS study and others form the basis of several ongoing projects to elucidate the role of the human genome and metagenome in metabolic diseases.