Our research
We conduct basic, translational and clinical research focused on cardiometabolic diseases, including obesity, cardiovascular disease, diabetes and liver disorders and cancer. Our overarching ambition is to identify the biological mechanisms that drive disease development and to translate these insights into improved prevention, diagnosis and treatment.
The research groups investigate disease processes from the molecular and cellular level through to the individual and population level. A key area of research is the interaction between the host and the microbiota, where experimental models are used to explore how gut microorganisms influence metabolism, immune function and disease development. Research also focuses on the barrier function of the intestinal mucosa and its links to inflammation and metabolism.
Integrative and data-driven research
The laboratory has a strong profile in integrative and data-driven research, using multi-omics and systems biology approaches to map cross-tissue mechanisms underlying cardiometabolic diseases. Experimental models are combined with clinical studies to identify causal mechanisms and novel therapeutic targets, including those related to adipose tissue biology, insulin resistance and metabolic complications.
In cardiovascular research, both molecular mechanisms and clinical disease trajectories are investigated, with a particular focus on lipoprotein metabolism and atherosclerosis. Research also encompasses cardiac structure and function, as well as the ways in which metabolic and inflammatory processes influence cardiovascular risk.
Register-based research and large cohorts
The laboratory also conducts extensive population-based research using large cohorts and national health registries, including SCAPIS and the Swedish Obese Subjects (SOS) study, to analyse the genetic, environmental and lifestyle-related factors that influence disease development and treatment outcomes.
By integrating experimental models, clinical studies and population data, the Wallenberg Laboratory seeks to generate mechanistically grounded insights that can contribute to the future prevention, diagnosis and treatment of cardiometabolic diseases.
Meet our researchers
Interviews with our researchers
- Karolina Sjöberg Jabbar explores the deep sea of the gut (External link)
- Muhammad Arif builds bridges between cells and data (External link)
- Antonio Molinaro works towards new treatment for a rare liver disease (External link)
- Soffia Gudbjörnsdottir advances diabetes care through register research. (External link)
- More interviews and films in Swedish (External link)