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Antiviral treatment of chronic hepatitis C and the effect on quality of life, cognitive function and cerebrospinal fluid markers of neuronal injury and inflammation.

Research project
Active research
Project owner
Institute of Biomedicine

Short description

Patients with chronic hepatitis C typically describe cognitive dysfunction and fatigue. These symptoms generally decline after successful antiviral treatment and clearance of the infection. In this study we investigate patients before and after treatment of hepatitis C using questionnairs, cognitive tests and analysis of cerebrospinal fluid for markers of neuronal injury and inflammation

Patients with chronic hepatitis C typically describe cognitive dysfunction and fatigue. These symptoms generally decline after sussessful antiviral treatment and clearance of the infection. The pathogenetic background of these symtoms is unknown. Many viral infections involves the central nervous system and for example in hiv infection may lead to cognitive dysfunction and even overt dementia. In this study we investigate patients before and after treatment of hepatitis C using questionnairs, cognitive tests and analysis of cerebrospinal fluid for markers of neuronal injury and inflammation. We also study the liver fibrosis decline during and after antiviral treatment and the impact of alcohol consumption and inflammation on noninvasive fibrosis assessment.

 

Group members

Christoffer Ruus

Gunnar Norkrans

Magnus Gisslén

 Henrik Zetterberg

Magdalena Ydreborg

Johan Westin