Research at the Memory clinic
The Gothenburg MCI study is a large, prospective, clinical study, initiated in 1999. With this study, we aim to investigate why some patients with mild cognitive impairment (MCI) develop dementia, while others do not. Another important aim is to clarify the borders and overlap between closely related dementia disorders. The Gothenburg MCI study is also the source of several substudies.
Patients aged between 50 and 79 seeking care for cognitive difficulties and diagnosed with MCI or mild dementia are included into the Gothenburg MCI study. The diagnosis of MCI or mild dementia is made using simple clinical instruments, independently of neuropsychological assessment. Patients who exhibit signs of severe concurrent psychiatric or somatic disorder are not included. All participants are examined at baseline, and after 2, 4, 6, and 10 years. Clinical and biochemical analyses of blood and cerebrospinal fluids are made at all examinations. The clinical examination consists of a systematic anamnesis with instruments designed to pick up on symptoms reported by participants and their relatives, as well as cognitive, neurological, psychiatric, and somatic status. Symptoms attributable to different brain regions are examined, as well as depressive symptoms. A comprehensive neuropsychological assessment is made at baseline, and after 2 and 6 years. Genetic analyses are carried out at baseline, MRI and SPECT at baseline and after 2 years. Healthy controls are recruited via associations for senior citizens, and go through the same procedures as the patients.
When possible, the patient meets the same staff (teams consisting of a physician, a licensed psychologist, a counselor, and a nurse) throughout the study period.
Data collection is integrated into clinical practice. This places high demands of logistics and cooperation on the people who work with the study.
To date, over 600 participants have been included, 400 have been followed up after 2 years, 200 after 4 years, 100 after 6 years, and 20 after 10 years. 150 healthy controls have been included, 70 have been followed up after 2 years, 50 after 4 years, and 30 after 6 years.