Anti-obesity treatment and the brain
Our research aims to identify and functionally define the neural circuits that inhibit food intake. Our focus is currently on long-acting GLP-1 analogues and the mechanisms behind their efficiency in reducing body weight. For this purpose, we are e.g. utilizing innovative transgenic mouse models, chemo- and optogenetics, complemented by modern histology (e.g. multiplex immunofluorescence and RNAscope). The results are expected to contribute to our fundamental understanding of how the brain controls our body weight, but also to improved future pharmacological treatment of obesity.