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- Jeremie Boucher
Jeremie Boucher
Affiliated Researcher
Department of Molecular and Clinical-
The SGLT2 inhibitor dapagliflozin promotes systemic FFA mobilization, enhances hepatic β-oxidation, and induces
ketosis
K. Wallenius, Tobias Kroon, T. Hagstedt, L. Löfgren, M. Sörhede-Winzell, Jeremie Boucher, D. Lindén, N. D. Oakes
Journal of Lipid Research - 2022 -
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of
NAFLD/NASH
Ritesh Baboota, Aidin Rawshani, Laurianne Bonnet, X. Y. Li, H. Yang, A. Mardinoglu, T. Tchkonia, J. L. Kirkland, A. Hoffmann, A. Dietrich, Jeremie Boucher, M. Bluher, Ulf Smith
Nature Metabolism - 2022 -
Of mice and men: Pinpointing species differences in adipose tissue
biology
Emma Börgeson, Jeremie Boucher, C. E. Hagberg
Frontiers in Cell and Developmental Biology - 2022 -
Chronic hyperinsulinemia promotes human hepatocyte
senescence.
Ritesh Baboota, Rosa Spinelli, Malin Erlandsson, Bruna B Brandao, Marsel Lino, Hong Yang, Adil Mardinoglu, Maria Bokarewa, Jeremie Boucher, C Ronald Kahn, Ulf Smith
Molecular metabolism - 2022 -
Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant
cultures
Matus Sotak, Meenu Rohin Rajan, Madison Clark, M. Harms, Alankrita Rani, Jamie D. Kraft, David Tandio, T. Shen, K. Borkowski, O. Fiehn, J. W. Newman, Marianne Quiding-Järbrink, Christina Biörserud, Peter Apelgren, Trude Staalesen, C. E. Hagberg, Jeremie Boucher, Ville Wallenius, Stefan Lange, Emma Börgeson
iScience - 2022 -
Cellular senescence in hepatocytes contributes to metabolic disturbances in
NASH
Laurianne Bonnet, Ida Alexandersson, Ritesh Baboota, Tobias Kroon, J. Oscarsson, Ulf Smith, Jeremie Boucher
Frontiers in Endocrinology - 2022 -
Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker
rats
Tobias Kroon, T. Hagstedt, I. Alexandersson, A. Ferm, M. Petersson, S. Maurer, B. Zarrouki, K. Wallenius, N. D. Oakes, Jeremie Boucher
Science translational medicine - 2022 -
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and
senesce
Q. Li, C. E. Hagberg, H. S. Cascales, S. Lang, M. T. Hyvonen, F. Salehzadeh, P. Chen, I. Alexandersson, E. Terezaki, M. J. Harms, M. Kutschke, N. Arifen, N. Kramer, M. Aouadi, C. Knibbe, Jeremie Boucher, A. Thorell, K. L. Spalding
Nature Medicine - 2021 -
The colorful versatility of adipocytes: white-to-brown transdifferentiation and its therapeutic potential in
man
S. Maurer, M. Harms, Jeremie Boucher
FEBS Journal - 2021 -
A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human
hepatocytes
Se Hyung Park, Robert N. Helsley, Leila Noetzli, Ho Chou Tu, Kristina Wallenius, Gavin O'Mahony, Jeremie Boucher, Jianming Liu, Samir Softic
STAR Protocols - 2021 -
A Method to Induce Brown/Beige Adipocyte Differentiation from Murine
Preadipocytes
A. L. Rocha, B. A. Guerra, Jeremie Boucher, M. A. Mori
Bio-Protocol - 2021 -
Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the
liver
Roxana Khatib Shahidi, Jenny M Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh Baboota, S. Heasman, C. Church, I. Elias, F. Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith
PLoS ONE - 2021 -
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and
therapeutics
P. Morigny, Jeremie Boucher, P. Arner, D. Langin
Nature Reviews Endocrinology - 2021 -
PPARγ and PPARα synergize to induce robust browning of white fat in
vivo
Tobias Kroon, M. Harms, S. Maurer, Laurianne Bonnet, Ida Alexandersson, A. Lindblom, A. Ahnmark, Daniel Nilsson, P. Gennemark, G. O'Mahony, V. Osinski, C. McNamara, Jeremie Boucher
Molecular Metabolism - 2020 -
An Obesogenic Dietary Mouse Model of Nonalcoholic
Steatohepatitis
B. Zarrouki, Jeremie Boucher
Kupffer Cells - 2020 -
Isolation and Culture of Human Mature Adipocytes Using Membrane Mature Adipocyte Aggregate Cultures
(MAAC)
I. Alexandersson, M. J. Harms, Jeremie Boucher
Jove-Journal of Visualized Experiments - 2020 -
BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese
mice
Jenny M Hoffmann, John Grünberg, Ann Hammarstedt, T. Kroon, Thomas U. Greiner, S. Maurer, I. Elias, Vilborg Palsdottir, F. Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith
Molecular Metabolism - 2020 -
Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA
expression
A. L. Rocha, T. I. de Lima, G. P. de Souza, R. O. Correa, D. L. Ferrucci, B. Rodrigues, C. Lopes-Ramos, Daniel Nilsson, T. L. Knittel, P. R. Castro, M. F. Fernandes, F. D. Martins, R. B. Parmigiani, L. R. Silveira, H. F. Carvalho, J. Auwerx, M. A. R. Vinolo, Jeremie Boucher, M. A. Mori
Science Advances - 2020 -
Fructose and hepatic insulin
resistance
S. Softic, K. L. Stanhope, Jeremie Boucher, S. Divanovic, M. A. Lanaspa, R. J. Johnson, C. R. Kahn
Critical Reviews in Clinical Laboratory Sciences - 2020 -
The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and Is Increased in Type 2 Diabetes and
NAFLD/NASH
Shahram Hedjazifar, Roxana Khatib Shahidi, Ann Hammarstedt, Laurianne Bonnet, C. Church, Jeremie Boucher, M. Bluher, Ulf Smith
Diabetes - 2020 -
In vivo liposomal delivery of PPAR alpha/gamma dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug
effects
V. Osinski, D. K. Bauknight, S. S. K. Dasa, M. J. Harms, T. Kroon, M. A. Marshall, J. C. Garmey, A. T. Nguyen, J. Hartman, A. Upadhye, P. Srikakulapu, A. Zhou, G. O'Mahony, A. L. Klibanov, K. A. Kelly, Jeremie Boucher, C. A. McNamara
Theranostics - 2020 -
Liver macrophages regulate systemic metabolism through non-inflammatory
factors
C. Morgantini, J. Jager, X. D. Li, L. Levi, V. Azzimato, A. Sulen, E. Barreby, C. N. Xu, M. Tencerova, E. Naslund, C. Kumar, F. Verdeguer, S. Straniero, K. Hultenby, N. K. Bjorkstrom, E. Ellis, M. Ryden, C. Kutter, T. Hurrell, V. M. Lauschke, Jeremie Boucher, A. Tomcala, G. Krejcova, A. Bajgar, M. Aouadi
Nature Metabolism - 2019 -
Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic
effects
D. K. Bauknight, V. Osinski, S. S. K. Dasa, A. T. Nguyen, M. A. Marshall, J. Hartman, M. Harms, G. O’Mahony, Jeremie Boucher, A. L. Klibanov, C. A. McNamara, K. A. Kelly
PLoS ONE - 2019 -
Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like
Adipocytes
M. J. Harms, Q. Li, S. Lee, C. Zhang, B. Kull, S. Hallen, A. Thorell, I. Alexandersson, C. E. Hagberg, X. R. Peng, A. Mardinoglu, K. L. Spalding, Jeremie Boucher
Cell Reports - 2019 -
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular
Heterogeneity
C. E. Hagberg, Q. Li, M. Kutschke, D. Bhowmick, E. Kiss, I. G. Shabalina, M. J. Harms, O. Shilkova, V. Kozina, J. Nedergaard, Jeremie Boucher, A. Thorell, K. L. Spalding
Cell Reports - 2018