Transcriptional regulation of metabolic pathways
The fat cell plays an important role in the regulation of systemic metabolism and its energy turnover changes in relation to metabolic stress such as starvation, disease (type 2 diabetes), etc. The focus of our group is to try to better understand the transcriptional regulation of metabolic pathways, including glycolysis, the TCA cycle, and oxidative phosphorylation. Our goal is to increase the understanding of how the regulation of enzyme levels, transporters of different kinds and substrate flows work to optimize metabolism. We also aim to better understand how the various organs and cell types interact by regulating different substrate flows in order for the entire organism's metabolism to function as efficiently as possible.