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Leukemia cells
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Molecular mechanisms in the development of acute myeloid leukemia

Research group

Short description

Acute myeloid leukemia (AML) is the most common form of acute leukemia and affects both children and adults and this form of leukemia is in general associated with a poor prognosis. Our project aims to reveal the mechanisms behind leukemia development and to find new treatments. For this purpose, we use both different animal models as well as cells from patients with leukemia.

Acute myeloid leukemia (AML) is the most common form of acute leukemia and affects both children and adults and this form of leukemia is in general associated with a poor prognosis. Better understanding of the mechanisms behind this form of leukemia and improved treatment are of outmost importance for the fighting of this disease.

The overall aim of our projects is to identify molecular mechanisms involved in the development of AML and find novel ways of targeting leukemic cells in patients. Pathogenic mechanisms for the development of this disease and response to different treatments are studied in different animal models but also in induced pluripotent stem cells (iPSC) were we can introduce genetic alterations of our choice. Our studies are performed on samples from patients with acute myeloid leukemia. We believe that our investigations will lead to a better understanding of the development of AML and ultimately to better treatment of patients with acute myeloid leukemia.
 

Lars Palmqvist porträtt

Group members

Ahmed Waraky, PhD, post doc

Anders Östlund, PhD student 

Laleh Arabanian, PhD, researcher

Christina Nilsson, MSc

Jenni Adamsson, MSc