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Johan Zelano
Photo: Johan Wingborg
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Johan Zelano Group

Research group
Active research
Project period
2020 - ongoing
Project owner
University of Gothenburg, Sahlgrenska University Hospital

Short description

Johan Zelano is a consultant neurologist at Sahlgrenska university hospital and assistant professor at Sahlgrenska academy, University of Gothenburg.

About Zelano Group

Johan Zelano is a consultant neurologist at Sahlgrenska university hospital and assistant professor at Sahlgrenska academy, University of Gothenburg. He is the adult epilepsy team director at Sahlgrenska university hospital. The research group belongs to the Institute of Neuroscience and Physiology, and became a part of the Wallenberg Centre for Molecular and Translational medicine in June 2020.

Research goals

The goal of the research is to improve diagnosis, treatment, and health care of persons with epilepsy, with a specific focus on epilepsy acquired in adulthood. From animal models, we know that inflammation and reorganization of brain networks are key aspects of development of epilepsy and an important aim is to identify biomarkers of these processes to allow early detection, diagnosis and in the longer run prevention.

Once epilepsy is established, there is also a need for biomarkers of seizures (treatment effect) and more information on optimal choice of antiepileptic drugs, and the impact of epilepsy on overall prognosis.

Research methods

We do clinical studies collecting blood or csf biobanks linked to clinical follow-up, epidemiological research based on national registers, and neuroimaging. The group has multiple national and international collaborations. In 2020 we plan to start a large biobank study of epilepsy in VGR (see information below)

Johan Zelano - portrait
Photo: Johan Wingborg

Contact Information

johan.zelano@neuro.gu.se

Department of Clinical Neuroscience at Institute of Neuroscience and Physiology
Box 430
405 30 Göteborg
Visiting Address: Blå Stråket 7, Plan 3, Sahlgrenska , 413 45 Göteborg

Group Members

PhD-students

David Larsson, david.gw.larsson@vgregion.se
Research area: Poststroke epilepsy

Zamzam Mahamud, zamzam.mahamud@gu.se
Research area: Epilepsy in Multiple Sclerosis

Hanna Eriksson, hanna.eriksson@gu.se
Research area: Risk factors and biomarkers for acquired epilepsy

Markus Karlander, markus.karlander@vgregion.se
Research area: Epilepsy after traumatic brain injury

Samuel Håkansson, samuel.hakansson@gu.se
Research area: AI/Machine learning for individualized epilepsy treatment

Post doc

Rakesh Banote, rakesh.banote@neuro.gu.se
Research area: Biomarkers for acquired epilepsy

Current Projects

fMRI
We evaluate the potential of resting state fMRI to identify individuals with acquired epilepsy. Recruitment is closed.

Biomarkers in focal epilepsy
In this biobank study, blood samples from individuals with and without epilepsy are analyzed for biomarkers that can indicate epilepsy and/or seizures. Recruitment is closed.

PREDICT
This VGR-region-spanning epilepsy biobank study will start in 2021 and collect blood samples and conduct yearly surveys from individuals with epilepsy. The main aims are to identify biomarkers or genetic predisposition for epilepsy or severe side effects with particular epilepsy treatments, to study access to and use of epilepsy care, and psychosocial consequences of epilepsy.

Epidemiology of acquired epilepsy
By using national health registers, we study risk factors, prognosis, and treatment of acquired epilepsy in many brain diseases.

Geographic mapping of epilepsy and seizures in Western Sweden
We map the prevalence of epilepsy and incidence of seizures in VGR, to identify underserved areas with regard to epilepsy care.

Digitization tools
We are evaluating an online platform for women with epilepsy offering patient education and therapeutic drug monitoring.

Publications

How to diagnose and treat post-stroke seizures and epilepsy
Johan Zelano, M. Holtkamp, N. Agarwal, S. Lattanzi, E. Trinka, F. Brigo
Epileptic Disorders - 2020-01-01

Reperfusion therapies and poststroke  seizures
C. Bentes, F. Brigo, Johan Zelano, J. M. Ferro
Epilepsy and Behavior - 2020-01-01

Prognosis of poststroke epilepsy
Johan Zelano
Epilepsy and Behavior - 2020-01-01

Acute symptomatic seizures and epilepsy after mechanical thrombectomy
Hanna Eriksson, Pia Löwhagen Hendén, Alexandros Rentzos, Fani Pujol-Calderón, Jan-Erik Karlsson, Kina Höglund, Kaj Blennow, Henrik Zetterberg, Lars Rosengren, Johan Zelano
Epilepsy and Behavior - 2020-01-01

Socioeconomic outcome and access to care in adults with epilepsy in Sweden: A nationwide cohort study.
Klara Andersson, Anneli Ozanne, Anna Edelvik Tranberg, John Chaplin, Kristian Bolin, Kristina Malmgren, Johan Zelano
Seizure - 2020-01-01

Prognostic impact of epilepsy in multiple sclerosis
Zamzam Mahamud, J. Burman, Johan Zelano
Multiple Sclerosis and Related Disorders - 2020-01-01

Increased risk of epilepsy in patients registered in the Swedish Dementia Registry
Johan Zelano, F. Brigo, S. Garcia-Patek
European Journal of Neurology - 2020-01-01

Family history increases the risk of late seizures after stroke
Hanna Eriksson, K. Wirdefeldt, S. Åsberg, Johan Zelano
Neurology - 2019-01-01

Neuronal antibodies in adult patients with new-onset seizures: A prospective study
Johan Zelano, Markus Axelsson, Radu Constantinescu, Clas Malmeström, E. Kumlien
Brain and Behavior - 2019-01-01

High-resolution mapping of epilepsy prevalence, ambulance use, and socioeconomic deprivation in an urban area of Sweden
Carl Magnusson, Johan Zelano
Epilepsia - 2019-01-01

The provision of epilepsy care across Europe 2017: A 17-year follow-up survey.
Johan Zelano, Judith Klecki, Jakob Christensen, Torbjörn Tomson, Kristina Malmgren
Epilepsia open - 2019-01-01

Retention rate of first antiepileptic drug in poststroke epilepsy: A nationwide study
David Larsson, S. Åsberg, E. Kumlien, Johan Zelano
Seizure - 2019-01-01

Nya reviderade klassifikationer av epilepsianfall och sjukdomstyp - Den internationella epilepsiorganisationen har även lanserat en ny klinisk definition av epilepsi.
Johan Zelano, Tommy Stödberg, Torbjörn Tomson
Lakartidningen - 2018-01-01

Randomized controlled trials of antiepileptic drugs for the treatment of post-stroke seizures: A systematic review with network meta-analysis.
F Brigo, S Lattanzi, Johan Zelano, N L Bragazzi, V Belcastro, R Nardone, E Trinka
Seizure - 2018-01-01

Treatment of epilepsy in multiple sclerosis
Ioanna Dagiasi, V. Vall, E. Kumlien, J. Burman, Johan Zelano
Seizure-European Journal of Epilepsy - 2018-01-01

Risk of epilepsy after a single seizure in multiple sclerosis.
Zamzam Mahamud, J Burman, Johan Zelano
European journal of neurology - 2018-01-01

Epilepsy in multiple sclerosis: A nationwide population-based register study.
Joachim Burman, Johan Zelano
Neurology - 2017-01-01

Pre-stroke seizures: A nationwide register-based investigation
Johan Zelano, David Larsson, E. Kumlien, S. Asberg
Seizure-European Journal of Epilepsy - 2017-01-01

Comment on Epilepsy in cerebrovascular diseases: Review of experimental and clinical data with meta-analysis of risk factors.
Johan Zelano
Epilepsia - 2017-01-01

Cause of death in patients with poststroke epilepsy: Results from a nationwide cohort study.
Julia Hansen, Signild Åsberg, Eva Kumlien, Johan Zelano
PloS one - 2017-01-01

Association between poststroke epilepsy and death: A nationwide cohort study
Johan Zelano, Petra Redfors, S. Asberg, E. Kumlien
European Stroke Journal - 2016-01-01

Eslicarbazepine acetate for the treatment of partial epilepsy.
Johan Zelano, Elinor Ben-Menachem
Expert opinion on pharmacotherapy - 2016-01-01

Treating epileptic emergencies - pharmacological advances
Johan Zelano, Elinor Ben-Menachem
Expert Opinion on Pharmacotherapy - 2016-01-01

Poststroke epilepsy: Update and future directions
Johan Zelano
Therapeutic Advances in Neurological Disorders - 2016-01-01

Axonal Regeneration after Sciatic Nerve Lesion Is Delayed but Complete in GFAP- and Vimentin-Deficient Mice.
Alexander Berg, Marcela Pekna, Johan Zelano, Ulrika Wilhelmsson, Milos Pekny, Staffan Cullheim
PloS one - 2013-01-01

Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3
A. Berg, Johan Zelano, A. Stephan, S. Thams, B. A. Barres, Milos Pekny, Marcela Pekna, S. Cullheim
Experimental Neurology - 2012-01-01

"Who´ll be the next director?" Project for better succession in clinical management
Lena Ekselius, Johan Zelano, Thomas Lindén
J Swe Med Assoc - 2010-01-01

Open Positions

There are currently no open positions, but externally funded master students and post docs are always welcome. Do contact Johan Zelano for information on potential projects.