Clinical Brain Tumor Research
Short description
Clinical Brain Tumor Research focuses on optimizing the diagnosis, treatment and care of patients with various types of brain tumors. We perform interventional, observational and epidemiological studies, and are involved in translational studies in close collaboration with basic researchers.
Summary of research
We are an interdisciplinary group that studies areas related to clinical brain tumor research with a broad focus, both in terms of area and methodology. We conduct research in all stages of patient care, from diagnostics and treatment to quality of life, mostly for different types of gliomas, but also meningioma and other tumors involving the central nervous system.
The goals of the research group are to improve the quality of life and survival for patients with brain tumors, stimulate evidence-based research and teaching in the brain tumor area, create a stimulating scientific environment in neuro-oncology and encourage interdisciplinary collaborations with basic researchers.
In addition to a close collaboration between and within GU and VGR, we collaborate with Chalmers in projects involving machine learning, as well as several other research groups, both in Sweden and abroad.
Ongoing research projects in selection:
- Supramarginal surgery in glioblastoma (https://www.supramarginaltrial.com)
- Long-term follow-up of patients with brain tumors
- Low-grade gliomas and consequences for daily life
- Liquid biopsies for tumors within the central nervous system
- Imaging analyses for diagnosis/classification, prognostication, and evaluation of treatment in patients with brain tumors
- Incidental meningiomas
- Evaluation of novel surgical techniques (in treating brain tumors)
- Biomarker and diagnostic studies in patients with brain tumors, focusing in methylation-based techniques, immunohistochemistry and proteomics
Conferences our team will present at during autumn 2023
- National brain tumor day, Stockholm, August 2023
- EANS (European Association of Neurosurgical Societies) Congress, Barcelona, September 2023
- EANO (European Association of Neuro-Oncology) Annual Meeting, Rotterdam, September 2023
- ESMO (European Society for Medical Oncology) Congress, Madrid, October 2023
- Norwegian annual neurosurgical meeting, Oslo, October 2023
- SNO (Society for Neuro-Oncology) Annual Meeting, Vancouver, November 2023
Scandinavian Neuro-oncology Group (SNOG) symposium, save the date!
The SNOG symposium will be held April 25-27, 2024 in Gothenburg at Hotel Draken, which will open in autumn 2023 in the city center. Professor Jakola is SNOG president and organizer of the upcoming meeting, and the program already contains top Nordic and international experts from basic to clinical research. Stay tuned for updates!
Group members
Principal Investigators:
Bertil Rydenhag
Asgeir Jakola
Anja Smits
Researchers:
Malin Blomstrand
Alba Corell
Tora Dunås
Anneli Ozanne
Erik Thurin
Research assistants:
Annie Andersson
Lovisa Aronsson
Anna Dénes
Doctoral students:
Hanna Barchéus
Louise Carstam
Boglarka Fekete
Tomás Gómez Vecchio
Paula Klurfan
Alice Neimantaite
Olivia Näslund
Isabelle Rydén
Pernilla Ståhl
Katja Werlenius
Preparatory studies:
Mohammad Al Masri
Dima Harba
Anna Lipatnikova
Okizeva Rapi
Collaborators
Helena Carén
Thomas Olsson Bontell
Irene Gu
Ida Häggström
Selected publications
Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma.
Ramachandran M, Vaccaro A, van de Walle T, Georganaki M, Lugano R, Vemuri K, Kourougkiaouri D, Vazaios K, Hedlund M, Tsaridou G, Uhrbom L, Pietilä I, Martikainen M, van Hooren L, Olsson Bontell T, Jakola AS, Yu D, Westermark B, Essand M, Dimberg A.Cancer Cell. 2023 Jun 12;41(6):1134-1151.e10. doi: 10.1016/j.ccell.2023.04.010. Epub 2023 May 11.PMID: 37172581
Stemness and clinical features in relation to the subventricular zone in diffuse lower-grade glioma: an exploratory study.
Corell A, Gómez Vecchio T, Ferreyra Vega S, Dénes A, Neimantaite A, Hagerius A, Barchéus H, Solheim O, Lindskog C, Bontell TO, Carén H, Jakola AS, Smits A.Neurooncol Adv. 2022 Jun 4;4(1):vdac074. doi: 10.1093/noajnl/vdac074. eCollection 2022 Jan-Dec.PMID: 35795469
Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma: A Randomized Clinical Trial.
Werlenius K, Kinhult S, Solheim TS, Magelssen H, Löfgren D, Mudaisi M, Hylin S, Bartek J Jr, Strandéus M, Lindskog M, Bahroz Rashid H, Carstam L, Gulati S, Solheim O, Bartek J, Salvesen Ø, Jakola AS. JAMA Netw Open. 2023;6(3):e234149. doi:10.1001/jamanetworkopen.2023.4149
Longitudinal DNA methylation analysis of adult-type IDH-mutant gliomas.
Ferreyra Vega S, Olsson Bontell T, Kling T, Jakola AS, Carén H. Acta Neuropathol Commun. 2023;11(1). doi:10.1186/s40478-023-01520-1
WHO Grade Loses Its Prognostic Value in Molecularly Defined Diffuse Lower-Grade Gliomas.
Carstam L, Corell A, Smits A, Dénes A, Barchéus H, Modin K, Sjögren H, Ferreyra Vega S, Bontell TO, Carén H, Jakola AS.
Front Oncol. 2022 Jan 10;11:803975. doi: 10.3389/fonc.2021.803975. eCollection 2021.
A randomized phase II trial of efficacy and safety of the immunotherapy ALECSAT as an adjunct to radiotherapy and temozolomide for newly diagnosed glioblastoma.
Werlenius K, Stragliotto G, Strandeus M, Blomstrand M, Carén H, Jakola AS, Rydenhag B, Dyregaard D, Dzhandzhugazyan KN, Kirkin AF, Raida MK, Smits A, Kinhult S.
Neurooncol Adv. 2021 Oct 22;3(1):vdab156. doi: 10.1093/noajnl/vdab156. eCollection 2021 Jan-Dec.PMID: 34765977
Reviews and guidelines
Overview and recent advances in incidental meningioma.
Näslund O, Strand PS, Skoglund T, Solheim O, Jakola AS. Expert Rev Anticancer Ther. 2023;23(4):397-406. doi:10.1080/14737140.2023.2193333
EANO - EURACAN - SNO Guidelines on circumscribed astrocytic gliomas, glioneuronal, and neuronal tumors.
Rudà R, Capper D, Waldman AD, Pallud J, Minniti G, Kaley TJ, Bouffet E, Tabatabai G, Aronica E, Jakola AS, Pfister SM, Schiff D, Lassman AB, Solomon DA, Soffietti R, Weller M, Preusser M, Idbaih A, Wen PY, van den Bent MJ.
Neuro Oncol. 2022 Dec 1;24(12):2015-2034. doi: 10.1093/neuonc/noac188.
EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood.
Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G, Bendszus M, Balana C, Chinot O, Dirven L, French P, Hegi ME, Jakola AS, Platten M, Roth P, Rudà R, Short S, Smits M, Taphoorn MJB, von Deimling A, Westphal M, Soffietti R, Reifenberger G, Wick W.
Nat Rev Clin Oncol. 2021 Mar;18(3):170-186. doi: 10.1038/s41571-020-00447-z. Epub 2020 Dec 8.PMID: 33293629
