University of Gothenburg

Studies to elucidate the binding capacities of Enterotoxigenic Escherichia coli (ETEC) colonisation factor fimbriae to human glycans

In this project we are glyco-engineering CHO-K1 cell lines to study human small intestinal glycan/ETEC CF fimbriae binding interactions. In parallel to this work, we are also using molecular docking to identify novel glycan binding sites on ETEC CF fimbriae, as well as aid our understanding of why these intestinal/ETEC CF interactions may occur.