Diagnostics
Rapid diagnostic tools is of great importance in modern healthcare and essential for correct identification of bacterial infections and effective antibiotic treatment. The global increase in antimicrobial resistance, which is leading to, what the World Health Organization calls, ‘a post-antibiotic era’, together with the lack of development in new antibiotics, has made improved diagnostics tools and protocols increasingly important.
Current methods are often based on cultivation, which is an inherently slow process. Empirical antimicrobial therapy is therefore necessary and leads to excess in mortality and over-prescription of antibiotics.
In CARe, we aim to develop novel and comprehensive molecular diagnostics tools to complement existing cultivation-based methods. The fundamental technologies used for these analyses rely on high-throughput technologies, such as next-generation sequencing (NGS) and mass spectrometry shotgun proteomics.
Research projects
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Prediction of antibiotic resistance phenotypes using the genomes of carbapenem-resistant pathogens
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Development of Tailored Antimicrobial Treatment Regimens and Novel Host-Pathogen Insights for Respiratory Tract Infections and Sepsis
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Proteomics and Genomics Diagnostics of Infection, Virulence and Anti-Microbial Resistance: Rapid Applications for Septicemia and Sepsis
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Diarrheal disease in llamas (Lama glama) in the South American Altiplano region
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Antibiotic resistance in chronic biofilm infections - Novel mechanisms and approaches to the diagnosis and treatment of periprosthetic joint infections