Rapid diagnostic tools is of great importance in modern healthcare and essential for correct identification of bacterial infections and effective antibiotic treatment. The global increase in antimicrobial resistance, which is leading to, what the World Health Organization calls, ‘a post-antibiotic era’, together with the lack of development in new antibiotics, has made improved diagnostics tools and protocols increasingly important.
Current methods are often based on cultivation, which is an inherently slow process. Empirical antimicrobial therapy is therefore necessary and leads to excess in mortality and over-prescription of antibiotics.
In CARe, we aim to develop novel and comprehensive molecular diagnostics tools to complement existing cultivation-based methods. The fundamental technologies used for these analyses rely on high-throughput technologies, such as next-generation sequencing (NGS) and mass spectrometry shotgun proteomics.