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Sam Polesie
Adjunct Senior Lecturer
Department of Dermatology and VenereologyAbout Sam Polesie
Sam Polesie (S.P.) is a consultant and an associate professor in dermatology and venereology working at the Department of Dermatology and Venereology at Sahlgrenska University Hospital. He defended his dissertation in 2019, and his PhD project was based on his own formulated question that appeared during an outpatient clinic. The question was whether methotrexate (MTX) was associated with an enhanced risk of cutaneous melanoma. The first five papers of the dissertation consisted of epidemiological studies that used health care registries from the National Board of Health and Welfare and Statistics Sweden. Overall, use of MTX was only weakly associated with risk of melanoma. The studies have contributed to an increased understanding of the risk benefit assessment of MTX, especially for patients with a history of melanoma disease, where the results showed that the patients who had previously had a melanoma and then were exposed to MTX did not have a significantly increased risk of developing a new primary melanoma.
The PhD-project has also led to a collaboration with the pharmacoepidemiological unit at the University of Southern Denmark in Odense and which used the Danish population to see if use of MTX was associated with the risk of skin cancer including melanoma. The results was published in February 2023 in British Journal of Cancer. The interest in epidemiological studies is palpable and in a recently published study S.P. and colleagues analyzed whether patients with psoriasis have an increased risk of cutaneous melanoma. The study demonstrated a minimal increase in risk for melanoma compared to matched controls without psoriasis. The investigation contributes to an increased understanding of psoriasis and associated comorbidities.
Since 2018, S.P. has conducted research revolving machine learning (ML) and artificial intelligence (AI). The work began with examining the attitudes towards artificial intelligence (AI) among dermatologists and dermatopathologists. These studies were initiated by S.P. and were conducted with international collaborators from the USA, Italy, Greece and Austria. Overall, attitudes towards AI were positive and both dermatologists and dermatopathologists saw great potential with an increased use of ML.
The ML-related research has continued by developing applications in imaging that can prove valuable for healthcare. Although melanoma is usually easy to detect, it is often more difficult to discriminate in situ melanoma from invasive melanoma preoperatively. This classification problem is important since it may affect the selection of appropriate excision margin for the first operation. S.P. and co-workers have developed an algorithm that performs at the level of dermatologists. The work has received attention in press releases and media. The work of refining and developing the algorithm further is ongoing. The aim is to find applications that have practical importance for doctors in a real-life practice.
S.P. conducts research on dermatoscopic findings that may distinguish between in situ and invasive melanomas. This research is carried out partly in collaboration with a research group in Austria. S.P. has experience in clinical studies and is a co-investigator in a prospective clinical trial that evaluates different treatment models for basal cell carcinoma.
S.P. is involved as a co-author in several projects at the Department of Dermatology and Venereology and works closely with former co-supervisor Professor John Paoli and statistician Martin Gillstedt who is the statistician and data analyst employed at our department.
During dermatology residency, S.P. worked a year at the departments of clinical genetics and clinical pathology. S.P. is interested in genetic diseases that affect the skin (genodermatoses) and has also co-authored a publication describing phenotypic traits in individuals with 12q12 duplications. Since 2021, S.P. also is also a part of the research group led by Professor Sirkku Peltonen, which will, among other things, investigate epidemiological aspects of genodermatosis in Sweden.
Overall, S.P. has a profound interest in dermatology research and is an active supervisor. Since 2020 he has supervised eight medical students in their degree project and is currently co-supervisor for six doctoral students (main supervisors John Paoli and Sirkku Peltonen) and the principal supervisor for one doctoral student.
Another major interest is to be a reviewer for scientific publications. Since 2022 S.P. works as a deputy editor for Acta Dermato-Venereologica, where he is mainly involved with manuscripts revolving "Machine learning and artificial intelligence".
More research:
- Melanoma thickness equally hard for algorithms and dermatologists to judge (Pressrelease 2022-07-20)
- Use of methotrexate is associated with an increased risk of skin cancer (Pressrelease 2023-02-07)
Web cites:
- Publication list https://pubmed.ncbi.nlm.nih.gov/?term=Polesie+S&cauthor_id=31304556
- Web of Science - https://www.webofscience.com/wos/author/record/1991370
- ORCID-ID https://orcid.org/0000-0002-5398-6200
- LinkedIn https://se.linkedin.com/in/sam-polesie-262924114
- Researchgate https://www.researchgate.net/profile/Sam-Polesie
- Acta DV https://medicaljournalssweden.se/actadv/about/editorialTeam
-
Importance of Both Clinical and Dermoscopic Findings in Predicting High-Risk Histopathological Subtype in Facial Basal Cell
Carcinomas
Hannah Ceder, Eva Johansson Backman, Ashfaq Marghoob, Cristian Navarrete-Dechent, Sam Polesie, Ofer Reiter, John Paoli
DERMATOLOGY PRACTICAL & CONCEPTUAL - 2024 -
Evaluation of an artificial intelligence-based decision support for the detection of cutaneous melanoma in primary care: a prospective real-life clinical
trial
Panagiotis Papachristou, My Soderholm, Jon Pallon, Marina Taloyan, Sam Polesie, John Paoli, Chris D. Anderson, Magnus Falk
BRITISH JOURNAL OF DERMATOLOGY - 2024 -
Persistence of advanced systemic pharmacological treatment of moderate-to-severe psoriasis among bio-naive patients-A retrospective register-based cohort study in Finland and
Sweden
G. Tskhvarashvili, K. Aher, I. Sveide, U. Katus, A. Westerlund, F. Hoti, C. Wennerstrom, F. Hassan, J. Lee, C. Hermanrud, I. Johnsson, A. Passey, R. Nissinen, Sam Polesie, T. Malkonen, L. Saarelainen
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY - 2024 -
A systematic review investigating the proportion of clinical images shared in prospective randomized controlled trials involving patients with atopic dermatitis and systemic
pharmacotherapy
Sam Polesie, Mikael Alsterholm
Journal of dermatological treatment - 2024 -
Bör individualiserad utbildning för läkarstudenter
eftersträvas?
Jenny Lindberg, Sam Polesie, Marit Karlsson, Erik Malmqvist, Goran Mijaljica
Läkartidningen - 2024 -
Incidence and Prevalence of 73 Different Genodermatoses: A Nationwide Study in
Sweden
Theofanis Zagoras, Rahime Inci, Despoina Kantere, Peter Holmström, Jenny Broström, Martin Gillstedt, Sam Polesie, Sirkku Peltonen
Acta Dermato-Venereologica - 2023 -
A systematic review investigating at what proportion clinical images are shared in prospective randomized controlled trials involving patients with psoriasis and biological
agents.
Sam Polesie, Farzad Alinaghi, Alexander Egeberg
The Journal of dermatological treatment - 2023 -
Use of methotrexate and risk of skin cancer: a nationwide case-control
study.
Sam Polesie, Martin Gillstedt, Sigrún Alba Jóhannesdóttir Schmidt, Alexander Egeberg, Anton Pottegård, Kasper Kristensen
British journal of cancer - 2023 -
Attitudes Towards Artificial Intelligence Among Dermatologists Working in Saudi
Arabia.
Fatima Al-Ali, Sam Polesie, John Paoli, Mohammed Aljasser, Louai A Salah
Dermatology practical & conceptual - 2023 -
How Does a Convolutional Neural Network Trained to Differentiate between Invasive Melanoma and Melanoma In situ Generalize when Assessing Dysplastic
Naevi?
Martin Gillstedt, Klara Segerholm, Ludwig Mannius, John Paoli, Sam Polesie
Acta dermato-venereologica - 2023 -
Use of Large Language Models: Editorial
Comments.
Sam Polesie, Olle Larkö
Acta dermato-venereologica - 2023 -
Curettage plus one or two cycles of cryosurgery for basal cell carcinoma with clinically nodular features: A prospective randomized controlled
trial.
Eva Johansson Backman, Sam Polesie, Martin Gillstedt, Alexandra Sjöholm Hylén, Azad Nerwey, John Paoli
Journal of the American Academy of Dermatology - 2023 -
Etik på nya läkarprogrammet – nationell målbeskrivning
föreslås
Sam Polesie, Jenny Lindberg, Saima Diderichsen, Ulrik Kihlbom, Niklas Juth, Marit Karlsson, Erik Malmqvist, Goran Mijaljica, Jessica Nihlén Fahlquist, Lars Sandman, David Sundemo, Helena Walfridsson
Läkartidningen - 2023 -
Dermoscopic Findings in Intraepidermal Carcinoma: an Interobserver Agreement
Study
Julia Fougelberg, Alfred Luong, J. Bowling, A. Chamberlain, A. Lallas, A. Marghoob, Sam Polesie, G. Salerni, M. Tanaka, Oscar Zaar, I. Zalaudek, Magdalena Claeson, John Paoli
Dermatology Practical & Conceptual - 2023 -
Evaluation of Melanoma Thickness with Clinical Close-up and Dermoscopic Images Using a Convolutional Neural
Network
Martin Gillstedt, Ludwig Mannius, John Paoli, Johan Dahlén Gyllencreutz, Julia Fougelberg, Eva Johansson Backman, Jenna Pakka, Oscar Zaar, Sam Polesie
Acta dermato-venereologica - 2022 -
Psoriasis and risk of cutaneous melanoma: A retrospective, comparative, registry-based cohort
study.
Sam Polesie, Martin Gillstedt
Journal of the American Academy of Dermatology - 2022 -
Discrimination between invasive and in situ melanomas using a convolutional neural
network.
Martin Gillstedt, John Paoli, Sam Polesie
Journal of the American Academy of Dermatology - 2022 -
Iridescent Changes Observed During Dynamic Cross-polarized
Dermoscopy.
John Paoli, Lykke Barck, Eva Johansson Backman, Ashfaq Marghoob, Sam Polesie
Dermatology practical & conceptual - 2022 -
Curettage vs. cryosurgery for superficial basal cell carcinoma: a prospective, randomised and controlled
trial.
Eva Johansson Backman, Sam Polesie, Sofia Berglund, Martin Gillstedt, Alexandra Sjöholm Hylén, Maja Modin, John Paoli
Journal of the European Academy of Dermatology and Venereology : JEADV - 2022 -
Assessment of melanoma thickness based on dermoscopy images: an open, web-based, international, diagnostic
study
Sam Polesie, Martin Gillstedt, H. Kittler, C. Rinner, P. Tschandl, John Paoli
Journal of the European Academy of Dermatology and Venereology - 2022 -
Hyperspectral Imaging for Non-invasive Diagnostics of Melanocytic
Lesions.
John Paoli, Ilkka Pölönen, Mari Salmivuori, Janne Räsänen, Oscar Zaar, Sam Polesie, Sari Koskenmies, Sari Pitkänen, Meri Övermark, Kirsi Isoherranen, Susanna Juteau, Annamari Ranki, Mari Grönroos, Noora Neittaanmäki
Acta dermato-venereologica - 2022 -
Ability to Predict Melanoma Within 5 Years Using Registry Data and a Convolutional Neural Network: A Proof of Concept
Study
Martin Gillstedt, Sam Polesie
Acta Dermato-Venereologica - 2022 -
Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with
Psoriasis.
Maria Siekkeri Vandikas, Kerstin Landin-Wilhelmsen, Sam Polesie, Martin Gillstedt, Amra Osmancevic
Acta dermato-venereologica - 2021 -
Dermoscopy of porokeratosis: results from a multicentre study of the International Dermoscopy
Society
Oscar Zaar, Sam Polesie, C. Navarrete-Dechent, E. Errichetti, B. N. Akay, J. Jaimes, H. Cabo, E. C. Sabban, John Paoli
Journal of the European Academy of Dermatology and Venereology - 2021 -
Tinea Capitis Caused by Microsporum audouinii: Lessons from a Swedish Community
Outbreak.
Sara Calander, Ditte M L Saunte, Sam Polesie
Acta dermato-venereologica - 2021 -
Frequency of Publication of Dermoscopic Images in Inter-observer Studies: A Systematic
Review
Sam Polesie, Oscar Zaar
Acta dermato-venereologica - 2021 -
Methotrexate Use for Patients with Psoriasis and Risk of Cutaneous Squamous Cell Carcinoma: A Nested Case-control
Study.
Filippos Giannopoulos, Martin Gillstedt, Marta Laskowski, Kasper Bruun Kristensen, Sam Polesie
Acta dermato-venereologica - 2021 -
Discrimination Between Invasive and In Situ Melanomas Using Clinical Close-Up Images and a De Novo Convolutional Neural
Network
Sam Polesie, Martin Gillstedt, Gustav Ahlgren, Hannah Ceder, Johan Dahlén Gyllencreutz, Julia Fougelberg, Eva Johansson Backman, Jenna Pakka, Oscar Zaar, John Paoli
Frontiers in Medicine - 2021 -
Interobserver Agreement on Dermoscopic Features and their Associations with In Situ and Invasive Cutaneous
Melanomas.
Sam Polesie, Lisa Sundback, Martin Gillstedt, Hannah Ceder, Johan Dahlén Gyllencreutz, Julia Fougelberg, Eva Johansson Backman, Jenna Pakka, Oscar Zaar, John Paoli
Acta dermato-venereologica - 2021 -
Can Dermoscopy Be Used to Predict if a Melanoma Is In Situ or
Invasive?
Sam Polesie, Edvin Jergéus, Martin Gillstedt, Hannah Ceder, Johan Dahlén Gyllencreutz, Julia Fougelberg, Eva Johansson Backman, Jenna Pakka, Oscar Zaar, John Paoli
Dermatology Practical & Conceptual - 2021 -
Variable neurodevelopmental and morphological phenotypes of carriers with 12q12
duplications
L. Myers, M. Blyth, K. Moradkhani, D. Hranilovic, Sam Polesie, J. Isaksson, A. Nordgren, M. Bucan, M. Vincent, S. Bolte, B. M. Anderlid, K. Tammimies
Molecular Genetics & Genomic Medicine - 2020 -
Evaluation of the Diagnostic Accuracy of an Online Artificial Intelligence Application for Skin Disease
Diagnosis.
Oscar Zaar, Alexander Larson, Sam Polesie, Karim Saleh, Mikael Tarstedt, Antonio Olives, Andrea Suárez, Martin Gillstedt, Noora Neittaanmäki
Acta dermato-venereologica - 2020 -
Attitudes towards artificial intelligence within dermatology: an international online
survey.
Sam Polesie, Martin Gillstedt, H Kittler, A Lallas, P Tschandl, I Zalaudek, John Paoli
The British journal of dermatology - 2020 -
Attitudes Toward Artificial Intelligence Within Dermatopathology: An International Online
Survey.
Sam Polesie, Phillip H McKee, Jerad M Gardner, Martin Gillstedt, Jan Siarov, Noora Neittaanmäki, John Paoli
Frontiers in medicine - 2020 -
Methotrexate treatment for patients with psoriasis and risk of cutaneous melanoma: a nested case-control
study
Sam Polesie, Martin Gillstedt, John Paoli, Amra Osmancevic
British Journal of Dermatology - 2020 -
Methotrexate and melanoma-specific
mortality.
Sam Polesie, Martin Gillstedt, John Paoli, Amra Osmancevic
Journal of the European Academy of Dermatology and Venereology : JEADV - 2019 -
Nonsurgical Options for the Treatment of Basal Cell
Carcinoma.
John Paoli, Johan Dahlén Gyllencreutz, Julia Fougelberg, Eva Johansson Backman, Maja Modin, Sam Polesie, Oscar Zaar
Dermatology practical & conceptual - 2019 -
Methotrexate and Risk of Cutaneous
Melanoma
Sam Polesie
2019 -
Dermoscopic Features of Melanomas in Organ Transplant
Recipients.
Sam Polesie, Martin Gillstedt, Oscar Zaar, Amra Osmancevic, John Paoli
Acta Dermato-Venereologica - 2019 -
Methotrexate Exposure and Risk of Cutaneous Malignant Melanoma: No Evidence of a Dose-response
Relationship
Sam Polesie, Martin Gillstedt, John Paoli, Amra Osmancevic
Acta Dermato-Venereologica - 2018 -
Methotrexate treatment in patients with a history of cutaneous melanoma and the risk of a consecutive primary melanoma: A national retrospective registry-based cohort
study
Sam Polesie, Martin Gillstedt, John Paoli, Amra Osmancevic
Journal of the American Academy of Dermatology - 2017 -
Methotrexate Treatment and Risk for Cutaneous Malignant Melanoma - a Retrospective Comparative Registry-based Cohort
Study.
Sam Polesie, Martin Gillstedt, Henrik H. Sönnergren, Amra Osmancevic, John Paoli
The British journal of dermatology - 2017 -
Waxing and Waning Bullous Hand Lesions: A
Quiz.
Sam Polesie, Maja Modin
Acta dermato-venereologica - 2017 -
Clinical Outcomes of Punch-grafting for Chronic Leg and Foot Ulcers: A Retrospective Non-comparative Cohort
Study.
Lisa Groening, Livia Dunér Holthuis, Sam Polesie, Henrik H. Sönnergren
Acta dermato-venereologica - 2017 -
Secukinumab in the Treatment of Generalized Pustular Psoriasis: A Case
report.
Sam Polesie, Anette Gente-Lidholm
Acta dermato-venereologica - 2017 -
Bacteria Aerosol Spread and Wound Bacteria Reduction with Different Methods for Wound Debridement in an Animal
Model.
Henrik H. Sönnergren, Sam Polesie, Louise Strömbeck, Frank Aldenborg, Bengt R Johansson, Jan Faergemann
Acta dermato-venereologica - 2015 -
Unchanging incidence of hip fracture in southeastern
norway.
Sam Polesie, Ulf Sigurdsen, Kristian Bjørgul
Geriatric orthopaedic surgery & rehabilitation - 2013 -
Lipid droplets interact with mitochondria using
SNAP23.
Sara Jägerström, Sam Polesie, Ylva Wickström, Bengt R Johansson, Henrik D Schröder, Kurt Højlund, Pontus Boström
Cell biology international - 2009