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Pär Matsson
Professor
Department ofAbout Pär Matsson
Research in the Matsson group
Our research aims to clarify molecular and cellular mechanisms of drug disposition through a combination of wet-lab experiments and computational modeling and simulation. We particularly focus on disposition mechanisms and intracellular exposure of new drug modalities, and development of methodologies to study this in vitro and in silico.
Projects
- Intracellular drug exposure
- Pharmacokinetics of non-traditional drug classes
- Membrane transporters in drug disposition
- Computational drug disposition modeling
Research group
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Membrane transporters in drug development and as determinants of precision
medicine
Aleksandra Galetin, Kim L. R. Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjostedt, Lauren Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J. Hafey, Yurong Lai, Pär Matsson, Andrew Riselli, Hong Shen, Alex Sparreboom, Manthena V. S. Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J. Zamek-Gliszczynski, Lei Zhang, Kathleen M. Giacomini
NATURE REVIEWS DRUG DISCOVERY - 2024 -
Challenges in Permeability Assessment for Oral Drug Product
Development
M. Koziolek, P. Augustijns, C. Berger, R. Cristofoletti, D. Dahlgren, J. Keemink, Pär Matsson, F. McCartney, M. Metzger, M. Mezler, J. Niessen, J. E. Polli, M. Vertzoni, W. Weitschies, J. Dressman
Pharmaceutics - 2023 -
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3,
OCT3
E. C. Chen, Pär Matsson, M. Azimi, X. Zhou, N. Handin, S. W. Yee, P. Artursson, K. M. Giacomini
Pharmaceutical Research - 2022 -
New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook from the International Transporter
Consortium
K. M. Giacomini, S. W. Yee, M. L. Koleske, L. Zou, Pär Matsson, E. C. Chen, D. L. Kroetz, M. A. Miller, E. Gozalpour, X. Y. Chu
Clinical Pharmacology & Therapeutics - 2022 -
CHAPTER 6: OATs and OCTs: The SLC22 Family of Organic Anion and Cation
Transporters
Pär Matsson, M. Karlgren
The Medicinal Chemist’s Guide to Solving ADMET Challenges. Patrick Schnider (red.) - 2021 -
CHAPTER 7: OATPs: The SLCO Family of Organic Anion Transporting Polypeptide
Transporters
M. Karlgren, Pär Matsson
The Medicinal Chemist’s Guide to Solving ADMET Challenges. Patrick Schnider (red.) - 2021 -
Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and
OAT3
L. Zou, Pär Matsson, A. Stecula, H. X. Ngo, A. A. Zur, K. M. Giacomini
Journal of Pharmaceutical Sciences - 2021 -
A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction
(fu,cell)
A. Treyer, S. Walday, H. Boriss, Pär Matsson, P. Artursson
Pharm Res - 2019 -
Intracellular Drug Bioavailability: Effect of Neutral Lipids and
Phospholipids
A. Treyer, A. Mateus, J. R. Wisniewski, H. Boriss, Pär Matsson, P. Artursson
Mol Pharm - 2018 -
Molecular Modeling of Drug-Transporter Interactions-An International Transporter Consortium
Perspective
A. Schlessinger, M. A. Welch, H. van Vlijmen, K. Korzekwa, P. W. Swaan, Pär Matsson
Clin Pharmacol Ther - 2018 -
Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of
5
M. Rossi Sebastiano, B. C. Doak, M. Backlund, V. Poongavanam, B. Over, G. Ermondi, G. Caron, Pär Matsson, J. Kihlberg
J Med Chem - 2018 -
Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling
Approaches
Y. Guo, X. Chu, N. J. Parrott, K. L. R. Brouwer, V. Hsu, S. Nagar, Pär Matsson, P. Sharma, J. Snoeys, Y. Sugiyama, D. Tatosian, J. D. Unadkat, S. M. Huang, A. Galetin
Clin Pharmacol Ther - 2018 -
Erratum: Structural and conformational determinants of macrocycle cell
permeability
B. Over, Pär Matsson, C. Tyrchan, P. Artursson, B. C. Doak, M. A. Foley, C. Hilgendorf, S. E. Johnston, M. D. th Lee, R. J. Lewis, P. McCarren, G. Muncipinto, U. Norinder, M. W. D. Perry, J. R. Duvall, J. Kihlberg
Nat Chem Biol - 2017 -
How Big Is Too Big for Cell
Permeability?
Pär Matsson, J. Kihlberg
J Med Chem - 2017 -
Intracellular drug bioavailability: a new predictor of system dependent drug
disposition
A. Mateus, A. Treyer, C. Wegler, M. Karlgren, Pär Matsson, P. Artursson
Sci Rep - 2017 -
Prediction of intracellular exposure bridges the gap between target- and cell-based drug
discovery
A. Mateus, L. J. Gordon, G. J. Wayne, H. Almqvist, H. Axelsson, B. Seashore-Ludlow, A. Treyer, Pär Matsson, T. Lundback, A. West, M. M. Hann, P. Artursson
Proc Natl Acad Sci U S A - 2017 -
Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by
CRISPR-Cas9
I. Simoff, M. Karlgren, M. Backlund, A. C. Lindstrom, F. Z. Gaugaz, Pär Matsson, P. Artursson
J Pharm Sci - 2016 -
Structural and conformational determinants of macrocycle cell
permeability
B. Over, Pär Matsson, C. Tyrchan, P. Artursson, B. C. Doak, M. A. Foley, C. Hilgendorf, S. E. Johnston, M. D. th Lee, R. J. Lewis, P. McCarren, G. Muncipinto, U. Norinder, M. W. Perry, J. R. Duvall, J. Kihlberg
Nat Chem Biol - 2016 -
The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug
Disposition
M. Olander, J. R. Wisniewski, Pär Matsson, P. Lundquist, P. Artursson
J Pharm Sci - 2016 -
The Need for Speed-Kinetic Limits of Drug
Transporters
Pär Matsson, P. Lundquist, P. Artursson
Trends Pharmacol Sci - 2016 -
Cell permeability beyond the rule of
5
Pär Matsson, B. C. Doak, B. Over, J. Kihlberg
Adv Drug Deliv Rev - 2016 -
Quantifying the impact of transporters on cellular drug
permeability
Pär Matsson, L. A. Fenu, P. Lundquist, J. R. Wisniewski, M. Kansy, P. Artursson
Trends Pharmacol Sci - 2015 -
Addendum to 'Quantifying the impact of transporters on cellular drug
permeability'
Pär Matsson, L. A. Fenu, P. Lundquist, J. R. Wisniewski, M. Kansy, P. Artursson
Trends Pharmacol Sci - 2015 -
Computational modeling to predict the functions and impact of drug
transporters
Pär Matsson, C. A. Bergstrom
In Silico Pharmacol - 2015 -
Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical
properties
B. Over, P. McCarren, P. Artursson, M. Foley, F. Giordanetto, G. Gronberg, C. Hilgendorf, M. D. th Lee, Pär Matsson, G. Muncipinto, M. Pellisson, M. W. Perry, R. Svensson, J. R. Duvall, J. Kihlberg
J Med Chem - 2014 -
A high-throughput cell-based method to predict the unbound drug fraction in the
brain
A. Mateus, Pär Matsson, P. Artursson
J Med Chem - 2014 -
Intracellular drug concentrations and transporters: measurement, modeling, and implications for the
liver
X. Chu, K. Korzekwa, R. Elsby, K. Fenner, A. Galetin, Y. Lai, Pär Matsson, A. Moss, S. Nagar, G. R. Rosania, J. P. Bai, J. W. Polli, Y. Sugiyama, K. L. Brouwer
Clin Pharmacol Ther - 2013 -
Computational prospecting for drug-transporter
interactions
Pär Matsson, P. Artursson
Clin Pharmacol Ther - 2013 -
Early identification of clinically relevant drug interactions with the human bile salt export pump
(BSEP/ABCB11)
J. M. Pedersen, Pär Matsson, C. A. Bergstrom, J. Hoogstraate, A. Noren, E. L. LeCluyse, P. Artursson
Toxicol Sci - 2013 -
Rapid measurement of intracellular unbound drug
concentrations
A. Mateus, Pär Matsson, P. Artursson
Mol Pharm - 2013 -
Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait
mapping
Pär Matsson, S. W. Yee, S. Markova, K. Morrissey, G. Jenkins, J. Xuan, E. Jorgenson, D. L. Kroetz, K. M. Giacomini
Pharmacogenomics J - 2012 -
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter
2
Y. Kido, Pär Matsson, K. M. Giacomini
J Med Chem - 2011 -
Understanding polymer-lipid solid dispersions--the properties of incorporated lipids govern the crystallisation behaviour of
PEG
J. Unga, Pär Matsson, D. Mahlin
Int J Pharm - 2010 -
Comparison of human solute
carriers
A. Schlessinger, Pär Matsson, J. E. Shima, U. Pieper, S. W. Yee, L. Kelly, L. Apeltsin, R. M. Stroud, T. E. Ferrin, K. M. Giacomini, A. Sali
Protein Sci - 2010 -
Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered
drugs
Pär Matsson, J. M. Pedersen, U. Norinder, C. A. Bergstrom, P. Artursson
Pharm Res - 2009 -
Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict
variation
S. E. Hesselson, Pär Matsson, J. E. Shima, H. Fukushima, S. W. Yee, Y. Kobayashi, J. M. Gow, C. Ha, B. Ma, A. Poon, S. J. Johns, D. Stryke, R. A. Castro, H. Tahara, J. H. Choi, L. Chen, N. Picard, E. Sjodin, M. J. Roelofs, T. E. Ferrin, R. Myers, D. L. Kroetz, P. Y. Kwok, K. M. Giacomini
PLoS One - 2009 -
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2;
ABCC2)
J. M. Pedersen, Pär Matsson, C. A. Bergstrom, U. Norinder, J. Hoogstraate, P. Artursson
J Med Chem - 2008 -
Structural requirements for drug inhibition of the liver specific human organic cation transport protein
1
G. Ahlin, J. Karlsson, J. M. Pedersen, L. Gustavsson, R. Larsson, Pär Matsson, U. Norinder, C. A. Bergstrom, P. Artursson
J Med Chem - 2008 -
A global drug inhibition pattern for the human ATP-binding cassette transporter breast cancer resistance protein
(ABCG2)
Pär Matsson, G. Englund, G. Ahlin, C. A. Bergstrom, U. Norinder, P. Artursson
J Pharmacol Exp Ther - 2007 -
Exploring the role of different drug transport routes in permeability
screening
Pär Matsson, C. A. Bergstrom, N. Nagahara, S. Tavelin, U. Norinder, P. Artursson
J Med Chem - 2005