New biomaterials-a clinical improvement or an increased risk?
Hip and knee joint replacements are treatment with a very high cost-benefit through the increase in patient mobility and increased quality of life, after a successful surgery. The materials that are being used in the clinic for this purpose are not always fully evaluated from all aspects, and theoretically side effects could therefore arise. A common material used in in hip/knee arthroplasty is Zirconia (ZrO2) also used in dental implant treatment. In the area of disc regeneration and oral surgery, PEEK is often used, which has worked satisfactorily clinically, but without the material having been tested for possible side effects. Results from published in vivo analyzes performed within our research group indicate that PEEK induces strong immunological reaction and that fat cell degeneration occurred during a 28-day test period.
Oral implants, similarly to hip and knee implants, have provided good long-term clinical results, but factors related to the patient, treating team, and implant can affect the degree of bone loss around the implants and the frequency of implant loss over time. One contributing factor to complications can be particle release from the implant structures. In particular, Zirconia in contact with titanium appears to be able to give rise to large particle release due to wear during load. An additional risk is that the use of new implant materials such as Zirconia with different hardness and titanium/zirconia (TiZr) alloys increases, even though there is too little knowledge about their clinical effects after a longer follow-up period.
The project studies clinical effects of oral biomaterials materials. Specifically, cellular, immunological and molecular response to new prosthetic materials and combinations of materials.
Material och Metod
Retrospective studies of the clinical outcome when using new implant and prostheses materials. Also we aim to investigate the molecular and immunological response in the peri-implant soft tissue around implants with abutment of zirconia or titanium/zirconium as compared to titanium. The presence of wear particles in the tissues will be analyzed as well as molecular analyses of the immunological and inflammatory expression using quantitative real-time PCR, scanning electron microscopy (SEM), x-ray photoelectron spectroscopy (XPS).