Skip to main content

Mechanism of action of Carbapenemases, and development of inhibitors against these

Research project
Active research
Project owner
Prof Leif A. Eriksson (PI), Prof Johan Gottfries and Sonali Chavan (PhD student), Dep. of Chemistry and Molecular Biology at GU.

Swedish Research Council and CARe

Short description

In this project we investigate by means of high-level QM/MM-methodology, the mechanism of action of carbapenemases, and in particular KPC-2, towards representative compounds from the different classes of beta-lactam antibiotics to better understand detailed structural and electronic features.