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University of Gothenburg
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Virulence inhibitors for the treatment of soft tissue infections

The overall objective is to present an alternative treatment to antibiotics for wound management. This novel strategy is based on the inhibition of bacterial signalling (quorum sensing, QS), which controls bacterial virulence (toxicity) and resistance to immune cells. This approach would render bacteria incapable of establishing infection or disarm an established biofilm with low risk for resistance.