Astrid von Mentzer
About Astrid von Mentzer
Enterotoxigenic Escherichia coli (ETEC) is a bacterial pathogen which causes diarrheal illness in low-income countries lacking access to clean water and fundamental sanitation. ETEC is one of the major causes of diarrhea in developing countries and, consequently deaths among both children and adults.
My research project involves both genomic analyses and experimental methods to study this highly variable pathogen. Using genomics I study the population structure of ETEC and investigate how pathogenic ETEC strains may arise and are spread. In addition, using sequencing I investigate both known and novel virulence factors, mainly proteins involved in attachment of the bacteria to the human intestine, which can be used as a basis for future vaccine research. Two approaches to identify and characterize novel adhesive proteins using both genomics and experimental methods as been developed.
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Long-read-sequenced reference genomes of the seven major lineages of enterotoxigenic Escherichia coli (ETEC) circulating in modern
time
Astrid von Mentzer, G. A. Blackwell, D. Pickard, C. J. Boinett, E. Joffre, A. J. Page, Ann-Mari Svennerholm, G. Dougan, A. Sjoling
Scientific Reports - 2021 -
Colonization factor CS30 from enterotoxigenic Escherichia coli binds to sulfatide in human and porcine small
intestine
Astrid von Mentzer, Dani Zalem, Zofia Chrienova, Susann Teneberg
Virulence - 2020 -
Phenotypic and genomic analyses of bacteriophages targeting environmental and clinical CS3-expressing enterotoxigenic Escherichia coli (ETEC)
strains
S. Chakraborty, Astrid von Mentzer, Y. A. Begum, M. Manzur, M. Hasan, A. N. Ghosh, M. A. Hossein, A. Camilli, F. Qadri
PLoS ONE - 2018 -
An untypeable enterotoxigenic Escherichia coli represents one of the dominant types causing human
disease
Atsushi Iguchi, Astrid von Mentzer, Taisei Kikuchi, Nicholas R. Thomson
Microbial Genomics - 2017 -
Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli
(ETEC)
Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, M. Aslett, G. Dougan, A. Sjoling, Ann-Mari Svennerholm
Scientific Reports - 2017 -
Identification of new heat-stable (STa) enterotoxin allele variants produced by human enterotoxigenic Escherichia coli
(ETEC)
Enrique Joffre, Astrid von Mentzer, Ann-Mari Svennerholm, A. Sjoling
International Journal of Medical Microbiology - 2016 -
Whole Genome Sequencing of Enterotoxigenic Escherichia
coli
Astrid von Mentzer
2016 -
Stability of the Encoding Plasmids and Surface Expression of CS6 Differs in Enterotoxigenic Escherichia coli (ETEC) Encoding Different Heat-Stable (ST) Enterotoxins (STh and
STp)
Joshua Tobias, Astrid von Mentzer, Patricia Loayza Frykberg, M. Aslett, A. J. Page, Åsa Sjöling, Ann-Mari Svennerholm
Plos One - 2016 -
Treg-cell depletion promotes chemokine production and accumulation of CXCR3(+) conventional T cells in intestinal
tumors.
Paulina Akeus, Veronica Langenes, Jonas Kristensen, Astrid von Mentzer, Tim Sparwasser, Sukanya Raghavan, Marianne Quiding-Järbrink
European journal of immunology - 2015 -
Allele Variants of Enterotoxigenic Escherichia coli Heat-Labile Toxin Are Globally Transmitted and Associated with Colonization
Factors
Enrique Joffre, Astrid von Mentzer, M. Abd El Ghany, N. Oezguen, T. Savidge, G. Dougan, Ann-Mari Svennerholm, Åsa Sjöling
Journal of Bacteriology - 2015 -
Implications of enterotoxigenic Escherichia coli genomics for vaccine
development
Åsa Sjöling, Astrid von Mentzer, Ann-Mari Svennerholm
Expert Review of Vaccines - 2015 -
Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global
distribution
Astrid von Mentzer, T. R. Connor, L. H. Wieler, T. Semmler, A. Iguchi, N. R. Thomson, D. A. Rasko, Enrique Joffre, J. Corander, D. Pickard, Gudrun Wiklund, Ann-Mari Svennerholm, Åsa Sjöling, G. Dougan
Nature Genetics - 2014 -
Altered chemokine production and accumulation of regulatory T cells in intestinal adenomas of APC(Min/+)
mice.
Paulina Akeus, Veronica Langenes, Astrid von Mentzer, Ulf Yrlid, Åsa Sjöling, Pushpa Saksena, Sukanya Raghavan, Marianne Quiding-Järbrink
Cancer immunology, immunotherapy : CII - 2014 -
Expression of colonization factor CS5 of enterotoxigenic Escherichia coli (ETEC) is enhanced in vivo and by the bile component Na glycocholate
hydrate.
Matilda Nicklasson, Åsa Sjöling, Astrid von Mentzer, Firdausi Qadri, Ann-Mari Svennerholm
PloS one - 2012