The Environment as a Driver of Antibiotic Resistance - EDAR
This multidisciplinary project address several critical knowledge gaps related to the environmental dimensions of antibiotic resistance. We aim to: 1. Understand the origin and evolution of antibiotic resistance, i.e. in what species and from what environments they likely were mobilized and transferred 2. Identify already mobilized resistance genes to last-resort antibiotics that have not (yet) been described in pathogens. 3. Understand drivers and mechanisms of resistance evolution (selection, mobilization, transfer) in the environment. 4. Provide an economic analysis of the costs and benefits of environmental interventions. 5. Analyze incentives and counterincentives for such mitigations.