Modulating adipose tissue phenotype for the treatment of metabolic diseases
Adipose tissue plays a central role in the development of insulin resistance and diabetes. We are working on modulating adipose tissue phenotype for the treatment of metabolic diseases
1) Increasing brown adipose tissue abundance or activity or converting white into brown adipocytes holds promise for the treatment of metabolic diseases. We are characterizing the molecular pathways controlling the development, differentiation and function of white, beige and brown adipose cells.
2) Senescence (aging of cells) of adipose tissue is closely associated with age associated diseases including metabolic disorders. We are investigating the key drivers of senescence in the different adipose tissue cells in metabolic diseases, how senescent cells communicate with other cells and tissues to impact metabolism, and how to inhibit senescence in adipose.