Proteostasis minisymposium
Research
Welcome to a minisymposium on protein homeostasis. Speakers: Professor Harm H. Kampinga, University of Groningen, and Professor Claes Andréasson, University of Stockholm.
Seminar
Welcome to a minisymposium on protein homeostasis. Speakers: Professor Harm H. Kampinga, University of Groningen, and Professor Claes Andréasson, University of Stockholm.
14:15-15:00 - Disassembly and disposal of protein aggregates in mammalian cells, Professor Harm H. Kampinga, University of Groningen.
The central theme of Kampinga’s research is related to the consequences of protein un- or misfolding on cellular functions. Initially, his work was centered around the biological effects of heat shock on cells in relation to the use of hyperthermia in combination with radiation or/and chemotherapy in cancer treatments. During these studies, Kampinga became interested in Heat Shock Proteins (HSP) that could protect cells from the cell biological effects of heat shock and focused his research on the functional regulation and diversity HSPs.
Kampinga’ s lab was the first to clone a majority of all human and Drosophila HSPs and subsequently screened them for activity in several (age-related) cell and drosophila models for neurodegenerative diseases (in particular CAG repeat expansion diseases) and cardiac diseases. Major discoveries from his lab include the asymmetric segregation of protein damage in stem cells, the functional diversity of HSPs and their role in dealing with different disease-associated protein aggregation diseases, and the discovery of set of specific DNAJ family protein members (DNAJB6 and DNAJB8) with an exquisitely high potency to delay amyloidogenesis.
15:00-15:45 - Toxic misfolding of newly synthesized proteins in the cytosol - detection and suppression, Professor Claes Andréasson, Stockholm University.
Andreasson studies how cells maintain their proteomes functional with the help of the proteostasis system to ensure health and aging. Our projects develop insight into the mechanisms of the proteostasis system, including chaperone-assisted protein folding at the ribosome, protein quality control (UPS and autophagy) and transcriptional stress responses (Hsf1). The experimental approaches integrate genetics, biochemistry and cell biology and we employ budding yeast and mammalian cell culture as models.
The mini-symposium is open for everyone. Welcome!