Catarina Mörck
About Catarina Mörck
Correct migration and guidance of cells and axons are important for animal development and other processes such as immunity and wound healing. Failure to migrate or migration to improper locations can cause severe conditions such as brain defects and lethality. Metastasis, the movement and spread of cancer cells from a primary tumor site, is the main factor accounting for cancer treatment failure and is responsible for 90 % of cancer deaths. Cells and growth cones are guided by attractant and repellent molecules that are conserved in organisms as diverse as human and worms. Many of the genes that encode these guidance molecules and their receptors have already been identified, but how they are regulated genetically and how they signal to downstream pathways are poorly understood. We want to identify novel genes that are involved in guidance and migration. As model system we are using the nematode C. elegans and in particular we are focusing our research on two pairs of neurons, the canal-associated neurons that migrate a long distance posterior and send out axons that grow both posterior and anterior and the hermaphrodite specific neurons that migrate anterior and have axons that grow ventral and anterior. To discover new genes we will use a novel strategy where we will study the gene expression levels specifically in the neurons. Genes found to be upregulated during the migration will later be silenced with RNAi. To find more new genes we will screen for migration mutants and also study suppressors of a mutant that exhibit severe posterior migration defects.
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The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signalling
Pathway.
Jason Chien, Fred W Wolf, Sarah Grosche, Nebeyu Yosef, Gian Garriga, Catarina Mörck
Genetics - 2019 -
Regulation of Axon Guidance by the Wnt Receptor Ror/CAM-1 in the PVT Guidepost Cell in Caenorhabditis
elegans
Jason Chien, Ranjan Devkota, N. Yosef, Catarina Mörck
Genetics - 2017 -
The Adiponectin Receptor Homologs in C-elegans Promote Energy Utilization and
Homeostasis
Emma Svensson, L. Olsen, Catarina Mörck, Christian Brackmann, Annika Enejder, N. J. Faergeman, Marc Pilon
PLoS ONE - 2011 -
Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx
model.
Gholamali Jafari, Jan Burghoorn, Takehiro Kawano, Manoj Mathew, Catarina Mörck, Claes Axäng, Michael Ailion, James H Thomas, Joseph G Culotti, Peter Swoboda, Marc Pilon
Genetics - 2010 -
C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective
mutants.
Catarina Mörck, Vivekanand Vivekanand, Gholamali Jafari, Marc Pilon
BMC developmental biology - 2010 -
Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis
elegans
Catarina Mörck, L. Olsen, C. Kurth, Annelie Persson, N. J. Storm, Emma Svensson, John-Olov Jansson, Marika Hellqvist, Annika Enejder, N. J. Faergeman, Marc Pilon
Proceedings of the National Academy of Sciences - 2009 -
Development of the Caenorhabditis elegans pharynx, with emphasis on its nervous
system.
Marc Pilon, Catarina Mörck
Acta Pharmacol. Sin. - 2008 -
C. elegans feeding defective mutants have shorter body lengths and increased
autophagy
Catarina Mörck, Marc Pilon
BMC Developmental Biology - 2006 -
Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle
cells
Catarina Mörck, Claes Axäng, Mattias Goksör, Marc Pilon
Developmental Biology - 2006 -
Caloric restriction and autophagy in C.
elegans.
Catarina Mörck, Marc Pilon
Autophagy - 2006 -
pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal
isthmus.
Catarina Mörck, Manish Rauthan, Fredrik Wågberg, Marc Pilon
Developmental Biology - 2004 -
A genetic analysis of axon guidance in the C elegans
pharynx
Catarina Mörck, Claes Axäng, Marc Pilon
Developmental Biology - 2003 -
A genetic analysis of axon guidance in the C. elegans
pharynx.
Catarina Mörck, Claes Axäng, Marc Pilon
Developmental Biology - 2003