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Development of inhibitors targetting Leukotoxins

Research project
Pågående forskning
Project owner
Prof Leif A. Eriksson (PI), Prof Johan Gottfries and Sonali Chavan (PhD student), Dep. of Chemistry and Molecular Biology at GU.

Financier
Swedish Research Council and CARe

Short description

In this project we employ a range of bioinformatics tools such as homology modelling, protein-protein docking, binding site analyses and virtual screening/docking, as well as extensive molecular dynamics simulations, to identify new candidate drugs that are able to disrupt the alpha-beta-dimer interactions and thus disbale pore formation and reduce the bacterial virulence.