Johan Gobom
-
Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer's disease
biomarkers
Sophia Weiner, M. Sauer, P. J. Visser, B. M. Tijms, Egor Vorontsov, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Clinical Proteomics - 2022-01-01 -
Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal
cognition
K. E. J. Wesenhagen, Johan Gobom, I. Bos, S. J. B. Vos, P. Martinez-Lage, J. Popp, M. Tsolaki, R. Vandenberghe, Y. Freund-Levi, F. Verhey, S. Lovestone, J. Streffer, V. Dobricic, L. Bertram, Kaj Blennow, M. Pikkarainen, M. Hallikainen, J. Kuusisto, M. Laakso, H. Soininen, P. Scheltens, Henrik Zetterberg, C. E. Teunissen, P. J. Visser, B. M. Tijms
Alzheimer's & Dementia - 2022-01-01 -
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's
disease
P. J. Visser, L. M. Reus, Johan Gobom, I. Jansen, E. Dicks, S. J. Van der Lee, M. Tsolaki, F. R. J. Verhey, J. Popp, P. Martinez-Lage, R. Vandenberghe, A. Lleo, J. L. Molinuevo, S. Engelborghs, Y. Freund-Levi, L. Froelich, K. Sleegers, V. Dobricic, S. Lovestone, J. Streffer, S. J. B. Vos, I. Bos, A. B. Smit, Kaj Blennow, P. Scheltens, C. E. Teunissen, L. Bertram, Henrik Zetterberg, B. M. Tijms, Adni, Adni,
Molecular Neurodegeneration - 2022-01-01 -
Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal
fluid.
Johan Gobom, Lucilla Parnetti, Pedro Rosa-Neto, Martin Vyhnalek, Serge Gauthier, Samuela Cataldi, Ondrej Lerch, Jan Laczo, Katerina Cechova, Marcus Clarin, Andrea I Benet, Tharick A Pascoal, Neserine Rahmouni, Manu Vandijck, Else Huyck, Nathalie Le Bastard, Jenna Stevenson, Mira Chamoun, Daniel Alcolea, Alberto Lleó, Ulf Andreasson, Marcel M Verbeek, Giovanni Bellomo, Roberta Rinaldi, Nicholas J. Ashton, Henrik Zetterberg, Katerina Sheardova, Jakub Hort, Kaj Blennow
Clinical chemistry and laboratory medicine - 2022-01-01 -
Alzheimer's disease genetic risk variants show brain cell type-specific associations with protein levels in cerebrospinal
fluid
L. M. Reus, S. J. Van Der Lee, C. E. Teunissen, Johan Gobom, S. J. B. Vos, Kaj Blennow, Henrik Zetterberg, L. Bertram, P. J. Visser, B. M. Tijms
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Genome-scale metabolic network reconstruction of model animals as a platform for translational
research
Hao Wang, J. L. Robinson, P. Kocabas, J. Gustafsson, M. Anton, P. E. Cholley, S. Huang, Johan Gobom, T. Svensson, M. Uhlen, Henrik Zetterberg, J. Nielsen
Proceedings of the National Academy of Sciences of the United States of America - 2021-01-01 -
CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative
Individuals
B. M. Tijms, Johan Gobom, C. Teunissen, V. Dobricic, M. Tsolaki, F. Verhey, J. Popp, P. Martinez-Lage, R. Vandenberghe, A. Lleo, J. L. Molinuevo, S. Engelborghs, Y. Freund-Levi, L. Froelich, L. Bertram, S. Lovestone, J. Streffer, S. Vos, Kaj Blennow, P. Scheltens, H. Zetterberg, P. J. Visser, Adni, Adni,
Proteomes - 2021-01-01 -
Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's
disease
Johanna Nilsson, Johan Gobom, Simon Sjödin, Gunnar Brinkmalm, Nicholas J. Ashton, Johan Svensson, Per Johansson, E. Portelius, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2021-01-01 -
The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome
profiles
A. Mallach, Johan Gobom, Henrik Zetterberg, J. Hardy, T. M. Piers, S. Wray, J. M. Pocock
Brain Communications - 2021-01-01 -
Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting
Neurons
A. Mallach, Johan Gobom, C. Arber, T. M. Piers, J. Hardy, S. Wray, Henrik Zetterberg, J. Pocock
Cells - 2021-01-01 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021-01-01 -
A mass spectrometric approach to study the interaction of amyloid beta peptides with human
alpha-2-macroglobulin
A. V. Protasov, O. A. Mirgorodskaya, Y. P. Kozmin, Johan Gobom
Biochimie - 2021-01-01 -
Sample Preparation for Proteomic Analysis of Cerebrospinal
Fluid
Johan Gobom
Cerebrospinal Fluid Biomarkers. Teunissen C.E., Zetterberg H. (red.) - 2021-01-01 -
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic
biomarkers
Elena Camporesi, T. Lashley, Johan Gobom, Juan Lantero Rodriguez, O. Hansson, Henrik Zetterberg, Kaj Blennow, Bruno Becker
Acta Neuropathologica Communications - 2021-01-01 -
Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid
proteomics
B. M. Tijms, Johan Gobom, L. Reus, I. Jansen, S. J. Hong, V. Dobricic, F. Kilpert, M. ten Kate, F. Barkhof, M. Tsolaki, F. R. J. Verhey, J. Popp, P. Martinez-Lage, R. Vandenberghe, A. Lle, J. L. Molinuevo, S. Engelborghs, L. Bertram, S. Lovestone, J. Streffer, S. Vos, I. Bos, Kaj Blennow, P. Scheltens, C. E. Teunissen, Henrik Zetterberg, P. J. Visser
Brain - 2020-01-01 -
Author reply to the Letter to the Editor by Prof.Dr. Dr Mischak: "Re-analysis of peptidomic analysis of cartilage and subchondral bone in OA
patients".
Birgitta Gatenholm, Johan Gobom, Henrik Zetterberg, Mats Brittberg
European journal of clinical investigation - 2020-01-01 -
Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's
disease.
Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Shengjun Hong, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijms
medRxiv : the preprint server for health sciences - 2020-01-01 -
First amyloid β1-42 certified reference material for re-calibrating commercial
immunoassays
S. Boulo, J. Kuhlmann, Ulf Andreasson, B. Brix, I. Venkataraman, V. Herbst, S. Rutz, E. Manuilova, M. Vandijck, F. Dekeyser, Maria Bjerke, Josef Pannee, J. Charoud-Got, G. Auclair, S. Mazoua, G. Pinski, S. Trapmann, H. Schimmel, H. Emons, M. Quaglia, Erik Portelius, M. Korecka, L. M. Shaw, M. Lame, E. Chambers, H. Vanderstichele, E. Stoops, A. Leinenbach, T. Bittner, R. G. Jenkins, V. Kostanjevecki, P. Lewczuk, Johan Gobom, Henrik Zetterberg, I. Zegers, Kaj Blennow
Alzheimer's and Dementia - 2020-01-01 -
APOE ϵ4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's
disease
E. Konijnenberg, B. M. Tijms, Johan Gobom, V. Dobricic, I. Bos, S. Vos, M. Tsolaki, F. Verhey, J. Popp, P. Martinez-Lage, R. Vandenberghe, A. Lleó, L. Frölich, S. Lovestone, J. Streffer, L. Bertram, Kaj Blennow, C. E. Teunissen, R. Veerhuis, A. B. Smit, P. Scheltens, Henrik Zetterberg, P. J. Visser
Alzheimer's Research and Therapy - 2020-01-01 -
Protein aggregate formation permits millennium-old brain
preservation
A. Petzold, C. H. Lu, M. Groves, Johan Gobom, Henrik Zetterberg, G. Shaw, S. O'Connor
Journal of the Royal Society Interface - 2020-01-01 -
Peptidomic analysis of cartilage and subchondral bone in OA
patients
Birgitta Gatenholm, Johan Gobom, Tobias Skillbäck, Kaj Blennow, Henrik Zetterberg, Mats Brittberg
European Journal of Clinical Investigation - 2019-01-01 -
Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's
disease.
Claudia Cicognola, Gunnar Brinkmalm, Johan Gobom, Jessica Wahlgren, Nicholas C Cullen, Lucilla Parnetti, Radu Constantinescu, Kristin Wildsmith, Hsu-Hsin Chen, Thomas G Beach, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Kina Höglund
Acta neuropathologica - 2019-01-01 -
Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer's
disease
Karl Hansson, Rahil Dahlén, O. Hansson, Elin Pernevik, R. Paterson, J. M. Schott, N. Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Clinical Mass Spectrometry - 2019-01-01 -
Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative
diseases.
Ann Brinkmalm-Westman, Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Rahil Dahlén, Johan Gobom, Kaj Blennow, Henrik Zetterberg
Journal of neurochemistry - 2019-01-01 -
Levels of ADAM10 are reduced in Alzheimer's disease
CSF
A. Sogorb-Esteve, M. S. Garcia-Ayllon, Johan Gobom, J. Alom, Henrik Zetterberg, Kaj Blennow, J. Saez-Valero
Journal of Neuroinflammation - 2018-01-01 -
Expanding the cerebrospinal fluid
endopeptidome
Karl Hansson, Tobias Skillbäck, Elin Pernevik, Silke Kern, Erik Portelius, Kina Höglund, Gunnar Brinkmalm, Jessica Holmén Larsson, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Proteomics - 2017-01-01 -
Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker
Candidates.
Claire L Russell, Vikram Mitra, Karl Hansson, Kaj Blennow, Johan Gobom, Henrik Zetterberg, Mikko Hiltunen, Malcolm Ward, Ian Pike
Journal of Alzheimer's disease : JAD - 2017-01-01 -
Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer's disease: an
update.
Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Rahil Dahlén, Ann Brinkmalm-Westman, Johan Gobom
Expert review of proteomics - 2017-01-01 -
Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal
Fluid
Karl Hansson, Tobias Skillbäck, Elin Pernevik, Jessica Holmén Larsson, Gunnar Brinkmalm, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Jove-Journal of Visualized Experiments - 2017-01-01 -
A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer's
disease
Tobias Skillbäck, Niklas Mattsson, Karl Hansson, Ekaterina Mirgorodskaya, Rahil Dahlén, W. van der Flier, P. Scheltens, F. Duits, O. Hansson, C. Teunissen, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Scientific Reports - 2017-01-01 -
Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative
proteomics
N. K. Magdalinou, A. J. Noyce, R. Pinto, E. Lindström, Jessica Holmén Larsson, Mikko Hölttä, Kaj Blennow, H. R. Morris, Tobias Skillbäck, T. T. Warner, A. J. Lees, I. Pike, M. Ward, Henrik Zetterberg, Johan Gobom
Parkinsonism & Related Disorders - 2017-01-01 -
Ex vivo (18)O-labeling mass spectrometry identifies a peripheral amyloid β clearance
pathway.
Erik Portelius, Niklas Mattson, Josef Pannee, Henrik Zetterberg, Magnus Gisslén, Hugo Vanderstichele, Eleni Gkanatsiou, Gabriela A N Crespi, Michael W Parker, Luke A Miles, Johan Gobom, Kaj Blennow
Molecular neurodegeneration - 2017-01-01 -
Reference measurement procedure for CSF Aβ1-42 and the CSF Aβ1-42 /Aβ1-40 ratio - a cross-validation study against Amyloid
PET.
Josef Pannee, Erik Portelius, Lennart Minthon, Johan Gobom, Ulf Andreasson, Henrik Zetterberg, Oskar Hansson, Kaj Blennow
Journal of neurochemistry - 2016-01-01 -
A single dose of the gamma-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in
humans
Mikko Hölttä, R. A. Dean, E. Siemers, K. G. Mawuenyega, W. Sigurdson, P. C. May, D. M. Holtzman, Erik Portelius, Henrik Zetterberg, R. J. Bateman, Kaj Blennow, Johan Gobom
Alzheimers Research & Therapy - 2016-01-01 -
Round robin test on quantification of amyloid-β 1-42 in cerebrospinal fluid by mass
spectrometry.
Josef Pannee, Johan Gobom, Leslie M Shaw, Magdalena Korecka, Erin E Chambers, Mary Lame, Rand Jenkins, William Mylott, Maria C Carrillo, Ingrid Zegers, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2016-01-01 -
An integrated workflow for multiplex CSF proteomics and peptidomics - identification of candidate cerebrospinal fluid biomarkers of Alzheimer's
disease.
Mikko Hölttä, Lennart Minthon, Oscar Hansson, Jessica Holmén Larsson, Ian Pike, Malcolm Ward, Karsten Kuhn, Ulla Rüetschi, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Journal of proteome research - 2015-01-01 -
Advancing cerebrospinal fluid biomarker discovery by mass
spectrometry
Johan Gobom
Neurodegenerative disease management - 2015-01-01 -
Explorative and targeted neuroproteomics in Alzheimer's
disease.
Ann Brinkmalm-Westman, Erik Portelius, Annika Öhrfelt, Gunnar Brinkmalm, Ulf Andreasson, Johan Gobom, Kaj Blennow, Henrik Zetterberg
Biochimica et biophysica acta - 2015-01-01 -
Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-β in cerebrospinal
fluid.
Andreas Leinenbach, Josef Pannee, Thomas Dülffer, Andreas Huber, Tobias Bittner, Ulf Andreasson, Johan Gobom, Henrik Zetterberg, Uwe Kobold, Erik Portelius, Kaj Blennow
Clinical chemistry - 2014-01-01 -
The amyloid-β degradation pattern in plasma-A possible tool for clinical trials in Alzheimer's
disease
Josef Pannee, Ulrika Törnqvist, Annie Westerlund, M. Ingelsson, L. Lannfelt, Gunnar Brinkmalm, Rita Persson, Johan Gobom, Johan Svensson, Per Johansson, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Neuroscience Letters - 2014-01-01 -
Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's
disease.
Erik Portelius, Maria Olsson, Gunnar Brinkmalm, Ulla Rüetschi, Niklas Mattsson, Ulf Andreasson, Johan Gobom, Ann Brinkmalm-Westman, Mikko Hölttä, Kaj Blennow, Henrik Zetterberg
Journal of Alzheimer's disease : JAD - 2013-01-01 -
A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's Disease patients and healthy
controls.
Josef Pannee, Erik Portelius, Madalina Oppermann, Alan Atkins, Martin Hornshaw, Ingrid Zegers, Peter Höjrup, Lennart Minthon, Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Journal of Alzheimer's Disease - 2013-01-01 -
Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and
serum
B. Krastins, A. Prakash, D. A. Sarracino, D. Nedelkov, E. E. Niederkofler, U. A. Kiernan, R. Nelson, M. S. Vogelsang, G. Vadali, A. Garces, J. N. Sutton, S. Peterman, G. Byram, B. Darbouret, J. R. Perusse, N. G. Seidah, B. Coulombe, Johan Gobom, Erik Portelius, Josef Pannee, Kaj Blennow, V. Kulasingam, L. Couchman, C. Moniz, M. F. Lopez
Clinical Biochemistry - 2013-01-01 -
Amyloid-β metabolism in Niemann-Pick C disease models and
patients.
Niklas Mattsson, Maria Olsson, Mikael K Gustavsson, Marko Kosicek, Martina Malnar, Jan-Eric Månsson, Maria K. Blomqvist, Johan Gobom, Ulf Andreasson, Gunnar Brinkmalm, Charles Vite, Silva Hecimovic, Caroline Hastings, Kaj Blennow, Henrik Zetterberg, Erik Portelius
Metabolic brain disease - 2012-01-01 -
Exhaled Endogenous Particles Contain Lung
Proteins.
Anna Bredberg, Johan Gobom, Ann-Charlotte Almstrand, Per Larsson, Kaj Blennow, Anna-Carin Olin, Ekaterina Mirgorodskaya
Clinical Chemistry - 2012-01-01 -
Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid
β42.
Niklas Mattsson, Ingrid Zegers, Ulf Andreasson, Maria Bjerke, Marinus A Blankenstein, Robert Bowser, Maria C Carrillo, Johan Gobom, Theresa Heath, Rand Jenkins, Andreas Jeromin, June Kaplow, Daniel Kidd, Omar F Laterza, Andrew Lockhart, Michael P Lunn, Robert L Martone, Kevin Mills, Josef Pannee, Marianne Ratcliffe, Leslie M Shaw, Adam J Simon, Holly Soares, Charlotte E Teunissen, Marcel M Verbeek, Robert M Umek, Hugo Vanderstichele, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Biomarkers in medicine - 2012-01-01 -
An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal
fluid.
Gunnar Brinkmalm, Erik Portelius, Annika Öhrfelt, Niklas Mattsson, Rita Persson, Mikael K Gustavsson, Charles H Vite, Johan Gobom, Jan-Eric Månsson, Jonas Nilsson, Adnan Halim, Göran Larson, Ulla Rüetschi, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm-Westman
Journal of mass spectrometry : JMS - 2012-01-01 -
Peptidome Analysis of Cerebrospinal Fluid by LC-MALDI
MS
Mikko Hölttä, Henrik Zetterberg, Ekaterina Mirgorodskaya, Niklas Mattsson, Kaj Blennow, Johan Gobom
Plos One - 2012-01-01 -
Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's
disease.
Annika Thorsell, Maria Bjerke, Johan Gobom, Eva Brunhage, Eugeen Vanmechelen, Niels Andreasen, Oskar Hansson, Lennart Minthon, Henrik Zetterberg, Kaj Blennow
Brain research - 2010-01-01 -
Targeted proteomics in Alzheimer's disease: focus on
amyloid-beta.
Erik Portelius, Henrik Zetterberg, Johan Gobom, Ulf Andreasson, Kaj Blennow
Expert review of proteomics - 2008-01-01 -
Characterization of tau in cerebrospinal fluid using mass
spectrometry.
Erik Portelius, Sara Folkesson Hansson, Ai Jun Tran, Henrik Zetterberg, Pierre Grognet, Eugeen Vanmechelen, Kina Höglund, Gunnar Brinkmalm, Ann Brinkmalm-Westman, Eckhard Nordhoff, Kaj Blennow, Johan Gobom
Journal of proteome research - 2008-01-01