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- Laia Montoliu-Gaya
Laia Montoliu-Gaya
Researcher
Department of Psychiatry and Neurochemistry-
Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and
monitoring
Melissa E. Petersen, Lisi Flores-Aguilar, Elizabeth Head, Laia Montoliu-Gaya, Andre Strydom, Sarah E. Pape, Juan Fortea, Nicholas J. Ashton, Chinedu Udeh-Momoh, Sid E. O'Bryant, Dwight German, Florin Despa, Mark Mapstone, Henrik Zetterberg
ALZHEIMERS & DEMENTIA - 2025 -
The detection of GRN mutation carriers by progranulin blood protein levels from finger-stick
collection
Hanna Huber, Valentina Cantoni, Daniele Altomare, Lana Grötschel, Laia Montoliu-Gaya, Francisco J Meda, Hlin Kvartsberg, Ilenia Libri, Maria Sofia Cotelli, Henrik Zetterberg, Kaj Blennow, Barbara Borroni, Nicholas J. Ashton
ALZHEIMERS & DEMENTIA - 2025 -
Biofluid-based staging of Alzheimer's
disease
Juan Lantero Rodriguez, Laia Montoliu-Gaya, Nicholas J. Ashton, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Wagner Scheeren Brum, Stijn Servaes, Jenna Stevenson, Guglielmo Di Molfetta, Burak Arslan, Jesse Klostranec, Paolo Vitali, Maxime Montembeault, Serge Gauthier, Cecile Tissot, Arthur C. Macedo, Tharick A. Pascoal, Andreas Jeromin, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L Benedet
ACTA NEUROPATHOLOGICA - 2025 -
The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin
study.
Nicholas J. Ashton, Ashvini Keshavan, Wagner Scheeren Brum, Ulf Andreasson, Burak Arslan, Mathias Droescher, Stefan Barghorn, Jeroen Vanbrabant, Charlotte Lambrechts, Maxime Van Loo, Erik Stoops, Shweta Iyengar, HaYeun Ji, Xiaomei Xu, Alex Forrest-Hay, Bingqing Zhang, Yuling Luo, Andreas Jeromin, Manu Vandijck, Nathalie Le Bastard, Hartmuth Kolb, Gallen Triana-Baltzer, Divya Bali, Shorena Janelidze, Shieh-Yueh Yang, Catherine Demos, Daniel Romero, George Sigal, Jacob Wohlstadter, Kishore Malyavantham, Meenakshi Khare, Alexander Jethwa, Laura Stoeckl, Johan Gobom, Przemysław R Kac, Fernando Gonzalez-Ortiz, Laia Montoliu-Gaya, Oskar Hansson, Robert A Rissman, Maria C Carillo, Leslie M Shaw, Kaj Blennow, Jonathan M Schott, Henrik Zetterberg
medRxiv : the preprint server for health sciences - 2024 -
Tau protein profiling in tauopathies: a human brain
study
Juan Lantero Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko-Burmann, Bruno Becker, Ann Brinkmalm, Björn Marcus Burmann, Michael Perkinton, Nicholas J. Ashton, Nick C. Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm
MOLECULAR NEURODEGENERATION - 2024 -
Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimer's
disease.
Przemysław R Kac, Daniel Alcolea, Laia Montoliu-Gaya, Susana Fernández, Juan Lantero Rodriguez, Lucía Maure, Fernando Gonzalez-Ortiz, Bessy Benejam, Michael Turton, Isabel Barroeta, Peter Harrison, Laura Videla, Nicholas J. Ashton, Alberto Lleó, Henrik Zetterberg, María Carmona-Iragui, Thomas Karikari, Juan Fortea, Kaj Blennow
medRxiv : the preprint server for health sciences - 2024 -
Quantification of neurofilament light and glial fibrillary acidic protein in finger-prick
blood
Magdalena A. Kolanko, Hanna Huber, Michael C. B. David, Laia Montoliu-Gaya, Joel Simrén, Kaj Blennow, Henrik Zetterberg, Ramin Nilforooshan, Paresh Malhotra, David J. Sharp, Nicholas J. Ashton, Neil S. N. Graham
BRAIN COMMUNICATIONS - 2024 -
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease
neuropathology.
Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas Karikari
Nature communications - 2024 -
Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote
settings
Hanna Huber, Kaj Blennow, Henrik Zetterberg, Merce Boada, Andreas Jeromin, Haley Weninger, Raul Nunez-Llaves, Nuria Aguilera, Maribel Ramis, Joel Simrén, Johanna Nilsson, Juan Lantero Rodriguez, Adelina Orellana, Fernando Garcia-Gutierrez, Xavier Morato, Nicholas J. Ashton, Laia Montoliu-Gaya
ALZHEIMERS & DEMENTIA - 2024 -
Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy
study.
Laia Montoliu-Gaya, Michael L Alosco, Eukyung Yhang, Yorghos Tripodis, Daniel Sconzo, Madeline Ally, Lana Grötschel, Nicholas J. Ashton, Juan Lantero Rodriguez, Mathias Sauer, Bárbara Fernandes Gomes, Johanna Nilsson, Gunnar Brinkmalm, Michael A Sugarman, Hugo J Aparicio, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Katherine W Turk, Andrew E Budson, Rhoda Au, Lindsay Farrer, Gyungah R Jun, Neil W Kowall, Robert A Stern, Lee E Goldstein, Wei Qiao Qiu, Jesse Mez, Bertrand Russell Huber, Victor E Alvarez, Ann C McKee, Henrik Zetterberg, Johan Gobom, Thor D Stein, Kaj Blennow
Acta neuropathologica - 2024 -
A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's
disease.
Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand González-Escalante, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R. Kac, Michael Turton, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Minguillon, Jose Contador, Marc Suárez-Calvet, Thomas Karikari, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2024 -
Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy
individuals
Wagner Scheeren Brum, Nicholas J. Ashton, Joel Simrén, Guiglielmo di Molfetta, Thomas Karikari, Andréa Lessa Benedet, Eduardo R. Zimmer, Juan Lantero Rodriguez, Laia Montoliu-Gaya, Andreas Jeromin, Aasne K. Aarsand, William A. Bartlett, Pilar Fernández Calle, Abdurrahman Coşkun, Jorge Díaz–Garzón, Niels Jonker, Henrik Zetterberg, Sverre Sandberg, Anna Carobene, Kaj Blennow
Alzheimer's and Dementia - 2024 -
Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease
Pathology
Nicholas J. Ashton, Wagner Scheeren Brum, Guglielmo Di Molfetta, Andréa Lessa Benedet, Burak Arslan, Erin Jonaitis, Rebecca E. Langhough, Karly Cody, Rachael Wilson, Cynthia M. Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleo, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg
JAMA NEUROLOGY - 2024 -
Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease
pathology
Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto
Molecular Neurodegeneration - 2024 -
CSF p-tau205: a biomarker of tau pathology in Alzheimer's
disease.
Juan Lantero Rodriguez, Laia Montoliu-Gaya, Andréa Lessa Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner Scheeren Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2024 -
Diagnostic accuracy of the plasma ALZpath pTau217 immunoassay to identify Alzheimer's disease
pathology.
Nicholas J. Ashton, Wagner Scheeren Brum, Guglielmo Di Molfetta, Andréa Lessa Benedet, Burak Arslan, Erin Jonatis, Rebecca E Langhough, Karly Cody, Rachael Wilson, Cynthia M Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg
medRxiv : the preprint server for health sciences - 2023 -
Longitudinal blood biomarker trajectories in preclinical Alzheimer's
disease
Y. Yakoub, Nicholas J. Ashton, C. Strikwerda-Brown, Laia Montoliu-Gaya, Thomas Karikari, Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, J. Gallego-Rudolf, P. F. Meyer, F. St-Onge, Michael Schöll, J. P. Soucy, J. C. S. Breitner, Henrik Zetterberg, Kaj Blennow, J. Poirier, S. Villeneuve
Alzheimers & Dementia - 2023 -
Levels of Alzheimer's disease blood biomarkers are altered after food intake-A pilot intervention study in healthy
adults
Hanna Huber, Nicholas J. Ashton, A. Schieren, Laia Montoliu-Gaya, Guglielmo Di Molfetta, Wagner Scheeren Brum, Juan Lantero Rodriguez, Lana Grötschel, B. Stoffel-Wagner, M. Coenen, L. Weinhold, M. Schmid, Kaj Blennow, P. Stehle, Henrik Zetterberg, M. C. Simon
Alzheimers & Dementia - 2023 -
Plasma and CSF concentrations of N-terminal tau fragments associate with in vivo neurofibrillary tangle
burden
Juan Lantero Rodriguez, C. Tissot, Anniina Snellman, S. Servaes, Andréa Lessa Benedet, N. Rahmouni, Laia Montoliu-Gaya, J. Therriault, Wagner Scheeren Brum, J. Stevenson, F. Z. Lussier, G. Bezgin, A. C. Macedo, M. Chamoun, S. S. Mathotaarachi, T. A. Pascoal, Nicholas J. Ashton, Henrik Zetterberg, P. R. Neto, Kaj Blennow
Alzheimers & Dementia - 2023 -
A novel ultrasensitive assay for plasma p-tau217: performance in individuals with subjective cognitive decline and early Alzheimer's
disease.
Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand Gonzalez, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R. Kac, Michael Turton, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Miguillon, Jose Contador, Marc Suarez-Calvet, Thomas Karikari, Kaj Blennow
medRxiv : the preprint server for health sciences - 2023 -
New mass spectrometry method to simultaneously quantify several tau species in
blood
Laia Montoliu-Gaya, Kaj Blennow
NATURE AGING - 2023 -
Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic
cohorts
Juan Lantero Rodriguez, A. Vrillon, A. Fernandez-Lebrero, P. Ortiz-Romero, Anniina Snellman, Laia Montoliu-Gaya, Wagner Scheeren Brum, E. Cognat, J. Dumurgier, A. Puig-Pijoan, I. Navalpotro-Gomez, G. Garcia-Escobar, Thomas Karikari, E. Vanmechelen, Nicholas J. Ashton, Henrik Zetterberg, M. Suarez-Calvet, C. Paquet, Kaj Blennow
Alzheimers Research & Therapy - 2023 -
Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease
neuropathology.
Przemyslaw R. Kac, Fernándo González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas Karikari
medRxiv : the preprint server for health sciences - 2023 -
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau
pathologies
Laia Montoliu-Gaya, Andréa Lessa Benedet, C. Tissot, A. Vrillon, Nicholas J. Ashton, Wagner Scheeren Brum, Juan Lantero Rodriguez, J. Stevenson, Johanna Nilsson, Mathias Sauer, N. Rahmouni, Gunnar Brinkmalm, F. Z. Lussier, T. A. Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, C. Paquet, Johan Gobom, P. Rosa-Neto, Kaj Blennow
Nature Aging - 2023 -
Plasma and cerebrospinal fluid glial fibrillary acidic protein levels in adults with Down syndrome: a longitudinal cohort
study
Laia Montoliu-Gaya, D. Alcolea, Nicholas J. Ashton, J. Pegueroles, J. Levin, B. Bosch, Juan Lantero Rodriguez, M. Carmona-Iragui, O. Wagemann, M. Balasa, Przemyslaw R. Kac, I. Barroeta, A. Llado, Wagner Scheeren Brum, L. Videla, Fernando Gonzalez-Ortiz, B. Benejam, J. J. A. Martinez, Thomas Karikari, G. Nubling, A. Bejanin, Andréa Lessa Benedet, R. Blesa, A. Lleo, Kaj Blennow, R. Sanchez-Valle, Henrik Zetterberg, J. Fortea
eBioMedicine - 2023 -
Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer's
disease
Johanna Nilsson, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Johan Gobom, T. A. Pascoal, M. Chamoun, E. Portelius, A. Jeromin, M. Mendes, Henrik Zetterberg, P. Rosa-Neto, Ann Brinkmalm, Kaj Blennow
Alzheimer's Research & Therapy - 2022 -
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease
continuum.
Johan Gobom, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Molecular neurodegeneration - 2022 -
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical
utility
Thomas Karikari, Nicholas J. Ashton, Gunnar Brinkmalm, Wagner Scheeren Brum, Andréa Lessa Benedet, Laia Montoliu-Gaya, Juan Lantero Rodriguez, T. A. Pascoal, M. Suarez-Calvet, P. Rosa-Neto, Kaj Blennow, Henrik Zetterberg
Nature Reviews Neurology - 2022 -
Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's
disease.
Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó, Paula Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Eugeen Vanmechelen, Theresa A Day, Armand González-Escalante, Gonzalo Sánchez-Benavides, Carolina Minguillon, Karine Fauria, José Luis Molinuevo, Jeffrey L Dage, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez-Calvet, Kaj Blennow
Nature medicine - 2022 -
Plasma p-tau231 and p-tau217 as state markers of amyloid-beta pathology in preclinical Alzheimer's
disease
M. Mila-Aloma, Nicholas J. Ashton, M. Shekari, G. Salvado, P. Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, E. Vanmechelen, T. A. Day, A. Gonzalez-Escalante, G. Sanchez-Benavides, C. Minguillon, K. Fauria, J. L. Molinuevo, J. L. Dage, Henrik Zetterberg, J. D. Gispert, M. Suarez-Calvet, Kaj Blennow
Nature Medicine - 2022 -
Amyloid-beta peptide and tau protein crosstalk in Alzheimer's
disease
A. R. Roda, G. Serra-Mir, Laia Montoliu-Gaya, L. Tiessler, S. Villegas
Neural Regeneration Research - 2022 -
Production of Therapeutic Single-Chain Variable Fragments (ScFv) in Pichia
pastoris
Laia Montoliu-Gaya, Sandra Villegas
Therapeutic Antibodies. Methods and Protocols. Gunnar Houen (red.) - 2022 -
Bi-allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis-like
disease.
Kalliopi Sofou, Kolja Meier, Leslie E Sanderson, Debora Kaminski, Laia Montoliu-Gaya, Emma Samuelsson, Maria K. Blomqvist, Lotta Agholme, Jutta Gärtner, Chris Mühlhausen, Niklas Darin, Tahsin Stefan Barakat, Lars Schlotawa, Tjakko van Ham, Jorge Asin-Cayuela, Fredrik H Sterky
EMBO molecular medicine - 2021 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021 -
P-tau235: a novel biomarker for staging preclinical Alzheimer's
disease.
Juan Lantero Rodriguez, Anniina Snellman, Andréa Lessa Benedet, Marta Milà-Alomà, Elena Camporesi, Laia Montoliu-Gaya, Nicholas J. Ashton, Agathe Vrillon, Thomas Karikari, Juan Domingo Gispert, Gemma Salvadó, Mahnaz Shekari, Christina E Toomey, Tammaryn L Lashley, Henrik Zetterberg, Marc Suárez-Calvet, Gunnar Brinkmalm, Pedro Rosa Neto, Kaj Blennow
EMBO molecular medicine - 2021 -
CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory
pathway
Laia Montoliu-Gaya, Daniel Tietze, Debora Kaminski, E. Mirgorodskaya, Alesia A. Tietze, Fredrik H Sterky
Embo Reports - 2021 -
Blood Biomarkers for Alzheimer's Disease in Down
Syndrome
Laia Montoliu-Gaya, A. Strydom, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Journal of Clinical Medicine - 2021 -
Both Amyloid-beta Peptide and Tau Protein Are Affected by an Anti-Amyloid-beta Antibody Fragment in Elderly 3xTg-AD
Mice
A. R. Roda, Laia Montoliu-Gaya, G. Serra-Mir, S. Villegas
International Journal of Molecular Sciences - 2020 -
Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β
Burden
Gisela Esquerda-Canals, Alejandro R. Roda, Joaquim Martí-Clúa, Laia Montoliu-Gaya, Geovanny Rivera-Hernández, Sandra Villegas
Journal of Alzheimer's Disease - 2019 -
The Role of Apolipoprotein E Isoforms in Alzheimer's
Disease
A. R. Roda, Laia Montoliu-Gaya, S. Villegas
Journal of Alzheimers Disease - 2019