Silke Kern
SENIOR LECTURER/ CHIEF PHYSICIAN
Department of Psychiatry andAvd-/Sektionschef, Bitr, Inst
Department of Psychiatry andAbout Silke Kern
Dr. Silke Kern is an Associate Professor, Senior Lecturer and Senior Consultant Neurologist and Psychiatrist at the Institute of Neuroscience and Physiology, Centre for Ageing and Health, Sahlgrenska Academy at the University of Gothenburg. She is leading all clinical research conducted at the Memory Clinic, Sahlgrenska University Hospital.
Research areas
Dr. Kern's main research focus is fluid biomarkers for Alzheimer's disease in clinical settings as well as in epidemiological research. Dr Kern is leading all clinical research at the Memory Clinic, Sahlgrenska University Hospital and is Principal Investigator for the European Prevention of Alzheimer's disease Trial Delivery Center at the Memory Clinic at Sahlgrenska University Hospital. Dr. Silke Kerns research aim is to increase knowledge about dementia and cognitive disorders from early diagnosis to treatment.
Main research areas are:
- Biomarkers of Alzheimer's disease in cerebrospinal fluid
- MRI brain imaging as biomarker for different neurodegenerative diseases
- Riskfactors for development of different neurodegenerative diseases
- Incidence and time-changes of dementia over the last decades
Research group
-
Depression in relation to sex and gender expression among Swedish septuagenarians-Results from the H70
study
Therese Rydberg Sterner, Pia Gudmundsson, Hanna Falk, Nazib Seidu, Felicia Ahlner, Hanna Wetterberg, Lina Rydén, Robert Sigström, Svante Östling, Anna Zettergren, Silke Kern, Margda Waern, Ingmar Skoog
Plos One - 2020-01-01 -
Reproductive period and dementia: A 44-year longitudinal population study of Swedish
women
Jenna Najar, Svante Östling, Margda Waern, Anna Zettergren, Silke Kern, Hanna Wetterberg, Tore Hällström, Ingmar Skoog
Alzheimers & Dementia - 2020-01-01 -
Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts
Consortium.
Frank J Wolters, Lori B Chibnik, Reem Waziry, Roy Anderson, Claudine Berr, Alexa Beiser, Joshua C Bis, Deborah Blacker, Daniel Bos, Carol Brayne, Jean-François Dartigues, Sirwan K L Darweesh, Kendra L Davis-Plourde, Frank de Wolf, Stephanie Debette, Carole Dufouil, Myriam Fornage, Jaap Goudsmit, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M Arfan Ikram, M Kamran Ikram, Erik Joas, Silke Kern, Lewis H Kuller, Lenore Launer, Oscar L Lopez, Fiona E Matthews, Kevin McRae-McKee, Osorio Meirelles, Thomas H Mosley, Matthew P Pase, Bruce M Psaty, Claudia L Satizabal, Sudha Seshadri, Ingmar Skoog, Blossom C M Stephan, Hanna Wetterberg, Mei Mei Wong, Anna Zettergren, Albert Hofman
Neurology - 2020-01-01 -
Epidemiology of suicidal feelings in an ageing Swedish population: From old to very old age in the Gothenburg H70 Birth Cohort
Studies
Madeleine Mellqvist Fässberg, Barbara Vanaelst, Mattias Jonson, Therese Rydberg Sterner, Felicia Ahlner, Hanna Wetterberg, Lina Rydén, Silke Kern, Robert Sigström, Anna Zettergren, Ingmar Skoog, Margda Waern
Epidemiology and Psychiatric Sciences - 2020-01-01 -
Predicting Fazekas scores from automatic segmentations of white matter signal
abnormalities
N. Cedres, D. Ferreira, A. Machado, S. Shams, Simona Sacuiu, Margda Waern, L. O. Wahlund, Anna Zettergren, Silke Kern, Ingmar Skoog, E. Westman
Aging-Us - 2020-01-01 -
Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and
neurogranin.
Michelle M Mielke, Jeremy A Syrjanen, Kaj Blennow, Henrik Zetterberg, Ingmar Skoog, Prashanthi Vemuri, Mary M Machulda, Jonathan Graff-Radford, David S Knopman, Clifford R Jack, Ronald C Petersen, Silke Kern
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2019-01-01 -
Amyloid β42 and Total Tau Levels in Cerebrospinal Fluid Associate with Survival in an 85-Year-Old Population-Based Cohort Followed until
Death
Mats Ribbe, Anne Börjesson-Hanson, Silke Kern, Svante Östling, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog
Dementia and Geriatric Cognitive Disorders - 2019-01-01 -
Agreement between self-reports, proxy-reports and the National Patient Register regarding diagnoses of cardiovascular disorders and diabetes mellitus in a population-based sample of
80-year-olds
Lina Rydén, Robert Sigström, Johan Nilsson, Valter Sundh, Hanna Falk, Silke Kern, Margda Waern, Svante Östling, Katarina Wilhelmson, Ingmar Skoog
Age and Ageing - 2019-01-01 -
Atrial fibrillation increases the risk of dementia amongst older adults even in the absence of
stroke
Lina Rydén, Anna Zettergren, Nazib Seidu, Xinxin Guo, Silke Kern, Kaj Blennow, Henrik Zetterberg, Simona Sacuiu, Ingmar Skoog
Journal of Internal Medicine - 2019-01-01 -
Plasma and CSF neurofilament light Relation to longitudinal neuroimaging and cognitive
measures
M. M. Mielke, J. A. Syrjanen, Kaj Blennow, Henrik Zetterberg, P. Vemuri, Ingmar Skoog, M. M. Machulda, W. K. Kremers, D. S. Knopman, C. Jack, R. C. Petersen, Silke Kern
Neurology - 2019-01-01 -
Longstanding psychological stress in relation to biomarkers of neuronal dysfunction in cerebrospinal fluid: a 25-year follow-up study in
women
Lena Johansson, Simona Sacuiu, Silke Kern, Xinxin Guo, Henrik Zetterberg, Kaj Blennow, Anna Zettergren, Ingmar Skoog
Neurobiology of Aging - 2019-01-01 -
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease
progression
S. De, D. R. Whiten, F. S. Ruggeri, C. Hughes, M. Rodrigues, D. I. Sideris, C. G. Taylor, F. A. Aprile, S. Muyldermans, T. P. J. Knowles, M. Vendruscolo, C. Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, D. Klenerman
Acta Neuropathologica Communications - 2019-01-01 -
Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE
genotype
L. Vermunt, S. A. M. Sikkes, A. van den Hout, R. Handels, I. Bos, W. M. van der Flier, Silke Kern, P. J. Ousset, P. Maruff, Ingmar Skoog, F. R. J. Verhey, Y. Freund-Levi, M. Tsolaki, A. K. Wallin, M. O. Rikkert, H. Soininen, L. Spiru, Henrik Zetterberg, Kaj Blennow, P. Scheltens, G. Muniz-Terrera, P. J. Visser, B. Vellas, E. Reynish, P. J. Ousset, S. Andrieu, A. Burns, F. Pasquier, G. Frisoni, E. Salmon, J. P. Michel, D. S. Zekry, M. Boada, J. F. Dartigues, M. G. M. Olde-Rikkert, A. S. Rigaud, B. Winblad, A. Malick, A. Sinclair, L. Frolich, P. Scheltens, C. Ribera, J. Touchon, P. Robert, A. Salva, G. Waldemar, R. Bullock, M. Tsolaki, G. Rodriguez, L. Spiru, R. W. Jones, G. Stiens, G. Stoppe, M. E. Jonhagen, A. Cherubini, P. M. Lage, T. Gomezisla, V. Camus, E. Aguera-Morales, F. Lopez, S. Savy, C. Cantet, N. Coley
Alzheimers & Dementia - 2019-01-01 -
Urate and risk of Alzheimer's disease and vascular dementia: A population-based
study
Lieke Scheepers, Lennart T. H. Jacobsson, Silke Kern, Lena Johansson, Mats Dehlin, Ingmar Skoog
Alzheimers & Dementia - 2019-01-01 -
Depression and neuroticism decrease among women but not among men between 1976-2016 in Swedish
septuagenarians
Therese Rydberg Sterner, Pia Gudmundsson, Robert Sigström, Felicia Ahlner, Nazib Seidu, Anna Zettergren, Silke Kern, Svante Östling, Margda Waern, Ingmar Skoog
Acta Psychiatrica Scandinavica - 2019-01-01 -
The Gothenburg H70 Birth cohort study 2014-16: design, methods and study
population.
Therese Rydberg Sterner, Felicia Ahlner, Kaj Blennow, Synneve Dahlin-Ivanoff, Hanna Falk, Lena Havstam Johansson, Maria Hoff, Mathias Holm, Helena M Hörder, Tina Jacobsson, Boo Johansson, Lena Johansson, Jürgen Kern, Silke Kern, Alejandra Machado, Madeleine Mellqvist Fässberg, Johan Nilsson, Mats Ribbe, Elisabeth Rothenberg, Lina Rydén, André M. Sadeghi, Simona Sacuiu, Jessica Samuelsson, Robert Sigström, Johan Skoog, Valgeir Thorvaldsson, Margda Waern, Eric Westman, Hanna Wetterberg, Henrik Zetterberg, Madeleine Zetterberg, Anna Zettergren, Svante Östling, Ingmar Skoog
European journal of epidemiology - 2019-01-01 -
Cognitive and physical activity and dementia A 44-year longitudinal population study of
women
Jenna Najar, Svante Östling, Pia Gudmundsson, Valter Sundh, Lena Johansson, Silke Kern, Xinxin Guo, Tore Hällström, Ingmar Skoog
Neurology - 2019-01-01 -
Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive
Impairment.
Silke Kern, Jeremy A Syrjanen, Kaj Blennow, Ingmar Skoog, Henrik Zetterberg, Margda Waern, Clinton E Hagen, Argonde C van Harten, David S Knopman, Clifford R Jack, Ronald C Petersen, Michelle M Mielke
JAMA neurology - 2019-01-01 -
Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau
protein
Anna Zettergren, Kina Höglund, Silke Kern, Valgeir Thorvaldsson, Johan Skoog, O. Hansson, N. Andreasen, N. Bogdanovic, Kaj Blennow, Ingmar Skoog, Henrik Zetterberg
Scientific Reports - 2019-01-01 -
Increased Alcohol Consumption Among Swedish 70-Year-Olds 1976 to 2016: Analysis of Data from The Gothenburg H70 Birth Cohort Studies,
Sweden
Felicia Ahlner, Robert Sigström, Therese Rydberg Sterner, Madeleine Mellqvist Fässberg, Silke Kern, Svante Östling, Margda Waern, Ingmar Skoog
Alcoholism: Clinical and Experimental Research - 2018-01-01 -
Prevalence of preclinical Alzheimer disease Comparison of current classification
systems
Silke Kern, Henrik Zetterberg, Jürgen Kern, Anna Zettergren, Margda Waern, Kina Höglund, Ulf Andreasson, Hanna Wetterberg, Anne Börjesson-Hanson, Kaj Blennow, Ingmar Skoog
Neurology - 2018-01-01 -
A 10-Year Follow-Up of Adiposity and Dementia in Swedish Adults Aged 70 Years and
Older
I. A. C. Arnoldussen, Valter Sundh, Kristoffer Bäckman, Silke Kern, Svante Östling, Kaj Blennow, Henrik Zetterberg, Ingmar Skoog, Amanda Kiliaan, Deborah Gustafson
Journal of Alzheimers Disease - 2018-01-01 -
Low Cerebrospinal Fluid Aβ42 and Aβ40 are Related to White Matter Lesions in Cognitively Normal
Elderly.
Ingmar Skoog, Silke Kern, Henrik Zetterberg, Svante Östling, Anne Börjesson-Hanson, Xinxin Guo, Kaj Blennow
Journal of Alzheimer's disease : JAD - 2018-01-01 -
Subjective Sleep Disturbance is associated with preclinical Alzheimer’s Disease in Cerebrospinal Fluid in a Population-Based Study of 70-Year-Olds without
dementia.
Johan Skoog, Henrik Zetterberg, Kaj Blennow, Silke Kern, Valgeir Thorvaldsson, Ingmar Skoog, Boo Johansson
The 24th Nordic Conference of Gerontology, 2-4 May, Oslo, Norge - 2018-01-01 -
Poor Sleep Is Associated with CSF-Markers of Alzheimer’s Disease in 70-Year-Olds without
Dementia
Johan Skoog, Henrik Zetterberg, Kaj Blennow, Silke Kern, Boo Johansson, Ingmar Skoog, Valgeir Thorvaldsson
2018’s Alzheimer's Association International Conference, Chicago, USA. - 2018-01-01 -
Subjective Sleep Disturbance is associated with preclinical Alzheimer’s Disease in Cerebrospinal Fluid in a Population-Based Study of 70-Year-Olds without
dementia
Johan Skoog, Boo Johansson, Henrik Zetterberg, Kaj Blennow, Valgeir Thorvaldsson, Ingmar Skoog, Silke Kern
The 19th congress of the Section of Epidemiology and Social Psychiatry of the European Psychiatric Association (EPA), Wien, Österrike. - 2018-01-01 -
Increased risk of dementia in subjective cognitive decline if CT brain changes are
present
Simona Sacuiu, Marie Eckerström, Lena Johansson, Silke Kern, Robert Sigström, Xinxin Guo, Svante Östling, Ingmar Skoog
Journal of Alzheimer's Disease - 2018-01-01 -
Genetic variation in FOXO3 is associated with self-rated health in a population-based sample of older
individuals.
Anna Zettergren, Silke Kern, Lina Rydén, Svante Östling, Kaj Blennow, Henrik Zetterberg, Hanna Falk, Ingmar Skoog
The journals of gerontology. Series A, Biological sciences and medical sciences - 2018-01-01 -
Increased risk for dementia both before and after stroke: A population-based study in women followed over 44
years
Xinxin Guo, Svante Östling, Silke Kern, Lena Johansson, Ingmar Skoog
Alzheimers & Dementia - 2018-01-01 -
Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: A 25-Year Follow-Up
Study.
Lena Johansson, Silke Kern, Henrik Zetterberg, Kaj Blennow, Lars Rosengren, Xinxin Guo, Ingmar Skoog
Dementia and geriatric cognitive disorders - 2018-01-01 -
Midlife cardiovascular fitness and dementia A 44-year longitudinal population study in
women
Helena M Hörder, Lena Johansson, Xinxin Guo, Gunnar Grimby, Silke Kern, Svante Östling, Ingmar Skoog
Neurology - 2018-01-01 -
Author response: Calcium supplementation and risk of dementia in women with cerebrovascular
disease.
Silke Kern, Jürgen Kern, Kaj Blennow, Henrik Zetterberg, Margda Waern, Xinxin Guo, Anne Börjesson-Hanson, Ingmar Skoog, Svante Östling
Neurology - 2017-01-01 -
Multi-infarct dementia of Swedish type is caused by a 3'UTR mutation of
COL4A1.
Maija Siitonen, Anne Börjesson-Hanson, Minna Pöyhönen, Ari Ora, Petra Pasanen, Jose Bras, Silke Kern, Jürgen Kern, Oluf Andersen, Horia Stanescu, Robert Kleta, Marc Baumann, Rajesh Kalaria, H Kalimo, Andy Singleton, John Hardy, Matti Viitanen, Liisa Myllykangas, Rita Guerreiro
Brain : a journal of neurology - 2017-01-01 -
Expanding the cerebrospinal fluid
endopeptidome
Karl Hansson, Tobias Skillbäck, Elin Pernevik, Silke Kern, Erik Portelius, Kina Höglund, Gunnar Brinkmalm, Jessica Holmén Larsson, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Proteomics - 2017-01-01 -
The relation between subjective sleep disturbance and Amyloid
β.
Johan Skoog, Silke Kern, Valgeir Thorvaldsson, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Boo Johansson
IAGG-2017, San Francisco, USA: 23-27 july - 2017-01-01 -
Investigation of associations between ILRAP-related genetic variation and CSF-biomarkers of amyloid- and tangle pathology, AD-risk, and cognitive
decline.
Anna Zettergren, Silke Kern, Valgeir Thorvaldsson, Johan Skoog, Ingmar Skoog, Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Kina Höglund
2017’s Alzheimer's Association International Conference (AAIC), London, Storbritannien: 16-20 July - 2017-01-01 -
Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts
Consortium
L. B. Chibnik, F. J. Wolters, Kristoffer Bäckman, A. Beiser, C. Berr, J. C. Bis, E. Boerwinkle, D. Bos, C. Brayne, J. F. Dartigues, S. K. L. Darweesh, S. Debette, K. L. Davis-Plourde, C. Dufouil, M. Fornage, L. Grasset, V. Gudnason, C. Hadjichrysanthou, C. Helmer, M. A. Ikram, M. K. Ikram, Silke Kern, L. H. Kuller, L. Launer, O. L. Lopez, F. Matthews, O. Meirelles, T. Mosley, A. Ower, B. M. Psaty, C. L. Satizabal, S. Seshadri, Ingmar Skoog, B. C. M. Stephan, C. Tzourio, R. Waziry, M. M. Wong, Anna Zettergren, A. Hofman
European Journal of Epidemiology - 2017-01-01 -
CSF YKL-40 and GAP-43 are related to suicidal ideation in older
women
Irma Rymo, Silke Kern, Maria Bjerke, Henrik Zetterberg, Thomas Marlow, Kaj Blennow, Pia Gudmundsson, Ingmar Skoog, Margda Waern
Acta Psychiatrica Scandinavica - 2017-01-01 -
Sex differences in time trends of blood pressure among Swedish septuagenarians examined three decades apart: a longitudinal population
study
Erik Joas, Xinxin Guo, Silke Kern, Svante Östling, Ingmar Skoog
Journal of Hypertension - 2017-01-01 -
Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and
stroke
Ingmar Skoog, Anne Börjesson-Hanson, Silke Kern, Lena Johansson, Hanna Falk, Robert Sigström, Svante Östling
Scientific Reports - 2017-01-01 -
Preclinical amyloid pathology biomarker positivity: effects on tau pathology and
neurodegeneration
Kina Höglund, Silke Kern, Anna Zettergren, Anne Börjesson-Hanson, Henrik Zetterberg, Ingmar Skoog, Kaj Blennow
Translational Psychiatry - 2017-01-01 -
Cerebrospinal Fluid Fatty Acid-Binding Protein 3 is Related to Dementia Development in a Population-Based Sample of Older Adult Women Followed for 8
Years.
Maria Bjerke, Silke Kern, Kaj Blennow, Henrik Zetterberg, Margda Waern, Anne Börjesson-Hanson, Svante Östling, Jürgen Kern, Ingmar Skoog
Journal of Alzheimer's disease : JAD - 2016-01-01 -
The Gothenburg MCI study: design and distribution of Alzheimer's disease and subcortical vascular disease diagnoses from baseline to 6-year
follow-up.
Anders Wallin, Arto Nordlund, Michael Jonsson, Karin Lind, Åke Edman, Mattias Göthlin, Jacob Stålhammar, Marie Eckerström, Silke Kern, Anne Börjesson-Hanson, Mårten Carlsson, Erik Olsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Annika Öhrfelt Olsson, Maria Bjerke, Sindre Rolstad, Carl Eckerström
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 2016-01-01 -
Vascular factors in suspected normal pressure hydrocephalus. A population-based
study
Daniel Jaraj, Simon Agerskov, Katrin Rabiei, Thomas Marlow, Christer Jensen, Xinxin Guo, Silke Kern, Carsten Wikkelsö, Ingmar Skoog
Neurology - 2016-01-01 -
Calcium supplementation and risk of dementia in women with cerebrovascular
disease.
Jürgen Kern, Silke Kern, Kaj Blennow, Henrik Zetterberg, Margda Waern, Xinxin Guo, Anne Börjesson-Hanson, Ingmar Skoog, Svante Östling
Neurology - 2016-01-01 -
The distribution of apolipoprotein E genotype over the adult lifespan and in relation to country of
birth
Silke Kern, Kirsten Mehlig, Jürgen Kern, Henrik Zetterberg, Dag Thelle, Ingmar Skoog, Lauren Lissner, Kaj Blennow, Anne Börjesson-Hanson
American Journal of Epidemiology - 2015-01-01 -
A 9-Year Prospective Population-Based Study on the Association Between the APOE*E4 Allele and Late-Life Depression in
Sweden
Ingmar Skoog, Margda Waern, P Duberstein, Kaj Blennow, Henrik Zetterberg, Anne Börjesson-Hanson, Svante Östling, Xinxin Guo, Deborah Gustafson, Pia Gudmundsson, Thomas Marlow, Silke Kern
Biological Psychiatry - 2015-01-01 -
White Matter Lesions and Temporal Lobe Atrophy Related to incidence of both Dementia and Major Depression in 70-year-olds followed over 10
years
Pia Gudmundsson, Pernille J Olesen, Michela Simoni, Leonardo Pantoni, Svante Östling, Silke Kern, Xinxin Guo, Ingmar Skoog
European Journal of Neurology - 2015-01-01 -
Higher CSF interleukin-6 and CSF interleukin-8 in current depression in older women. Results from a population-based
sample.
Silke Kern, Ingmar Skoog, Anne Börjesson-Hanson, Kaj Blennow, Henrik Zetterberg, Svante Östling, Jürgen Kern, Pia Gudmundsson, Lars Rosengren, Margda Waern
Brain, behavior, and immunity - 2014-01-01 -
Lower CSF interleukin-6 predicts future depression in a population-based sample of older women followed for 17
years
Silke Kern, Ingmar Skoog, Anne Börjesson-Hanson, Kaj Blennow, Henrik Zetterberg, Svante Östling, Jürgen Kern, Pia Gudmundsson, Thomas Marlow, Lars Rosengren, Margda Waern
Brain Behavior and Immunity - 2013-01-01 -
Does low-dose acetylsalicylic acid prevent cognitive decline in women with high cardiovascular risk? A 5-year follow-up of a non-demented population-based cohort of Swedish elderly
women.
Silke Kern, Svante Östling, Ingmar Skoog, Jürgen Kern, Anne Börjesson-Hanson
BMJ Open - 2012-01-01