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- Guglielmo Di Molfetta
Guglielmo Di Molfetta
Doctoral Student
Department of Psychiatry and Neurochemistry-
Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical
Utility?
Andrea Lessa Benedet, Burak Arslan, Kubra Tan, Hanna Huber, Ilaria Pola, Guglielmo Di Molfetta, Hlin Kvartsberg, Anna Orduna Dolado, Shorena Janelidze, Kaj Blennow, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Nicholas Ashton
CLINICAL CHEMISTRY - 2025 -
Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down
syndrome.
Hanna Huber, Javier Arranz, Burak Arslan, Antoine Leuzy, Oscar Kittel, Guglielmo Di Molfetta, Bessy Benejam, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Lucía Maure-Blesa, Íñigo Rodríguez-Baz, José Enrique Arriola Infante, Ignacio Illán-Gala, Alexandre Bejanin, Laia Montoliu-Gaya, Alberto Lleó, María Carmona-Iragui, Daniel Alcolea, Kaj Blennow, Henrik Zetterberg, Juan Fortea, Nicholas Ashton
Nature communications - 2025 -
Glia inflammation and cell death pathways drive disease progression in preclinical and early
AD.
Marcel S Woo, Joseph Therriault, Seyyed Ali Hosseini, Yi-Ting Wang, Arthur C Macedo, Nesrine Rahmouni, Étienne Aumont, Stijn Servaes, Cécile Tissot, Jaime Fernandez-Arias, Lydia Trudel, Brandon Hall, Gleb Bezgin, Kely Quispialaya-Socualaya, Marina Goncalves, Tevy Chan, Jenna Stevenson, Yansheng Zheng, Stuart Mitchell, Robert Hopewell, Ilaria Pola, Kubra Tan, Guglielmo Di Molfetta, Firoza Z Lussier, Gassan Massarweh, Paolo Vitali, Jean-Paul Soucy, Serge Gauthier, Nicholas Ashton, Kaj Blennow, Tharick A Pascoal, Henrik Zetterberg, Andrea Lessa Benedet, Pedro Rosa-Neto
EMBO molecular medicine - 2025 -
Profiling Plasma Biomarkers, Particularly pTau217 and pTau217/Aβ42, and Their Relation to Cognition in Memory Clinic
Patients
Marco Bucci, Ove Almkvist, Marina Bluma, Nicholas Ashton, Irina Savitcheva, Konstantinos Chiotis, Guglielmo Di Molfetta, Kaj Blennow, Henrik Zetterberg, Agneta Nordberg
JOURNAL OF NEUROCHEMISTRY - 2025 -
Early microglial and astrocyte reactivity in preclinical Alzheimer's
disease
Marta Fernandez-Matarrubia, Andrea Valera-Barrero, Monica Renuncio-Garcia, Marcos Aguilella, Carmen Lage, Sara Lopez-Garcia, J. Gonzalo Ocejo-Vinyals, Francisco Martinez-Dubarbie, Guglielmo Di Molfetta, Ana Pozueta-Cantudo, Maria Garcia-Martinez, Andrea Corrales-Pardo, Maria Bravo, Marcos Lopez-Hoyos, Juan Irure-Ventura, Kaj Blennow, Nicholas Ashton, Henrik Zetterberg, Pascual Sanchez-Juan, Eloy Rodriguez-Rodriguez
ALZHEIMERS & DEMENTIA - 2025 -
Disentangling relationships between Alzheimer's disease plasma biomarkers and established biomarkers in patients of tertiary memory
clinics.
Marina Bluma, Konstantinos Chiotis, Marco Bucci, Irina Savitcheva, Anna Matton, Miia Kivipelto, Andreas Jeromin, Giovanni de Santis, Guglielmo Di Molfetta, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Agneta Nordberg
EBioMedicine - 2025 -
Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich
Assay
Nicholas J. Ashton, Andrea L Benedet, Guglielmo Di Molfetta, Ilaria Pola, Federica Anastasi, Aida Fernandez-Lebrero, Albert Puig-Pijoan, Ashvini Keshavan, Jonathan Schott, Kubra Tan, Joel Simrén, Bárbara Fernandes Gomes, Laia Montoliu-Gaya, Richard Isaacson, Matilde Bongianni, Chiara Tolassi, Valentina Cantoni, Antonella Alberici, Alessandro Padovani, Gianluigi Zanusso, Andrea Pilotto, Barbara Borroni, Marc Suarez-Calvet, Kaj Blennow, Henrik Zetterberg
ALZHEIMERS & DEMENTIA - 2025 -
Identify biological Alzheimer's disease using a novel nucleic acid-linked protein
immunoassay
Yi-Ting Wang, Nicholas J. Ashton, Joseph Therriault, Andrea L Benedet, Arthur C. Macedo, Ilaria Pola, Etienne Aumont, Guglielmo Di Molfetta, Jaime Fernandez-Arias, Kübra Tan, Nesrine Rahmouni, Stijn Johannes G. Servaes, Richard Isaacson, Tevy Chan, Seyyed Ali Hosseini, Cecile Tissot, Sulantha Mathotaarachchi, Jenna Stevenson, Firoza Z. Lussier, Tharick A. Pascoal, Serge Gauthier, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto
Brain Communications - 2025 -
Biofluid-based staging of Alzheimer's
disease
Juan Lantero Rodriguez, Laia Montoliu-Gaya, Nicholas J. Ashton, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Wagner Scheeren Brum, Stijn Servaes, Jenna Stevenson, Guglielmo Di Molfetta, Burak Arslan, Jesse Klostranec, Paolo Vitali, Maxime Montembeault, Serge Gauthier, Cecile Tissot, Arthur C. Macedo, Tharick A. Pascoal, Andreas Jeromin, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L Benedet
ACTA NEUROPATHOLOGICA - 2025 -
Inflammation biomarkers and Alzheimer's disease: A pilot study using
NULISAseq
Guglielmo Di Molfetta, Ilaria Pola, Kübra Tan, Richard Isaacson, Kaj Blennow, Nicholas J. Ashton, Andrea L Benedet, Henrik Zetterberg
Alzheimer's & Dementia - 2025 -
Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease
Pathology
Nicholas J. Ashton, Wagner Scheeren Brum, Guglielmo Di Molfetta, Andréa Lessa Benedet, Burak Arslan, Erin Jonaitis, Rebecca E. Langhough, Karly Cody, Rachael Wilson, Cynthia M. Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleo, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg
JAMA NEUROLOGY - 2024 -
Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander
disease
Nicholas J. Ashton, Guglielmo Di Molfetta, Kübra Tan, Kaj Blennow, Henrik Zetterberg, Albee Messing
Neurological Sciences - 2024 -
Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid
PET
Steffi De Meyer, Jolien M. Schaeverbeke, Emma S. Luckett, Mariska Reinartz, Elena R. Blujdea, Isabelle Cleynen, Patrick Dupont, Koen Van Laere, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Guglielmo Di Molfetta, Henrik Zetterberg, Nicholas J. Ashton, Charlotte E. Teunissen, Koen Poesen, Rik Vandenberghe
BRAIN COMMUNICATIONS - 2024 -
Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer's risk-enhanced
sample
Lianlian Du, Rebecca E. Langhough, Rachael E. Wilson, Ramiro Eduardo Rea Reyes, Bruce P. Hermann, Erin M. Jonaitis, Tobey J. Betthauser, Nathaniel A. Chin, Bradley Christian, Lauren Chaby, Andreas Jeromin, Guglielmo Di Molfetta, Wagner Scheeren Brum, Burak Arslan, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson
ALZHEIMERS & DEMENTIA - 2024 -
Plasma Phosphorylated Tau 231 Increases at One-Year Intervals in Cognitively Unimpaired
Subjects
Francisco Martinez-Dubarbie, Sara Lopez-Garcia, Carmen Lage, Guglielmo Di Molfetta, Marta Fernandez-Matarrubia, Ana Pozueta-Cantudo, Maria Garcia-Martinez, Andrea Corrales-Pardo, Maria Bravo, Julio Jimenez-Bonilla, Remedios Quirce, Enrique Marco de Lucas, Marta Drake-Perez, Diana Tordesillas, Marcos Lopez-Hoyos, Juan Irure-Ventura, Elizabeth Valeriano-Lorenzo, Kaj Blennow, Nicholas J. Ashton, Henrik Zetterberg, Eloy Rodriguez-Rodriguez, Pascual Sanchez-Juan
JOURNAL OF ALZHEIMERS DISEASE - 2024 -
Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's
pathology.
Joseph Therriault, Nicholas J. Ashton, Ilaria Pola, Gallen Triana-Baltzer, Wagner Scheeren Brum, Guglielmo Di Molfetta, Burak Arslan, Nesrine Rahmouni, Cecile Tissot, Stijn Servaes, Jenna Stevenson, Arthur Cassa Macedo, Tharick Ali Pascoal, Hartmuth Christian Kolb, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andréa Lessa Benedet
EBioMedicine - 2024 -
Diagnostic accuracy of the plasma ALZpath pTau217 immunoassay to identify Alzheimer's disease
pathology.
Nicholas J. Ashton, Wagner Scheeren Brum, Guglielmo Di Molfetta, Andréa Lessa Benedet, Burak Arslan, Erin Jonatis, Rebecca E Langhough, Karly Cody, Rachael Wilson, Cynthia M Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg
medRxiv : the preprint server for health sciences - 2023 -
Levels of Alzheimer's disease blood biomarkers are altered after food intake-A pilot intervention study in healthy
adults
Hanna Huber, Nicholas J. Ashton, A. Schieren, Laia Montoliu-Gaya, Guglielmo Di Molfetta, Wagner Scheeren Brum, Juan Lantero Rodriguez, Lana Grötschel, B. Stoffel-Wagner, M. Coenen, L. Weinhold, M. Schmid, Kaj Blennow, P. Stehle, Henrik Zetterberg, M. C. Simon
Alzheimers & Dementia - 2023 -
Blood beta-synuclein is related to amyloid PET positivity in memory clinic
patients
P. Oeckl, M. Bluma, M. Bucci, S. Halbgebauer, K. Chiotis, A. Sandebring-Matton, Nicholas J. Ashton, Guglielmo Di Molfetta, Lana Grötschel, M. Kivipelto, Kaj Blennow, Henrik Zetterberg, I. Savitcheva, A. Nordberg, M. Otto
Alzheimers & Dementia - 2023 -
Profiling of plasma biomarkers in the context of memory assessment in a tertiary memory
clinic
M. Bucci, M. Bluma, I. Savitcheva, Nicholas J. Ashton, K. Chiotis, A. Matton, M. Kivipelto, Guglielmo Di Molfetta, Kaj Blennow, Henrik Zetterberg, A. Nordberg
Translational Psychiatry - 2023 -
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer's trial selection and disease
monitoring.
Nicholas J. Ashton, Shorena Janelidze, Niklas Mattsson-Carlgren, Alexa Pichet Binette, Olof Strandberg, Wagner Scheeren Brum, Thomas Karikari, Fernándo González-Ortiz, Guglielmo Di Molfetta, Francisco J Meda, Erin M Jonaitis, Rebecca Langhough Koscik, Karly Cody, Tobey J Betthauser, Yan Li, Eugeen Vanmechelen, Sebastian Palmqvist, Erik Stomrud, Randall J Bateman, Henrik Zetterberg, Sterling C Johnson, Kaj Blennow, Oskar Hansson
Nature medicine - 2022