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Thomas Karikari
Researcher
Department of Psychiatry and Neurochemistry-
Neuronal plasma biomarkers in acute ischemic
stroke
Julia K. Gundersen, Fernando Gonzalez-Ortiz, Thomas Karikari, Bjorn-Eivind Kirsebom, Katrin Mertes, Henrik Zetterberg, Hlin Kvartsberg, Ole Morten Ronning, Berglind Gisladottir, Kaj Blennow, Tormod Fladby
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM - 2025 -
Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid
onset
Cassandra M. Joynes, Murat Bilgel, Yang An, Abhay R. Moghekar, Nicholas J. Ashton, Przemyslaw R. Kac, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Madhav Thambisetty, Luigi Ferrucci, Susan M. Resnick, Keenan A. Walker
ALZHEIMERS & DEMENTIA - 2025 -
Sex differences on tau, astrocytic, and neurodegenerative plasma
biomarkers
Jacob Labonte, Michael A. Sugarman, Erika Pettway, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas Karikari, Hugo J. Aparicio, Brandon Frank, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Irene Simkin, Lindsay A. Farrer, Gyungah R. Jun, Katherine W. Turk, Andrew E. Budson, Maureen K. O'Connor, Rhoda Au, Lee E. Goldstein, Robert A. Stern, Thor D. Stein, Ann C. Mckee, Wei Qiao Qiu, Jesse Mez, Sarah J. Banks, Michael L. Alosco
JOURNAL OF ALZHEIMERS DISEASE - 2025 -
Dementia in a resource-constrained sub-Saharan African setting: A comprehensive retrospective analysis of prevalence, risk factors, and management at the only neuropsychiatric facility in Northeastern
Nigeria
Ibrahim Abdu Wakawa, Umar Baba Musami, Suleiman Hamidu Kwairanga, Placidus Nwankuba Ogualili, Mohammed Yusuf Mahmood, Muhammad Abba Fugu, Mohammed Mala Gimba, Muktar Mohammed Allamin, Zaharadeen Umar Abbas, Muhammad Kawu Sunkani, Zainab Bukar Yaganami, Fatima Mustapha Kadau, Nasir Muhammad Sani, Peter Danmallam, Luka Nanjul, Larema Babazau, Zaid Muhammad, Baba Waru Goni, Babagana Kundi Machina, Celeste M. Karch, Chinedu Udeh-Momoh, Thomas Karikari, Chiadi U. Onyike, Mahmoud Bukar Maina
ALZHEIMERS & DEMENTIA - 2025 -
Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal
Cohorts
Antonio Terracciano, Keenan A. Walker, Yang An, Murat Bilgel, Angelina R. Sutin, Martina Luchetti, Selin Karakose, Yannick Stephan, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Thomas Karikari, Przemyslaw R. Kac, Abhay R. Moghekar, Madhav Thambisetty, Luigi Ferrucci, Susan M. Resnick
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES - 2025 -
Impact of the polygenic risk scores for attention-deficit/hyperactivity disorder in Alzheimer's
disease
Douglas T. Leffa, Guilherme Povala, Bruna Bellaver, Joao Pedro Ferrari-Souza, Pamela C. L. Ferreira, Firoza Z. Lussier, Cristiano Schaffer Aguzzoli, Carolina Soares, Hussein Zalzale, Francieli Rohden, Guilherme Bauer-Negrini, Sarah Abbas, Maite Schneider, Joseph Therriault, Oscar L. Lopez, Victor L. Villemagne, William E. Klunk, Dana L. Tudorascu, Ann D. Cohen, Pedro Rosa-Neto, Eduardo R. Zimmer, Thomas Karikari, Luis Augusto Rohde, Brooke S. G. Molina, Tharick A. Pascoal
ALZHEIMERS & DEMENTIA - 2025 -
Opening for a new type of drug for Alzheimer’s
Disease.
Tohidul Islam, Kaj Blennow, Thomas Karikari
Press release, University of Gothenburg - 2025 -
Tau Aggregates in Cerebrospinal Fluid: A Promising Biomarker for Neurodegenerative
Diseases
Tohidul Islam, Kaj Blennow, Thomas Karikari
Alzheimer's & Dementia - 2025 -
Comparison of Plasma p-tau217 and [18F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical
Dementia.
Kely Monica Quispialaya, Joseph Therriault, Antonio Aliaga, Andrea L Benedet, Nicholas J. Ashton, Thomas Karikari, Arthur Cassa Macedo, Nesrine Rahmouni, Cécile Tissot, Jaime Fernandez Arias, Yi-Ting Tina Wang, Lydia Trudel, Seyyed Ali Hosseini, Takashi Matsudaira, Tevy Chan, Tharick Pascoal, Brian Gilfix, Paolo Vitali, Eduardo R Zimmer, Karine Provost, Jean-Paul Soucy, Serge Gauthier, Henrik Zetterberg, Bertrand J Jean-Claude, Kaj Blennow, Pedro Rosa-Neto
Neurology - 2025 -
Development of an immunoassay for the quantification of Tau aggregates in Alzheimer´s
disease
Tohidul Islam, Thomas Karikari, Henrik Zetterberg, Kaj Blennow
Alzheimer's & Parkinson's Diseases - 2024 -
Cerebrospinal Fluid Tau Amplification and Immunoassay: A Combinational Approach in Tauopathy
Diagnosis
Tohidul Islam, Thomas Karikari, Kaj Blennow
Society for CSF analysis and clinical neurochemistry - 2024 -
Hippocampal degeneration is associated with GFAP levels in individuals with vascular dementia independently of
amyloidosis
Markley Oliveira, Bruna Bellaver, Firoza Z. Lussier, Pamela C.L. Ferreira, Guilherme Povala, Douglas Teixeira Leffa, Guilherme Bauer-Negrini, Matheus Scarpatto Rodrigues, Sarah Abbas, Hussein Zalzale, Francieli Rohden, Cynthia Felix, Carolina Soares, Pampa Saha, Emma Patrice Ruppert, Vitor Hugo Machado, Andreia Silva da Rocha, Dana Tudorascu, Andrea L Benedet, Nicholas J. Ashton, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Chang Hyung Hong, Hyun Woong Roh, Eduardo R. Zimmer, Kaj Blennow, Henrik Zetterberg, Thomas Karikari, Pedro Rosa-Neto, Sang Joon Son, Tharick A. Pascoal
Alzheimer's & Dementia - 2024 -
Proteome-wide analyses identifies plasma immune regulators of amyloid-beta
progression
Michael R. Duggan, Gabriela T. Gomez, Murat Bilgel, Jingsha Chen, Nicola Fattorelli, Timothy J. Hohman, Renzo Mancuso, Jenifer Cordon, Tonnar Castellano, Mary Ellen I. Koran, Julián Candia, Alexandria Lewis, Abhay Moghekar, Nicholas J. Ashton, Przemysław R Kac, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Anna Martinez-Muriana, Bart De Strooper, Madhav Thambisetty, Luigi Ferrucci, Rebecca F. Gottesman, Josef Coresh, Susan M. Resnick, Keenan A. Walker
Alzheimer's & Dementia - 2024 -
Evaluating Congruence Between Clinical and Biological Staging Across The Alzheimer’s Disease
Spectrum
Hussein Zalzale, Marina Scop Madeiros, Carolina Soares, Guilherme Bauer-Negrini, Guilherme Povala, Pamela C.L. Ferreira, Livia Amaral, Firoza Z. Lussier, Bruna Bellaver, Sarah Abbas, Matheus Scarpatto Rodrigues, Dana Tudorascu, Markley Oliveira, Cynthia Felix, Douglas Teixeira Leffa, Cécile Tissot, Cristiano Schaffer Aguzzoli, Emma Patrice Ruppert, Pampa Saha, Nesrine Rahmouni, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Belen Pascual, Brian A. Gordon, William J. Jagust, Val J. Lowe, Thomas Karikari, Hwamee Oh, William E. Klunk, David N. Soleimani-Meigooni, Pedro Rosa-Neto, Suzanne L. Baker, Tharick A. Pascoal
Alzheimer's & Dementia - 2024 -
Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical
probability.
Joseph Therriault, Shorena Janelidze, Andréa Lessa Benedet, Nicholas J. Ashton, Javier Arranz Martínez, Armand Gonzalez-Escalante, Bruna Bellaver, Daniel Alcolea, Agathe Vrillon, Helmet Karim, Michelle M Mielke, Chang Hyung Hong, Hyun Woong Roh, José Contador, Albert Puig Pijoan, Alicia Algeciras-Schimnich, Prashanthi Vemuri, Jonathan Graff-Radford, Val J Lowe, Thomas Karikari, Erin Jonaitis, Wagner Scheeren Brum, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur C Macedo, Jenna Stevenson, Jaime Fernandez-Arias, Yi-Ting Wang, Marcel S Woo, Manuel A Friese, Wan Lu Jia, Julien Dumurgier, Claire Hourregue, Emmanuel Cognat, Pamela Lukasewicz Ferreira, Paolo Vitali, Sterling Johnson, Tharick A Pascoal, Serge Gauthier, Alberto Lleó, Claire Paquet, Ronald C Petersen, David Salmon, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Erik Stomrud, Douglas Galasko, Sang Joon Son, Henrik Zetterberg, Juan Fortea, Marc Suárez-Calvet, Clifford R Jack, Kaj Blennow, Oskar Hansson, Pedro Rosa-Neto
Nature aging - 2024 -
Vascular risk burden is a key player in the early progression of Alzheimer's
disease
Joao Pedro Ferrari-Souza, Wagner Scheeren Brum, Lucas A. Hauschild, Lucas U. Da Ros, Pamela C. L. Ferreira, Bruna Bellaver, Douglas T. Leffa, Andrei Bieger, Cecile Tissot, Firoza Z. Lussier, Marco Antonio De Bastiani, Guilherme Povala, Andréa Lessa Benedet, Joseph Therriault, Yi-Ting Wang, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Sheila O. Martins, Diogo O. Souza, Pedro Rosa-Neto, Thomas Karikari, Tharick A. Pascoal, Eduardo R. Zimmer
NEUROBIOLOGY OF AGING - 2024 -
Plasma phosphorylated tau181 outperforms [18F] fluorodeoxyglucose positron emission tomography in the identification of early Alzheimer
disease
Kely Monica Quispialaya, Joseph Therriault, Antonio Aliaga, Cecile Tissot, Stijn Servaes, Nesrine Rahmouni, Thomas Karikari, Andréa Lessa Benedet, Nicholas J. Ashton, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Yi-Ting Wang, Jaime Fernandez Arias, Ali Hosseini, Takashi Matsudaira, Bertrand Jean-Claude, Brian M. Gilfix, Eduardo R. Zimmer, Jean-Paul Soucy, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
EUROPEAN JOURNAL OF NEUROLOGY - 2024 -
Cerebrospinal fluid p-tau181, 217, and 231 in definite Creutzfeldt-Jakob disease with and without concomitant
pathologies
Andreja Emersic, Nicholas J. Ashton, Agathe Vrillon, Juan Lantero Rodriguez, Jernej Mlakar, Milica Gregoric Kramberger, Fernando Gonzalez-Ortiz, Przemyslaw R. Kac, Maciej Dulewicz, Jörg Hanrieder, Eugeen Vanmechelen, Uros Rot, Henrik Zetterberg, Thomas Karikari, Sasa Cucnik, Kaj Blennow
ALZHEIMERS & DEMENTIA - 2024 -
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's
disease.
Georgette Argiris, Muge Akinci, Cleofé Peña-Gómez, Eleni Palpatzis, Marina Garcia-Prat, Mahnaz Shekari, Kaj Blennow, Henrik Zetterberg, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nicholas J. Ashton, Thomas Karikari, Ann Brinkmalm-Westman, Juan Lantero Rodriguez, Karine Fauria, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Marc Suárez-Calvet, Eider M Arenaza-Urquijo, For The Alfa Study
Alzheimer's research & therapy - 2024 -
Glial reactivity is linked to synaptic dysfunction across the aging and Alzheimer's disease
spectrum.
Tharick Pascoal, Francieli Rohden, Pamela Ferreira, Bruna Bellaver, João Pedro Ferrari-Souza, Cristiano Aguzzoli, Carolina Soares, Sarah Abbas, Hussein Zalzale, Guilherme Povala, Firoza Lussier, Douglas Leffa, Guilherme Bauer-Negrini, Nesrine Rahmouni, Cécile Tissot, Joseph Therriault Therriault, Stijn Servaes, Jenna Stevenson, Andrea L Benedet, Nicholas J. Ashton, Thomas Karikari, Dana Tudorascu, Henrik Zetterberg, Kaj Blennow, Eduardo Zimmer, Diogo Souza, Pedro Rosa-Neto
Research square - 2024 -
Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimer's
disease.
Przemysław R Kac, Daniel Alcolea, Laia Montoliu-Gaya, Susana Fernández, Juan Lantero Rodriguez, Lucía Maure, Fernando Gonzalez-Ortiz, Bessy Benejam, Michael Turton, Isabel Barroeta, Peter Harrison, Laura Videla, Nicholas J. Ashton, Alberto Lleó, Henrik Zetterberg, María Carmona-Iragui, Thomas Karikari, Juan Fortea, Kaj Blennow
medRxiv : the preprint server for health sciences - 2024 -
Plasma phosphorylated-tau217 is increased in Niemann-Pick disease type
C
Fernando Gonzalez-Ortiz, Thomas Karikari, Danielle Taylor-Te Vruchte, Dawn Shepherd, Bjorn-Eivind Kirsebom, Tormod Fladby, Frances Platt, Kaj Blennow
BRAIN COMMUNICATIONS - 2024 -
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired
elderly
Mikko Koivumäki, Laura Ekblad, Juan Lantero Rodriguez, Nicholas J. Ashton, Thomas Karikari, Semi Helin, Riitta Parkkola, Jyrki Lötjönen, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne, Anniina Snellman
Alzheimer's Research and Therapy - 2024 -
Biomarkers of tau phosphorylation state are associated with the clinical course of multiple
sclerosis
Andreja Emersic, Thomas Karikari, Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Maciej Dulewicz, Nicholas J. Ashton, Gregor Brecl Jakob, Alenka Horvat Ledinek, Jörg Hanrieder, Henrik Zetterberg, Uros Rot, Sasa Cucnik, Kaj Blennow
MULTIPLE SCLEROSIS AND RELATED DISORDERS - 2024 -
18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired
athletes
Anna Vasilevskaya, Chloe Anastassiadis, Simrika Thapa, Foad Taghdiri, Mozhgan Khodadadi, Namita Multani, Pablo Rusjan, Miracle Ozzoude, Apameh Tarazi, Asma Mushtaque, Richard Wennberg, Sylvain Houle, Robin Green, Brenda Colella, Neil Vasdev, Kaj Blennow, Henrik Zetterberg, Thomas Karikari, Christine Sato, Danielle Moreno, Ekaterina Rogaeva, David Mikulis, Karen Deborah Davis, Charles Tator, Maria Carmela Tartaglia
JOURNAL OF NEUROLOGY - 2024 -
Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result
reporting
Xuemei Zeng, Yijun Chen, Anuradha Sehrawat, Jihui Lee, Tara K. Lafferty, Julia Kofler, Sarah B. Berman, Robert A. Sweet, Dana L. Tudorascu, William E. Klunk, Milos D. Ikonomovic, Anna Pfister, Henrik Zetterberg, Beth E. Snitz, Anne D. Cohen, Victor L. Villemagne, Tharick A. Pascoal, M. llyas Kamboh, Oscar I. Lopez, Kaj Blennow, Thomas Karikari
MOLECULAR NEURODEGENERATION - 2024 -
Sex differences in Alzheimer's disease blood biomarkers in a Caribbean population of African ancestry: The Tobago Health
Study
Caterina Rosano, Thomas Karikari, Ryan Cvejkus, Bruna Bellaver, Pamela C. L. Ferreira, Joseph Zmuda, Victor Wheeler, Tharick A. Pascoal, Iva Miljkovic
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS - 2024 -
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's
disease.
Fernando Gonzalez-Ortiz, Bjørn-Eivind Kirsebom, José Contador, Jordan E Tanley, Per Selnes, Berglind Gísladóttir, Lene Pålhaugen, Mathilde Suhr Hemminghyth, Jonas Jarholm, Ragnhild Skogseth, Geir Bråthen, Gøril Grøndtvedt, Atle Bjørnerud, Sandra Tecelao, Knut Waterloo, Dag Aarsland, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Michael Turton, Agnes Hesthamar, Przemyslaw R. Kac, Johanna Nilsson, Jose Luchsinger, Kathleen M Hayden, Peter Harrison, Albert Puig-Pijoan, Henrik Zetterberg, Timothy M Hughes, Marc Suárez-Calvet, Thomas Karikari, Tormod Fladby, Kaj Blennow
Nature communications - 2024 -
Novel ultrasensitive immunoassay for the selective quantification of tau oligomers and related soluble
aggregates
Tohidul Islam, Hlin Kvartsberg, Anuradha Sehrawat, Przemyslaw R. Kac, Bruno Becker, Maria Olsson, Eric E. Abrahamson, Henrik Zetterberg, Milos D. Ikonomovic, Kaj Blennow, Thomas Karikari
ALZHEIMERS & DEMENTIA - 2024 -
Association of Plasma Brain-Derived Tau With Functional Outcome After Ischemic
Stroke.
Tara M Stanne, Fernando Gonzalez-Ortiz, Cecilia Brännmark, Katarina Jood, Thomas Karikari, Kaj Blennow, Christina Jern
Neurology - 2024 -
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease
neuropathology.
Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas Karikari
Nature communications - 2024 -
Analytical and clinical validation of Alzheimer's disease blood biomarkers with a focus on plasma
p-tau217.
Fernando Gonzalez-Ortiz, Thomas Karikari, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2024 -
Biomarker-based staging of Alzheimer disease: rationale and clinical
applications.
Joseph Therriault, Suzanne E Schindler, Gemma Salvadó, Tharick A Pascoal, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Liana Apostolova, Melissa E Murray, Inge Verberk, Jacob W Vogel, Renaud La Joie, Serge Gauthier, Charlotte Teunissen, Gil D Rabinovici, Henrik Zetterberg, Randall J Bateman, Philip Scheltens, Kaj Blennow, Reisa Sperling, Oskar Hansson, Clifford R Jack, Pedro Rosa-Neto
Nature reviews. Neurology - 2024 -
Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease
progression
Miriam Rabl, Leonardo Zullo, Piotr Lewczuk, Johannes Kornhuber, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Francesco Bavato, Boris B. Quednow, Erich Seifritz, Armin von Gunten, Christopher Clark, Julius Popp
ALZHEIMERS RESEARCH & THERAPY - 2024 -
Levels of plasma brain-derived tau and p-tau181 in Alzheimer's disease and rapidly progressive
dementias.
Fernando Gonzalez-Ortiz, Thomas Karikari, Giuseppe Mario Bentivenga, Simone Baiardi, Angela Mammana, Michael Turton, Przemyslaw R. Kac, Andrea Mastrangelo, Peter Harrison, Sabina Capellari, Henrik Zetterberg, Kaj Blennow, Piero Parchi
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2024 -
A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's
disease.
Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand González-Escalante, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R. Kac, Michael Turton, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Minguillon, Jose Contador, Marc Suárez-Calvet, Thomas Karikari, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2024 -
Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy
individuals
Wagner Scheeren Brum, Nicholas J. Ashton, Joel Simrén, Guiglielmo di Molfetta, Thomas Karikari, Andréa Lessa Benedet, Eduardo R. Zimmer, Juan Lantero Rodriguez, Laia Montoliu-Gaya, Andreas Jeromin, Aasne K. Aarsand, William A. Bartlett, Pilar Fernández Calle, Abdurrahman Coşkun, Jorge Díaz–Garzón, Niels Jonker, Henrik Zetterberg, Sverre Sandberg, Anna Carobene, Kaj Blennow
Alzheimer's and Dementia - 2024 -
Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease
pathology
Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto
Molecular Neurodegeneration - 2024 -
Astrocyte reactivity influences the association of amyloid-β and tau biomarkers in preclinical Alzheimer's
disease.
Tharick Pascoal, Bruna Bellaver, Guilherme Povala, Pamela Ferreira, João Pedro Ferrari-Souza, Douglas Leffa, Firoza Lussier, Andréa Lessa Benedet, Nicholas J. Ashton, Gallen Triana-Baltzerz, Hartmuth Kolbzh, Cèile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar Lopez, Dana Tudorascu, Victor Villemagne, Milos Ikonomovic, Serge Gauthier, Eduardo Zimmer, Henrik Zetterberg, Kaj Blennow, Howard Aizenstein, William Klunk, Beth Snitz, Pauline Maki, Rebecca Thurston, Ann Cohen, Mary Ganguli, Thomas Karikari, Pedro Rosa-Neto
Research square - 2023 -
Brain-derived Tau for Monitoring Brain Injury in Acute Ischemic
Stroke.
Naomi Vlegels, Fernando Gonzalez-Ortiz, Nicoló Luca Knuth, Nada Khalifeh, Benno Gesierich, Franziska Müller, Philipp Müller, Matthias Klein, Konstantinos Dimitriadis, Nicolai Franzmeier, Thomas Liebig, Marco Duering, Paul Reidler, Martin Dichgans, Thomas Karikari, Kaj Blennow, Steffen Tiedt
medRxiv : the preprint server for health sciences - 2023 -
Longitudinal blood biomarker trajectories in preclinical Alzheimer's
disease
Y. Yakoub, Nicholas J. Ashton, C. Strikwerda-Brown, Laia Montoliu-Gaya, Thomas Karikari, Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, J. Gallego-Rudolf, P. F. Meyer, F. St-Onge, Michael Schöll, J. P. Soucy, J. C. S. Breitner, Henrik Zetterberg, Kaj Blennow, J. Poirier, S. Villeneuve
Alzheimers & Dementia - 2023 -
Preanalytical stability of plasma/serum brain-derived
tau
Fernando Gonzalez-Ortiz, A. Dias, M. Turton, R. Magalhaes, Przemyslaw R. Kac, M. Correia, P. Harrison, Henrik Zetterberg, L. F. Maia, Kaj Blennow, Thomas Karikari
Alzheimers & Dementia - 2023 -
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac
Arrest
Nicholas J. Ashton, M. Moseby-Knappe, Andréa Lessa Benedet, Lana Grötschel, Juan Lantero Rodriguez, Thomas Karikari, C. Hassager, M. P. Wise, P. Stammet, J. Kjaergaard, H. Friberg, N. Nielsen, T. Cronberg, Henrik Zetterberg, Kaj Blennow
Jama Neurology - 2023 -
A novel ultrasensitive assay for plasma p-tau217: performance in individuals with subjective cognitive decline and early Alzheimer's
disease.
Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand Gonzalez, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R. Kac, Michael Turton, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Miguillon, Jose Contador, Marc Suarez-Calvet, Thomas Karikari, Kaj Blennow
medRxiv : the preprint server for health sciences - 2023 -
Blood-brain barrier integrity impacts the use of plasma amyloid-beta as a proxy of brain amyloid-beta
pathology
B. Bellaver, A. Puig-Pijoan, J. P. Ferrari-Souza, D. T. Leffa, F. Z. Lussier, P. C. L. Ferreira, C. Tissot, G. Povala, J. Therriault, Andréa Lessa Benedet, Nicholas J. Ashton, S. Servaes, M. Chamoun, J. Stevenson, N. Rahmouni, M. Vermeiren, A. C. Macedo, A. Fernandez-Lebrero, G. Garcia-Escobar, I. Navalpotro-Gomez, O. Lopez, D. L. Tudorascu, A. Cohen, V. L. Villemagne, W. E. Klunk, S. Gauthier, E. R. Zimmer, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, M. Suarez-Calvet, P. Rosa-Neto, T. A. Pascoal
Alzheimers & Dementia - 2023 -
APOEε4 potentiates amyloid β effects on longitudinal tau
pathology
J. P. Ferrari-Souza, B. Bellaver, P. C. L. Ferreira, Andréa Lessa Benedet, G. Povala, F. Z. Lussier, D. T. Leffa, J. Therriault, C. Tissot, C. Soares, Y. T. Wang, M. Chamoun, S. Servaes, A. C. Macedo, M. Vermeiren, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, A. Cohen, O. L. Lopez, W. E. Klunk, J. P. Soucy, S. Gauthier, D. O. Souza, G. Triana-Baltzer, Z. S. Saad, H. C. Kolb, Thomas Karikari, V. L. Villemagne, D. L. Tudorascu, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Nature Aging - 2023 -
Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based
cohort
P. C. L. Ferreira, Y. J. Zhang, B. Snitz, C. C. H. Chang, B. Bellaver, E. Jacobsen, M. I. Kamboh, Henrik Zetterberg, Kaj Blennow, T. A. Pascoal, V. L. Villemagne, M. Ganguli, Thomas Karikari
Alzheimers & Dementia - 2023 -
Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau
immunoassays
Nicholas J. Ashton, A. Puig-Pijoan, M. Mila-Aloma, A. Fernandez-Lebrero, G. Garcia-Escobar, Fernando Gonzalez-Ortiz, Przemyslaw R. Kac, Wagner Scheeren Brum, Andréa Lessa Benedet, Juan Lantero Rodriguez, T. A. Day, J. Vanbrabant, E. Stoops, E. Vanmechelen, G. Triana-Baltzer, S. Moughadam, H. Kolb, P. Ortiz-Romero, Thomas Karikari, C. Minguillon, J. J. H. Sanchez, I. Navalpotro-Gomez, O. Grau-Rivera, R. M. Manero, V. Puente-Periz, R. de la Torre, J. Roquer, J. L. Dage, Henrik Zetterberg, Kaj Blennow, M. Suarez-Calvet
Alzheimers & Dementia - 2023 -
Longitudinal changes in Alzheimer's-related plasma biomarkers and brain
amyloid
M. Bilgel, Y. An, K. A. Walker, A. R. Moghekar, Nicholas J. Ashton, Przemyslaw R. Kac, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, B. M. Jedynak, M. Thambisetty, L. Ferrucci, S. M. Resnick
Alzheimers & Dementia - 2023 -
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer's
disease.
Kaja Nordengen, Bjørn-Eivind Kirsebom, Grit Richter, Lene Pålhaugen, Berglind Gísladóttir, Nikias Siafarikas, Arne Nakling, Arvid Rongve, Geir Bråthen, Gøril Rolfseng Grøntvedt, Fernando Gonzalez-Ortiz, Knut Waterloo, Kulbhushan Sharma, Thomas Karikari, Eleonora M Vromen, Betty M Tijms, Pieter J Visser, Per Selnes, Milicia G Kramberger, Bengt Winblad, Kaj Blennow, Tormod Fladby
Journal of neuroinflammation - 2023 -
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's
disease.
Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx, Lutgarde Serneels, Dries T'Syen, Iordana Chrysidou, Amaia M Arranz, Annerieke Sierksma, Joel Simrén, Thomas Karikari, Henrik Zetterberg, Wei-Ting Chen, Dietmar Rudolf Thal, Evgenia Salta, Mark Fiers, Bart De Strooper
Science (New York, N.Y.) - 2023 -
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired
individuals
P. C. L. Ferreira, J. Therriault, C. Tissot, J. P. Ferrari-Souza, Andréa Lessa Benedet, G. Povala, B. Bellaver, D. T. Leffa, W. S. Brum, F. Z. Lussier, G. Bezgin, S. Servaes, M. Vermeiren, A. C. Macedo, A. Cabrera, J. Stevenson, G. Triana-Baltzer, H. Kolb, N. Rahmouni, W. E. Klunk, O. L. Lopez, V. L. Villemagne, A. Cohen, D. L. Tudorascu, E. R. Zimmer, Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, K. Blennow, S. Gauthier, P. Rosa-Neto, T. A. Pascoal
Alzheimers & Dementia - 2023 -
Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical
Trials
P. C. L. Ferreira, J. P. Ferrari-Souza, C. Tissot, B. Bellaver, D. T. Leffa, F. Lussier, G. Povala, J. Therriault, Andréa Lessa Benedet, Nicholas J. Ashton, A. D. Cohen, O. L. Lopez, D. L. Tudorascu, W. E. Klunk, J. P. Soucy, S. Gauthier, V. Villemagne, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto, E. R. Zimmer, Thomas Karikari, T. A. Pascoal, Neuroimaging Alzheimers Dis
NEUROLOGY - 2023 -
Astrocyte reactivity influences amyloid-beta effects on tau pathology in preclinical Alzheimer's
disease
B. Bellaver, G. Povala, P. C. L. Ferreira, J. P. Ferrari-Souza, D. T. Leffa, F. Z. Lussier, Andréa Lessa Benedet, Nicholas J. Ashton, G. Triana-Baltzer, H. C. Kolb, C. Tissot, J. Therriault, S. Servaes, J. Stevenson, N. Rahmouni, O. L. Lopez, D. L. Tudorascu, V. L. Villemagne, M. D. Ikonomovic, S. Gauthier, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, H. J. Aizenstein, W. E. Klunk, B. E. Snitz, P. Maki, R. C. Thurston, A. D. Cohen, M. Ganguli, Thomas Karikari, P. Rosa-Neto, T. A. Pascoal
Nature Medicine - 2023 -
Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta
oscillations
J. Brown, Elena Camporesi, Juan Lantero Rodriguez, M. Olsson, A. L. C. Wang, B. Medem, Henrik Zetterberg, Kaj Blennow, Thomas Karikari, M. Wall, E. Hill
Acta Neuropathologica Communications - 2023 -
Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic
cohorts
Juan Lantero Rodriguez, A. Vrillon, A. Fernandez-Lebrero, P. Ortiz-Romero, Anniina Snellman, Laia Montoliu-Gaya, Wagner Scheeren Brum, E. Cognat, J. Dumurgier, A. Puig-Pijoan, I. Navalpotro-Gomez, G. Garcia-Escobar, Thomas Karikari, E. Vanmechelen, Nicholas J. Ashton, Henrik Zetterberg, M. Suarez-Calvet, C. Paquet, Kaj Blennow
Alzheimers Research & Therapy - 2023 -
Hippocampal GFAP-positive astrocyte responses to amyloid and tau
pathologies.
Marco Antônio De Bastiani, Bruna Bellaver, Wagner Scheeren Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimmer
Brain, behavior, and immunity - 2023 -
Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer's disease pathophysiology in cognitively unimpaired older
adults
D. T. Leffa, J. P. Ferrari-Souza, B. Bellaver, C. Tissot, P. C. L. Ferreira, Wagner Scheeren Brum, A. Caye, J. Lord, P. Proitsi, T. Martins-Silva, L. Tovo-Rodrigues, D. L. Tudorascu, V. L. Villemagne, A. D. Cohen, O. L. Lopez, W. E. Klunk, Thomas Karikari, P. Rosa-Neto, E. R. Zimmer, B. S. G. Molina, L. A. Rohde, T. A. Pascoal, Initi Alzheimer's Dis Neuroimaging
Molecular Psychiatry - 2023 -
Association of Serum Brain-Derived Tau With Clinical Outcome and Longitudinal Change in Patients With Severe Traumatic Brain
Injury.
Fernando Gonzalez-Ortiz, Maciej Dulewicz, Nicholas J. Ashton, Przemyslaw R. Kac, Henrik Zetterberg, Emma Andersson, Yara Yakoub, Jörg Hanrieder, Michael Turton, Peter Harrison, Bengt Nellgård, Thomas Karikari, Kaj Blennow
JAMA network open - 2023 -
Plasma biomarkers for neurodegenerative disorders: ready for prime
time?
W. G. Balogun, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Current Opinion in Psychiatry - 2023 -
Comparison of CSF and plasma NfL and pNfH for Alzheimer’s disease diagnosis: a memory clinic
study
Agathe Vrillon, Nicholas J. Ashton, Thomas Karikari, Karl Götze, Emmanuel Cognat, Julien Dumurgier, Matthieu Lilamand, Henrik Zetterberg, Kaj Blennow, Claire Paquet
Journal of Neurology - 2023 -
Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer
Disease
Cristiano Schaffer Aguzzoli, Pâmela C.L. Ferreira, Guilherme Povala, João Pedro Ferrari-Souza, Bruna Bellaver, Carolina Soares Katz, Hussein Zalzale, Firoza Z. Lussier, Francieli Rohden, Sarah Abbas, Douglas T. Leffa, Marina Scop Medeiros, Joseph Therriault, Andréa Lessa Benedet, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Vanessa Pallen, Ann Cohen, Oscar L. Lopez, Dana L. Tudorascu, William E. Klunk, Victor L. Villemagne, Jean Paul Soucy, Eduardo R. Zimmer, Lucas P. Schilling, Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Victor Valcour, Bruce L. Miller, Pedro Rosa-Neto, Tharick A. Pascoal
JAMA network open - 2023 -
Revealing the combined roles of Aβ and tau in Alzheimer's disease via a pathophysiological activity
decoder.
Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Thomas Karikari, Nicholas J. Ashton, Andréa Lessa Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medina
bioRxiv : the preprint server for biology - 2023 -
Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease
neuropathology.
Przemyslaw R. Kac, Fernándo González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas Karikari
medRxiv : the preprint server for health sciences - 2023 -
Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's
disease
M. Ally, M. A. Sugarman, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas Karikari, H. J. Aparicio, B. Frank, Y. Tripodis, B. Martin, J. N. Palmisano, E. G. Steinberg, I. Simkin, L. A. Farrer, G. R. Jun, K. W. Turk, A. E. Budson, M. K. O'Connor, R. Au, L. E. Goldstein, N. W. Kowall, R. Killiany, R. A. Stern, T. D. Stein, A. C. McKee, W. Q. Qiu, J. Mez, M. L. Alosco
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - 2023 -
14-3-3 ζ/δ-reported early synaptic injury in Alzheimer's disease is independently mediated by
sTREM2
M. S. Woo, J. Nilsson, J. Therriault, N. Rahmouni, A. Brinkmalm, Andréa Lessa Benedet, Nicholas J. Ashton, A. C. Macedo, S. Servaes, Y. T. Wang, C. Tissot, J. F. Arias, S. A. Hosseini, M. Chamoun, F. Z. Lussier, Thomas Karikari, J. Stevenson, C. Mayer, J. P. Ferrari-Souza, E. Kobayashi, G. Massarweh, M. A. Friese, T. A. Pascoal, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Journal of Neuroinflammation - 2023 -
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's
disease
J. Therriault, S. Servaes, C. Tissot, N. Rahmouni, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, A. C. Macedo, F. Z. Lussier, J. Stevenson, Y. T. Wang, J. Fernandez-Arias, A. Stevenson, K. Q. Socualaya, A. Haeger, T. Nazneen, Aumont, Aumont,, A. Hosseini, S. Rej, P. Vitali, G. Triana-Baltzer, H. C. Kolb, J. P. Soucy, T. A. Pascoal, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Alzheimers & Dementia - 2023 -
Brain atrophy and white matter hyperintensities are independently associated with plasma neurofilament light chain in an Asian cohort of cognitively impaired patients with concomitant cerebral small vessel
disease
J. R. Chong, S. Hilal, Nicholas J. Ashton, Thomas Karikari, A. Reilhac, H. Vrooman, Michael Schöll, Henrik Zetterberg, Kaj Blennow, C. P. Chen, M. K. P. Lai
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2023 -
Plasma and cerebrospinal fluid glial fibrillary acidic protein levels in adults with Down syndrome: a longitudinal cohort
study
Laia Montoliu-Gaya, D. Alcolea, Nicholas J. Ashton, J. Pegueroles, J. Levin, B. Bosch, Juan Lantero Rodriguez, M. Carmona-Iragui, O. Wagemann, M. Balasa, Przemyslaw R. Kac, I. Barroeta, A. Llado, Wagner Scheeren Brum, L. Videla, Fernando Gonzalez-Ortiz, B. Benejam, J. J. A. Martinez, Thomas Karikari, G. Nubling, A. Bejanin, Andréa Lessa Benedet, R. Blesa, A. Lleo, Kaj Blennow, R. Sanchez-Valle, Henrik Zetterberg, J. Fortea
eBioMedicine - 2023 -
Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial
applications
Fernando Gonzalez-Ortiz, Przemyslaw R. Kac, Wagner Scheeren Brum, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Molecular Neurodegeneration - 2023 -
Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's
disease
Anniina Snellman, L. L. Ekblad, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, E. Pietila, M. Koivumaki, S. Helin, M. Karrasch, Henrik Zetterberg, Kaj Blennow, J. O. Rinne
Neurobiology of Disease - 2023 -
APOEε4 associates with microglial activation independently of Aβ plaques and tau
tangles
J. P. Ferrari-Souza, F. Z. Lussier, D. T. Leffa, J. Therriault, C. Tissot, B. Bellaver, P. C. L. Ferreira, M. Malpetti, Y. T. Wang, G. Povala, Andréa Lessa Benedet, Nicholas J. Ashton, M. Chamoun, S. Servaes, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, J. T. O'Brlen, J. B. Rowe, A. D. Cohen, O. L. Lopez, D. L. Tudorascu, Thomas Karikari, W. E. Klunk, V. L. Villemagne, J. P. Soucy, S. Gauthier, D. O. Souza, Henrik Zetterberg, Kaj Blennow, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Science Advances - 2023 -
APOE epsilon 4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired
elderly
Anniina Snellman, L. L. Ekblad, J. Tuisku, M. Koivumaki, Nicholas J. Ashton, Juan Lantero Rodriguez, Thomas Karikari, S. Helin, M. Bucci, E. Loyttyniemi, R. Parkkola, M. Karrasch, Michael Schöll, Henrik Zetterberg, Kaj Blennow, J. O. Rinne
Alzheimers Research & Therapy - 2023 -
Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused
ultrasound
Y. Meng, M. Goubran, J. S. Rabin, M. McSweeney, J. Ottoy, C. B. Pople, Y. X. Huang, A. Storace, M. Ozzoude, A. Bethune, B. Lam, W. Swardfager, C. Heyn, A. Abrahao, B. Davidson, C. Hamani, I. Aubert, Henrik Zetterberg, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, S. E. Black, K. Hynynen, N. Lipsman
Brain - 2023 -
Functional Applications of Stable Tau Oligomers in Cell Biology and Electrophysiology
Studies
E. Hill, K. G. Moffat, M. J. Wall, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Methods in molecular biology (Clifton, N.J.) - 2023 -
A Validated Method to Prepare Stable Tau
Oligomers
E. Hill, K. G. Moffat, M. J. Wall, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Methods in molecular biology (Clifton, N.J.) - 2023 -
Blood Tests for Alzheimer's Disease: Increasing Efforts to Expand and Diversify Research Participation Is Critical for Widespread Validation and
Acceptance
Thomas Karikari
Journal of Alzheimer's Disease - 2022 -
Astrocyte biomarker signatures of amyloid-beta and tau pathologies in Alzheimer's
disease
J. P. Ferrari-Souza, P. C. L. Ferreira, B. Bellaver, C. Tissot, Y. T. Wang, D. T. Leffa, Wagner Scheeren Brum, Andréa Lessa Benedet, Nicholas J. Ashton, M. A. De Bastiani, A. Rocha, J. Therriault, F. Z. Lussier, M. Chamoun, S. Servaes, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, W. E. Klunk, D. L. Tudorascu, A. D. Cohen, V. L. Villemagne, S. Gauthier, Kaj Blennow, Henrik Zetterberg, D. O. Souza, Thomas Karikari, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Molecular Psychiatry - 2022 -
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's
disease
Nicholas J. Ashton, Andréa Lessa Benedet, Tharick A. Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Wagner Scheeren Brum, S. Mathotaarachchi, J. Therriault, M. Savard, M. Chamoun, E. Stoops, C. Francois, E. Vanmechelen, S. Gauthier, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Ebiomedicine - 2022 -
Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy
Bodies.
Maria C Gonzalez, Nicholas J. Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
JAMA neurology - 2022 -
Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total
tau.
Brandon Frank, Madeline Ally, Bailee Brekke, Henrik Zetterberg, Kaj Blennow, Michael A Sugarman, Nicholas J. Ashton, Thomas Karikari, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkina, Katherine W Turk, Andrew E Budson, Maureen K O'Connor, Rhoda Au, Lee E Goldstein, Gyungah R Jun, Neil W Kowall, Thor D Stein, Ann C McKee, Ronald Killiany, Wei Qiao Qiu, Robert A Stern, Jesse Mez, Michael L Alosco
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2022 -
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired
individuals.
Joel Simrén, Wagner Scheeren Brum, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Alzheimer's research & therapy - 2022 -
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer's trial selection and disease
monitoring.
Nicholas J. Ashton, Shorena Janelidze, Niklas Mattsson-Carlgren, Alexa Pichet Binette, Olof Strandberg, Wagner Scheeren Brum, Thomas Karikari, Fernándo González-Ortiz, Guglielmo Di Molfetta, Francisco J Meda, Erin M Jonaitis, Rebecca Langhough Koscik, Karly Cody, Tobey J Betthauser, Yan Li, Eugeen Vanmechelen, Sebastian Palmqvist, Erik Stomrud, Randall J Bateman, Henrik Zetterberg, Sterling C Johnson, Kaj Blennow, Oskar Hansson
Nature medicine - 2022 -
A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's
disease.
Wagner Scheeren Brum, Marco Antônio de Bastiani, Andrei Bieger, Joseph Therriault, João P Ferrari-Souza, Andréa Lessa Benedet, Paramita Saha-Chaudhuri, Diogo O Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa-Neto, Eduardo R Zimmer
Alzheimer's & dementia (New York, N. Y.) - 2022 -
Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type
neurodegeneration.
Fernando Gonzalez-Ortiz, Michael Turton, Przemyslaw R. Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J. Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Brain : a journal of neurology - 2022 -
Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission
Tomography.
Joseph Therriault, Marie Vermeiren, Stijn Servaes, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Wagner Scheeren Brum, Firoza Z Lussier, Gleb Bezgin, Jenna Stevenson, Nesrine Rahmouni, Peter Kunach, Yi-Ting Wang, Jaime Fernandez-Arias, Kely Quispialaya Socualaya, Arthur C Macedo, João Pedro Ferrari-Souza, Pâmela C L Ferreira, Bruna Bellaver, Douglas T Leffa, Eduardo R Zimmer, Paolo Vitali, Jean-Paul Soucy, Gallen Triana-Baltzer, Hartmuth C Kolb, Tharick A Pascoal, Paramita Saha-Chaudhuri, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
JAMA neurology - 2022 -
Biomarker modeling of Alzheimer’s disease using PET-based Braak
staging
J. Therriault, T. A. Pascoal, F. Z. Lussier, C. Tissot, M. Chamoun, G. Bezgin, S. Servaes, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, P. Kunach, Y. T. Wang, J. Fernandez-Arias, G. Massarweh, P. Vitali, J. P. Soucy, P. Saha-Chaudhuri, Kaj Blennow, Henrik Zetterberg, S. Gauthier, P. Rosa-Neto
Nature Aging - 2022 -
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease
continuum.
Johan Gobom, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Molecular neurodegeneration - 2022 -
N-terminal and mid-region tau fragments as fluid biomarkers in neurological
diseases.
Anniina Snellman, Juan Lantero Rodriguez, Andreja Emeršič, Agathe Vrillon, Thomas Karikari, Nicholas J. Ashton, Milica Gregorič Kramberger, Saša Čučnik, Claire Paquet, Uroš Rot, Henrik Zetterberg, Kaj Blennow
Brain : a journal of neurology - 2022 -
Editorial: Blood Biomarkers of Neurodegenerative
Diseases.
Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow
Frontiers in molecular neuroscience - 2022 -
Comorbidities confound Alzheimer’s blood
tests
S. E. Schindler, Thomas Karikari
Nature Medicine - 2022 -
Investigating the use of plasma pTau181 in retired contact sports
athletes
A. Vasilevskaya, F. Taghdiri, N. Multani, M. Ozzoude, A. Tarazi, M. Khodadadi, R. Wennberg, P. Rusjan, S. Houle, R. Green, B. Colella, Kaj Blennow, Henrik Zetterberg, Thomas Karikari, D. Mikulis, L. N. Hazrati, G. G. Kovacs, K. D. Davis, C. Tator, M. C. Tartaglia
Journal of Neurology - 2022 -
Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240
tau-PET
C. Tissot, J. Therriault, P. Kunach, Andréa Lessa Benedet, T. A. Pascoal, N. J. Ashton, Thomas Karikari, S. Servaes, F. Z. Lussier, M. Chamoun, D. L. Tudorascu, J. Stevenson, N. Rahmouni, N. M. Poltronetti, V. Pallen, G. Bezgin, M. S. Kang, S. S. Mathotaarachchi, Y. T. Wang, J. Fernandez Arias, P. C. L. Ferreira, J. P. Ferrari-Souza, E. Vanmechelen, K. Blennow, H. Zetterberg, S. Gauthier, P. Rosa-Neto
Ebiomedicine - 2022 -
CSF biomarkers and plasma p-tau181 as predictors of longitudinal tau accumulation: Implications for clinical trial
design
Alexis Moscoso Rial, Thomas Karikari, Michel J. Grothe, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Alzheimer's and Dementia - 2022 -
Plasma p-tau231, p-tau181, PET Biomarkers, and Cognitive Change in Older
Adults.
Pierre-François Meyer, Nicholas J. Ashton, Thomas Karikari, Cherie Strikwerda-Brown, Theresa Köbe, Julie Gonneaud, Alexa Pichet Binette, Hazal Ozlen, Yara Yakoub, Joel Simrén, Josef Pannee, Juan Lantero Rodriguez, Anne Labonté, Suzanne L Baker, Michael Schöll, Eugeen Vanmechelen, John C S Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve
Annals of neurology - 2022 -
Alzheimer's Disease Plasma Biomarkers Distinguish Clinical Diagnostic Groups in Memory Clinic
Patients
M. Gerards, A. K. Schild, D. Meiberth, A. Rostamzadeh, J. J. Vehreschild, S. Wingen-Heimann, W. Johannis, P. M. Adami, O. A. Onur, A. Ramirez, Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, F. Maier, F. Jessen
Dementia and Geriatric Cognitive Disorders - 2022 -
Diagnostic value of serum versus plasma phospho-tau for Alzheimer's
disease
Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Joel Simrén, N. Dewit, E. Vanmechelen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas Karikari
Alzheimer's Research & Therapy - 2022 -
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical
utility
Thomas Karikari, Nicholas J. Ashton, Gunnar Brinkmalm, Wagner Scheeren Brum, Andréa Lessa Benedet, Laia Montoliu-Gaya, Juan Lantero Rodriguez, T. A. Pascoal, M. Suarez-Calvet, P. Rosa-Neto, Kaj Blennow, Henrik Zetterberg
Nature Reviews Neurology - 2022 -
The accuracy and robustness of plasma biomarker models for amyloid PET
positivity
Andréa Lessa Benedet, Wagner Scheeren Brum, O. Hansson, A. D. N. Initiative, Thomas Karikari, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Alzheimers Research & Therapy - 2022 -
Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive
change
D. S. Smirnov, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Joel Simrén, Juan Lantero Rodriguez, Thomas Karikari, A. Hiniker, R. A. Rissman, D. P. Salmon, D. Galasko
Acta Neuropathologica - 2022 -
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament
Light.
Suzanne E Schindler, Thomas Karikari, Nicholas J. Ashton, Rachel L Henson, Kevin E Yarasheski, Tim West, Mathew R Meyer, Kristopher M Kirmess, Yan Li, Benjamin Saef, Krista L Moulder, David Bradford, Anne M Fagan, Brian A Gordon, Tammie L S Benzinger, Joyce Balls-Berry, Randall J Bateman, Chengjie Xiong, Henrik Zetterberg, Kaj Blennow, John C Morris
Neurology - 2022 -
Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's
disease.
Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó, Paula Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Eugeen Vanmechelen, Theresa A Day, Armand González-Escalante, Gonzalo Sánchez-Benavides, Carolina Minguillon, Karine Fauria, José Luis Molinuevo, Jeffrey L Dage, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez-Calvet, Kaj Blennow
Nature medicine - 2022 -
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's
disease.
Pratishtha Chatterjee, Steve Pedrini, Nicholas J. Ashton, Michelle Tegg, Kathryn Goozee, Abhay K Singh, Thomas Karikari, Joel Simrén, Eugeen Vanmechelen, Nicola J Armstrong, Eugene Hone, Prita R Asih, Kevin Taddei, Vincent Doré, Victor L Villemagne, Hamid R Sohrabi, Henrik Zetterberg, Colin L Masters, Kaj Blennow, Ralph N Martins
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2022 -
Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged
78-94
M. M. Michalowska, K. Herholz, R. Hinz, C. Amadi, L. McInnes, J. M. Anton-Rodriguez, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, N. Pendleton, S. F. Carter
Molecular Psychiatry - 2022 -
Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at
autopsy
M. S. Morrison, H. J. Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Thomas Karikari, Y. Tripodis, B. Martin, J. N. Palmisano, M. A. Sugarman, B. Frank, E. G. Steinberg, K. W. Turk, A. E. Budson, R. Au, L. E. Goldstein, G. R. Jun, N. W. Kowall, R. Killiany, W. Q. Qiu, R. A. Stern, J. Mez, A. C. McKee, T. D. Stein, M. L. Alosco
Brain - 2022 -
Plasma p-tau231 and p-tau217 as state markers of amyloid-beta pathology in preclinical Alzheimer's
disease
M. Mila-Aloma, Nicholas J. Ashton, M. Shekari, G. Salvado, P. Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, E. Vanmechelen, T. A. Day, A. Gonzalez-Escalante, G. Sanchez-Benavides, C. Minguillon, K. Fauria, J. L. Molinuevo, J. L. Dage, Henrik Zetterberg, J. D. Gispert, M. Suarez-Calvet, Kaj Blennow
Nature Medicine - 2022 -
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's
disease.
Cécile Tissot, Andréa Lessa Benedet, Joseph Therriault, Tharick A Pascoal, Firoza Z Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto
Alzheimer's Research & Therapy - 2021 -
Associations of Fully Automated CSF and Novel Plasma Biomarkers With Alzheimer Disease Neuropathology at
Autopsy.
Michel J. Grothe, Alexis Moscoso Rial, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Neurology - 2021 -
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age
70.
Ashvini Keshavan, Josef Pannee, Thomas Karikari, Juan Rodriguez, Nicholas J. Ashton, Jennifer M Nicholas, David M Cash, William Coath, Christopher A Lane, Thomas D Parker, Kirsty Lu, Sarah M Buchanan, Sarah E Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M Schott
Brain : a journal of neurology - 2021 -
Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease
diagnosis.
Thomas Karikari, Agathe Vrillon, Juan Lantero Rodriguez, Nicholas J. Ashton, Milica Gregorič Kramberger, Julien Dumurgier, Claire Hourregue, Saša Čučnik, Gunnar Brinkmalm, Uroš Rot, Henrik Zetterberg, Claire Paquet, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
A genome-wide association study of plasma phosphorylated
tau181
Jodie Lord, Anna Zettergren, Nicholas J. Ashton, Thomas Karikari, Andréa Lessa Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proitsi
Neurobiology of aging - 2021 -
Association of plasma P-tau181 with memory decline in non-demented
adults
J. Therriault, A. L. Benedet, T. A. Pascoal, F. Z. Lussier, C. Tissot, Thomas Karikari, Nicholas J. Ashton, M. Chamoun, G. Bezgin, S. Mathotaarachchi, S. Gauthier, P. Saha-Chaudhuri, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021 -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's
disease.
Joel Simrén, Antoine Leuzy, Thomas Karikari, Abdul Hye, Andréa Lessa Benedet, Juan Lantero Rodriguez, Niklas Mattsson-Carlgren, Michael Schöll, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular
disease.
Joyce R Chong, Nicholas J. Ashton, Thomas Karikari, Tomotaka Tanaka, Francis N Saridin, Anthonin Reilhac, Edward G Robins, Ying-Hwey Nai, Henri Vrooman, Saima Hilal, Henrik Zetterberg, Kaj Blennow, Mitchell K P Lai, Christopher P Chen
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Prodromal frontotemporal dementia: clinical features and predictors of
progression.
Alberto Benussi, Nicholas J. Ashton, Thomas Karikari, Antonella Alberici, Claudia Saraceno, Roberta Ghidoni, Luisa Benussi, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Alzheimer's research & therapy - 2021 -
P-tau235: a novel biomarker for staging preclinical Alzheimer's
disease.
Juan Lantero Rodriguez, Anniina Snellman, Andréa Lessa Benedet, Marta Milà-Alomà, Elena Camporesi, Laia Montoliu-Gaya, Nicholas J. Ashton, Agathe Vrillon, Thomas Karikari, Juan Domingo Gispert, Gemma Salvadó, Mahnaz Shekari, Christina E Toomey, Tammaryn L Lashley, Henrik Zetterberg, Marc Suárez-Calvet, Gunnar Brinkmalm, Pedro Rosa Neto, Kaj Blennow
EMBO molecular medicine - 2021 -
Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease
Continuum
Andréa Lessa Benedet, M. Mila-Aloma, A. Vrillon, Nicholas J. Ashton, T. A. Pascoal, F. Lussier, Thomas Karikari, C. Hourregue, E. Cognat, J. Dumurgier, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, G. Salvado, M. Shekari, G. Operto, J. D. Gispert, C. Minguillon, K. Fauria, G. Kollmorgen, I. Suridjan, E. R. Zimmer, Henrik Zetterberg, J. L. Molinuevo, C. Paquet, P. Rosa-Neto, Kaj Blennow, M. Suarez-Calvet
Jama Neurology - 2021 -
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down
syndrome
A. Lleo, Henrik Zetterberg, J. Pegueroles, Thomas Karikari, M. Carmona-Iragui, Nicholas J. Ashton, V. Montal, I. Barroeta, Juan Lantero Rodriguez, L. Videla, M. Altuna, B. Benejam, S. Fernandez, S. Valldeneu, D. Garzon, A. Bejanin, M. F. Iulita, V. Camacho, S. Medrano-Martorell, O. Belbin, J. Clarimon, S. Lehmann, D. Alcolea, R. Blesa, Kaj Blennow, J. Fortea
Nature Communications - 2021 -
Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive
individuals
F. Z. Lussier, A. L. Benedet, J. Therriault, T. A. Pascoal, C. Tissot, M. Chamoun, S. Mathotaarachchi, M. Savard, Nicholas J. Ashton, Thomas Karikari, Juan Rodriguez, Anniina Snellman, G. Bezgin, M. S. Kang, J. F. Arias, Y. T. Wang, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021 -
A multicentre validation study of the diagnostic value of plasma neurofilament
light.
Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L van der Ende, Thomas Karikari, Andrea L Benedet, Tharick A Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Nature communications - 2021 -
Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease
progression.
Christopher Clark, Piotr Lewczuk, Johannes Kornhuber, Jonas Richiardi, Bénédicte Maréchal, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Julius Popp
Alzheimer's research & therapy - 2021 -
The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD
biomarkers
Nicholas J. Ashton, A. Leuzy, Thomas Karikari, N. Mattsson-Carlgren, A. Dodich, M. Boccardi, J. Corre, A. Drzezga, A. Nordberg, R. Ossenkoppele, Henrik Zetterberg, Kaj Blennow, G. B. Frisoni, V. Garibotto, O. Hansson
European Journal of Nuclear Medicine and Molecular Imaging - 2021 -
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease
pathology.
Nicholas J. Ashton, Tharick A Pascoal, Thomas Karikari, Andréa Lessa Benedet, Juan Lantero Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2021 -
Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer
Disease.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Kaj Blennow, Henrik Zetterberg, Michael Schöll
JAMA Neurology - 2021 -
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort
study
A. O'Connor, Thomas Karikari, T. Poole, Nicholas J. Ashton, Juan Rodriguez, A. Khatun, I. Swift, A. J. Heslegrave, E. Abel, E. Chung, P. S. J. Weston, I. M. Pavisic, N. S. Ryan, S. Barker, M. N. Rossor, J. M. Polke, C. Frost, S. Mead, Kaj Blennow, Henrik Zetterberg, N. C. Fox
Molecular Psychiatry - 2021 -
Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and
neurodegeneration.
Nicholas J. Ashton, Marc Suárez-Calvet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Joel Simrén, Carolina Minguillon, Karine Fauria, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia (Amsterdam, Netherlands) - 2021 -
Time course of phosphorylated-tau181 in blood across the Alzheimer's disease
spectrum.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suarez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Brain : a journal of neurology - 2021 -
Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging
Initiative.
Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow
Alzheimer's research & therapy - 2021 -
Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andrea L Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021 -
Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive
Outcomes
M. M. Mielke, R. D. Frank, J. L. Dage, A. Jeromin, Nicholas J. Ashton, Kaj Blennow, Thomas Karikari, E. Vanmechelen, Henrik Zetterberg, A. Algeciras-Schimnich, D. S. Knopman, V. Lowe, G. J. Bu, P. Vemuri, J. Graff-Radford, C. R. Jack, R. C. Petersen
JAMA Neurology - 2021 -
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging
Initiative.
Thomas Karikari, Andréa L Benedet, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Paramita Saha-Chaudhuri, Firoza Lussier, Hlin Kvartsberg, Alexis Moscoso Rial, Tharick A Pascoal, Ulf Andreasson, Michael Schöll, Michael W Weiner, Pedro Rosa-Neto, John Q Trojanowski, Leslie M Shaw, Kaj Blennow, Henrik Zetterberg
Molecular psychiatry - 2021 -
Truncating tau reveals different pathophysiological actions of oligomers in single
neurons
E. Hill, Thomas Karikari, Juan Lantero Rodriguez, Henrik Zetterberg, Kaj Blennow, M. J. Richardson, M. J. Wall
Communications Biology - 2021 -
Use of plasma biomarkers for AT(N) classification of neurodegenerative
dementias
D. Alcolea, C. Delaby, L. Muñoz, S. Torres, T. Estellés, N. Zhu, I. Barroeta, M. Carmona-Iragui, I. Illán-Gala, M. Á Santos-Santos, M. Altuna, I. Sala, Mª B. Sánchez-Saudinós, L. Videla, S. Valldeneu, A. Subirana, J. Pegueroles, C. Hirtz, J. Vialaret, S. Lehmann, Thomas Karikari, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, O. Belbin, R. Blesa, J. Clarimón, J. Fortea, A. Lleó
Journal of Neurology, Neurosurgery and Psychiatry - 2021 -
Publisher Correction: Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andréa Lessa Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021 -
Synedrella nodiflora Extract Depresses Excitatory Synaptic Transmission and Chemically-Induced In Vitro Seizures in the Rat
Hippocampus
P. Amoateng, T. A. Tagoe, Thomas Karikari, K. K. E. Kukuia, D. Osei-Safo, E. Woode, B. G. Frenguelli, S. B. Kombian
Frontiers in Pharmacology - 2021 -
Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive
decline.
Juan Lantero Rodriguez, Thomas Karikari, Marc Suárez-Calvet, Claire Troakes, Andrew King, Andreja Emersic, Dag Aarsland, Abdul Hye, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Acta neuropathologica - 2020 -
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are
detected.
Marc Suárez-Calvet, Thomas Karikari, Nicholas J. Ashton, Juan Lantero Rodriguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuevo
EMBO molecular medicine - 2020 -
An extensive plasmid library to prepare tau protein variants and study their functional
biochemistry.
Thomas Karikari, Sophie Keeling, Emily Hill, Juan Lantero Rodriguez, David A Nagel, Bruno Becker, Kina Höglund, Henrik Zetterberg, Kaj Blennow, Eric J Hill, Kevin G Moffat
ACS chemical neuroscience - 2020 -
Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological
Approaches
E. Hill, M. J. Wall, K. G. Moffat, Thomas Karikari
Frontiers in Molecular Neuroscience - 2020 -
An update on blood-based biomarkers for non-Alzheimer neurodegenerative
disorders.
Nicholas J. Ashton, Abdul Hye, Anto P Rajkumar, Antoine Leuzy, Stuart Snowden, Marc Suárez-Calvet, Thomas Karikari, Michael Schöll, Renaud La Joie, Gil D Rabinovici, Kina Höglund, Clive Ballard, Tibor Hortobágyi, Per Svenningsson, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
Nature Reviews Neurology - 2020 -
The C291R Tau Variant Forms Different Types of
Protofibrils
Thomas Karikari, R. Thomas, K. G. Moffat
Frontiers in Molecular Neuroscience - 2020 -
Construction and reconstruction of brain circuits: normal and pathological axon
guidance
S. Roig-Puiggros, R. J. Vigouroux, D. Beckman, N. I. Bocai, B. Chiou, J. Davimes, G. Gomez, S. Grassi, A. Hoque, Thomas Karikari, F. Kiffer, M. Lopez, G. Lunghi, P. Mazengenya, S. Meier, M. Olguin-Albuerne, M. M. Oliveira, J. Paraiso-Luna, J. Pradhan, A. Radiske, A. B. Ramos-Hryb, M. C. Ribeiro, R. Schellino, M. C. Selles, S. Singh, P. Theotokis, A. Chedotal
Journal of Neurochemistry - 2020 -
Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar
degeneration.
Alberto Benussi, Thomas Karikari, Nicholas J. Ashton, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Joel Simrén, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of neurology, neurosurgery, and psychiatry - 2020 -
Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar
Degeneration.
Alberto Benussi, Nicholas J. Ashton, Thomas Karikari, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of Alzheimer's disease : JAD - 2020 -
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective
cohorts.
Thomas Karikari, Tharick A Pascoal, Nicholas J. Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
The Lancet. Neurology - 2020 -
Preparation of stable tau oligomers for cellular and biochemical
studies
Thomas Karikari, David A. Nagel, Alastair Grainger, Charlotte Clarke-Bland, Eric J. Hill, Kevin G. Moffat
ANALYTICAL BIOCHEMISTRY - 2019 -
International science
education
Thomas Karikari, Miriam Segura-Totten, Esperanza C. Cabrera, Diana E. Waturangi, Erin E. Barding, Tatiana Ascencio
Journal of Microbiology and Biology Education - 2019 -
Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and
Plasticity
E. Hill, Thomas Karikari, K. G. Moffat, M. J. E. Richardson, M. J. Wall
Eneuro - 2019