Thomas Karikari
-
Brain atrophy and white matter hyperintensities are independently associated with plasma neurofilament light chain in an Asian cohort of cognitively impaired patients with concomitant cerebral small vessel
disease
J. R. Chong, S. Hilal, Nicholas J. Ashton, Thomas Karikari, A. Reilhac, H. Vrooman, Michael Schöll, Henrik Zetterberg, Kaj Blennow, C. P. Chen, M. K. P. Lai
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2023 -
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac
Arrest
Nicholas J. Ashton, M. Moseby-Knappe, Andréa Lessa Benedet, Lana Grötschel, Juan Lantero Rodriguez, Thomas Karikari, C. Hassager, M. P. Wise, P. Stammet, J. Kjaergaard, H. Friberg, N. Nielsen, T. Cronberg, Henrik Zetterberg, Kaj Blennow
Jama Neurology - 2023 -
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's
disease
J. Therriault, S. Servaes, C. Tissot, N. Rahmouni, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, A. C. Macedo, F. Z. Lussier, J. Stevenson, Y. T. Wang, J. Fernandez-Arias, A. Stevenson, K. Q. Socualaya, A. Haeger, T. Nazneen, Aumont, Aumont,, A. Hosseini, S. Rej, P. Vitali, G. Triana-Baltzer, H. C. Kolb, J. P. Soucy, T. A. Pascoal, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Alzheimers & Dementia - 2023 -
APOE epsilon 4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired
elderly
Anniina Snellman, L. L. Ekblad, J. Tuisku, M. Koivumaki, Nicholas J. Ashton, Juan Lantero Rodriguez, Thomas Karikari, S. Helin, M. Bucci, E. Loyttyniemi, R. Parkkola, M. Karrasch, Michael Schöll, Henrik Zetterberg, Kaj Blennow, J. O. Rinne
Alzheimers Research & Therapy - 2023 -
Hippocampal GFAP-positive astrocyte responses to amyloid and tau
pathologies.
Marco Antônio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimmer
Brain, behavior, and immunity - 2023 -
Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based
cohort
P. C. L. Ferreira, Y. J. Zhang, B. Snitz, C. C. H. Chang, B. Bellaver, E. Jacobsen, M. I. Kamboh, Henrik Zetterberg, Kaj Blennow, T. A. Pascoal, V. L. Villemagne, M. Ganguli, Thomas Karikari
Alzheimers & Dementia - 2023 -
Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial
applications
Fernando Gonzalez-Ortiz, Przemyslaw R. Kac, Wagner S. Brum, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Molecular Neurodegeneration - 2023 -
Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic
cohorts
Juan Lantero Rodriguez, A. Vrillon, A. Fernandez-Lebrero, P. Ortiz-Romero, Anniina Snellman, Laia Montoliu-Gaya, Wagner S. Brum, E. Cognat, J. Dumurgier, A. Puig-Pijoan, I. Navalpotro-Gomez, G. Garcia-Escobar, Thomas Karikari, E. Vanmechelen, Nicholas J. Ashton, Henrik Zetterberg, M. Suarez-Calvet, C. Paquet, Kaj Blennow
Alzheimers Research & Therapy - 2023 -
Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused
ultrasound
Y. Meng, M. Goubran, J. S. Rabin, M. McSweeney, J. Ottoy, C. B. Pople, Y. X. Huang, A. Storace, M. Ozzoude, A. Bethune, B. Lam, W. Swardfager, C. Heyn, A. Abrahao, B. Davidson, C. Hamani, I. Aubert, Henrik Zetterberg, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, S. E. Black, K. Hynynen, N. Lipsman
Brain - 2023 -
Plasma biomarkers for neurodegenerative disorders: ready for prime
time?
W. G. Balogun, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Current Opinion in Psychiatry - 2023 -
Functional Applications of Stable Tau Oligomers in Cell Biology and Electrophysiology
Studies
E. Hill, K. G. Moffat, M. J. Wall, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Methods in molecular biology (Clifton, N.J.) - 2023 -
A Validated Method to Prepare Stable Tau
Oligomers
E. Hill, K. G. Moffat, M. J. Wall, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Methods in molecular biology (Clifton, N.J.) - 2023 -
Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type
neurodegeneration.
Fernando Gonzalez-Ortiz, Michael Turton, Przemyslaw R. Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J. Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas Karikari
Brain : a journal of neurology - 2022 -
Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission
Tomography.
Joseph Therriault, Marie Vermeiren, Stijn Servaes, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Wagner S. Brum, Firoza Z Lussier, Gleb Bezgin, Jenna Stevenson, Nesrine Rahmouni, Peter Kunach, Yi-Ting Wang, Jaime Fernandez-Arias, Kely Quispialaya Socualaya, Arthur C Macedo, João Pedro Ferrari-Souza, Pâmela C L Ferreira, Bruna Bellaver, Douglas T Leffa, Eduardo R Zimmer, Paolo Vitali, Jean-Paul Soucy, Gallen Triana-Baltzer, Hartmuth C Kolb, Tharick A Pascoal, Paramita Saha-Chaudhuri, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
JAMA neurology - 2022 -
Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's
disease.
Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó, Paula Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Eugeen Vanmechelen, Theresa A Day, Armand González-Escalante, Gonzalo Sánchez-Benavides, Carolina Minguillon, Karine Fauria, José Luis Molinuevo, Jeffrey L Dage, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez-Calvet, Kaj Blennow
Nature medicine - 2022 -
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease
continuum.
Johan Gobom, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Molecular neurodegeneration - 2022 -
CSF biomarkers and plasma p-tau181 as predictors of longitudinal tau accumulation: Implications for clinical trial
design
Alexis Moscoso Rial, Thomas Karikari, Michel J. Grothe, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Alzheimer's and Dementia - 2022 -
Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer's disease pathophysiology in cognitively unimpaired older
adults
D. T. Leffa, J. P. Ferrari-Souza, B. Bellaver, C. Tissot, P. C. L. Ferreira, Wagner S. Brum, A. Caye, J. Lord, P. Proitsi, T. Martins-Silva, L. Tovo-Rodrigues, D. L. Tudorascu, V. L. Villemagne, A. D. Cohen, O. L. Lopez, W. E. Klunk, Thomas Karikari, P. Rosa-Neto, E. R. Zimmer, B. S. G. Molina, L. A. Rohde, T. A. Pascoal, Initi Alzheimer's Dis Neuroimaging
Molecular Psychiatry - 2022 -
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired
individuals.
Joel Simrén, Wagner S. Brum, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Alzheimer's research & therapy - 2022 -
Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive
change
D. S. Smirnov, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Joel Simrén, Juan Lantero Rodriguez, Thomas Karikari, A. Hiniker, R. A. Rissman, D. P. Salmon, D. Galasko
Acta Neuropathologica - 2022 -
Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total
tau.
Brandon Frank, Madeline Ally, Bailee Brekke, Henrik Zetterberg, Kaj Blennow, Michael A Sugarman, Nicholas J. Ashton, Thomas Karikari, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkina, Katherine W Turk, Andrew E Budson, Maureen K O'Connor, Rhoda Au, Lee E Goldstein, Gyungah R Jun, Neil W Kowall, Thor D Stein, Ann C McKee, Ronald Killiany, Wei Qiao Qiu, Robert A Stern, Jesse Mez, Michael L Alosco
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2022 -
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's
disease.
Pratishtha Chatterjee, Steve Pedrini, Nicholas J. Ashton, Michelle Tegg, Kathryn Goozee, Abhay K Singh, Thomas Karikari, Joel Simrén, Eugeen Vanmechelen, Nicola J Armstrong, Eugene Hone, Prita R Asih, Kevin Taddei, Vincent Doré, Victor L Villemagne, Hamid R Sohrabi, Henrik Zetterberg, Colin L Masters, Kaj Blennow, Ralph N Martins
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2022 -
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer's trial selection and disease
monitoring.
Nicholas J. Ashton, Shorena Janelidze, Niklas Mattsson-Carlgren, Alexa Pichet Binette, Olof Strandberg, Wagner S. Brum, Thomas Karikari, Fernándo González-Ortiz, Guglielmo Di Molfetta, Francisco J Meda, Erin M Jonaitis, Rebecca Langhough Koscik, Karly Cody, Tobey J Betthauser, Yan Li, Eugeen Vanmechelen, Sebastian Palmqvist, Erik Stomrud, Randall J Bateman, Henrik Zetterberg, Sterling C Johnson, Kaj Blennow, Oskar Hansson
Nature medicine - 2022 -
Comorbidities confound Alzheimer’s blood
tests
S. E. Schindler, Thomas Karikari
Nature Medicine - 2022 -
Editorial: Blood Biomarkers of Neurodegenerative
Diseases.
Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow
Frontiers in molecular neuroscience - 2022 -
Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged
78-94
M. M. Michalowska, K. Herholz, R. Hinz, C. Amadi, L. McInnes, J. M. Anton-Rodriguez, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, N. Pendleton, S. F. Carter
Molecular Psychiatry - 2022 -
Investigating the use of plasma pTau181 in retired contact sports
athletes
A. Vasilevskaya, F. Taghdiri, N. Multani, M. Ozzoude, A. Tarazi, M. Khodadadi, R. Wennberg, P. Rusjan, S. Houle, R. Green, B. Colella, Kaj Blennow, Henrik Zetterberg, Thomas Karikari, D. Mikulis, L. N. Hazrati, G. G. Kovacs, K. D. Davis, C. Tator, M. C. Tartaglia
Journal of Neurology - 2022 -
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's
disease
Nicholas J. Ashton, Andréa Lessa Benedet, Tharick A. Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Wagner S. Brum, S. Mathotaarachchi, J. Therriault, M. Savard, M. Chamoun, E. Stoops, C. Francois, E. Vanmechelen, S. Gauthier, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Ebiomedicine - 2022 -
Plasma p-tau231, p-tau181, PET Biomarkers, and Cognitive Change in Older
Adults.
Pierre-François Meyer, Nicholas J. Ashton, Thomas Karikari, Cherie Strikwerda-Brown, Theresa Köbe, Julie Gonneaud, Alexa Pichet Binette, Hazal Ozlen, Yara Yakoub, Joel Simrén, Josef Pannee, Juan Lantero Rodriguez, Anne Labonté, Suzanne L Baker, Michael Schöll, Eugeen Vanmechelen, John C S Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve
Annals of neurology - 2022 -
Biomarker modeling of Alzheimer’s disease using PET-based Braak
staging
J. Therriault, T. A. Pascoal, F. Z. Lussier, C. Tissot, M. Chamoun, G. Bezgin, S. Servaes, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, P. Kunach, Y. T. Wang, J. Fernandez-Arias, G. Massarweh, P. Vitali, J. P. Soucy, P. Saha-Chaudhuri, Kaj Blennow, Henrik Zetterberg, S. Gauthier, P. Rosa-Neto
Nature Aging - 2022 -
Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau
immunoassays
Nicholas J. Ashton, A. Puig-Pijoan, M. Mila-Aloma, A. Fernandez-Lebrero, G. Garcia-Escobar, Fernando Gonzalez-Ortiz, Przemyslaw R. Kac, Wagner S. Brum, Andréa Lessa Benedet, Juan Lantero Rodriguez, T. A. Day, J. Vanbrabant, E. Stoops, E. Vanmechelen, G. Triana-Baltzer, S. Moughadam, H. Kolb, P. Ortiz-Romero, Thomas Karikari, C. Minguillon, J. J. H. Sanchez, I. Navalpotro-Gomez, O. Grau-Rivera, R. M. Manero, V. Puente-Periz, R. de la Torre, J. Roquer, J. L. Dage, Henrik Zetterberg, Kaj Blennow, M. Suarez-Calvet
Alzheimers & Dementia - 2022 -
Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at
autopsy
M. S. Morrison, H. J. Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Thomas Karikari, Y. Tripodis, B. Martin, J. N. Palmisano, M. A. Sugarman, B. Frank, E. G. Steinberg, K. W. Turk, A. E. Budson, R. Au, L. E. Goldstein, G. R. Jun, N. W. Kowall, R. Killiany, W. Q. Qiu, R. A. Stern, J. Mez, A. C. McKee, T. D. Stein, M. L. Alosco
Brain - 2022 -
N-terminal and mid-region tau fragments as fluid biomarkers in neurological
diseases.
Anniina Snellman, Juan Lantero Rodriguez, Andreja Emeršič, Agathe Vrillon, Thomas Karikari, Nicholas J. Ashton, Milica Gregorič Kramberger, Saša Čučnik, Claire Paquet, Uroš Rot, Henrik Zetterberg, Kaj Blennow
Brain : a journal of neurology - 2022 -
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical
utility
Thomas Karikari, Nicholas J. Ashton, Gunnar Brinkmalm, Wagner S. Brum, Andréa Lessa Benedet, Laia Montoliu-Gaya, Juan Lantero Rodriguez, T. A. Pascoal, M. Suarez-Calvet, P. Rosa-Neto, Kaj Blennow, Henrik Zetterberg
Nature Reviews Neurology - 2022 -
Plasma p-tau231 and p-tau217 as state markers of amyloid-beta pathology in preclinical Alzheimer's
disease
M. Mila-Aloma, Nicholas J. Ashton, M. Shekari, G. Salvado, P. Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, E. Vanmechelen, T. A. Day, A. Gonzalez-Escalante, G. Sanchez-Benavides, C. Minguillon, K. Fauria, J. L. Molinuevo, J. L. Dage, Henrik Zetterberg, J. D. Gispert, M. Suarez-Calvet, Kaj Blennow
Nature Medicine - 2022 -
Astrocyte biomarker signatures of amyloid-beta and tau pathologies in Alzheimer's
disease
J. P. Ferrari-Souza, P. C. L. Ferreira, B. Bellaver, C. Tissot, Y. T. Wang, D. T. Leffa, Wagner S. Brum, Andréa Lessa Benedet, Nicholas J. Ashton, M. A. De Bastiani, A. Rocha, J. Therriault, F. Z. Lussier, M. Chamoun, S. Servaes, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, W. E. Klunk, D. L. Tudorascu, A. D. Cohen, V. L. Villemagne, S. Gauthier, Kaj Blennow, Henrik Zetterberg, D. O. Souza, Thomas Karikari, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Molecular Psychiatry - 2022 -
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament
Light.
Suzanne E Schindler, Thomas Karikari, Nicholas J. Ashton, Rachel L Henson, Kevin E Yarasheski, Tim West, Mathew R Meyer, Kristopher M Kirmess, Yan Li, Benjamin Saef, Krista L Moulder, David Bradford, Anne M Fagan, Brian A Gordon, Tammie L S Benzinger, Joyce Balls-Berry, Randall J Bateman, Chengjie Xiong, Henrik Zetterberg, Kaj Blennow, John C Morris
Neurology - 2022 -
Diagnostic value of serum versus plasma phospho-tau for Alzheimer's
disease
Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Joel Simrén, N. Dewit, E. Vanmechelen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas Karikari
Alzheimer's Research & Therapy - 2022 -
Alzheimer's Disease Plasma Biomarkers Distinguish Clinical Diagnostic Groups in Memory Clinic
Patients
M. Gerards, A. K. Schild, D. Meiberth, A. Rostamzadeh, J. J. Vehreschild, S. Wingen-Heimann, W. Johannis, P. M. Adami, O. A. Onur, A. Ramirez, Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, F. Maier, F. Jessen
Dementia and Geriatric Cognitive Disorders - 2022 -
A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's
disease.
Wagner S. Brum, Marco Antônio de Bastiani, Andrei Bieger, Joseph Therriault, João P Ferrari-Souza, Andréa Lessa Benedet, Paramita Saha-Chaudhuri, Diogo O Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa-Neto, Eduardo R Zimmer
Alzheimer's & dementia (New York, N. Y.) - 2022 -
Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240
tau-PET
C. Tissot, J. Therriault, P. Kunach, Andréa Lessa Benedet, T. A. Pascoal, N. J. Ashton, Thomas Karikari, S. Servaes, F. Z. Lussier, M. Chamoun, D. L. Tudorascu, J. Stevenson, N. Rahmouni, N. M. Poltronetti, V. Pallen, G. Bezgin, M. S. Kang, S. S. Mathotaarachchi, Y. T. Wang, J. Fernandez Arias, P. C. L. Ferreira, J. P. Ferrari-Souza, E. Vanmechelen, K. Blennow, H. Zetterberg, S. Gauthier, P. Rosa-Neto
Ebiomedicine - 2022 -
The accuracy and robustness of plasma biomarker models for amyloid PET
positivity
Andréa Lessa Benedet, Wagner S. Brum, O. Hansson, A. D. N. Initiative, Thomas Karikari, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Alzheimers Research & Therapy - 2022 -
Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy
Bodies.
Maria C Gonzalez, Nicholas J. Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
JAMA neurology - 2022 -
Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular
disease.
Joyce R Chong, Nicholas J. Ashton, Thomas Karikari, Tomotaka Tanaka, Francis N Saridin, Anthonin Reilhac, Edward G Robins, Ying-Hwey Nai, Henri Vrooman, Saima Hilal, Henrik Zetterberg, Kaj Blennow, Mitchell K P Lai, Christopher P Chen
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging
Initiative.
Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow
Alzheimer's research & therapy - 2021 -
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's
disease.
Cécile Tissot, Andréa Lessa Benedet, Joseph Therriault, Tharick A Pascoal, Firoza Z Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto
Alzheimer's research & therapy - 2021 -
Association of plasma P-tau181 with memory decline in non-demented
adults
J. Therriault, A. L. Benedet, T. A. Pascoal, F. Z. Lussier, C. Tissot, Thomas Karikari, Nicholas J. Ashton, M. Chamoun, G. Bezgin, S. Mathotaarachchi, S. Gauthier, P. Saha-Chaudhuri, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021 -
Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andrea L Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021 -
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort
study
A. O'Connor, Thomas Karikari, T. Poole, Nicholas J. Ashton, Juan Rodriguez, A. Khatun, I. Swift, A. J. Heslegrave, E. Abel, E. Chung, P. S. J. Weston, I. M. Pavisic, N. S. Ryan, S. Barker, M. N. Rossor, J. M. Polke, C. Frost, S. Mead, Kaj Blennow, Henrik Zetterberg, N. C. Fox
Molecular Psychiatry - 2021 -
Time course of phosphorylated-tau181 in blood across the Alzheimer's disease
spectrum.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suarez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Brain : a journal of neurology - 2021 -
Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer
Disease.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Kaj Blennow, Henrik Zetterberg, Michael Schöll
JAMA Neurology - 2021 -
Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive
Outcomes
M. M. Mielke, R. D. Frank, J. L. Dage, A. Jeromin, Nicholas J. Ashton, Kaj Blennow, Thomas Karikari, E. Vanmechelen, Henrik Zetterberg, A. Algeciras-Schimnich, D. S. Knopman, V. Lowe, G. J. Bu, P. Vemuri, J. Graff-Radford, C. R. Jack, R. C. Petersen
JAMA Neurology - 2021 -
Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive
individuals
F. Z. Lussier, A. L. Benedet, J. Therriault, T. A. Pascoal, C. Tissot, M. Chamoun, S. Mathotaarachchi, M. Savard, Nicholas J. Ashton, Thomas Karikari, Juan Rodriguez, Anniina Snellman, G. Bezgin, M. S. Kang, J. F. Arias, Y. T. Wang, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021 -
A genome-wide association study of plasma phosphorylated
tau181
Jodie Lord, Anna Zettergren, Nicholas J. Ashton, Thomas Karikari, Andréa Lessa Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proitsi
Neurobiology of aging - 2021 -
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down
syndrome
A. Lleo, Henrik Zetterberg, J. Pegueroles, Thomas Karikari, M. Carmona-Iragui, Nicholas J. Ashton, V. Montal, I. Barroeta, Juan Lantero Rodriguez, L. Videla, M. Altuna, B. Benejam, S. Fernandez, S. Valldeneu, D. Garzon, A. Bejanin, M. F. Iulita, V. Camacho, S. Medrano-Martorell, O. Belbin, J. Clarimon, S. Lehmann, D. Alcolea, R. Blesa, Kaj Blennow, J. Fortea
Nature Communications - 2021 -
P-tau235: a novel biomarker for staging preclinical Alzheimer's
disease.
Juan Lantero Rodriguez, Anniina Snellman, Andréa Lessa Benedet, Marta Milà-Alomà, Elena Camporesi, Laia Montoliu-Gaya, Nicholas J. Ashton, Agathe Vrillon, Thomas Karikari, Juan Domingo Gispert, Gemma Salvadó, Mahnaz Shekari, Christina E Toomey, Tammaryn L Lashley, Henrik Zetterberg, Marc Suárez-Calvet, Gunnar Brinkmalm, Pedro Rosa Neto, Kaj Blennow
EMBO molecular medicine - 2021 -
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age
70.
Ashvini Keshavan, Josef Pannee, Thomas Karikari, Juan Rodriguez, Nicholas J. Ashton, Jennifer M Nicholas, David M Cash, William Coath, Christopher A Lane, Thomas D Parker, Kirsty Lu, Sarah M Buchanan, Sarah E Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M Schott
Brain : a journal of neurology - 2021 -
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging
Initiative.
Thomas Karikari, Andréa L Benedet, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Paramita Saha-Chaudhuri, Firoza Lussier, Hlin Kvartsberg, Alexis Moscoso Rial, Tharick A Pascoal, Ulf Andreasson, Michael Schöll, Michael W Weiner, Pedro Rosa-Neto, John Q Trojanowski, Leslie M Shaw, Kaj Blennow, Henrik Zetterberg
Molecular psychiatry - 2021 -
Truncating tau reveals different pathophysiological actions of oligomers in single
neurons
E. Hill, Thomas Karikari, Juan Lantero Rodriguez, Henrik Zetterberg, Kaj Blennow, M. J. Richardson, M. J. Wall
Communications Biology - 2021 -
Associations of Fully Automated CSF and Novel Plasma Biomarkers With Alzheimer Disease Neuropathology at
Autopsy.
Michel J. Grothe, Alexis Moscoso Rial, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Neurology - 2021 -
Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent
advances
J. R. Chong, Nicholas J. Ashton, Thomas Karikari, T. Tanaka, Michael Schöll, Henrik Zetterberg, Kaj Blennow, C. P. Chen, M. K. P. Lai
Journal of Neurology Neurosurgery and Psychiatry - 2021 -
Prodromal frontotemporal dementia: clinical features and predictors of
progression.
Alberto Benussi, Nicholas J. Ashton, Thomas Karikari, Antonella Alberici, Claudia Saraceno, Roberta Ghidoni, Luisa Benussi, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Alzheimer's research & therapy - 2021 -
Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease
Continuum
Andréa Lessa Benedet, M. Mila-Aloma, A. Vrillon, Nicholas J. Ashton, T. A. Pascoal, F. Lussier, Thomas Karikari, C. Hourregue, E. Cognat, J. Dumurgier, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, G. Salvado, M. Shekari, G. Operto, J. D. Gispert, C. Minguillon, K. Fauria, G. Kollmorgen, I. Suridjan, E. R. Zimmer, Henrik Zetterberg, J. L. Molinuevo, C. Paquet, P. Rosa-Neto, Kaj Blennow, M. Suarez-Calvet
Jama Neurology - 2021 -
Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and
neurodegeneration.
Nicholas J. Ashton, Marc Suárez-Calvet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Joel Simrén, Carolina Minguillon, Karine Fauria, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia (Amsterdam, Netherlands) - 2021 -
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease
pathology.
Nicholas J. Ashton, Tharick A Pascoal, Thomas Karikari, Andréa Lessa Benedet, Juan Lantero Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2021 -
Use of plasma biomarkers for AT(N) classification of neurodegenerative
dementias
D. Alcolea, C. Delaby, L. Muñoz, S. Torres, T. Estellés, N. Zhu, I. Barroeta, M. Carmona-Iragui, I. Illán-Gala, M. Á Santos-Santos, M. Altuna, I. Sala, Mª B. Sánchez-Saudinós, L. Videla, S. Valldeneu, A. Subirana, J. Pegueroles, C. Hirtz, J. Vialaret, S. Lehmann, Thomas Karikari, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, O. Belbin, R. Blesa, J. Clarimón, J. Fortea, A. Lleó
Journal of Neurology, Neurosurgery and Psychiatry - 2021 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021 -
Publisher Correction: Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andréa Lessa Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021 -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's
disease.
Joel Simrén, Antoine Leuzy, Thomas Karikari, Abdul Hye, Andréa Lessa Benedet, Juan Lantero Rodriguez, Niklas Mattsson-Carlgren, Michael Schöll, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD
biomarkers
Nicholas J. Ashton, A. Leuzy, Thomas Karikari, N. Mattsson-Carlgren, A. Dodich, M. Boccardi, J. Corre, A. Drzezga, A. Nordberg, R. Ossenkoppele, Henrik Zetterberg, Kaj Blennow, G. B. Frisoni, V. Garibotto, O. Hansson
European Journal of Nuclear Medicine and Molecular Imaging - 2021 -
A multicentre validation study of the diagnostic value of plasma neurofilament
light.
Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L van der Ende, Thomas Karikari, Andrea L Benedet, Tharick A Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Nature communications - 2021 -
Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease
diagnosis.
Thomas Karikari, Agathe Vrillon, Juan Lantero Rodriguez, Nicholas J. Ashton, Milica Gregorič Kramberger, Julien Dumurgier, Claire Hourregue, Saša Čučnik, Gunnar Brinkmalm, Uroš Rot, Henrik Zetterberg, Claire Paquet, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease
progression.
Christopher Clark, Piotr Lewczuk, Johannes Kornhuber, Jonas Richiardi, Bénédicte Maréchal, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Julius Popp
Alzheimer's research & therapy - 2021 -
Synedrella nodiflora Extract Depresses Excitatory Synaptic Transmission and Chemically-Induced In Vitro Seizures in the Rat
Hippocampus
P. Amoateng, T. A. Tagoe, Thomas Karikari, K. K. E. Kukuia, D. Osei-Safo, E. Woode, B. G. Frenguelli, S. B. Kombian
Frontiers in Pharmacology - 2021 -
Construction and reconstruction of brain circuits: normal and pathological axon
guidance
S. Roig-Puiggros, R. J. Vigouroux, D. Beckman, N. I. Bocai, B. Chiou, J. Davimes, G. Gomez, S. Grassi, A. Hoque, Thomas Karikari, F. Kiffer, M. Lopez, G. Lunghi, P. Mazengenya, S. Meier, M. Olguin-Albuerne, M. M. Oliveira, J. Paraiso-Luna, J. Pradhan, A. Radiske, A. B. Ramos-Hryb, M. C. Ribeiro, R. Schellino, M. C. Selles, S. Singh, P. Theotokis, A. Chedotal
Journal of Neurochemistry - 2020 -
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are
detected.
Marc Suárez-Calvet, Thomas Karikari, Nicholas J. Ashton, Juan Lantero Rodriguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuevo
EMBO molecular medicine - 2020 -
Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar
degeneration.
Alberto Benussi, Thomas Karikari, Nicholas J. Ashton, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Joel Simrén, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of neurology, neurosurgery, and psychiatry - 2020 -
Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar
Degeneration.
Alberto Benussi, Nicholas J. Ashton, Thomas Karikari, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of Alzheimer's disease : JAD - 2020 -
An update on blood-based biomarkers for non-Alzheimer neurodegenerative
disorders.
Nicholas J. Ashton, Abdul Hye, Anto P Rajkumar, Antoine Leuzy, Stuart Snowden, Marc Suárez-Calvet, Thomas Karikari, Michael Schöll, Renaud La Joie, Gil D Rabinovici, Kina Höglund, Clive Ballard, Tibor Hortobágyi, Per Svenningsson, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
Nature Reviews Neurology - 2020 -
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective
cohorts.
Thomas Karikari, Tharick A Pascoal, Nicholas J. Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
The Lancet. Neurology - 2020 -
An extensive plasmid library to prepare tau protein variants and study their functional
biochemistry.
Thomas Karikari, Sophie Keeling, Emily Hill, Juan Lantero Rodriguez, David A Nagel, Bruno Becker, Kina Höglund, Henrik Zetterberg, Kaj Blennow, Eric J Hill, Kevin G Moffat
ACS chemical neuroscience - 2020 -
Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological
Approaches
E. Hill, M. J. Wall, K. G. Moffat, Thomas Karikari
Frontiers in Molecular Neuroscience - 2020 -
Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive
decline.
Juan Lantero Rodriguez, Thomas Karikari, Marc Suárez-Calvet, Claire Troakes, Andrew King, Andreja Emersic, Dag Aarsland, Abdul Hye, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Acta neuropathologica - 2020 -
The C291R Tau Variant Forms Different Types of
Protofibrils
Thomas Karikari, R. Thomas, K. G. Moffat
Frontiers in Molecular Neuroscience - 2020 -
Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and
Plasticity
E. Hill, Thomas Karikari, K. G. Moffat, M. J. E. Richardson, M. J. Wall
Eneuro - 2019 -
International science
education
Thomas Karikari, Miriam Segura-Totten, Esperanza C. Cabrera, Diana E. Waturangi, Erin E. Barding, Tatiana Ascencio
Journal of Microbiology and Biology Education - 2019