Thomas Karikari
-
Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andrea L Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021-01-01 -
A multicentre validation study of the diagnostic value of plasma neurofilament
light.
Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L van der Ende, Thomas Karikari, Andrea L Benedet, Tharick A Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Nature communications - 2021-01-01 -
Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive
Outcomes
M. M. Mielke, R. D. Frank, J. L. Dage, A. Jeromin, Nicholas J. Ashton, Kaj Blennow, Thomas Karikari, E. Vanmechelen, Henrik Zetterberg, A. Algeciras-Schimnich, D. S. Knopman, V. Lowe, G. J. Bu, P. Vemuri, J. Graff-Radford, C. R. Jack, R. C. Petersen
JAMA Neurology - 2021-01-01 -
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's
disease.
Pratishtha Chatterjee, Steve Pedrini, Nicholas J. Ashton, Michelle Tegg, Kathryn Goozee, Abhay K Singh, Thomas Karikari, Joel Simrén, Eugeen Vanmechelen, Nicola J Armstrong, Eugene Hone, Prita R Asih, Kevin Taddei, Vincent Doré, Victor L Villemagne, Hamid R Sohrabi, Henrik Zetterberg, Colin L Masters, Kaj Blennow, Ralph N Martins
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down
syndrome
A. Lleo, Henrik Zetterberg, J. Pegueroles, Thomas Karikari, M. Carmona-Iragui, Nicholas J. Ashton, V. Montal, I. Barroeta, J. Lantero-Rodriguez, L. Videla, M. Altuna, B. Benejam, S. Fernandez, S. Valldeneu, D. Garzon, A. Bejanin, M. F. Iulita, V. Camacho, S. Medrano-Martorell, O. Belbin, J. Clarimon, S. Lehmann, D. Alcolea, R. Blesa, Kaj Blennow, J. Fortea
Nature Communications - 2021-01-01 -
Association of plasma P-tau181 with memory decline in non-demented
adults
J. Therriault, A. L. Benedet, T. A. Pascoal, F. Z. Lussier, C. Tissot, Thomas Karikari, Nicholas J. Ashton, M. Chamoun, G. Bezgin, S. Mathotaarachchi, S. Gauthier, P. Saha-Chaudhuri, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021-01-01 -
Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive
individuals
F. Z. Lussier, A. L. Benedet, J. Therriault, T. A. Pascoal, C. Tissot, M. Chamoun, S. Mathotaarachchi, M. Savard, Nicholas J. Ashton, Thomas Karikari, Juan Rodriguez, Anniina Snellman, G. Bezgin, M. S. Kang, J. F. Arias, Y. T. Wang, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Brain Communications - 2021-01-01 -
Use of plasma biomarkers for AT(N) classification of neurodegenerative
dementias
D. Alcolea, C. Delaby, L. Muñoz, S. Torres, T. Estellés, N. Zhu, I. Barroeta, M. Carmona-Iragui, I. Illán-Gala, M. Á Santos-Santos, M. Altuna, I. Sala, Mª B. Sánchez-Saudinós, L. Videla, S. Valldeneu, A. Subirana, J. Pegueroles, C. Hirtz, J. Vialaret, S. Lehmann, Thomas Karikari, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, O. Belbin, R. Blesa, J. Clarimón, J. Fortea, A. Lleó
Journal of Neurology, Neurosurgery and Psychiatry - 2021-01-01 -
Time course of phosphorylated-tau181 in blood across the Alzheimer's disease
spectrum.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suarez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Brain : a journal of neurology - 2021-01-01 -
Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease
diagnosis.
Thomas Karikari, Agathe Vrillon, Juan Lantero Rodriguez, Nicholas J. Ashton, Milica Gregorič Kramberger, Julien Dumurgier, Claire Hourregue, Saša Čučnik, Gunnar Brinkmalm, Uroš Rot, Henrik Zetterberg, Claire Paquet, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and
neurodegeneration.
Nicholas J. Ashton, Marc Suárez-Calvet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Joel Simrén, Carolina Minguillon, Karine Fauria, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia (Amsterdam, Netherlands) - 2021-01-01 -
A genome-wide association study of plasma phosphorylated
tau181
Jodie Lord, Anna Zettergren, Nicholas J. Ashton, Thomas Karikari, Andréa Lessa Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proitsi
Neurobiology of aging - 2021-01-01 -
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age
70.
Ashvini Keshavan, Josef Pannee, Thomas Karikari, Juan Rodriguez, Nicholas J. Ashton, Jennifer M Nicholas, David M Cash, William Coath, Christopher A Lane, Thomas D Parker, Kirsty Lu, Sarah M Buchanan, Sarah E Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M Schott
Brain : a journal of neurology - 2021-01-01 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021-01-01 -
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease
pathology.
Nicholas J. Ashton, Tharick A Pascoal, Thomas Karikari, Andréa Lessa Benedet, Juan Lantero Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2021-01-01 -
Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging
Initiative.
Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow
Alzheimer's research & therapy - 2021-01-01 -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's
disease.
Joel Simrén, Antoine Leuzy, Thomas Karikari, Abdul Hye, Andréa Lessa Benedet, Juan Lantero Rodriguez, Niklas Mattsson-Carlgren, Michael Schöll, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease
progression.
Christopher Clark, Piotr Lewczuk, Johannes Kornhuber, Jonas Richiardi, Bénédicte Maréchal, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Julius Popp
Alzheimer's research & therapy - 2021-01-01 -
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's
disease.
Cécile Tissot, Andréa Lessa Benedet, Joseph Therriault, Tharick A Pascoal, Firoza Z Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto
Alzheimer's research & therapy - 2021-01-01 -
Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular
disease.
Joyce R Chong, Nicholas J. Ashton, Thomas Karikari, Tomotaka Tanaka, Francis N Saridin, Anthonin Reilhac, Edward G Robins, Ying-Hwey Nai, Henri Vrooman, Saima Hilal, Henrik Zetterberg, Kaj Blennow, Mitchell K P Lai, Christopher P Chen
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021-01-01 -
Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer
Disease.
Alexis Moscoso Rial, Michel J. Grothe, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Kaj Blennow, Henrik Zetterberg, Michael Schöll
JAMA Neurology - 2021-01-01 -
The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD
biomarkers
Nicholas J. Ashton, A. Leuzy, Thomas Karikari, N. Mattsson-Carlgren, A. Dodich, M. Boccardi, J. Corre, A. Drzezga, A. Nordberg, R. Ossenkoppele, Henrik Zetterberg, Kaj Blennow, G. B. Frisoni, V. Garibotto, O. Hansson
European Journal of Nuclear Medicine and Molecular Imaging - 2021-01-01 -
Synedrella nodiflora Extract Depresses Excitatory Synaptic Transmission and Chemically-Induced In Vitro Seizures in the Rat
Hippocampus
P. Amoateng, T. A. Tagoe, Thomas Karikari, K. K. E. Kukuia, D. Osei-Safo, E. Woode, B. G. Frenguelli, S. B. Kombian
Frontiers in Pharmacology - 2021-01-01 -
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging
Initiative.
Thomas Karikari, Andréa L Benedet, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Paramita Saha-Chaudhuri, Firoza Lussier, Hlin Kvartsberg, Alexis Moscoso Rial, Tharick A Pascoal, Ulf Andreasson, Michael Schöll, Michael W Weiner, Pedro Rosa-Neto, John Q Trojanowski, Leslie M Shaw, Kaj Blennow, Henrik Zetterberg
Molecular psychiatry - 2021-01-01 -
Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar
degeneration.
Alberto Benussi, Thomas Karikari, Nicholas J. Ashton, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Joel Simrén, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of neurology, neurosurgery, and psychiatry - 2020-01-01 -
Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar
Degeneration.
Alberto Benussi, Nicholas J. Ashton, Thomas Karikari, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of Alzheimer's disease : JAD - 2020-01-01 -
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective
cohorts.
Thomas Karikari, Tharick A Pascoal, Nicholas J. Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
The Lancet. Neurology - 2020-01-01 -
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are
detected.
Marc Suárez-Calvet, Thomas Karikari, Nicholas J. Ashton, Juan Lantero Rodriguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuevo
EMBO molecular medicine - 2020-01-01 -
An extensive plasmid library to prepare tau protein variants and study their functional
biochemistry.
Thomas Karikari, Sophie Keeling, Emily Hill, Juan Lantero Rodriguez, David A Nagel, Bruno Becker, Kina Höglund, Henrik Zetterberg, Kaj Blennow, Eric J Hill, Kevin G Moffat
ACS chemical neuroscience - 2020-01-01 -
Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological
Approaches
E. Hill, M. J. Wall, K. G. Moffat, Thomas Karikari
Frontiers in Molecular Neuroscience - 2020-01-01 -
Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive
decline.
Juan Lantero Rodriguez, Thomas Karikari, Marc Suárez-Calvet, Claire Troakes, Andrew King, Andreja Emersic, Dag Aarsland, Abdul Hye, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Acta neuropathologica - 2020-01-01 -
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort
study
A. O'Connor, Thomas Karikari, T. Poole, Nicholas J. Ashton, Juan Rodriguez, A. Khatun, I. Swift, A. J. Heslegrave, E. Abel, E. Chung, P. S. J. Weston, I. M. Pavisic, N. S. Ryan, S. Barker, M. N. Rossor, J. M. Polke, C. Frost, S. Mead, Kaj Blennow, Henrik Zetterberg, N. C. Fox
Molecular Psychiatry - 2020-01-01 -
The C291R Tau Variant Forms Different Types of
Protofibrils
Thomas Karikari, R. Thomas, K. G. Moffat
Frontiers in Molecular Neuroscience - 2020-01-01 -
An update on blood-based biomarkers for non-Alzheimer neurodegenerative
disorders.
Nicholas J. Ashton, Abdul Hye, Anto P Rajkumar, Antoine Leuzy, Stuart Snowden, Marc Suárez-Calvet, Thomas Karikari, Michael Schöll, Renaud La Joie, Gil D Rabinovici, Kina Höglund, Clive Ballard, Tibor Hortobágyi, Per Svenningsson, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
Nature Reviews Neurology - 2020-01-01 -
Construction and reconstruction of brain circuits: normal and pathological axon
guidance
S. Roig-Puiggros, R. J. Vigouroux, D. Beckman, N. I. Bocai, B. Chiou, J. Davimes, G. Gomez, S. Grassi, A. Hoque, Thomas Karikari, F. Kiffer, M. Lopez, G. Lunghi, P. Mazengenya, S. Meier, M. Olguin-Albuerne, M. M. Oliveira, J. Paraiso-Luna, J. Pradhan, A. Radiske, A. B. Ramos-Hryb, M. C. Ribeiro, R. Schellino, M. C. Selles, S. Singh, P. Theotokis, A. Chedotal
Journal of Neurochemistry - 2019-01-01 -
Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and
Plasticity
E. Hill, Thomas Karikari, K. G. Moffat, M. J. E. Richardson, M. J. Wall
Eneuro - 2019-01-01 -
International science
education
Thomas Karikari, Miriam Segura-Totten, Esperanza C. Cabrera, Diana E. Waturangi, Erin E. Barding, Tatiana Ascencio
Journal of Microbiology and Biology Education - 2019-01-01