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- Andrea Lessa Benedet
Andrea Lessa Benedet
Researcher
Department of Psychiatry and Neurochemistry-
Identification of late-stage tau accumulation using plasma
phospho-tau217
Marcel S. Woo, Joseph Therriault, Erin M. Jonaitis, Rachael Wilson, Rebecca E. Langhough, Nesrine Rahmouni, Andréa Lessa Benedet, Nicholas J. Ashton, Cecile Tissot, Juan Lantero Rodriguez, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J. Betthauser, Firoza Z. Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C. Kolb, Andreas Jeromin, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Jesse Klostranec, Paolo Vilali, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Sterling C. Johnson, Pedro Rosa-Neto
EBIOMEDICINE - 2024 -
Plasma phosphorylated tau181 outperforms [18F] fluorodeoxyglucose positron emission tomography in the identification of early Alzheimer
disease
Kely Monica Quispialaya, Joseph Therriault, Antonio Aliaga, Cecile Tissot, Stijn Servaes, Nesrine Rahmouni, Thomas Karikari, Andréa Lessa Benedet, Nicholas J. Ashton, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Yi-Ting Wang, Jaime Fernandez Arias, Ali Hosseini, Takashi Matsudaira, Bertrand Jean-Claude, Brian M. Gilfix, Eduardo R. Zimmer, Jean-Paul Soucy, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
EUROPEAN JOURNAL OF NEUROLOGY - 2024 -
Influence of Different Diagnostic Criteria on Alzheimer Disease Clinical
Research
Andrei Bieger, Wagner Scheeren Brum, Wyllians V. Borelli, Joseph Therriault, Marco A. De Bastiani, Amanda G. Moreira, Andréa Lessa Benedet, Joao Pedro Ferrari-Souza, Jaderson C. Da Costa, Diogo O. Souza, Raphael M. Castilhos, Artur Francisco Schumacher Schuh, Marcia L. Fagundes Chaves, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Tharick A. Pascoal, Serge Gauthier, Pedro Rosa-Neto, Lucas P. Schilling, Eduardo R. Zimmer
NEUROLOGY - 2024 -
Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer's
disease.
Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Thomas K Karikari, Nicholas J. Ashton, Andréa Lessa Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medina
Communications biology - 2024 -
Sex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in
females
Yi-Ting Wang, Joseph Therriault, Stijn Servaes, Cécile Tissot, Nesrine Rahmouni, Arthur Cassa Macedo, Jaime Fernandez-Arias, Sulantha S Mathotaarachchi, Andréa Lessa Benedet, Jenna Stevenson, Nicholas J. Ashton, Firoza Z Lussier, Tharick A Pascoal, Henrik Zetterberg, Maria Natasha Rajah, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto
Brain : a journal of neurology - 2024 -
A blood-based biomarker workflow for optimal tau-PET referral in memory clinic
settings.
Wagner Scheeren Brum, Nicholas C Cullen, Joseph Therriault, Shorena Janelidze, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Andréa Lessa Benedet, Eduardo R Zimmer, Erik Stomrud, Sebastian Palmqvist, Henrik Zetterberg, Giovanni B Frisoni, Nicholas J. Ashton, Kaj Blennow, Niklas Mattsson-Carlgren, Pedro Rosa-Neto, Oskar Hansson
Nature Communications - 2024 -
Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's
pathology.
Joseph Therriault, Nicholas J. Ashton, Ilaria Pola, Gallen Triana-Baltzer, Wagner Scheeren Brum, Guglielmo Di Molfetta, Burak Arslan, Nesrine Rahmouni, Cecile Tissot, Stijn Servaes, Jenna Stevenson, Arthur Cassa Macedo, Tharick Ali Pascoal, Hartmuth Christian Kolb, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andréa Lessa Benedet
EBioMedicine - 2024 -
Vascular risk burden is a key player in the early progression of Alzheimer's
disease
Joao Pedro Ferrari-Souza, Wagner Scheeren Brum, Lucas A. Hauschild, Lucas U. Da Ros, Pamela C. L. Ferreira, Bruna Bellaver, Douglas T. Leffa, Andrei Bieger, Cecile Tissot, Firoza Z. Lussier, Marco Antonio De Bastiani, Guilherme Povala, Andréa Lessa Benedet, Joseph Therriault, Yi-Ting Wang, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Sheila O. Martins, Diogo O. Souza, Pedro Rosa-Neto, Thomas Karikari, Tharick A. Pascoal, Eduardo R. Zimmer
NEUROBIOLOGY OF AGING - 2024 -
Biomarker-based staging of Alzheimer disease: rationale and clinical
applications.
Joseph Therriault, Suzanne E Schindler, Gemma Salvadó, Tharick A Pascoal, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Liana Apostolova, Melissa E Murray, Inge Verberk, Jacob W Vogel, Renaud La Joie, Serge Gauthier, Charlotte Teunissen, Gil D Rabinovici, Henrik Zetterberg, Randall J Bateman, Philip Scheltens, Kaj Blennow, Reisa Sperling, Oskar Hansson, Clifford R Jack, Pedro Rosa-Neto
Nature reviews. Neurology - 2024 -
Plasma GFAP and its association with disease severity in Huntington's
disease.
Kübra Tan, Melanie Alpaugh, Nicholas J. Ashton, Sylvain Chouinard, Roger A Barker, Kaj Blennow, Henrik Zetterberg, Francesca Cicchetti, Andréa Lessa Benedet
Journal of neurology - 2024 -
Plasma pTau-217 and N-terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid-β positive
individuals
M. S. Woo, C. Tissot, Juan Lantero Rodriguez, Anniina Snellman, J. Therriault, N. Rahmouni, A. C. Macedo, S. Servaes, Y. T. Wang, J. F. Arias, S. A. Hosseini, M. Chamoun, F. Z. Lussier, Andréa Lessa Benedet, Nicholas J. Ashton, T. K. Karikari, G. Triana-Baltzer, H. C. Kolb, J. Stevenson, C. Mayer, E. Kobayashi, G. Massarweh, M. A. Friese, T. A. Pascoal, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Alzheimers & Dementia - 2024 -
Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy
individuals
Wagner Scheeren Brum, Nicholas J. Ashton, Joel Simrén, Guiglielmo di Molfetta, Thomas Karikari, Andréa Lessa Benedet, Eduardo R. Zimmer, Juan Lantero Rodriguez, Laia Montoliu-Gaya, Andreas Jeromin, Aasne K. Aarsand, William A. Bartlett, Pilar Fernández Calle, Abdurrahman Coşkun, Jorge Díaz–Garzón, Niels Jonker, Henrik Zetterberg, Sverre Sandberg, Anna Carobene, Kaj Blennow
Alzheimer's and Dementia - 2024 -
Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer's
Disease
Juan Lantero Rodriguez, Gemma Salvado, Anniina Snellman, Laia Montoliu-Gaya, Wagner Scheeren Brum, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Pontus Tideman, Shorena Janelidze, Sebastian Palmqvist, Erik Stomrud, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
MOLECULAR NEURODEGENERATION - 2024 -
Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease
Pathology
Nicholas J. Ashton, Wagner Scheeren Brum, Guglielmo Di Molfetta, Andréa Lessa Benedet, Burak Arslan, Erin Jonaitis, Rebecca E. Langhough, Karly Cody, Rachael Wilson, Cynthia M. Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleo, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg
JAMA NEUROLOGY - 2024 -
Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease
pathology
Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto
Molecular Neurodegeneration - 2024 -
CSF p-tau205: a biomarker of tau pathology in Alzheimer's
disease.
Juan Lantero Rodriguez, Laia Montoliu-Gaya, Andréa Lessa Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner Scheeren Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2024 -
Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's
disease
D. Herman, V. Andrea, L. Pablo, L. Simone, Andréa Lessa Benedet, Nicholas J. Ashton, C. Enrica, Henrik Zetterberg, Kaj Blennow, V. Eugeen, H. Harald
Alzheimers & Dementia - 2023 -
Plasma and CSF concentrations of N-terminal tau fragments associate with in vivo neurofibrillary tangle
burden
Juan Lantero Rodriguez, C. Tissot, Anniina Snellman, S. Servaes, Andréa Lessa Benedet, N. Rahmouni, Laia Montoliu-Gaya, J. Therriault, Wagner Scheeren Brum, J. Stevenson, F. Z. Lussier, G. Bezgin, A. C. Macedo, M. Chamoun, S. S. Mathotaarachi, T. A. Pascoal, Nicholas J. Ashton, Henrik Zetterberg, P. R. Neto, Kaj Blennow
Alzheimers & Dementia - 2023 -
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac
Arrest
Nicholas J. Ashton, M. Moseby-Knappe, Andréa Lessa Benedet, Lana Grötschel, Juan Lantero Rodriguez, Thomas Karikari, C. Hassager, M. P. Wise, P. Stammet, J. Kjaergaard, H. Friberg, N. Nielsen, T. Cronberg, Henrik Zetterberg, Kaj Blennow
Jama Neurology - 2023 -
Diagnostic accuracy of the plasma ALZpath pTau217 immunoassay to identify Alzheimer's disease
pathology.
Nicholas J. Ashton, Wagner Scheeren Brum, Guglielmo Di Molfetta, Andréa Lessa Benedet, Burak Arslan, Erin Jonatis, Rebecca E Langhough, Karly Cody, Rachael Wilson, Cynthia M Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg
medRxiv : the preprint server for health sciences - 2023 -
Blood-brain barrier integrity impacts the use of plasma amyloid-beta as a proxy of brain amyloid-beta
pathology
B. Bellaver, A. Puig-Pijoan, J. P. Ferrari-Souza, D. T. Leffa, F. Z. Lussier, P. C. L. Ferreira, C. Tissot, G. Povala, J. Therriault, Andréa Lessa Benedet, Nicholas J. Ashton, S. Servaes, M. Chamoun, J. Stevenson, N. Rahmouni, M. Vermeiren, A. C. Macedo, A. Fernandez-Lebrero, G. Garcia-Escobar, I. Navalpotro-Gomez, O. Lopez, D. L. Tudorascu, A. Cohen, V. L. Villemagne, W. E. Klunk, S. Gauthier, E. R. Zimmer, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, M. Suarez-Calvet, P. Rosa-Neto, T. A. Pascoal
Alzheimers & Dementia - 2023 -
Endocannabinoid System Biomarkers in Alzheimer's
Disease
Pamela C. L. Ferreira, Bruna Bellaver, Guilherme Povala, Wagner Scheeren Brum, Cecile Tissot, Atef Badji, Matthew E. Sloan, Andréa Lessa Benedet, Pedro Rosa-Neto, Nicholas J. Ashton, Tharick A. Pascoal, Antoine Leuzy, Eduardo R. Zimmer
CANNABIS AND CANNABINOID RESEARCH - 2023 -
APOEε4 potentiates amyloid β effects on longitudinal tau
pathology
J. P. Ferrari-Souza, B. Bellaver, P. C. L. Ferreira, Andréa Lessa Benedet, G. Povala, F. Z. Lussier, D. T. Leffa, J. Therriault, C. Tissot, C. Soares, Y. T. Wang, M. Chamoun, S. Servaes, A. C. Macedo, M. Vermeiren, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, A. Cohen, O. L. Lopez, W. E. Klunk, J. P. Soucy, S. Gauthier, D. O. Souza, G. Triana-Baltzer, Z. S. Saad, H. C. Kolb, Thomas Karikari, V. L. Villemagne, D. L. Tudorascu, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Nature Aging - 2023 -
Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau
immunoassays
Nicholas J. Ashton, A. Puig-Pijoan, M. Mila-Aloma, A. Fernandez-Lebrero, G. Garcia-Escobar, Fernando Gonzalez-Ortiz, Przemyslaw R. Kac, Wagner Scheeren Brum, Andréa Lessa Benedet, Juan Lantero Rodriguez, T. A. Day, J. Vanbrabant, E. Stoops, E. Vanmechelen, G. Triana-Baltzer, S. Moughadam, H. Kolb, P. Ortiz-Romero, Thomas Karikari, C. Minguillon, J. J. H. Sanchez, I. Navalpotro-Gomez, O. Grau-Rivera, R. M. Manero, V. Puente-Periz, R. de la Torre, J. Roquer, J. L. Dage, Henrik Zetterberg, Kaj Blennow, M. Suarez-Calvet
Alzheimers & Dementia - 2023 -
A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain
cases
Wagner Scheeren Brum, N. C. Cullen, S. Janelidze, Nicholas J. Ashton, E. R. Zimmer, J. Therriault, Andréa Lessa Benedet, N. Rahmouni, C. Tissot, J. Stevenson, S. Servaes, G. Triana-Baltzer, H. C. Kolb, S. Palmqvist, E. Stomrud, P. Rosa-Neto, Kaj Blennow, O. Hansson
Nature Aging - 2023 -
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired
individuals
P. C. L. Ferreira, J. Therriault, C. Tissot, J. P. Ferrari-Souza, Andréa Lessa Benedet, G. Povala, B. Bellaver, D. T. Leffa, W. S. Brum, F. Z. Lussier, G. Bezgin, S. Servaes, M. Vermeiren, A. C. Macedo, A. Cabrera, J. Stevenson, G. Triana-Baltzer, H. Kolb, N. Rahmouni, W. E. Klunk, O. L. Lopez, V. L. Villemagne, A. Cohen, D. L. Tudorascu, E. R. Zimmer, Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, K. Blennow, S. Gauthier, P. Rosa-Neto, T. A. Pascoal
Alzheimers & Dementia - 2023 -
Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical
Trials
P. C. L. Ferreira, J. P. Ferrari-Souza, C. Tissot, B. Bellaver, D. T. Leffa, F. Lussier, G. Povala, J. Therriault, Andréa Lessa Benedet, Nicholas J. Ashton, A. D. Cohen, O. L. Lopez, D. L. Tudorascu, W. E. Klunk, J. P. Soucy, S. Gauthier, V. Villemagne, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto, E. R. Zimmer, Thomas Karikari, T. A. Pascoal, Neuroimaging Alzheimers Dis
NEUROLOGY - 2023 -
Astrocyte reactivity influences amyloid-beta effects on tau pathology in preclinical Alzheimer's
disease
B. Bellaver, G. Povala, P. C. L. Ferreira, J. P. Ferrari-Souza, D. T. Leffa, F. Z. Lussier, Andréa Lessa Benedet, Nicholas J. Ashton, G. Triana-Baltzer, H. C. Kolb, C. Tissot, J. Therriault, S. Servaes, J. Stevenson, N. Rahmouni, O. L. Lopez, D. L. Tudorascu, V. L. Villemagne, M. D. Ikonomovic, S. Gauthier, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, H. J. Aizenstein, W. E. Klunk, B. E. Snitz, P. Maki, R. C. Thurston, A. D. Cohen, M. Ganguli, Thomas Karikari, P. Rosa-Neto, T. A. Pascoal
Nature Medicine - 2023 -
Hippocampal GFAP-positive astrocyte responses to amyloid and tau
pathologies.
Marco Antônio De Bastiani, Bruna Bellaver, Wagner Scheeren Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimmer
Brain, behavior, and immunity - 2023 -
The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of 18F MK6240 Tau PET in Target
Regions
C. Tissot, S. Servaes, F. Z. Lussier, J. P. Ferrai-Souza, J. Therriault, P. C. Ferreirat, G. Bezgin, B. Bellaver, D. T. Leffa, S. S. Mathotaarachchi, M. Chamoun, J. Stevenson, N. Rahmouni, M. S. Kang, V. Pallen, N. Margherita-Poltronetti, Y. T. Wang, J. Fernandez-Arias, Andréa Lessa Benedet, E. R. Zimmer, J. P. Soucy, D. L. Tudorascu, A. D. Cohen, M. Sharp, S. Gauthier, G. Massarweh, B. Lopresti, W. E. Klunk, S. L. Baker, V. L. Villemagne, P. Rosa-Neto, T. A. Pascoal
Journal of Nuclear Medicine - 2023 -
Plasma GFAP in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort
study.
Antoinette O'Connor, Emily Abel, Andréa Lessa Benedet, Teresa Poole, Nicholas J. Ashton, Philip Simon John Weston, Amanda J Heslegrave, Natalie Ryan, Suzie Barker, James M Polke, Kaj Blennow, Henrik Zetterberg, Nick C Fox
Journal of neurology, neurosurgery, and psychiatry - 2023 -
Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive
Individuals.
Annika Öhrfelt, Andréa Lessa Benedet, Nicholas J. Ashton, Hlin Kvartsberg, Manu Vandijck, Michael W Weiner, John Q Trojanowski, Leslie M Shaw, Henrik Zetterberg, Kaj Blennow
Neurology - 2023 -
Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer
Disease
Cristiano Schaffer Aguzzoli, Pâmela C.L. Ferreira, Guilherme Povala, João Pedro Ferrari-Souza, Bruna Bellaver, Carolina Soares Katz, Hussein Zalzale, Firoza Z. Lussier, Francieli Rohden, Sarah Abbas, Douglas T. Leffa, Marina Scop Medeiros, Joseph Therriault, Andréa Lessa Benedet, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Vanessa Pallen, Ann Cohen, Oscar L. Lopez, Dana L. Tudorascu, William E. Klunk, Victor L. Villemagne, Jean Paul Soucy, Eduardo R. Zimmer, Lucas P. Schilling, Thomas Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Victor Valcour, Bruce L. Miller, Pedro Rosa-Neto, Tharick A. Pascoal
JAMA network open - 2023 -
Revealing the combined roles of Aβ and tau in Alzheimer's disease via a pathophysiological activity
decoder.
Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Thomas Karikari, Nicholas J. Ashton, Andréa Lessa Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medina
bioRxiv : the preprint server for biology - 2023 -
Astrocyte reactivity influences the association of amyloid-β and tau biomarkers in preclinical Alzheimer's
disease.
Tharick Pascoal, Bruna Bellaver, Guilherme Povala, Pamela Ferreira, João Pedro Ferrari-Souza, Douglas Leffa, Firoza Lussier, Andréa Lessa Benedet, Nicholas J. Ashton, Gallen Triana-Baltzerz, Hartmuth Kolbzh, Cèile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar Lopez, Dana Tudorascu, Victor Villemagne, Milos Ikonomovic, Serge Gauthier, Eduardo Zimmer, Henrik Zetterberg, Kaj Blennow, Howard Aizenstein, William Klunk, Beth Snitz, Pauline Maki, Rebecca Thurston, Ann Cohen, Mary Ganguli, Thomas Karikari, Pedro Rosa-Neto
Research square - 2023 -
14-3-3 ζ/δ-reported early synaptic injury in Alzheimer's disease is independently mediated by
sTREM2
M. S. Woo, J. Nilsson, J. Therriault, N. Rahmouni, A. Brinkmalm, Andréa Lessa Benedet, Nicholas J. Ashton, A. C. Macedo, S. Servaes, Y. T. Wang, C. Tissot, J. F. Arias, S. A. Hosseini, M. Chamoun, F. Z. Lussier, Thomas Karikari, J. Stevenson, C. Mayer, J. P. Ferrari-Souza, E. Kobayashi, G. Massarweh, M. A. Friese, T. A. Pascoal, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Journal of Neuroinflammation - 2023 -
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's
disease
J. Therriault, S. Servaes, C. Tissot, N. Rahmouni, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, A. C. Macedo, F. Z. Lussier, J. Stevenson, Y. T. Wang, J. Fernandez-Arias, A. Stevenson, K. Q. Socualaya, A. Haeger, T. Nazneen, Aumont, Aumont,, A. Hosseini, S. Rej, P. Vitali, G. Triana-Baltzer, H. C. Kolb, J. P. Soucy, T. A. Pascoal, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Alzheimers & Dementia - 2023 -
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau
pathologies
Laia Montoliu-Gaya, Andréa Lessa Benedet, C. Tissot, A. Vrillon, Nicholas J. Ashton, Wagner Scheeren Brum, Juan Lantero Rodriguez, J. Stevenson, Johanna Nilsson, Mathias Sauer, N. Rahmouni, Gunnar Brinkmalm, F. Z. Lussier, T. A. Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, C. Paquet, Johan Gobom, P. Rosa-Neto, Kaj Blennow
Nature Aging - 2023 -
Association of the fibronectin type III domain-containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly
humans
R. A. S. Lima, Andréa Lessa Benedet, M. A. De Bastiani, G. Povala, D. Cozachenco, S. T. Ferreira, F. G. De Felice, P. Rosa-Neto, E. R. Zimmer, M. V. Lourenco
Brain Communications - 2023 -
Plasma and cerebrospinal fluid glial fibrillary acidic protein levels in adults with Down syndrome: a longitudinal cohort
study
Laia Montoliu-Gaya, D. Alcolea, Nicholas J. Ashton, J. Pegueroles, J. Levin, B. Bosch, Juan Lantero Rodriguez, M. Carmona-Iragui, O. Wagemann, M. Balasa, Przemyslaw R. Kac, I. Barroeta, A. Llado, Wagner Scheeren Brum, L. Videla, Fernando Gonzalez-Ortiz, B. Benejam, J. J. A. Martinez, Thomas Karikari, G. Nubling, A. Bejanin, Andréa Lessa Benedet, R. Blesa, A. Lleo, Kaj Blennow, R. Sanchez-Valle, Henrik Zetterberg, J. Fortea
eBioMedicine - 2023 -
APOEε4 associates with microglial activation independently of Aβ plaques and tau
tangles
J. P. Ferrari-Souza, F. Z. Lussier, D. T. Leffa, J. Therriault, C. Tissot, B. Bellaver, P. C. L. Ferreira, M. Malpetti, Y. T. Wang, G. Povala, Andréa Lessa Benedet, Nicholas J. Ashton, M. Chamoun, S. Servaes, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, J. T. O'Brlen, J. B. Rowe, A. D. Cohen, O. L. Lopez, D. L. Tudorascu, Thomas Karikari, W. E. Klunk, V. L. Villemagne, J. P. Soucy, S. Gauthier, D. O. Souza, Henrik Zetterberg, Kaj Blennow, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Science Advances - 2023 -
Astrocyte biomarker signatures of amyloid-beta and tau pathologies in Alzheimer's
disease
J. P. Ferrari-Souza, P. C. L. Ferreira, B. Bellaver, C. Tissot, Y. T. Wang, D. T. Leffa, Wagner Scheeren Brum, Andréa Lessa Benedet, Nicholas J. Ashton, M. A. De Bastiani, A. Rocha, J. Therriault, F. Z. Lussier, M. Chamoun, S. Servaes, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, W. E. Klunk, D. L. Tudorascu, A. D. Cohen, V. L. Villemagne, S. Gauthier, Kaj Blennow, Henrik Zetterberg, D. O. Souza, Thomas Karikari, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Molecular Psychiatry - 2022 -
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's
disease
Nicholas J. Ashton, Andréa Lessa Benedet, Tharick A. Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Wagner Scheeren Brum, S. Mathotaarachchi, J. Therriault, M. Savard, M. Chamoun, E. Stoops, C. Francois, E. Vanmechelen, S. Gauthier, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Ebiomedicine - 2022 -
Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer's
disease
Johanna Nilsson, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Johan Gobom, T. A. Pascoal, M. Chamoun, E. Portelius, A. Jeromin, M. Mendes, Henrik Zetterberg, P. Rosa-Neto, Ann Brinkmalm, Kaj Blennow
Alzheimer's Research & Therapy - 2022 -
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired
individuals.
Joel Simrén, Wagner Scheeren Brum, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Alzheimer's research & therapy - 2022 -
Differences between blood and cerebrospinal fluid glial fibrillary Acidic protein levels: The effect of sample
stability
Joel Simrén, Haley Weninger, Wagner Scheeren Brum, Shilla Khalil, Andréa Lessa Benedet, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimers & Dementia - 2022 -
A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's
disease.
Wagner Scheeren Brum, Marco Antônio de Bastiani, Andrei Bieger, Joseph Therriault, João P Ferrari-Souza, Andréa Lessa Benedet, Paramita Saha-Chaudhuri, Diogo O Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa-Neto, Eduardo R Zimmer
Alzheimer's & dementia (New York, N. Y.) - 2022 -
Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission
Tomography.
Joseph Therriault, Marie Vermeiren, Stijn Servaes, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Wagner Scheeren Brum, Firoza Z Lussier, Gleb Bezgin, Jenna Stevenson, Nesrine Rahmouni, Peter Kunach, Yi-Ting Wang, Jaime Fernandez-Arias, Kely Quispialaya Socualaya, Arthur C Macedo, João Pedro Ferrari-Souza, Pâmela C L Ferreira, Bruna Bellaver, Douglas T Leffa, Eduardo R Zimmer, Paolo Vitali, Jean-Paul Soucy, Gallen Triana-Baltzer, Hartmuth C Kolb, Tharick A Pascoal, Paramita Saha-Chaudhuri, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
JAMA neurology - 2022 -
Biomarker modeling of Alzheimer’s disease using PET-based Braak
staging
J. Therriault, T. A. Pascoal, F. Z. Lussier, C. Tissot, M. Chamoun, G. Bezgin, S. Servaes, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, P. Kunach, Y. T. Wang, J. Fernandez-Arias, G. Massarweh, P. Vitali, J. P. Soucy, P. Saha-Chaudhuri, Kaj Blennow, Henrik Zetterberg, S. Gauthier, P. Rosa-Neto
Nature Aging - 2022 -
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease
continuum.
Johan Gobom, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Molecular neurodegeneration - 2022 -
Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240
tau-PET
C. Tissot, J. Therriault, P. Kunach, Andréa Lessa Benedet, T. A. Pascoal, N. J. Ashton, Thomas Karikari, S. Servaes, F. Z. Lussier, M. Chamoun, D. L. Tudorascu, J. Stevenson, N. Rahmouni, N. M. Poltronetti, V. Pallen, G. Bezgin, M. S. Kang, S. S. Mathotaarachchi, Y. T. Wang, J. Fernandez Arias, P. C. L. Ferreira, J. P. Ferrari-Souza, E. Vanmechelen, K. Blennow, H. Zetterberg, S. Gauthier, P. Rosa-Neto
Ebiomedicine - 2022 -
Amyloid processing in COVID-19-associated neurological
syndromes
O. J. Ziff, Nicholas J. Ashton, P. R. Mehta, R. Brown, D. Athauda, J. Heaney, A. J. Heslegrave, Andréa Lessa Benedet, Kaj Blennow, A. M. Checkley, C. F. Houlihan, S. Gauthier, P. Rosa-Neto, N. C. Fox, J. M. Schott, Henrik Zetterberg, L. A. Benjamin, R. W. Paterson
Journal of Neurochemistry - 2022 -
Acute sleep loss increases CNS health biomarkers and compromises the ability to stay awake in a sex-and weight-specific
manner
L. T. van Egmond, S. Bukhari, Andréa Lessa Benedet, Nicholas J. Ashton, E. M. S. Meth, A. Boukas, J. Engstrom, M. Ilemosoglou, Kaj Blennow, Henrik Zetterberg, C. Benedict
Translational Psychiatry - 2022 -
Staging of Alzheimer?s disease: past, present and future
perspectives
J. Therriault, E. R. Zimmer, Andréa Lessa Benedet, T. A. Pascoal, S. Gauthier, P. Rosa-Neto
Trends in Molecular Medicine - 2022 -
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical
utility
Thomas Karikari, Nicholas J. Ashton, Gunnar Brinkmalm, Wagner Scheeren Brum, Andréa Lessa Benedet, Laia Montoliu-Gaya, Juan Lantero Rodriguez, T. A. Pascoal, M. Suarez-Calvet, P. Rosa-Neto, Kaj Blennow, Henrik Zetterberg
Nature Reviews Neurology - 2022 -
The accuracy and robustness of plasma biomarker models for amyloid PET
positivity
Andréa Lessa Benedet, Wagner Scheeren Brum, O. Hansson, A. D. N. Initiative, Thomas Karikari, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Alzheimers Research & Therapy - 2022 -
Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's
disease.
Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó, Paula Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Eugeen Vanmechelen, Theresa A Day, Armand González-Escalante, Gonzalo Sánchez-Benavides, Carolina Minguillon, Karine Fauria, José Luis Molinuevo, Jeffrey L Dage, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez-Calvet, Kaj Blennow
Nature medicine - 2022 -
Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's
continuum
G. Salvado, M. Mila-Aloma, M. Shekari, Nicholas J. Ashton, G. Operto, C. Falcon, R. Cacciaglia, C. Minguillon, K. Fauria, A. Ninerola-Baizan, A. Perissinotti, Andréa Lessa Benedet, G. Kollmorgen, I. Suridjan, N. Wild, J. L. Molinuevo, Henrik Zetterberg, Kaj Blennow, M. Suarez-Calvet, J. D. Gispert
European Journal of Nuclear Medicine and Molecular Imaging - 2022 -
Plasma p-tau231 and p-tau217 as state markers of amyloid-beta pathology in preclinical Alzheimer's
disease
M. Mila-Aloma, Nicholas J. Ashton, M. Shekari, G. Salvado, P. Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, E. Vanmechelen, T. A. Day, A. Gonzalez-Escalante, G. Sanchez-Benavides, C. Minguillon, K. Fauria, J. L. Molinuevo, J. L. Dage, Henrik Zetterberg, J. D. Gispert, M. Suarez-Calvet, Kaj Blennow
Nature Medicine - 2022 -
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's
disease.
Cécile Tissot, Andréa Lessa Benedet, Joseph Therriault, Tharick A Pascoal, Firoza Z Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto
Alzheimer's Research & Therapy - 2021 -
Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological
syndromes.
Ross W Paterson, Laura A Benjamin, Puja R Mehta, Rachel L Brown, Dilan Athauda, Nicholas J. Ashton, Claire A Leckey, Oliver J Ziff, Judith Heaney, Amanda J Heslegrave, Andréa Lessa Benedet, Kaj Blennow, Anna M Checkley, Catherine F Houlihan, Catherine J Mummery, Michael P Lunn, Hadi Manji, Michael S Zandi, Stephen Keddie, Michael Chou, Deepthi Vinayan Changaradil, Tom Solomon, Ashvini Keshavan, Suzanne Barker, Hans Rolf Jäger, Francesco Carletti, Robert Simister, David J Werring, Moira J Spyer, Eleni Nastouli, Serge Gauthier, Pedro Rosa-Neto, Henrik Zetterberg, Jonathan M Schott
Brain communications - 2021 -
A genome-wide association study of plasma phosphorylated
tau181
Jodie Lord, Anna Zettergren, Nicholas J. Ashton, Thomas Karikari, Andréa Lessa Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proitsi
Neurobiology of aging - 2021 -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's
disease.
Joel Simrén, Antoine Leuzy, Thomas Karikari, Abdul Hye, Andréa Lessa Benedet, Juan Lantero Rodriguez, Niklas Mattsson-Carlgren, Michael Schöll, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
P-tau235: a novel biomarker for staging preclinical Alzheimer's
disease.
Juan Lantero Rodriguez, Anniina Snellman, Andréa Lessa Benedet, Marta Milà-Alomà, Elena Camporesi, Laia Montoliu-Gaya, Nicholas J. Ashton, Agathe Vrillon, Thomas Karikari, Juan Domingo Gispert, Gemma Salvadó, Mahnaz Shekari, Christina E Toomey, Tammaryn L Lashley, Henrik Zetterberg, Marc Suárez-Calvet, Gunnar Brinkmalm, Pedro Rosa Neto, Kaj Blennow
EMBO molecular medicine - 2021 -
Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease
Continuum
Andréa Lessa Benedet, M. Mila-Aloma, A. Vrillon, Nicholas J. Ashton, T. A. Pascoal, F. Lussier, Thomas Karikari, C. Hourregue, E. Cognat, J. Dumurgier, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, G. Salvado, M. Shekari, G. Operto, J. D. Gispert, C. Minguillon, K. Fauria, G. Kollmorgen, I. Suridjan, E. R. Zimmer, Henrik Zetterberg, J. L. Molinuevo, C. Paquet, P. Rosa-Neto, Kaj Blennow, M. Suarez-Calvet
Jama Neurology - 2021 -
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease
pathology.
Nicholas J. Ashton, Tharick A Pascoal, Thomas Karikari, Andréa Lessa Benedet, Juan Lantero Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2021 -
Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak
stages
T. A. Pascoal, Andréa Lessa Benedet, D. L. Tudorascu, J. Therriault, S. Mathotaarachchi, M. Savard, F. Z. Lussier, C. Tissot, M. Chamoun, M. S. Kang, J. Stevenson, G. Massarweh, M. C. Guiot, J. P. Soucy, S. Gauthier, P. Rosa-Neto
Brain - 2021 -
Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging
Initiative.
Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow
Alzheimer's research & therapy - 2021 -
Publisher Correction: Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andréa Lessa Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021 -
Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's
disease.
Andréa Lessa Benedet, Antoine Leuzy, Nicholas J. Ashton, Sulantha Mathotaarachchi, Melissa Savard, Joseph Therriault, Min Su Kang, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Brain : a journal of neurology - 2020 -
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective
cohorts.
Thomas Karikari, Tharick A Pascoal, Nicholas J. Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
The Lancet. Neurology - 2020