Johan Svensson
Professor/överläkare
Avd för invärtesmedicin och kliniskOm Johan Svensson
Johan Svensson ägnar sin forskning åt hormoners betydelse för åldersrelaterade sjukdomar och livslängd. I första hand studeras tillväxtfaktorn insulin-like growth factor-I (IGF-I), men betydelsen av hormoner såsom tillväxthormon, sköldkörtelhormon och könshormon liksom vitamin D undersöks också.
Forskning
Flera studier visar att tillväxthormon/IGF-I gynnsamt påverkar kroppssammansättning, muskelstyrka och benmassa. IGF-I medierar en del av tillväxthormonets effekter men IGF-I har också egna effekter som är oberoende av tillväxthormon. Patienter med demens (Alzheimers sjukdom) har ett flertal hormonella förändringar med ändringar i nivåer av bl.a. könshormon och sköldkörtelhormon. Hormonnivåer skiljer sig dessutom mellan cirkulationen och ryggvätska hos patienter med Alzheimers sjukdom, vilket skulle kunna tyda på att transporten av vissa hormoner från cirkulationen till hjärnan är nedsatt vid demenssjukdom.
Epidemiologiska studier visar att lågt cirkulerande IGF-I är associerat med förkortad telomerlängd, vilket är en markör för åldrande. Vidare visar epidemiologiska studier en U-formad kurva mellan serum IGF-I och mortalitet där både högt och lågt IGF-I är associerat med ökad mortalitet. Lågt IGF-I är en riskfaktor för ökad mortalitet i hjärtkärlsjukdomar medan högt IGF-I är associerat med ökad mortalitet i cancer.
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Sex steroid levels in corresponding cerebrospinal fluid and serum samples quantified by mass spectrometry in
men.
Henrik Ryberg, Anna-Karin Norlén, Andreas Landin, Per Johansson, Zeinab Salman, Anders Wallin, Johan Svensson, Claes Ohlsson
Endocrine connections - 2023 -
Serum IGFBP-1 Concentration as a Predictor of Outcome after
Ischemic Stroke—A Prospective Observational
Study
Daniel Åberg, Gustaf Gadd, Katarina Jood, Petra Redfors, Tara M Stanne, Jörgen Isgaard, Kaj Blennow, Henrik Zetterberg, Christina Jern, N David Åberg, Johan Svensson
International Journal of Molecular Sciences - 2023 -
Higher CSF/serum free-T4 ratio is associated with improvement of quality of life during treatment with
L-thyroxine
A. Funkquist, B. Wandt, Kaj Blennow, Henrik Zetterberg, Johan Svensson, P. Bjellerup, Y. Freund-Levi, S. Sjoberg
Journal of Neuroendocrinology - 2023 -
Diagnostic Performance of Cerebrospinal Fluid Neurofilament Light Chain and Soluble Amyloid-β Protein Precursor β in the Subcortical Small Vessel Type of
Dementia.
Elin Axelsson Andrén, Petronella Kettunen, Maria Bjerke, Sindre Rolstad, Henrik Zetterberg, Kaj Blennow, Anders Wallin, Johan Svensson
Journal of Alzheimer's disease : JAD - 2023 -
Bone-Derived IGF-I Regulates Radial Bone Growth in Adult Male
Mice
Johan Svensson, Klara Sjögren, Lina Lawenius, A. Koskela, J. Tuukkanen, Karin H. Nilsson, Sofia Moverare-Skrtic, Claes Ohlsson
Endocrinology - 2023 -
The association between long-term glycemic control and all-cause mortality is different among older versus younger patients with diabetes mellitus and maintenance hemodialysis
treatment.
Henri Afghahi, Salmir Nasic, Helena Rydell, Johan Svensson, Björn Peters
Diabetes research and clinical practice - 2022 -
Blood-brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein-β in patients with subcortical small-vessel
disease.
Petronella Kettunen, Maria Bjerke, Carl Eckerström, Michael Jonsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Anders Wallin
Alzheimer's & dementia (Amsterdam, Netherlands) - 2022 -
Testosterone associates differently with body mass index and age in serum and cerebrospinal fluid in
men
Henrik Ryberg, Per Johansson, Anders Wallin, Johan Fredrik Emilsson, Elias Eriksson, Johan Svensson, Claes Ohlsson
Journal of Internal Medicine - 2022 -
Effects of 18 months of GH replacement on cardiovascular risk factors and quality of life in GH deficient adults; a randomized controlled trial using a fixed very low and a standard dose of
GH
Galina Götherström, Gudmundur Johannsson, Johan Svensson
Growth Hormone & Igf Research - 2022 -
Low Serum Insulin-like Growth Factor-I Is Associated with Decline in Hippocampal Volume in Stable Mild Cognitive Impairment but not in Alzheimer's
Disease
Alexandra Horvath, Patrick Quinlan, Carl Eckerström, N David Åberg, Anders Wallin, Johan Svensson
Journal of Alzheimers Disease - 2022 -
Higher thyroid function is associated with accelerated hippocampal volume loss in Alzheimer's
disease
Patrick Quinlan, Alexandra Horvath, Carl Eckerström, Anders Wallin, Johan Svensson
Psychoneuroendocrinology - 2022 -
Long-term glycemic variability and the risk of mortality in diabetic patients receiving peritoneal
dialysis.
Henri Afghahi, Salmir Nasic, Björn Peters, Helena Rydell, Henrik Hadimeri, Johan Svensson
PloS one - 2022 -
Cerebrospinal Fluid Sulfatide Levels Lack Diagnostic Utility in the Subcortical Small Vessel Type of
Dementia.
Johan Svensson, Maria K. Blomqvist, Petronella Kettunen, Carl Eckerström, Marcus Henricsson, Michael Jonsson, Maria Bjerke, Jan-Eric Månsson, Anders Wallin
Journal of Alzheimer's disease : JAD - 2021 -
Circulating granulocyte colony-stimulating factor and functional outcome after ischemic stroke: an observational
study
Alexander Wall, Olof Anger, Katarina Jood, Christian Blomstrand, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Jörgen Isgaard, Christina Jern, N David Åberg, Johan Svensson
Neurological Research - 2021 -
Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's
disease
Johanna Nilsson, Johan Gobom, Simon Sjödin, Gunnar Brinkmalm, Nicholas J. Ashton, Johan Svensson, Per Johansson, E. Portelius, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2021 -
Insulin-Like Growth Factor-II and Ischemic Stroke-A Prospective Observational
Study
Daniel Åberg, N David Åberg, Katarina Jood, Petra Redfors, Christian Blomstrand, Jörgen Isgaard, Christina Jern, Johan Svensson
Life-Basel - 2021 -
Brevican and Neurocan Peptides as Potential Cerebrospinal Fluid Biomarkers for Differentiation Between Vascular Dementia and Alzheimer's
Disease.
Karolina Minta, Gunnar Brinkmalm, Erik Portelius, Per Johansson, Johan Svensson, Petronella Kettunen, Anders Wallin, Henrik Zetterberg, Kaj Blennow, Ulf Andreasson
Journal of Alzheimer's disease : JAD - 2021 -
Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying
disorders.
Carl Eckerström, Johan Svensson, Petronella Kettunen, Michael Jonsson, Marie Eckerström
Alzheimer's & dementia - 2021 -
Growth Hormone and Neuronal Hemoglobin in the Brain-Roles in Neuroprotection and Neurodegenerative
Diseases
Marion Walser, Johan Svensson, Lars O Karlsson, Reza Motalleb, M. Aberg, Hans-Georg Kuhn, Jörgen Isgaard, N David Åberg
Frontiers in Endocrinology - 2021 -
Patients with Alzheimer's Disease Have Increased Levels of Insulin-like Growth Factor-I in Serum but not in Cerebrospinal
Fluid
Alexandra Horvath, Zeinab Salman, Patrick Quinlan, Anders Wallin, Johan Svensson
Journal of Alzheimer's Disease - 2020 -
Low CSF/serum ratio of free T4 is associated with decreased quality of life in mild hypothyroidism - A pilot
study.
Anders Funkquist, Anders Bengtsson, Per Johansson, Johan Svensson, Per Bjellerup, Kaj Blennow, Birger Wandt, Stefan Sjöberg
Journal of clinical & translational endocrinology - 2020 -
Association Between Levels of Serum Insulin-like Growth Factor I and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year
Follow-up.
N David Åberg, Daniel Åberg, Cecilia Lagging, Lukas Holmegaard, Petra Redfors, Katarina Jood, Michael Nilsson, Maria A I Åberg, Christian Blomstrand, Johan Svensson, Christina Jern, Jörgen Isgaard
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 2020 -
Identifying the Value of an eHealth Intervention Aimed at Cognitive Impairments: Observational Study in Different Contexts and Service
Models
M. Jurkeviciute, L. van Velsen, H. Eriksson, S. Lifvergren, P. D. Trimarchi, U. Andin, Johan Svensson
Journal of Medical Internet Research - 2020 -
Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor
I
N David Åberg, Gustaf Gadd, Daniel Åberg, P. Hallgren, Christian Blomstrand, Katarina Jood, M. Nilsson, F. R. Walker, Johan Svensson, Christina Jern, Jörgen Isgaard
Biomedicines - 2020 -
Circulating levels of vascular endothelial growth factor and post-stroke long-term functional
outcome
N David Åberg, Alexander Wall, Olof Anger, Katarina Jood, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Jörgen Isgaard, Christina Jern, Johan Svensson
Acta Neurologica Scandinavica - 2020 -
Characteristic Biomarker and Cognitive Profile in Incipient Mixed
Dementia.
Carl Eckerström, Marie Eckerström, Mattias Göthlin, Anna Molinder, Michael Jonsson, Petronella Kettunen, Johan Svensson, Sindre Rolstad, Anders Wallin
Journal of Alzheimer's disease : JAD - 2020 -
Patients with the Subcortical Small Vessel Type of Dementia Have Disturbed Cardiometabolic Risk
Profile
Elin Axelsson, Anders Wallin, Johan Svensson
Journal of Alzheimers Disease - 2020 -
Altered thyroid hormone profile in patients with Alzheimer's
disease
Patrick Quinlan, Alexandra Horvath, Carl Eckerström, Anders Wallin, Johan Svensson
Psychoneuroendocrinology - 2020 -
Latent Cognitive Profiles Differ Between Incipient Alzheimer’s Disease and Dementia with Subcortical Vascular Lesions in a Memory Clinic
Population
Mattias Göthlin, Marie Eckerström, Magnus Lindwall, Sindre Rolstad, Carl Eckerström, Michael Jonsson, Petronella Kettunen, Johan Svensson, Anders Wallin
Journal of Alzheimer's Disease - 2020 -
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease
risk
Y. Deming, F. Filipello, F. Cignarella, C. Cantoni, S. Hsu, R. Mikesell, Z. R. Li, J. L. Del-Aguila, U. Dube, F. G. Farias, J. Bradley, J. Budde, L. Ibanez, M. V. Fernandez, Kaj Blennow, Henrik Zetterberg, A. Heslegrave, Per Johansson, Johan Svensson, Bengt Nellgård, A. Lleo, D. Alcolea, J. Clarimon, L. Rami, J. L. Molinuevo, M. Suarez-Calvet, E. Morenas-Rodriguez, G. Kleinberger, M. Ewers, O. Harari, C. Haass, T. J. Brett, B. A. Benitez, C. M. Karch, L. Piccio, C. Cruchaga
Science Translational Medicine - 2019 -
Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer's disease
patients
Jonas Nilsson, Gunnar Brinkmalm, S. Ramadan, L. Gilborne, Fredrik Noborn, Kaj Blennow, Anders Wallin, Johan Svensson, M. A. Abo-Riyas, X. F. Huang, Göran Larson
Scientific Reports - 2019 -
The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive-like
rats
Henrik Michaëlsson, Mats Andersson, Johan Svensson, Lars O Karlsson, Johan Ehn, Georgia Culley, Anders Engström, Nicklas Bergström, Parthenia Savvidi, Hans-Georg Kuhn, Eric Hanse, Henrik Seth
Acta Physiologica - 2019 -
Liver-derived IGF-I is not required for protection against osteoarthritis in male
mice.
Anna E Törnqvist, Antonia Sophocleous, Stuart H Ralston, Claes Ohlsson, Johan Svensson
American journal of physiology. Endocrinology and metabolism - 2019 -
Homeostasis model assessment of insulin resistance and outcome of ischemic stroke in non-diabetic patients - a prospective observational
study
Daniel Åberg, N David Åberg, Katarina Jood, Lukas Holmegaard, Petra Redfors, Christian Blomstrand, Jörgen Isgaard, Christina Jern, Johan Svensson
BMC Neurology - 2019 -
Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of Alzheimer's
disease.
Patrick Quinlan, Alexandra Horvath, Anders Wallin, Johan Svensson
Psychoneuroendocrinology - 2019 -
Cognitive medicine - a new approach in health care
science.
Anders Wallin, Petronella Kettunen, Per Johansson, Ingibjörg H Jonsdottir, Christer Nilsson, Michael Nilsson, Marie Eckerström, Arto Nordlund, Lars Nyberg, Katharina Stibrant Sunnerhagen, Johan Svensson, Beata Terzis, Lars-Olof Wahlund, Hans-Georg Kuhn
BMC psychiatry - 2018 -
Altered levels of circulating insulin-like growth factor I (IGF-I) following ischemic stroke are associated with outcome - a prospective observational
study
N David Åberg, Daniel Åberg, Katarina Jood, Michael Nilsson, Christian Blomstrand, Hans-Georg Kuhn, Johan Svensson, Christina Jern, Jörgen Isgaard
BMC Neurology - 2018 -
Effects of peripheral administration of GH and IGF-I on gene expression in the hippocampus of hypophysectomised
rats
Marion Walser, J. Oscarsson, Maria A I Åberg, Johan Svensson, Jörgen Isgaard, N David Åberg
Neuroendocrinology Letters - 2018 -
Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing
rate
I. R. Botusan, X. Zheng, S. Narayanan, J. Grünler, V. G. Sunkari, F. S. Calissendorff, I. Ansurudeen, C. Illies, Johan Svensson, John-Olov Jansson, Claes Ohlsson, K. Brismar, S. B. Catrina
PLoS ONE - 2018 -
Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel
Disease
Anders Wallin, G. C. Román, M. Esiri, Petronella Kettunen, Johan Svensson, G. P. Paraskevas, E. Kapaki
Journal of Alzheimer's Disease - 2018 -
Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive
impairment.
Per Johansson, Erik G Almqvist, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
PloS one - 2017 -
Seven years of growth hormone (GH) replacement improves quality of life in hypopituitary patients with adult-onset GH
deficiency.
Mariam Elbornsson, Alexandra Horvath, Galina Götherström, Bengt-Åke Bengtsson, Gudmundur Johannsson, Johan Svensson
European journal of endocrinology - 2017 -
Longitudinal evaluation of criteria for subjective cognitive decline and preclinical Alzheimer's disease in a memory clinic
sample.
Marie Eckerström, Mattias Göthlin, Sindre Rolstad, Erik Hessen, Carl Eckerström, Arto Nordlund, Boo Johansson, Johan Svensson, Michael Jonsson, Simona Sacuiu, Anders Wallin
Alzheimer's & Dementia - 2017 -
Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer's
Disease.
Per Johansson, Erik G Almqvist, Maria Bjerke, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
Journal of Alzheimer's disease : JAD - 2017 -
Low serum insulin-like growth factor-I (IGF-I) level is associated with increased risk of vascular
dementia
Patrick Quinlan, Alexandra Horvath, Arto Nordlund, Anders Wallin, Johan Svensson
Psychoneuroendocrinology - 2017 -
Cerebrospinal Fluid Stanniocalcin-1 as a Biomarker for Alzheimer’s Disease and Other Neurodegenerative
Disorders
Pashtun Shahim, Kaj Blennow, Per Johansson, Johan Svensson, S. Lista, H. Hampel, L.C. Andersson, Henrik Zetterberg
NeuroMolecular Medicine - 2017 -
Mode of GH administration and gene expression in the female rat
brain.
Marion Walser, Linus Schiöler, Jan Oscarsson, Maria A I Åberg, Ruth Wickelgren, Johan Svensson, Jörgen Isgaard, N David Åberg
The Journal of endocrinology - 2017 -
A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer's disease
pathology.
R W Paterson, W E Heywood, A J Heslegrave, N K Magdalinou, Ulf Andreasson, E Sirka, E Bliss, C F Slattery, J Toombs, Johan Svensson, Per Johansson, N C Fox, Henrik Zetterberg, K Mills, J M Schott
Translational psychiatry - 2016 -
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related
traits
A. Teumer, Q. Qi, Maria Nethander, H. Aschard, S. Bandinelli, M. Beekman, S. I. Berndt, M. Bidlingmaier, L. Broer, A. Cappola, G. P. Ceda, S. Chanock, M. H. Chen, T. C. Chen, Y. D. I. Chen, J. Chung, F. Del Greco Miglianico, Joel Eriksson, L. Ferrucci, N. Friedrich, C. Gnewuch, M. O. Goodarzi, N. Grarup, T. Guo, E. Hammer, R. B. Hayes, A. A. Hicks, A. Hofman, J. J. Houwing-Duistermaat, F. Hu, D. J. Hunter, L. L. Husemoen, A. Isaacs, K. B. Jacobs, J. A. M. J. L. Janssen, John-Olov Jansson, N. Jehmlich, S. Johnson, A. Juul, M. Karlsson, T. O. Kilpelainen, P. Kovacs, P. Kraft, C. Li, A. Linneberg, Y. Liu, R. J. F. Loos, Mattias Lorentzon, Y. Lu, M. Maggio, R. Magi, J. Meigs, Dan Mellström, M. Nauck, A. B. Newman, M. N. Pollak, P. P. Pramstaller, I. Prokopenko, B. M. Psaty, M. Reincke, E. B. Rimm, J. I. Rotter, A. Saint Pierre, C. Schurmann, S. Seshadri, Klara Sjögren, P. E. Slagboom, H. D. Strickler, M. Stumvoll, Y. Suh, Q. Sun, C. Zhang, Johan Svensson, T. Tanaka, A. Tare, A. Tönjes, H. W. Uh, C. M. Van Duijn, D. van Heemst, Liesbeth Vandenput, R. S. Vasan, U. Völker, Sara M. Willems, Claes Ohlsson, H. Wallaschofski, R. C. Kaplan
Aging Cell - 2016 -
Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female
mice
Johan Svensson, Sara H Windahl, L. Saxon, Klara Sjögren, A. Koskela, J. Tuukkanen, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2016 -
Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's
Disease.
Annika Öhrfelt, Per Johansson, Anders Wallin, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, Johan Svensson
Dementia and geriatric cognitive disorders extra - 2016 -
Pro-inflammatory S100A9 protein as a robust biomarker differentiating early stages of cognitive impairment in Alzheimer's
disease.
Istvan Horvath, Xueen Jia, Per Johansson, Chao Wang, Roman Moskalenko, Andreas Steinau, Lars Forsgren, Thomas Wågberg, Johan Svensson, Henrik Zetterberg, Ludmilla Morozova-Roche
ACS chemical neuroscience - 2016 -
Alzheimer's disease-subcortical vascular disease spectrum in a hospital-based setting: overview of results from the Gothenburg MCI and dementia
studies.
Anders Wallin, Arto Nordlund, Michael Jonsson, Kaj Blennow, Henrik Zetterberg, Annika Öhrfelt Olsson, Jacob Stålhammar, Marie Eckerström, Mårten Carlsson, Erik Olsson, Mattias Göthlin, Johan Svensson, Sindre Rolstad, Carl Eckerström, Maria Bjerke
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 2016 -
The Gothenburg MCI study: design and distribution of Alzheimer's disease and subcortical vascular disease diagnoses from baseline to 6-year
follow-up.
Anders Wallin, Arto Nordlund, Michael Jonsson, Karin Lind, Åke Edman, Mattias Göthlin, Jacob Stålhammar, Marie Eckerström, Silke Kern, Anne Börjesson-Hanson, Mårten Carlsson, Erik Olsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Annika Öhrfelt Olsson, Maria Bjerke, Sindre Rolstad, Carl Eckerström
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 2016 -
Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's
disease.
Amanda Heslegrave, Wendy Heywood, Ross Paterson, Nadia Magdalinou, Johan Svensson, Per Johansson, Annika Öhrfelt, Kaj Blennow, John Hardy, Jonathan Schott, Kevin Mills, Henrik Zetterberg
Molecular neurodegeneration - 2016 -
Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic
Stroke.
Tara M Stanne, N David Åberg, Staffan Nilsson, Katarina Jood, Christian Blomstrand, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Jörgen Isgaard, Johan Svensson, Christina Jern
Stroke; a journal of cerebral circulation - 2016 -
Development of a Targeted Proteomic Multiplex CSF Assay for Neurodegenerative Markers in Alzheimer’s
Disease
RW Paterson, WE Heywood, AJ Heslegrave, NK Magdalinou, Ulf Andreasson, E Sirka, E Bliss, CF Slattery, J Toombs, Johan Svensson, Per Johansson, NC Fox, Henrik Zetterberg, K Mills, JM Schott
Alzheimer's and Dementia - 2016 -
Insulin-like growth factor I and risk of incident cancer in elderly men - results from MrOS (Osteoporotic Fractures in Men) in
Sweden.
Daniel Carlzon, Johan Svensson, Max Petzold, Magnus K Karlsson, Östen Ljunggren, Mohammad-Ali Haghsheno, Jan-Erik Damber, Dan Mellström, Claes Ohlsson
Clinical endocrinology - 2016 -
Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth
factor-I.
Johan Svensson, Klara Sjögren, Malin Levin, Jan Borén, Åsa Tivesten, Claes Ohlsson
Endocrine - 2016 -
Serum erythropoietin and outcome after ischaemic stroke: a prospective
study.
N David Åberg, Tara M Stanne, Katarina Jood, Linus Schiöler, Christian Blomstrand, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Jörgen Isgaard, Christina Jern, Johan Svensson
BMJ open - 2016 -
Cerebrospinal fluid substance P concentrations are elevated in patients with Alzheimer's
disease.
Per Johansson, Erik G Almqvist, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
Neuroscience letters - 2015 -
Increased Cerebrospinal Fluid Level of Insulin-like Growth Factor-II in Male Patients with Alzheimer's
Disease
Daniel Åberg, Per Johansson, Jörgen Isgaard, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, N David Åberg, Johan Svensson
Journal of Alzheimers Disease - 2015 -
Influence of Cardiovascular Fitness and Muscle Strength in Early Adulthood on Long-Term Risk of Stroke in Swedish
Men
N David Åberg, Hans-Georg Kuhn, Jenny Nyberg, Margda Waern, Peter Friberg, Johan Svensson, Kjell Torén, Annika Rosengren, Maria A I Åberg, Michael Nilsson
Stroke - 2015 -
Both Low and High Serum Insulin-like Growth Factor-I Levels Associate with Increased Risk of Cardiovascular Events in Elderly
Men.
Daniel Carlzon, Johan Svensson, Max Petzold, Magnus K Karlsson, Osten Ljunggren, Åsa Tivesten, Dan Mellström, Claes Ohlsson
The Journal of clinical endocrinology and metabolism - 2014 -
Leukocyte telomere length is not associated with mortality in older
men
Johan Svensson, M. K. Karlsson, O. Ljunggren, Åsa Tivesten, Dan Mellström, Sofia Movérare-Skrtic
Experimental Gerontology - 2014 -
Different modes of GH administration influence gene expression in the male rat
brain
Marion Walser, Linus Schiöler, Jan Oscarsson, Maria A I Åberg, Johan Svensson, N David Åberg, Jörgen Isgaard
Journal of Endocrinology - 2014 -
The amyloid-β degradation pattern in plasma-A possible tool for clinical trials in Alzheimer's
disease
Josef Pannee, Ulrika Törnqvist, Annie Westerlund, M. Ingelsson, L. Lannfelt, Gunnar Brinkmalm, Rita Persson, Johan Gobom, Johan Svensson, Per Johansson, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Neuroscience Letters - 2014 -
Psychosocial health and levels of employment in 851 hypopituitary Swedish patients on long-term GH
therapy.
Helene Holmer, Johan Svensson, Lars Rylander, Gudmundur Johannsson, Thord Rosén, Bengt-Åke Bengtsson, Marja Thorén, Charlotte Höybye, Marie Degerblad, Margareta Bramnert, Erik Hägg, Britt Edén Engström, Bertil Ekman, Eva-Marie Erfurth
Psychoneuroendocrinology - 2013 -
Liver-derived endocrine IGF-I is not critical for activation of skeletal muscle protein synthesis following oral
feeding.
Britt-Marie Iresjö, Johan Svensson, Claes Ohlsson, Kent Lundholm
BMC physiology - 2013 -
Fifteen years of GH replacement improves body composition and cardiovascular risk
factors
Mariam Elbornsson, Galina Götherström, Ingvar Bosaeus, Bengt-Åke Bengtsson, Gudmundur Johannsson, Johan Svensson
European Journal of Endocrinology - 2013 -
Baseline characteristics and effects of ten years of growth hormone (GH) replacement therapy in adults previously treated with pituitary
irradiation.
Mariam Elbornsson, Galina Götherström, Bengt-Åke Bengtsson, Gudmundur Johannsson, Johan Svensson
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 2013 -
Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's
disease.
Per Johansson, Daniel Åberg, Jan-Ove Johansson, Niklas Mattsson, Oskar Hansson, Bo Ahrén, Jörgen Isgaard, N David Åberg, Kaj Blennow, Henrik Zetterberg, Anders Wallin, Johan Svensson
Psychoneuroendocrinology - 2013 -
Cerebrospinal Fluid (CSF) 25-Hydroxyvitamin D Concentration and CSF Acetylcholinesterase Activity Are Reduced in Patients with Alzheimer's
Disease.
Per Johansson, Erik G Almqvist, Jan-Ove Johansson, Niklas Mattsson, Ulf Andreasson, Oskar Hansson, Anders Wallin, Kaj Blennow, Henrik Zetterberg, Johan Svensson
PloS one - 2013 -
Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating
IGF1.
N David Åberg, Sandra Olsson, Daniel Åberg, Katarina Jood, Tara M Stanne, Michael Nilsson, Christian Blomstrand, Johan Svensson, Jörgen Isgaard, Christina Jern
European journal of endocrinology / European Federation of Endocrine Societies - 2013 -
Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's
disease.
Per Johansson, Erik G Almqvist, Jan-Ove Johansson, Niklas Mattsson, Oskar Hansson, Anders Wallin, Kaj Blennow, Henrik Zetterberg, Johan Svensson
Psychoneuroendocrinology - 2013 -
Deaths Among Adult Patients With Hypopituitarism: Hypocortisolism During Acute Stress, and De Novo Malignant Brain Tumors Contribute to an Increased
Mortality
P. Burman, A. F. Mattsson, Gudmundur Johannsson, C. Hoybye, H. Holmer, P. Dahlqvist, K. Berinder, B. E. Engstrom, B. Ekman, E. M. Erfurth, Johan Svensson, J. Wahlberg, F. A. Karlsson
Journal of Clinical Endocrinology & Metabolism - 2013 -
The ELISA-Measured Increase in Cerebrospinal Fluid Tau that Discriminates Alzheimer's Disease from other Neurodegenerative Disorders is not Attributable to Differential Recognition of Tau Assembly
Forms.
Seán T O'Dowd, Mustafa T Ardah, Per Johansson, Aleksey Lomakin, George B Benedek, Kinley A Roberts, Gemma Cummins, Omar M El Agnaf, Johan Svensson, Henrik Zetterberg, Timothy Lynch, Dominic M Walsh
Journal of Alzheimer's disease : JAD - 2013 -
The role of IGF-1 for fracture risk in
men
Liesbeth Vandenput, Klara Sjögren, Johan Svensson, Claes Ohlsson
Frontiers in endocrinology - 2012 -
Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH
deficiency
Mariam Elbornsson, Galina Götherström, Ingvar Bosaeus, Bengt-Åke Bengtsson, Gudmundur Johannsson, Johan Svensson
European Journal of Endocrinology - 2012 -
Leukocyte Telomere Length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's Disease: A pilot
study.
Sofia Movérare-Skrtic, Per Johansson, Niklas Mattsson, Oskar Hansson, Anders Wallin, Jan-Ove Johansson, Henrik Zetterberg, Kaj Blennow, Johan Svensson
Experimental gerontology - 2012 -
Both low and high serum igf-I levels associate with cancer mortality in older
men.
Johan Svensson, Daniel Carlzon, Max Petzold, Magnus Karlsson, Osten Ljunggren, Åsa Tivesten, Dan Mellström, Claes Ohlsson
The Journal of clinical endocrinology and metabolism - 2012 -
Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction
remodeling
Margareta Scharin Täng, Björn Redfors, Malin Lindbom, Johan Svensson, Truls Råmunddal, Claes Ohlsson, Yangzhen Shao, Elmir Omerovic
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 2012 -
Factors influencing insulin sensitivity in patients with mild primary hyperparathyroidism before and after
parathyroidectomy.
Erik G Almqvist, Anne-Greth Bondeson, Lennart Bondeson, Dan Mellström, Johan Svensson
Scandinavian journal of clinical and laboratory investigation - 2012 -
Discriminatory Analysis of Biochip-Derived Protein Patterns in CSF and Plasma in Neurodegenerative
Diseases.
Christoffer Rosén, Niklas Mattsson, Per Johansson, Ulf Andreasson, Anders Wallin, Oskar Hansson, Jan-Ove Johansson, John Lamont, Johan Svensson, Kaj Blennow, Henrik Zetterberg
Frontiers in aging neuroscience - 2011 -
Liver-derived igf-I regulates mean life span in
mice
Johan Svensson, Klara Sjögren, Jenny Fäldt, Niklas Andersson, Olle Isaksson, John-Olov Jansson, Claes Ohlsson
PLoS ONE - 2011 -
Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic
utility.
Niklas Mattsson, Shahrzad Tabatabaei, Per Johansson, Oskar Hansson, Ulf Andreasson, Jan-Eric Månsson, Jan-Ove Johansson, Bob Olsson, Anders Wallin, Johan Svensson, Kaj Blennow, Henrik Zetterberg
Neuromolecular medicine - 2011 -
Mild dementia is associated with increased adrenal secretion of cortisol and precursor sex steroids in
women.
Per Johansson, Jan-Ove Johansson, Fernand Labrie, Niklas Mattsson, Oskar Hansson, Kaj Blennow, Henrik Zetterberg, Anders Wallin, Claes Ohlsson, Johan Svensson
Clinical endocrinology - 2011 -
Cerebrospinal fluid biomarkers for Alzheimer’s disease: diagnostic performance in a homogeneous mono-center
population.
Per Johansson, Niklas Mattsson, Oskar Hansson, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, Johan Svensson
Journal of Alzheimer's disease : JAD - 2011 -
Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated
mice.
Sara H Windahl, Niklas Andersson, Anna E Börjesson, Charlotte Swanson, Johan Svensson, Sofia Movérare-Skrtic, Klara Sjögren, Linus Ruijin Shao, Marie Lagerquist, Claes Ohlsson
PloS one - 2011 -
Effects of 3-year growth hormone (GH) replacement therapy on bonemineral density in younger and elderly adults with adult onset GH
deficiency.
Mariam Elbornsson, Galina Götherström, Celina Franco Ramos, Bengt-Åke Bengtsson, Gudmundur Johannsson, Johan Svensson
European journal of endocrinology / European Federation of Endocrine Societies - 2011 -
Converging pathways of chromogranin and amyloid metabolism in the
brain.
Niklas Mattsson, Per Johansson, Oskar Hansson, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Oluf Andersen, Sara Haghighi, Maria Olsson, Mats Stridsberg, Johan Svensson, Kaj Blennow, Henrik Zetterberg
Journal of Alzheimer's disease : JAD - 2010 -
Increased neck soft tissue mass and worsening of obstructive sleep apnoea after growth hormone treatment in men with abdominal
obesity
Mahssa Karimi, Josef Koranyi, Celina Franco, Yüksel Peker, Derek Eder, Jan-Erik Angelhed, Lars Lönn, Ludger Grote, Bengt-Åke Bengtsson, Johan Svensson, Jan A Hedner, Gudmundur Johannsson
Journal of Clinical Sleep Medicine - 2010 -
Stimulation of both estrogen and androgen receptors maintains skeletal muscle mass in gonadectomized male mice but mainly via different
pathways.
Johan Svensson, Sofia Movérare-Skrtic, Sara H Windahl, Charlotte Swanson, Klara Sjögren
Journal of molecular endocrinology - 2010 -
Ghrelinbrist efter gastrektomi möjlig indikation för
ghrelinanaloger.
Johan Svensson, John-Olov Jansson
Läkartidningen - 2010 -
Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1 and adult muscle
mass.
Johan Svensson, Klara Sjögren, Claes Ohlsson
Journal of applied physiology - 2010 -
Muscle strength in elderly adults with GH deficiency after 10 years of GH
replacement.
Galina Götherström, Mariam Elbornsson, Katharina Stibrant Sunnerhagen, Bengt-Åke Bengtsson, Gudmundur Johannsson, Johan Svensson
European journal of endocrinology / European Federation of Endocrine Societies - 2010 -
The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient
women.
Celina Franco Ramos, Josef Koranyi, John Brandberg, Lars Lönn, BK Bengtsson, Johan Svensson, Gudmundur Johannsson
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 2009 -
Ten years of growth hormone (GH) replacement normalizes muscle strength in GH-deficient
adults.
Galina Götherström, Mariam Elbornsson, Katharina Stibrant Sunnerhagen, Bengt-Åke Bengtsson, Gudmundur Johannsson, Johan Svensson
The Journal of clinical endocrinology and metabolism - 2009 -
Safety aspects of GH
replacement.
Johan Svensson, Bengt-Åke Bengtsson
European journal of endocrinology / European Federation of Endocrine Societies - 2009 -
Serum insulin-like growth factor-I concentration is associated with leukocyte telomere length in a population-based cohort of elderly
men.
Sofia Movérare-Skrtic, Johan Svensson, Magnus K Karlsson, Eric Orwoll, Osten Ljunggren, Dan Mellström, Claes Ohlsson
The Journal of clinical endocrinology and metabolism - 2009 -
The role of liver-derived insulin-like growth
factor-I.
Claes Ohlsson, Subburaman Mohan, Klara Sjögren, Åsa Tivesten, Jörgen Isgaard, Olle Isaksson, John-Olov Jansson, Johan Svensson
Endocrine reviews - 2009 -
Baseline characteristics and the effects of two years of growth hormone (GH) replacement therapy in adults with GH deficiency previously treated for
acromegaly.
Lise-Lott Norrman, Gudmundur Johannsson, Katharina Stibrant Sunnerhagen, Johan Svensson
The Journal of clinical endocrinology and metabolism - 2008 -
Liver-derived IGF1 enhances the androgenic response in
prostate.
Johan Svensson, Jon Kindblom, Linus Ruijin Shao, Sofia Movérare-Skrtic, Marie Lagerquist, Niklas Andersson, Klara Sjögren, Katrien Venken, Dirk Vanderschueren, John-Olov Jansson, Olle Isaksson, Claes Ohlsson
The Journal of endocrinology - 2008 -
Growth hormone (GH) replacement therapy in GH deficient adults: predictors of one-year metabolic and clinical
response.
Johan Svensson, Nick Finer, Pierre Bouloux, John Bevan, Björn Jonsson, Anders F Mattsson, Mikael Lundberg, Philip E Harris, Maria Koltowska-Häggström, John P Monson
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 2007 -
Ten-year GH replacement increases bone mineral density in hypopituitary patients with adult onset GH
deficiency.
Galina Götherström, Bengt-Åke Bengtsson, Ingvar Bosaeus, Gudmundur Johannsson, Johan Svensson
European journal of endocrinology / European Federation of Endocrine Societies - 2007 -
Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II
expression.
Johan Svensson, Åsa Tivesten, Klara Sjögren, Olle Isaksson, Göran Bergström, Subburaman Mohan, Johan Mölne, Jörgen Isgaard, Claes Ohlsson
The Journal of endocrinology - 2007 -
Management of growth hormone deficiency in
adults.
Anna G Nilsson, Johan Svensson, Gudmundur Johannsson
Growth Hormone IGF Res - 2007 -
Growth hormone reduces inflammation in postmenopausal women with abdominal obesity: a 12-month, randomized, placebo-controlled
trial.
Celina Franco Ramos, Björn Andersson, Lars Lönn, Bengt-Åke Bengtsson, Johan Svensson, Gudmundur Johannsson
The Journal of clinical endocrinology and metabolism - 2007 -
Fracture Incidence in GH-Deficient Patients on Complete Hormone Replacement Including
GH.
Holmer, Johan Svensson, Rylander, Gudmundur Johannsson, Thord Rosén, Bengt-Åke Bengtsson, Marja Thorén, Höybye, Marie Degerblad, Margareta Bramnert, Hägg, Engström, Ekman, Thorngren, Hagmar, Eva-Marie Erfurth
J Bone Miner Res - 2007 -
Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth
hormone.
Helene Holmer, Johan Svensson, Lars Rylander, Gudmundur Johannsson, Thord Rosén, Bengt-Åke Bengtsson, Marja Thorén, Charlotte Höybye, Marie Degerblad, Margareta Bramnert, Erik Hägg, Britt Edén Engström, Bertil Ekman, Bo Norrving, Lars Hagmar, Eva-Marie Erfurth
The Journal of clinical endocrinology and metabolism - 2007 -
A 10-year, prospective study of the metabolic effects of growth hormone replacement in
adults.
Galina Götherström, Bengt-Åke Bengtsson, Ingvar Bosaeus, Gudmundur Johannsson, Johan Svensson
The Journal of clinical endocrinology and metabolism - 2007 -
Sleep apnoea and quality of life in growth hormone (GH)-deficient adults before and after 6 months of GH replacement
therapy
Yüksel Peker, Johan Svensson, Jan A Hedner, Ludger Grote, Gudmundur Johannsson
Clin Endocrinol (Oxf). - 2006 -
GH secretory pattern in young adults who discontinued GH treatment for GH deficiency and decreased longitudinal growth in
childhood.
Johan Svensson, Gudmundur Johannsson, Ali Iranmanesh, Kerstin Albertsson-Wikland, Johannes D Veldhuis, Bengt-Åke Bengtsson
European journal of endocrinology / European Federation of Endocrine Societies - 2006 -
Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal
obesity.
Celina Franco Ramos, Johannes D Veldhuis, Ali Iranmanesh, John Brandberg, Lars Lönn, Björn Andersson, Bengt-Åke Bengtsson, Johan Svensson, Gudmundur Johannsson
European journal of endocrinology / European Federation of Endocrine Societies - 2006 -
Baseline characteristics and effects of growth hormone therapy over two years in younger and elderly adults with adult onset GH
deficiency.
Celina Franco Ramos, Gudmundur Johannsson, Bengt-Åke Bengtsson, Johan Svensson
The Journal of clinical endocrinology and metabolism - 2006 -
Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old
mice.
Johan Svensson, M Diez, Jörgen Engel, Caroline Wass, Åsa Tivesten, John-Olov Jansson, Olle Isaksson, Trevor Archer, Tomas Hökfelt, Claes Ohlsson
The Journal of endocrinology - 2006 -
Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized
mice.
Sofia Movérare-Skrtic, Katrien Venken, Niklas Andersson, Marie K Lindberg, Johan Svensson, Charlotte Swanson, Dirk Vanderschueren, Jan Oscarsson, Jan-Ake Gustafsson, Claes Ohlsson
Obesity (Silver Spring, Md.) - 2006 -
Increased plasma concentrations of N-terminal pro-B-type natriuretic peptide in patients with mild primary
hyperparathyroidism.
Erik G Almqvist, Charlotte Becker, Anne-Greth Bondeson, Lennart Bondeson, Johan Svensson, Sven-Eric Svensson
Clinical endocrinology - 2006 -
The effects of five-year growth hormone replacement therapy on muscle strength in elderly hypopituitary
patients.
Galina Götherström, Bengt-Åke Bengtsson, Katharina Stibrant Sunnerhagen, Gudmundur Johannsson, Johan Svensson
Clinical endocrinology - 2005 -
Liver-derived IGF-I regulates exploratory activity in old
mice.
Johan Svensson, Bo Söderpalm, Klara Sjögren, Jörgen Engel, Claes Ohlsson
American journal of physiology. Endocrinology and metabolism - 2005 -
Adiponectin, leptin, and erythrocyte sodium/lithium countertransport activity, but not resistin, are related to glucose metabolism in growth hormone-deficient
adults.
Johan Svensson, Hans Herlitz, Per-Arne Lundberg, Gudmundur Johannsson
The Journal of clinical endocrinology and metabolism - 2005 -
Growth hormone and the cardiovascular
function.
Johan Svensson, Åsa Tivesten, Jörgen Isgaard
Minerva endocrinologica - 2005 -
Baseline characteristics and the effects of two years of growth hormone replacement therapy in adults with growth hormone deficiency previously treated for Cushing's
disease.
Gudmundur Johannsson, Katharina Stibrant Sunnerhagen, Johan Svensson
Clinical endocrinology - 2004 -
Three-years of growth hormone (GH) replacement therapy in GH-deficient adults: effects on quality of life, patient-reported outcomes and healthcare
consumption.
Johan Svensson, Anders Mattsson, Thord Rosén, Lena Wirén, Gudmundur Johannsson, Bengt-Åke Bengtsson, Maria Koltowska Häggström
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 2004 -
Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement
therapy.
Johan Svensson, Bengt-Åke Bengtsson, Thord Rosén, A Odén, Gudmundur Johannsson
The Journal of clinical endocrinology and metabolism - 2004 -
Effekten av 5 års tillväxthormon-behandling på muskelstyrka hos äldre patienter med
hypofysinsufficiens.
Bengt-Åke Bengtsson, Galina Götherström, Katharina Stibrant Sunnerhagen, Gudmundur Johannsson, Johan Svensson
Läkarstämman 2004. - 2004 -
Growth hormone (GH) replacement in women in relation to their endogenous GH
secretion.
John-Olov Jansson, Johan Svensson
The Journal of clinical endocrinology and metabolism - 2004 -
Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient
adults.
Johan Svensson, Jesper Fowelin, Kerstin Landin-Wilhelmsen, Bengt-Åke Bengtsson, Jan-Ove Johansson
The Journal of clinical endocrinology and metabolism - 2002 -
Effects of growth hormone and its secretagogues on
bone.
Johan Svensson, S Lall, Suzanne L. Dickson, Bengt-Åke Bengtsson, J Rømer, I Ahnfelt-Rønne, Claes Ohlsson, John-Olov Jansson
Endocrine - 2001 -
The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female
rats.
Johan Svensson, S Lall, Suzanne L. Dickson, Bengt-Åke Bengtsson, J Rømer, I Ahnfelt-Rønne, Claes Ohlsson, John-Olov Jansson
The Journal of endocrinology - 2000 -
Treatment of obese subjects with the oral growth hormone secretagogue MK-677 affects serum concentrations of several lipoproteins, but not
lipoprotein(a).
Johan Svensson, John-Olov Jansson, Malin Ottosson, Gudmundur Johannsson, M R Taskinen, Olov Wiklund, Bengt-Åke Bengtsson
The Journal of clinical endocrinology and metabolism - 1999 -
Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young
males.
Johan Svensson, Claes Ohlsson, John-Olov Jansson, G Murphy, D Wyss, D Krupa, K Cerchio, W Polvino, B Gertz, D J Baylink, Subburaman Mohan, Bengt-Åke Bengtsson
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1998