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Om Muhammad Nawaz
Dr. Nawaz received his first degree in Bachelors of Science (BSc, 2006) in Chemistry and Biology, followed by Master's degree in Biochemistry & Molecular Biology (2009) with specialization in genetics, nucleic acids metabolism, protein chemistry and DNA recombinant biotechnology. In 2011, he completed M.Phil/MS thesis on inherited / congenital diseases with a particular focus on intellectual disability and cognition (neurological disorders) from QAU University, Islamabad. He then moved to Brazil, to peruse PhD at the University of Sao Paulo, Brazil (2013-2017) where he investigated the role of microRNAs in malignant progression of brain tumors (gliomas), with an aim to identify potential therapeutic targets and non-invasive biomarkers. He also developed a project to apply liposomes for transporting oligonucleotides (anti-miRs and antagonists: as silencing RNAs) to glioma cells. During his PhD, he joined the University of Gothenburg, Sweden as a one-year PhD exchange in the lab of Hadi Valadi, and then continued as a postdoc in 2017.
Currently, Dr. Nawaz is working with Hadi Valadi on projects funded by "Vinnova" (Swedish government's innovation agency), for developing new methods of RNA drug delivery and tools of stem cell based therapies and organ repairs. RNA therapy provides potential new treatment options in multiple diseases and has been tested in clinical trials of several diseases. RNA-based therapeutics, which function either by silencing pathological genes through delivery of siRNA or expressing therapeutic proteins through the delivery of exogenous mRNA to cells — hold great potential for the treatment of various diseases including cancer, infectious diseases, and various inherited genetic diseases.
He also partly works with "RNA/nucleotide Therapeutics Consortium" established between 3 Universities and different Biotech companies. The Consortium is funded by "Swedish Foundation for Strategic Research".
Previously, in the team of Hadi Valadi, Dr. Nawaz has been involved in collaborative projects in partnership with AstraZeneca for RNA drug delivery (particularly mRNA-based therapy using lipid nanoparticles and nanovesicles). The collaborative work was published in "Nature Communications" journal. Link!
Dr. Nawaz have received few national and international research grants, scholarships, and funding from Brazil and Sweden, and have participated in several national and international conferences and scientific networking.
He also serves as peer reviewer (Publons profile) for web of science (WOS) indexed journals and help publishers and editors in peer review process. Nonprofit, volunteer activities.
According to Dr. Nawaz, he loves to build networking with peers having long sought socio-scientific motives to make an impact on society. He believes that learning is never ending process, and thinks that getting new yet valuable resources might be easy for us but giving back to society might be often hard. One needs to be more open. After consuming that much resource from the society one should be able to reciprocate or pay back to society. It can be done in many forms, and according to him the best form is is knowledge sharing, and sharing the experiences, skill transfer, rendering some free services, especially to those who are in need or those who cannot afford. Knowledge belongs to society, not to individuals.
For the work he has presented, see this link on YouTube
miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting
Abbasi Majid, Jinxia Wang, Muhammad Nawaz, Sattar Abdul, Munawar Ayesha, Chunmei Guo, Qinglong Liu, Shuqing Liu, Ming-Zhong Sun
Frontiers in Molecular Biosciences - 2020-01-01
Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor
L. Salimi, A. Akbari, N. Jabbari, B. Mojarad, A. Vahhabi, S. Szafert, S. A. Kalashani, H. Soraya, Muhammad Nawaz, J. Rezaie
Cell and Bioscience - 2020-01-01
Free and hydrogel encapsulated exosome-based therapies in regenerative
Ali Akbari, Nassrollah Jabbari, Roholah Sharifi, Mahdi Ahmadi, Ali Vahhabi, Seyyed Javad Seyedzadeh, Muhammad Nawaz, Sławomir Szafert, Monireh Mahmoodi, Esmaiel Jabbari, Rahim Asghari, Jafar Rezaie
Life sciences - 2020-01-01
Bystander effects of ionizing radiation: conditioned media from X-ray irradiated MCF-7 cells increases the angiogenic ability of endothelial
Nasrollah Jabbari, Muhammad Nawaz, Jafar Rezaie
Cell communication and signaling : CCS - 2019-01-01
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other
Maugeri Marco, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, Manli Na, Mikko Hölttä, Pia Skantze, Svante Johansson, Martina Sundqvist, Johnny Lindquist, Tomas Kjellman, Inga-Lill Mårtensson, Tao Jin, Per Sunnerhagen, Sofia Östman, Lennart Lindfors, Hadi Valadi
Nature Communications - 2019-01-01
Ionizing Radiation Increases the Activity of Exosomal Secretory Pathway in MCF-7 Human Breast Cancer Cells: A Possible Way to Communicate Resistance against
N. Jabbari, Muhammad Nawaz, J. Rezaie
International Journal of Molecular Sciences - 2019-01-01
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014
C. Thery, K. W. Witwer, E. Aikawa, A. P. D. Rubio, Karin Ekström, Ganesh V Shelke, Maugeri Marco, Muhammad Nawaz, Rossella Crescitelli, Cecilia Lässer, Jan Lötvall, Jessica Wahlgren
Journal of Extracellular Vesicles - 2018-01-01
Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into
Luisa Statello, Maugeri Marco, Elena Garre, Muhammad Nawaz, Jessica Wahlgren, Alexandros Papadimitriou, Christina Lundqvist, Lennart Lindfors, Anna Collén, Per Sunnerhagen, Marco Ragusa, Michele Purrello, Cinzia Di Pietro, Natalie Tigue, Hadi Valadi
PLoS One - 2018-01-01
Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue
Technical challenges of working with extracellular
M. I. Ramirez, M. G. Amorim, C. Gadelha, I. Milic, J. A. Welsh, V. M. Freitas, Muhammad Nawaz, N. Akbar, Y. Couch, L. Makin, F. Cooke, A. L. Vettore, P. X. Batista, R. Freezor, J. A. Pezuk, L. Rosa-Fernandes, A. C. O. Carreira, A. Devitt, L. Jacobs, I. T. Silva, G. Coakley, D. N. Nunes, D. Carter, G. Palmisano, E. Dias-Neto
Nanoscale - 2018-01-01
Long Distance Metabolic Regulation through Adipose-Derived Circulating Exosomal miRNAs: A Trail for RNA-Based
Farah Fatima, Muhammad Nawaz
Frontiers in physiology - 2017-01-01
Non-coding RNAs in Mesenchymal Stem Cell-Derived Extracellular Vesicles: Deciphering Regulatory Roles in Stem Cell Potency, Inflammatory Resolve, and Tissue
Radiological features of experimental staphylococcal septic arthritis by micro computed tomography
Extracellular vesicle-mediated transport of non-coding RNAs between stem cells and cancer cells: implications in tumor progression and therapeutic
Stem cell investigation - 2017-01-01
Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing
Muhammad Nawaz, Farah Fatima
Frontiers in molecular biosciences - 2017-01-01
Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker
Extracellular Vesicles: Evolving Factors in Stem Cell
Muhammad Nawaz, Farah Fatima, Krishna C. Vallabhaneni, Patrice Penfornis, Hadi Valadi, Karin Ekström, Sharad Kholia, Jason D.Whitt, Joseph D. Fernandes, Radhika Pochampally, Jeremy A. Squire, Giovanni Camussi
Stem Cells International - 2016-01-01
Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer
Farah Fatima, Muhammad Nawaz
Cancer Communications - 2015-01-01
The emerging role of extracellular vesicles as biomarkers for urogenital
Muhammad Nawaz, Giovanni Camussi, Hadi Valadi, Irina Nazarenko, Karin Ekström, Xiaoqin Wang, Simona Principe, Neelam Shah, Naeem M Ashraf, Farah Fatima, Luciano Neder, Thomas Kislinger
Nature reviews. Urology - 2014-01-01