ForskareAvd för reumatologi och
Om Muhammad Nawaz
Dr. Nawaz received his first diploma in Bachelor of Science in Chemistry and Biology (BSc, 2006), and Master's degree in Biochemistry & Molecular Biology (2009) with specialization in genetics, nucleic acids metabolism, protein chemistry and DNA recombinant biotechnology. In 2011, he completed M.Phil/MS thesis on inherited / congenital diseases with a particular focus on intellectual disability and cognition (neurological disorders). He obtained PhD degree from the University of Sao Paulo, Brazil (2013-2017) where he investigated the role of microRNAs in malignant progression of brain tumors (gliomas), with an aim to identify potential therapeutic targets and non-invasive biomarkers. Along with his supervisor he also wrote a project to apply liposomes for transporting oligonucleotides (anti-miRs as silencing RNAs) to glioma cells, which was approved and funded by Brazilian health ministry - National Support Program for Oncology Care (PRONON).
During PhD, he wrote an independent project for PhD exchange to go abroad and joined Hadi Valadi lab at the University of Gothenburg, where he worked on exosomes' role in cell-to-cell communication. The project was funded by CAPSES - Brazilian funding agency. After completing PhD degree in 2017, Dr. Nawaz then continued as a postdoc.
During his postdoc at Valadi Lab Dr. Nawaz was involved in collaborative projects with AstraZeneca for developing RNA drug delivery systems (particularly mRNA-based therapy using lipid nanoparticles and exosomes). The recent collaborative works were published in top tire journals: ''Advanced Science'', and "Nature Communications" with following links here and here.
Currently, Dr. Nawaz is working as Forskare (Senior Researcher) at the Valadi Lab, with projects funded by "Vinnova" (Swedish Government's Agency for Innovation Systems), for developing new methods of RNA drug delivery and tools of stem cell-based therapies and organ repairs. He also works with "RNA/nucleotide Therapeutics Consortium - FormulaEx" established between Universities and different Biotech companies in Sweden. The Consortium is funded by "Swedish Foundation for Strategic Research-SSF". RNA-based therapeutics, which function either by silencing pathological genes through delivery of siRNA or expressing therapeutic proteins through the delivery of exogenous mRNA to cells — hold great potential for the treatment of various diseases including cancer, infectious diseases, and various inherited genetic diseases. RNA therapy provides potential new treatment options in multiple diseases and has been tested in clinical trials of several diseases, and lately applied in COVID-19 RNA vaccines.
He has received national and international research and travel grants, scholarships from Brazil and Sweden, and have participated in several national and international conferences. He also serves as peer reviewer (Publons profile) for web of science (WOS) indexed journals and help publishers and editors in peer review process.
According to Dr. Nawaz, one should be able to reciprocate or pay back to the society. It can be done in many forms, and according to him the best form is knowledge sharing, transferring the skills, offering some free services, especially to those who cannot afford or lack resources. Knowledge belongs to society, not to individuals.
For the works he has presented, see this link on YouTube
1. Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions (Advanced Science, 2023).
Muhammad Nawaz, Sepideh Heydarkhan‐Hagvall, Benyapa Tangruksa, Hernán González‐King Garibotti, Yujia Jing, Marco Maugeri, Franziska Kohl, Leif Hultin, Azadeh Reyahi, Alessandro Camponeschi, Bengt Kull, Jonas Christoffersson, Ola Grimsholm, Karin Jennbacken, Martina Sundqvist, John Wiseman, Abdel Wahad Bidar, Lennart Lindfors, Jane Synnergren, Hadi Valadi.
2. Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells (Nature Communications, 2019).
Marco Maugeri, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, Manli Na, Mikko Hölttä, Pia Skantze, Svante Johansson, Martina Sundqvist, Johnny Lindquist, Tomas Kjellman, Inga-Lill Mårtensson, Tao Jin, Per Sunnerhagen, Sofia Östman, Lennart Lindfors, Hadi Valadi.
3. The emerging role of extracellular vesicles as biomarkers for urogenital cancers (Nature Reviews Urology, 2014)
Muhammad Nawaz, Giovanni Camussi, Hadi Valadi, Irina Nazarenko, Karin Ekström, Xiaoqin Wang, Simona Principe, Neelam Shah, Naeem M Ashraf, Farah Fatima, Luciano Neder, Thomas Kislinger.
4. Extracellular vesicles: evolving factors in stem cell biology (Stem Cells International, 2016).
Muhammad Nawaz, Farah Fatima, Krishna C Vallabhaneni, Patrice Penfornis, Hadi Valadi, Karin Ekström, Sharad Kholia, Jason D Whitt, Joseph D Fernandes, Radhika Pochampally, Jeremy A Squire, Giovanni Camussi.
5. Long distance metabolic regulation through adipose-derived circulating exosomal miRNAs: a trail for RNA-based therapies? (Frontiers in physiology, 2017).
Farah Fatima, Muhammad Nawaz
Full list of Publications (Google Scholar)
Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional
Muhammad Nawaz, Sepideh Heydarkhan-Hagvall, Benyapa Tangruksa, Hernán González-King Garibotti, Yujia Jing, Maugeri Marco, Franziska Kohl, Leif Hultin, Azadeh Reyahi, Alessandro Camponeschi, Bengt Kull, Jonas Christoffersson, Ola Grimsholm, Karin Jennbacken, Martina Sundqvist, John Wiseman, Abdel Wahad Bidar, Lennart Lindfors, Jane Synnergren, Hadi Valadi
Advanced Science - 2023
Differential Treatment Responses in Pakistani Schizophrenia Samples: Correlation with Sociodemographic Parameters, Drug Addiction, Attitude to the Treatment and Antipsychotic
Umme Habiba, Aafia Malik, Ghazala Kaukab Raja, Muhammad Raza Memon, Asad Tameezud din Nizami , Rafaqat Ishaq, Muhammad Ilyas, Hadi Valadi, Muhammad Nawaz, Pakeeza Arzoo Shaiq
Brain Sciences - 2023
9p21 Locus Polymorphism Is A Strong Predictor of Metabolic Syndrome and Cardiometabolic Risk Phenotypes Regardless of Coronary Heart
Muhammad Mobeen Zafar, Muhammad Saqlain, Asad Mehmood Raja, Pakeeza Arzoo Shaiq, Muhammad Javaid Asad, Muhammad Kausar Nawaz Shah, Farah Fatima, Hadi Valadi, Muhammad Nawaz, Ghazala Kaukab Raja
Genes - 2022
Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV
Lucia Paolini , Marta Monguió-Tortajada, Marta Costa, Fabio Antenucci, Mario Barilani , Marta Clos-Sansalvador , André Cronemberger Andrade, Tom A. P. Driedonks, Sara Giancaterino , Stephanie M. Kronstadt , Rachel R. Mizenko, Muhammad Nawaz, Xabier Osteikoetxea , Carla Pereira, Surya Shrivastava, Anders Toftegaard Boysen, Simonides Immanuel van de Wakker, Martijn J. C. van Herwijnen, Xiaoqin Wang, Dionysios C. Watson, Mario Gimona, Maria Kaparakis-Liaskos, Konstantin Konstantinov, Sai Kiang Lim, Nicole Meisner-Kober, Michiel Stork , Peter Nejsum, Annalisa Radeghieri , Eva Rohde , Nicolas Touzet, Marca H. M. Wauben, Kenneth W. Witwer , Antonella Bongiovanni, Paolo Bergese
Journal of Extracellular Biology - 2022
Risk variants of obesity associated genes demonstrate BMI raising effect in a large
Muhammad Saqlain, Madiha Khalid, Muhammad Fiaz, Sadia Saeed, Asad Mehmood Raja, Muhammad Mobeen Zafar, Tahzeeb Fatima, João Bosco Pesquero, Cristina Maglio, Hadi Valadi, Muhammad Nawaz, Ghazala Kaukab Raja
PloS one - 2022
N-acetyl cysteine, selenium, and ascorbic acid rescue diabetic cardiac hypertrophy via mitochondrial-associated redox
Iram Mushtaq, Zainab Bashir, Mehvish Sarwar, Maria Arshad, Ayesha Ishtiaq, Wajiha Khan, Uzma Khan, Sobia Tabassum, Tahir Ali, Fatima Tahzeeb, Hadi Valadi, Muhammad Nawaz, Iram Murtaza
Molecules - 2021
Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor
L. Salimi, A. Akbari, N. Jabbari, B. Mojarad, A. Vahhabi, S. Szafert, S. A. Kalashani, H. Soraya, Muhammad Nawaz, J. Rezaie
Cell and Bioscience - 2020
miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting
Abbasi Majid, Jinxia Wang, Muhammad Nawaz, Sattar Abdul, Munawar Ayesha, Chunmei Guo, Qinglong Liu, Shuqing Liu, Ming-Zhong Sun
Frontiers in Molecular Biosciences - 2020
Synthesis of Functional Silver Nanoparticles and Microparticles with Modifiers and Evaluation of Their Antimicrobial, Anticancer, and Antioxidant
E. Dilshad, M. Bibi, N. A. Sheikh, K. F. Tamrin, Q. Mansoor, Q. Maqbool, Muhammad Nawaz
Journal of Functional Biomaterials - 2020
Genetic Risk of Autism Spectrum Disorder in a Pakistani
M. Khalid, H. Raza, T. M. Driessen, P. J. Lee, L. Tejwani, A. Sami, Muhammad Nawaz, S. M. Baig, J. Lim, G. K. Raja
Genes - 2020
Free and hydrogel encapsulated exosome-based therapies in regenerative
Ali Akbari, Nassrollah Jabbari, Roholah Sharifi, Mahdi Ahmadi, Ali Vahhabi, Seyyed Javad Seyedzadeh, Muhammad Nawaz, Sławomir Szafert, Monireh Mahmoodi, Esmaiel Jabbari, Rahim Asghari, Jafar Rezaie
Life sciences - 2020
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other
Maugeri Marco, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, Manli Na, Mikko Hölttä, Pia Skantze, Svante Johansson, Martina Sundqvist, Johnny Lindquist, Tomas Kjellman, Inga-Lill Mårtensson, Tao Jin, Per Sunnerhagen, Sofia Östman, Lennart Lindfors, Hadi Valadi
Nature Communications - 2019
Bystander effects of ionizing radiation: conditioned media from X-ray irradiated MCF-7 cells increases the angiogenic ability of endothelial
Nasrollah Jabbari, Muhammad Nawaz, Jafar Rezaie
Cell communication and signaling : CCS - 2019
Ionizing Radiation Increases the Activity of Exosomal Secretory Pathway in MCF-7 Human Breast Cancer Cells: A Possible Way to Communicate Resistance against
N. Jabbari, Muhammad Nawaz, J. Rezaie
International Journal of Molecular Sciences - 2019
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014
C. Thery, K. W. Witwer, E. Aikawa, A. P. D. Rubio, Karin Ekström, Ganesh V Shelke, Maugeri Marco, Muhammad Nawaz, Rossella Crescitelli, Cecilia Lässer, Jan Lötvall, Jessica Wahlgren
Journal of Extracellular Vesicles - 2018
Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into
Luisa Statello, Maugeri Marco, Elena Garre, Muhammad Nawaz, Jessica Wahlgren, Alexandros Papadimitriou, Christina Lundqvist, Lennart Lindfors, Anna Collén, Per Sunnerhagen, Marco Ragusa, Michele Purrello, Cinzia Di Pietro, Natalie Tigue, Hadi Valadi
PLoS One - 2018
Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue
Muhammad Nawaz, N. Shah, B. R. Zanetti, Maugeri Marco, R. N. Silvestre, F. Fatima, L. Neder, Hadi Valadi
Cells - 2018
Technical challenges of working with extracellular
M. I. Ramirez, M. G. Amorim, C. Gadelha, I. Milic, J. A. Welsh, V. M. Freitas, Muhammad Nawaz, N. Akbar, Y. Couch, L. Makin, F. Cooke, A. L. Vettore, P. X. Batista, R. Freezor, J. A. Pezuk, L. Rosa-Fernandes, A. C. O. Carreira, A. Devitt, L. Jacobs, I. T. Silva, G. Coakley, D. N. Nunes, D. Carter, G. Palmisano, E. Dias-Neto
Nanoscale - 2018
Long Distance Metabolic Regulation through Adipose-Derived Circulating Exosomal miRNAs: A Trail for RNA-Based
Farah Fatima, Muhammad Nawaz
Frontiers in physiology - 2017
Non-coding RNAs in Mesenchymal Stem Cell-Derived Extracellular Vesicles: Deciphering Regulatory Roles in Stem Cell Potency, Inflammatory Resolve, and Tissue
Farah Fatima, Karin Ekström, Irina Nazarenko, Maugeri Marco, Hadi Valadi, Andrew F. Hill, Giovanni Camussi, Muhammad Nawaz
Frontiers in Genetics - 2017
Radiological features of experimental staphylococcal septic arthritis by micro computed tomography
Farah Fatima, Ying Fei, Abukar Ali, Majd Mohammad, Malin Erlandsson, Maria Bokarewa, Muhammad Nawaz, Hadi Valadi, Manli Na, Tao Jin
PloS one - 2017
Extracellular vesicle-mediated transport of non-coding RNAs between stem cells and cancer cells: implications in tumor progression and therapeutic
Stem cell investigation - 2017
Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing
Muhammad Nawaz, Farah Fatima
Frontiers in molecular biosciences - 2017
Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker
Muhammad Nawaz, Farah Fatima, I. Nazarenko, Karin Ekström, I. Murtaza, M. Anees, A. Sultan, L. Neder, G. Camussi, Hadi Valadi, J. A. Squire, T. Kislinger
Expert Review of Proteomics - 2016
Extracellular Vesicles: Evolving Factors in Stem Cell
Muhammad Nawaz, Farah Fatima, Krishna C. Vallabhaneni, Patrice Penfornis, Hadi Valadi, Karin Ekström, Sharad Kholia, Jason D.Whitt, Joseph D. Fernandes, Radhika Pochampally, Jeremy A. Squire, Giovanni Camussi
Stem Cells International - 2016
Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer
Farah Fatima, Muhammad Nawaz
Cancer Communications - 2015
The emerging role of extracellular vesicles as biomarkers for urogenital
Muhammad Nawaz, Giovanni Camussi, Hadi Valadi, Irina Nazarenko, Karin Ekström, Xiaoqin Wang, Simona Principe, Neelam Shah, Naeem M Ashraf, Farah Fatima, Luciano Neder, Thomas Kislinger
Nature reviews. Urology - 2014