Muhammad Nawaz

Researcher

Department of Rheumatology and Inflammation Research

Mail

muhammad.nawaz@gu.se

Visiting address

Guldhedsgatan 10A

41346 Göteborg

Postal address

Box 480

40530 Göteborg

About Muhammad Nawaz

Longstanding interest in exosomes/extracellular vesicles (EV)-based delivery systems for RNA therapeutics with more than 10 years’ experience in exosomes research, along with lipid nanoparticle (LNP)-based RNA delivery systems and gene editing applications. Experience spans the EV/exosome production, purification, cargo loading, and in vivo biodistribution, tackling the challenges of targeted and functional delivery comprising bioassays in relevant in vitro and in vivo models. Expertise focus on the delivery of nucleic acid therapeutics, including mRNA, siRNA, antisense oligonucleotides and gene editing systems, with hands-on experience in evaluating functional delivery and biological outcomes in relevant models. Have developed new methods for efficient loading of therapeutic RNAs into EVs and demonstrated improved delivery to target cells and tissues using EVs and LNPs.

We investigate how diseased cells communicate with healthy cells using tiny particles called extracellular vesicles or exosomes (EVs) during the onset and progression of metabolic disorders such as obesity, diabetes, and liver-originated diseases.

We not only investigate the impact of EVs on pathophysiological functions of metabolic organs but we also use EVs as tools for new therapies to treat chronic metabolic disorders.

Using their innate built-in ability of carrying and transporting biologically active molecules between cells, we engineer and load EVs with therapeutic agents and deliver treatments to the molecular targets in the tissues and cells where metabolic disease originates.

Grants:

Sahlgrenska Academy's International Starting grant

Institute of Medicine → https://www.gu.se/en/medicine

Publications →