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- Joel Simrén
Joel Simrén
Doktorand
Sektionen för psykiatri och neurokemi-
Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich
Assay
Nicholas J. Ashton, Andrea L Benedet, Guglielmo Di Molfetta, Ilaria Pola, Federica Anastasi, Aida Fernandez-Lebrero, Albert Puig-Pijoan, Ashvini Keshavan, Jonathan Schott, Kubra Tan, Joel Simrén, Bárbara Fernandes Gomes, Laia Montoliu-Gaya, Richard Isaacson, Matilde Bongianni, Chiara Tolassi, Valentina Cantoni, Antonella Alberici, Alessandro Padovani, Gianluigi Zanusso, Andrea Pilotto, Barbara Borroni, Marc Suarez-Calvet, Kaj Blennow, Henrik Zetterberg
ALZHEIMERS & DEMENTIA - 2025 -
Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for
'X'
Sophia Weiner, Mathias Sauer, Laia Montoliu-Gaya, Andréa Lessa Benedet, Nicholas J. Ashton, Fernando Gonzalez-Ortiz, Joel Simrén, Nesrine Rahmouni, Cecile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Ville Leinonen, Tuomas Rauramaa, Mikko Hiltunen, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Johan Gobom
MOLECULAR NEURODEGENERATION - 2025 -
Proteomic analysis reveals distinct cerebrospinal fluid signatures across genetic frontotemporal dementia
subtypes
Aitana Sogorb-Esteve, Sophia Weiner, Joel Simrén, Imogen J. Swift, Martina Bocchetta, Emily G. Todd, David M. Cash, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry-Bolder, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonca, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Florence Pasquier, Simon Ducharme, Chris R. Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B. Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Kaj Blennow, Henrik Zetterberg, Jonathan D. Rohrer, Johan Gobom
SCIENCE TRANSLATIONAL MEDICINE - 2025 -
Functional and Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain
Levels
Elina Polunosika, Joel Simrén, Arta Akmene, Nikita Klimovskis, Kaj Blennow, Daina Pastare, Henrik Zetterberg, Renars Erts, Guntis Karelis
MEDICINA-LITHUANIA - 2025 -
Alzheimer's disease-Biomarkers, clinical evaluation or
both?
Joel Simrén, Nicholas J. Ashton, Marc Suárez-Calvet, Henrik Zetterberg
Journal of neuropsychology - 2024 -
Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and
pitfalls.
Francesco Bavato, Christian Barro, Laura K Schnider, Joel Simrén, Henrik Zetterberg, Erich Seifritz, Boris B Quednow
Molecular psychiatry - 2024 -
Concentrations of S100B and neurofilament light chain in blood as biomarkers for checkpoint inhibitor-induced CNS
inflammation
Sara Bjursten, Zhiyuan Zhao, Hifaa Al Remawi, Marie Studahl, Ankur Pandita, Joel Simrén, Henrik Zetterberg, Anna-Carin Lundell, Anna Rudin, Lars Ny, Max Levin
EBioMedicine - 2024 -
Quantification of neurofilament light and glial fibrillary acidic protein in finger-prick
blood
Magdalena A. Kolanko, Hanna Huber, Michael C. B. David, Laia Montoliu-Gaya, Joel Simrén, Kaj Blennow, Henrik Zetterberg, Ramin Nilforooshan, Paresh Malhotra, David J. Sharp, Nicholas J. Ashton, Neil S. N. Graham
BRAIN COMMUNICATIONS - 2024 -
Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote
settings
Hanna Huber, Kaj Blennow, Henrik Zetterberg, Merce Boada, Andreas Jeromin, Haley Weninger, Raul Nunez-Llaves, Nuria Aguilera, Maribel Ramis, Joel Simrén, Johanna Nilsson, Juan Lantero Rodriguez, Adelina Orellana, Fernando Garcia-Gutierrez, Xavier Morato, Nicholas J. Ashton, Laia Montoliu-Gaya
ALZHEIMERS & DEMENTIA - 2024 -
CT-based volumetric measures obtained through deep learning: Association with biomarkers of
neurodegeneration
Meera Srikrishna, Nicholas J. Ashton, Alexis Moscoso Rial, J. B. Pereira, Rolf A. Heckemann, D. van Westen, Giovanni Volpe, Joel Simrén, Anna Zettergren, Silke Kern, L. O. Wahlund, B. Gyanwali, S. Hilal, J. C. Ruifen, Henrik Zetterberg, Kaj Blennow, E. Westman, C. S. P. Chen, Ingmar Skoog, Michael Schöll
Alzheimers & Dementia - 2024 -
Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy
individuals
Wagner Scheeren Brum, Nicholas J. Ashton, Joel Simrén, Guiglielmo di Molfetta, Thomas Karikari, Andréa Lessa Benedet, Eduardo R. Zimmer, Juan Lantero Rodriguez, Laia Montoliu-Gaya, Andreas Jeromin, Aasne K. Aarsand, William A. Bartlett, Pilar Fernández Calle, Abdurrahman Coşkun, Jorge Díaz–Garzón, Niels Jonker, Henrik Zetterberg, Sverre Sandberg, Anna Carobene, Kaj Blennow
Alzheimer's and Dementia - 2024 -
Combining impact monitoring mouthguards and blood biomarkers to monitor head impacts among Muay Thai athletes – A case
study
Mikael Swarén, Joel Simrén, Hanna Huber, Henrik Zetterberg
JSAMS Plus - 2023 -
Prevalence and Clinical Implications of a β-Amyloid-Negative, Tau-Positive Cerebrospinal Fluid Biomarker Profile in Alzheimer
Disease.
Pontus Erickson, Joel Simrén, Wagner Scheeren Brum, Gilda E Ennis, Gwendlyn Kollmorgen, Ivonne Suridjan, Rebecca Langhough, Erin M Jonaitis, Carol A Van Hulle, Tobey J Betthauser, Cynthia M Carlsson, Sanjay Asthana, Nicholas J. Ashton, Sterling C Johnson, Leslie M Shaw, Kaj Blennow, Ulf Andreasson, Barbara B Bendlin, Henrik Zetterberg
JAMA neurology - 2023 -
Analytical and clinical validation of a blood progranulin ELISA in frontotemporal
dementias
Francisco J Meda, Joel Simrén, B. Borroni, V. Cantoni, S. Archetti, G. Biasiotto, Ulf Andreasson, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg
Clinical Chemistry and Laboratory Medicine - 2023 -
Traumatic Encephalopathy Syndrome and Tauopathy in a 19-Year-Old With Child
Abuse
Mike Rueb, Katrin Rauen, Inga Katharina Koerte, Alexandra Gersing, Henrik Zetterberg, Joel Simrén, Matthias Brendel, Kristina Adorjan
NEUROTRAUMA REPORTS - 2023 -
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's
disease.
Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx, Lutgarde Serneels, Dries T'Syen, Iordana Chrysidou, Amaia M Arranz, Annerieke Sierksma, Joel Simrén, Thomas Karikari, Henrik Zetterberg, Wei-Ting Chen, Dietmar Rudolf Thal, Evgenia Salta, Mark Fiers, Bart De Strooper
Science (New York, N.Y.) - 2023 -
Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical
COVID-19.
Lovisa Bark, Ing-Marie Larsson, Ewa Wallin, Joel Simrén, Henrik Zetterberg, Miklos Lipcsey, Robert Frithiof, Elham Rostami, Michael Hultström
Scientific reports - 2023 -
Association of Chronic Kidney Disease With Plasma NfL and Other Biomarkers of Neurodegeneration: The H70 Birth Cohort Study in
Gothenburg.
Anna Dittrich, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Anna Zettergren, Joel Simrén, Tobias Skillbäck, Sara Shams, Alejandra Machado, Eric Westman, Michael Schöll, Ingmar Skoog, Silke Kern
Neurology - 2023 -
Plasma and CSF NfL are differentially associated with biomarker evidence of neurodegeneration in a community-based sample of
70-year-olds
Anna Dittrich, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Joel Simrén, Fiona Geiger, Anna Zettergren, S. Shams, A. Machado, E. Westman, Michael Schöll, Ingmar Skoog, Silke Kern
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2022 -
Association of Plasma Biomarker Levels With Their CSF Concentration and the Number and Severity of Concussions in Professional
Athletes
Pashtun Shahim, Henrik Zetterberg, Joel Simrén, Nicholas J. Ashton, G. Norato, Michael Schöll, Y. Tegner, R. Diaz-Arrastia, Kaj Blennow
Neurology - 2022 -
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired
individuals.
Joel Simrén, Wagner Scheeren Brum, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Alzheimer's research & therapy - 2022 -
Differences between blood and cerebrospinal fluid glial fibrillary Acidic protein levels: The effect of sample
stability
Joel Simrén, Haley Weninger, Wagner Scheeren Brum, Shilla Khalil, Andréa Lessa Benedet, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimers & Dementia - 2022 -
Reply to Dr. Arieli regarding our article protein tau concentration in blood increases after SCUBA diving: an observational study published in European journal of applied physiology
2022;122:993-1005.
Anders Rosén, Mikael Gennser, Nicklas Oscarsson, Andreas Kvarnström, Göran Sandström, Helen Seeman-Lodding, Joel Simrén, Henrik Zetterberg
European journal of applied physiology - 2022 -
A Blood-Based Biomarker of Cognitive Decline and Interaction with
Lifestyle
Joel Simrén, Deborah Gustafson
Jama Network Open - 2022 -
Plasma p-tau231, p-tau181, PET Biomarkers, and Cognitive Change in Older
Adults.
Pierre-François Meyer, Nicholas J. Ashton, Thomas Karikari, Cherie Strikwerda-Brown, Theresa Köbe, Julie Gonneaud, Alexa Pichet Binette, Hazal Ozlen, Yara Yakoub, Joel Simrén, Josef Pannee, Juan Lantero Rodriguez, Anne Labonté, Suzanne L Baker, Michael Schöll, Eugeen Vanmechelen, John C S Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve
Annals of neurology - 2022 -
Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5-90
years
Joel Simrén, Ulf Andreasson, Johan Gobom, M. S. Calvet, B. Borroni, Christopher Gillberg, L. Nyberg, R. Ghidoni, Elisabeth Fernell, Mats Johnson, H. Depypere, Caroline Hansson, Ingibjörg H Jonsdottir, Henrik Zetterberg, Kaj Blennow
Brain Communications - 2022 -
Diagnostic value of serum versus plasma phospho-tau for Alzheimer's
disease
Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Joel Simrén, N. Dewit, E. Vanmechelen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas Karikari
Alzheimer's Research & Therapy - 2022 -
Post-acute blood biomarkers and disease progression in traumatic brain
injury.
Virginia F J Newcombe, Nicholas J. Ashton, Jussi P Posti, Ben Glocker, Anne Manktelow, Doris A Chatfield, Stefan Winzeck, Edward Needham, Marta M Correia, Guy B Williams, Joel Simrén, Riikka S K Takala, Ari J Katila, Henna-Riikka Maanpää, Jussi Tallus, Janek Frantzén, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, David K Menon
Brain : a journal of neurology - 2022 -
Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive
change
D. S. Smirnov, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Joel Simrén, Juan Lantero Rodriguez, Thomas Karikari, A. Hiniker, R. A. Rissman, D. P. Salmon, D. Galasko
Acta Neuropathologica - 2022 -
Protein tau concentration in blood increases after SCUBA diving: an observational
study
Anders Rosén, M. Gennser, Nicklas Oscarsson, Andreas Kvarnström, Göran Sandström, Heléne Seeman-Lodding, Joel Simrén, Henrik Zetterberg
European Journal of Applied Physiology - 2022 -
Early plasma biomarker dynamic profiles are associated with acute ischemic stroke
outcomes
M. Correia, I. Silva, D. Gabriel, Joel Simrén, A. Carneiro, S. Ribeiro, H. M. Doria, R. Varela, A. Aires, Karolina Minta, R. Antunes, R. Felgueiras, P. Castro, Kaj Blennow, R. Magalhaes, Henrik Zetterberg, L. F. Maia
European Journal of Neurology - 2022 -
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's
disease.
Pratishtha Chatterjee, Steve Pedrini, Nicholas J. Ashton, Michelle Tegg, Kathryn Goozee, Abhay K Singh, Thomas Karikari, Joel Simrén, Eugeen Vanmechelen, Nicola J Armstrong, Eugene Hone, Prita R Asih, Kevin Taddei, Vincent Doré, Victor L Villemagne, Hamid R Sohrabi, Henrik Zetterberg, Colin L Masters, Kaj Blennow, Ralph N Martins
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2022 -
Blood neurofilament light in remote settings: Alternative protocols to support sample collection in challenging pre-analytical
conditions.
Joel Simrén, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia - 2021 -
Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain
Injury.
Edward J Needham, Oda Stoevesandt, Eric P Thelin, Henrik Zetterberg, Elisa R Zanier, Faiez Al Nimer, Nicholas J. Ashton, Joanne G Outtrim, Virginia F J Newcombe, Hani S Mousa, Joel Simrén, Kaj Blennow, Zhihui Yang, Peter J Hutchinson, Fredrik Piehl, Adel E Helmy, Mike J Taussig, Kevin K W Wang, Joanne L Jones, David K Menon, Alasdair J Coles
Journal of immunology - 2021 -
A genome-wide association study of plasma phosphorylated
tau181
Jodie Lord, Anna Zettergren, Nicholas J. Ashton, Thomas Karikari, Andréa Lessa Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proitsi
Neurobiology of aging - 2021 -
Neurochemical biomarkers to study CNS effects of COVID-19: a narrative review and
synthesis.
Arvid Edén, Joel Simrén, Richard W. Price, Henrik Zetterberg, Magnus Gisslén
Journal of neurochemistry - 2021 -
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's
disease.
Deborah O T Alawode, Amanda J Heslegrave, Nicholas J. Ashton, Thomas Karikari, Joel Simrén, Laia Montoliu-Gaya, Josef Pannee, Antoinette O Connor, Philip S J Weston, Juan Lantero Rodriguez, Ashvini Keshavan, Anniina Snellman, Johan Gobom, Ross W Paterson, Jonathan M Schott, Kaj Blennow, Nick C Fox, Henrik Zetterberg
Journal of internal medicine - 2021 -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's
disease.
Joel Simrén, Antoine Leuzy, Thomas Karikari, Abdul Hye, Andréa Lessa Benedet, Juan Lantero Rodriguez, Niklas Mattsson-Carlgren, Michael Schöll, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Plasma neurofilament light chain levels predict improvement in late phase after
stroke.
Anna Stokowska, Lina Bunketorp Käll, Christian Blomstrand, Joel Simrén, Henrik Zetterberg, Kaj Blennow, Milos Pekny, Marcela Pekna
European journal of neurology - 2021 -
Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and
neurodegeneration.
Nicholas J. Ashton, Marc Suárez-Calvet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Joel Simrén, Carolina Minguillon, Karine Fauria, Kaj Blennow, Henrik Zetterberg
Alzheimer's & dementia (Amsterdam, Netherlands) - 2021 -
Saliva Neurofilament Light Chain Is Not a Diagnostic Biomarker for Neurodegeneration in a Mixed Memory Clinic
Population
H. S. Gleerup, Federica Sanna, P. Hogh, Joel Simrén, Kaj Blennow, Henrik Zetterberg, S. G. Hasselbalch, Nicholas J. Ashton, A. H. Simonsen
Frontiers in Aging Neuroscience - 2021 -
Plasma neurofilament light chain as a potential biomarker in Charcot-Marie-Tooth
disease.
Elina Millere, Dmitrijs Rots, Joel Simrén, Nicholas J. Ashton, Einars Kupats, Ieva Micule, Viktorija Priedite, Natalja Kurjane, Kaj Blennow, Linda Gailite, Henrik Zetterberg, Viktorija Kenina
European journal of neurology - 2021 -
Infection of Brain Pericytes Underlying Neuropathology of COVID-19
Patients.
Matteo Bocci, Clara Oudenaarden, Xavier Sàenz-Sardà, Joel Simrén, Arvid Edén, Jonas Sjölund, Christina Möller, Magnus Gisslén, Henrik Zetterberg, Elisabet Englund, Kristian Pietras
International journal of molecular sciences - 2021 -
Ghrelin Induces Place Preference for Social Interaction in the Larger Peer of a Male Rat
Pair.
Erik Schéle, Daniela M Pfabigan, Joel Simrén, Uta Sailer, Suzanne L. Dickson
Neuroscience - 2020 -
An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges
ahead.
Joel Simrén, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg
Current opinion in neurobiology - 2020 -
Comparing Glial Fibrillary Acidic Protein (GFAP) in Serum and Plasma Following Mild Traumatic Brain Injury in Older
Adults.
Nathan A Huebschmann, Teemu M Luoto, Justin E Karr, Ksenia Berghem, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Joel Simrén, Jussi P Posti, Jessica M Gill, Grant L Iverson
Frontiers in neurology - 2020 -
Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar
degeneration.
Alberto Benussi, Thomas Karikari, Nicholas J. Ashton, Stefano Gazzina, Enrico Premi, Luisa Benussi, Roberta Ghidoni, Juan Lantero Rodriguez, Andreja Emersic, Joel Simrén, Giuliano Binetti, Silvia Fostinelli, Marcello Giunta, Roberto Gasparotti, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Journal of neurology, neurosurgery, and psychiatry - 2020