Andrea Lessa Benedet
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The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of 18F MK6240 Tau PET in Target
Regions
C. Tissot, S. Servaes, F. Z. Lussier, J. P. Ferrai-Souza, J. Therriault, P. C. Ferreirat, G. Bezgin, B. Bellaver, D. T. Leffa, S. S. Mathotaarachchi, M. Chamoun, J. Stevenson, N. Rahmouni, M. S. Kang, V. Pallen, N. Margherita-Poltronetti, Y. T. Wang, J. Fernandez-Arias, Andréa Lessa Benedet, E. R. Zimmer, J. P. Soucy, D. L. Tudorascu, A. D. Cohen, M. Sharp, S. Gauthier, G. Massarweh, B. Lopresti, W. E. Klunk, S. L. Baker, V. L. Villemagne, P. Rosa-Neto, T. A. Pascoal
Journal of Nuclear Medicine - 2023 -
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau
pathologies
L. Montoliu-Gaya, Andréa Lessa Benedet, C. Tissot, A. Vrillon, Nicholas J. Ashton, Wagner S. Brum, Juan Lantero Rodriguez, J. Stevenson, Johanna Nilsson, Mathias Sauer, N. Rahmouni, Gunnar Brinkmalm, F. Z. Lussier, T. A. Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, C. Paquet, Johan Gobom, P. Rosa-Neto, Kaj Blennow
Nature Aging - 2023 -
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac
Arrest
Nicholas J. Ashton, M. Moseby-Knappe, Andréa Lessa Benedet, Lana Grötschel, Juan Lantero Rodriguez, Thomas Karikari, C. Hassager, M. P. Wise, P. Stammet, J. Kjaergaard, H. Friberg, N. Nielsen, T. Cronberg, Henrik Zetterberg, Kaj Blennow
Jama Neurology - 2023 -
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's
disease
J. Therriault, S. Servaes, C. Tissot, N. Rahmouni, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, A. C. Macedo, F. Z. Lussier, J. Stevenson, Y. T. Wang, J. Fernandez-Arias, A. Stevenson, K. Q. Socualaya, A. Haeger, T. Nazneen, Aumont, Aumont,, A. Hosseini, S. Rej, P. Vitali, G. Triana-Baltzer, H. C. Kolb, J. P. Soucy, T. A. Pascoal, S. Gauthier, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Alzheimers & Dementia - 2023 -
Hippocampal GFAP-positive astrocyte responses to amyloid and tau
pathologies.
Marco Antônio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimmer
Brain, behavior, and immunity - 2023 -
Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive
Individuals.
Annika Öhrfelt, Andréa Lessa Benedet, Nicholas J. Ashton, Hlin Kvartsberg, Manu Vandijck, Michael W Weiner, John Q Trojanowski, Leslie M Shaw, Henrik Zetterberg, Kaj Blennow
Neurology - 2023 -
Plasma GFAP in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort
study.
Antoinette O'Connor, Emily Abel, Andréa Lessa Benedet, Teresa Poole, Nicholas J. Ashton, Philip Simon John Weston, Amanda J Heslegrave, Natalie Ryan, Suzie Barker, James M Polke, Kaj Blennow, Henrik Zetterberg, Nick C Fox
Journal of neurology, neurosurgery, and psychiatry - 2023 -
Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission
Tomography.
Joseph Therriault, Marie Vermeiren, Stijn Servaes, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Wagner S. Brum, Firoza Z Lussier, Gleb Bezgin, Jenna Stevenson, Nesrine Rahmouni, Peter Kunach, Yi-Ting Wang, Jaime Fernandez-Arias, Kely Quispialaya Socualaya, Arthur C Macedo, João Pedro Ferrari-Souza, Pâmela C L Ferreira, Bruna Bellaver, Douglas T Leffa, Eduardo R Zimmer, Paolo Vitali, Jean-Paul Soucy, Gallen Triana-Baltzer, Hartmuth C Kolb, Tharick A Pascoal, Paramita Saha-Chaudhuri, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
JAMA neurology - 2022 -
Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's
disease.
Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó, Paula Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Eugeen Vanmechelen, Theresa A Day, Armand González-Escalante, Gonzalo Sánchez-Benavides, Carolina Minguillon, Karine Fauria, José Luis Molinuevo, Jeffrey L Dage, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez-Calvet, Kaj Blennow
Nature medicine - 2022 -
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease
continuum.
Johan Gobom, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Molecular neurodegeneration - 2022 -
Amyloid processing in COVID-19-associated neurological
syndromes
O. J. Ziff, Nicholas J. Ashton, P. R. Mehta, R. Brown, D. Athauda, J. Heaney, A. J. Heslegrave, Andréa Lessa Benedet, Kaj Blennow, A. M. Checkley, C. F. Houlihan, S. Gauthier, P. Rosa-Neto, N. C. Fox, J. M. Schott, Henrik Zetterberg, L. A. Benjamin, R. W. Paterson
Journal of Neurochemistry - 2022 -
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired
individuals.
Joel Simrén, Wagner S. Brum, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Alzheimer's research & therapy - 2022 -
Differences between blood and cerebrospinal fluid glial fibrillary Acidic protein levels: The effect of sample
stability
Joel Simrén, Haley Weninger, Wagner S. Brum, Shilla Khalil, Andréa Lessa Benedet, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimers & Dementia - 2022 -
Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's
continuum
G. Salvado, M. Mila-Aloma, M. Shekari, Nicholas J. Ashton, G. Operto, C. Falcon, R. Cacciaglia, C. Minguillon, K. Fauria, A. Ninerola-Baizan, A. Perissinotti, Andréa Lessa Benedet, G. Kollmorgen, I. Suridjan, N. Wild, J. L. Molinuevo, Henrik Zetterberg, Kaj Blennow, M. Suarez-Calvet, J. D. Gispert
European Journal of Nuclear Medicine and Molecular Imaging - 2022 -
Staging of Alzheimer?s disease: past, present and future
perspectives
J. Therriault, E. R. Zimmer, Andréa Lessa Benedet, T. A. Pascoal, S. Gauthier, P. Rosa-Neto
Trends in Molecular Medicine - 2022 -
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's
disease
Nicholas J. Ashton, Andréa Lessa Benedet, Tharick A. Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Wagner S. Brum, S. Mathotaarachchi, J. Therriault, M. Savard, M. Chamoun, E. Stoops, C. Francois, E. Vanmechelen, S. Gauthier, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, P. Rosa-Neto
Ebiomedicine - 2022 -
Biomarker modeling of Alzheimer’s disease using PET-based Braak
staging
J. Therriault, T. A. Pascoal, F. Z. Lussier, C. Tissot, M. Chamoun, G. Bezgin, S. Servaes, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas Karikari, Juan Lantero Rodriguez, P. Kunach, Y. T. Wang, J. Fernandez-Arias, G. Massarweh, P. Vitali, J. P. Soucy, P. Saha-Chaudhuri, Kaj Blennow, Henrik Zetterberg, S. Gauthier, P. Rosa-Neto
Nature Aging - 2022 -
Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau
immunoassays
Nicholas J. Ashton, A. Puig-Pijoan, M. Mila-Aloma, A. Fernandez-Lebrero, G. Garcia-Escobar, Fernando Gonzalez-Ortiz, Przemyslaw R. Kac, Wagner S. Brum, Andréa Lessa Benedet, Juan Lantero Rodriguez, T. A. Day, J. Vanbrabant, E. Stoops, E. Vanmechelen, G. Triana-Baltzer, S. Moughadam, H. Kolb, P. Ortiz-Romero, Thomas Karikari, C. Minguillon, J. J. H. Sanchez, I. Navalpotro-Gomez, O. Grau-Rivera, R. M. Manero, V. Puente-Periz, R. de la Torre, J. Roquer, J. L. Dage, Henrik Zetterberg, Kaj Blennow, M. Suarez-Calvet
Alzheimers & Dementia - 2022 -
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical
utility
Thomas Karikari, Nicholas J. Ashton, Gunnar Brinkmalm, Wagner S. Brum, Andréa Lessa Benedet, Laia Montoliu-Gaya, Juan Lantero Rodriguez, T. A. Pascoal, M. Suarez-Calvet, P. Rosa-Neto, Kaj Blennow, Henrik Zetterberg
Nature Reviews Neurology - 2022 -
Acute sleep loss increases CNS health biomarkers and compromises the ability to stay awake in a sex-and weight-specific
manner
L. T. van Egmond, S. Bukhari, Andréa Lessa Benedet, Nicholas J. Ashton, E. M. S. Meth, A. Boukas, J. Engstrom, M. Ilemosoglou, Kaj Blennow, Henrik Zetterberg, C. Benedict
Translational Psychiatry - 2022 -
Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's
disease
D. Herman, V. Andrea, L. Pablo, L. Simone, Andréa Lessa Benedet, Nicholas J. Ashton, C. Enrica, Henrik Zetterberg, Kaj Blennow, V. Eugeen, H. Harald
Alzheimers & Dementia - 2022 -
Plasma p-tau231 and p-tau217 as state markers of amyloid-beta pathology in preclinical Alzheimer's
disease
M. Mila-Aloma, Nicholas J. Ashton, M. Shekari, G. Salvado, P. Ortiz-Romero, Laia Montoliu-Gaya, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, E. Vanmechelen, T. A. Day, A. Gonzalez-Escalante, G. Sanchez-Benavides, C. Minguillon, K. Fauria, J. L. Molinuevo, J. L. Dage, Henrik Zetterberg, J. D. Gispert, M. Suarez-Calvet, Kaj Blennow
Nature Medicine - 2022 -
Astrocyte biomarker signatures of amyloid-beta and tau pathologies in Alzheimer's
disease
J. P. Ferrari-Souza, P. C. L. Ferreira, B. Bellaver, C. Tissot, Y. T. Wang, D. T. Leffa, Wagner S. Brum, Andréa Lessa Benedet, Nicholas J. Ashton, M. A. De Bastiani, A. Rocha, J. Therriault, F. Z. Lussier, M. Chamoun, S. Servaes, G. Bezgin, M. S. Kang, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, W. E. Klunk, D. L. Tudorascu, A. D. Cohen, V. L. Villemagne, S. Gauthier, Kaj Blennow, Henrik Zetterberg, D. O. Souza, Thomas Karikari, E. R. Zimmer, P. Rosa-Neto, T. A. Pascoal
Molecular Psychiatry - 2022 -
Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer's
disease
Johanna Nilsson, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Johan Gobom, T. A. Pascoal, M. Chamoun, E. Portelius, A. Jeromin, M. Mendes, Henrik Zetterberg, P. Rosa-Neto, Ann Brinkmalm, Kaj Blennow
Alzheimer's Research & Therapy - 2022 -
A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's
disease.
Wagner S. Brum, Marco Antônio de Bastiani, Andrei Bieger, Joseph Therriault, João P Ferrari-Souza, Andréa Lessa Benedet, Paramita Saha-Chaudhuri, Diogo O Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa-Neto, Eduardo R Zimmer
Alzheimer's & dementia (New York, N. Y.) - 2022 -
Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240
tau-PET
C. Tissot, J. Therriault, P. Kunach, Andréa Lessa Benedet, T. A. Pascoal, N. J. Ashton, Thomas Karikari, S. Servaes, F. Z. Lussier, M. Chamoun, D. L. Tudorascu, J. Stevenson, N. Rahmouni, N. M. Poltronetti, V. Pallen, G. Bezgin, M. S. Kang, S. S. Mathotaarachchi, Y. T. Wang, J. Fernandez Arias, P. C. L. Ferreira, J. P. Ferrari-Souza, E. Vanmechelen, K. Blennow, H. Zetterberg, S. Gauthier, P. Rosa-Neto
Ebiomedicine - 2022 -
The accuracy and robustness of plasma biomarker models for amyloid PET
positivity
Andréa Lessa Benedet, Wagner S. Brum, O. Hansson, A. D. N. Initiative, Thomas Karikari, E. R. Zimmer, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Alzheimers Research & Therapy - 2022 -
Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak
stages
T. A. Pascoal, Andréa Lessa Benedet, D. L. Tudorascu, J. Therriault, S. Mathotaarachchi, M. Savard, F. Z. Lussier, C. Tissot, M. Chamoun, M. S. Kang, J. Stevenson, G. Massarweh, M. C. Guiot, J. P. Soucy, S. Gauthier, P. Rosa-Neto
Brain - 2021 -
Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging
Initiative.
Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow
Alzheimer's research & therapy - 2021 -
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's
disease.
Cécile Tissot, Andréa Lessa Benedet, Joseph Therriault, Tharick A Pascoal, Firoza Z Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto
Alzheimer's research & therapy - 2021 -
Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological
syndromes.
Ross W Paterson, Laura A Benjamin, Puja R Mehta, Rachel L Brown, Dilan Athauda, Nicholas J. Ashton, Claire A Leckey, Oliver J Ziff, Judith Heaney, Amanda J Heslegrave, Andréa Lessa Benedet, Kaj Blennow, Anna M Checkley, Catherine F Houlihan, Catherine J Mummery, Michael P Lunn, Hadi Manji, Michael S Zandi, Stephen Keddie, Michael Chou, Deepthi Vinayan Changaradil, Tom Solomon, Ashvini Keshavan, Suzanne Barker, Hans Rolf Jäger, Francesco Carletti, Robert Simister, David J Werring, Moira J Spyer, Eleni Nastouli, Serge Gauthier, Pedro Rosa-Neto, Henrik Zetterberg, Jonathan M Schott
Brain communications - 2021 -
A genome-wide association study of plasma phosphorylated
tau181
Jodie Lord, Anna Zettergren, Nicholas J. Ashton, Thomas Karikari, Andréa Lessa Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proitsi
Neurobiology of aging - 2021 -
P-tau235: a novel biomarker for staging preclinical Alzheimer's
disease.
Juan Lantero Rodriguez, Anniina Snellman, Andréa Lessa Benedet, Marta Milà-Alomà, Elena Camporesi, Laia Montoliu-Gaya, Nicholas J. Ashton, Agathe Vrillon, Thomas Karikari, Juan Domingo Gispert, Gemma Salvadó, Mahnaz Shekari, Christina E Toomey, Tammaryn L Lashley, Henrik Zetterberg, Marc Suárez-Calvet, Gunnar Brinkmalm, Pedro Rosa Neto, Kaj Blennow
EMBO molecular medicine - 2021 -
Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease
Continuum
Andréa Lessa Benedet, M. Mila-Aloma, A. Vrillon, Nicholas J. Ashton, T. A. Pascoal, F. Lussier, Thomas Karikari, C. Hourregue, E. Cognat, J. Dumurgier, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, G. Salvado, M. Shekari, G. Operto, J. D. Gispert, C. Minguillon, K. Fauria, G. Kollmorgen, I. Suridjan, E. R. Zimmer, Henrik Zetterberg, J. L. Molinuevo, C. Paquet, P. Rosa-Neto, Kaj Blennow, M. Suarez-Calvet
Jama Neurology - 2021 -
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease
pathology.
Nicholas J. Ashton, Tharick A Pascoal, Thomas Karikari, Andréa Lessa Benedet, Juan Lantero Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2021 -
Publisher Correction: Microglial activation and tau propagate jointly across Braak
stages.
Tharick A Pascoal, Andréa Lessa Benedet, Nicholas J. Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Nature medicine - 2021 -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's
disease.
Joel Simrén, Antoine Leuzy, Thomas Karikari, Abdul Hye, Andréa Lessa Benedet, Juan Lantero Rodriguez, Niklas Mattsson-Carlgren, Michael Schöll, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's
disease.
Andréa Lessa Benedet, Antoine Leuzy, Nicholas J. Ashton, Sulantha Mathotaarachchi, Melissa Savard, Joseph Therriault, Min Su Kang, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Brain : a journal of neurology - 2020 -
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective
cohorts.
Thomas Karikari, Tharick A Pascoal, Nicholas J. Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
The Lancet. Neurology - 2020