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Elisabeth Nyström
Researcher
Department of Medical Biochemistry and Cell biology-
Ex vivo imaging and enzymatic analysis of intestinal
mucus
Elisabeth Nyström, Brendan Dolan, George Birchenough, Malin Johansson
Methods in Enzymology - 2026 -
Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage impeding type 2 immune
programs
Manuel O. Jakob, Nele Sterczyk, Sotiria Boulekou, Patrycja M. Forster, Luisa Barleben, Nadra Alzain, Katja J. Jarick, Roksana M. Pirzgalska, Bruno Raposo, Karl Hansson, Elisabeth Nyström, Aurelia Gondrand, Miguel Gonzalez-Acera, Pierre S. Leclere, Marlen S. Lapson, Sarah Poggenseier, Divija Deshpande, Laura Velleman, Tilman Breiderhoff, Max Felix Brunkhorst, Anton M. Schule, Gabriela M. Guerra, Pawel Durek, Mir-Farzin Mashreghi, Anja A. Kuhl, Coco Chu, Christoph Schneider, Carl Weidinger, Britta Siegmund, Thierry M. Nordmann, David Voehringer, Jay V. Patankar, Christoph Becker, George Birchenough, Henrique Veiga-Fernandes, Francesca Ronchi, Marina Kolesnichenko, Andreas Diefenbach, Christoph S. N. Klose
NATURE IMMUNOLOGY - 2025 -
Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse
colons
H. Arnesen, T. Markussen, George M. H. Birchenough, S. Birkeland, Elisabeth E. L. Nyström, Gunnar C. Hansson, H. Carlsen, P. Boysen
Scientific Reports - 2023 -
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus
layer
Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
Nature Communications - 2022 -
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier
function
Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
Science - 2021 -
Obesity-associated microbiota contributes to mucus layer defects in genetically obese
mice
Björn O. Schröder, George M. H. Birchenough, Meenakshi Pradhan, Elisabeth E. L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
Journal of Biological Chemistry - 2020 -
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or
function
Joana K. Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz Martinez Abad, Björn O. Schröder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E V Johansson, Gunnar C. Hansson, George M. H. Birchenough
Journal of Experimental Medicine - 2019 -
Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal
epithelium
Génesis Vega, Anita Guequén, Malin E V Johansson, Liisa Arike, Beatriz Martinez Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Frontiers in Physiology - 2019 -
Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing
properties
Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2019 -
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic
Activity
Elisabeth E. L. Nyström, George M. H. Birchenough, Sjoerd van der Post, Liisa Arike, A. D. Gruber, Gunnar C. Hansson, Malin E V Johansson
Ebiomedicine - 2018 -
Functional mucous layer and healing of proximal colonic anastomoses in an experimental
model.
J W A M Bosmans, A C H M Jongen, George M. H. Birchenough, Elisabeth E. L. Nyström, M J J Gijbels, J P M Derikx, N D Bouvy, Gunnar C. Hansson
The British journal of surgery - 2017 -
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2
secretion
George M. H. Birchenough, Elisabeth E. L. Nyström, Malin E V Johansson, Gunnar C. Hansson
Science - 2016 -
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune
system
Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014