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Hlin Kvartsberg
Affiliated to Research
Department of Psychiatry and Neurochemistry-
Data-driven evaluation of suitable immunogens for improved antibody
selection
Katharina Waury, Hlin Kvartsberg, Henrik Zetterberg, Kaj Blennow, Charlotte E. Teunissen, Sanne Abeln
PROTEIN SCIENCE - 2025 -
Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular
Diseases
Erlan Sanchez, Gillian T. Coughlan, Tim Wilkinson, Joel Ramirez, Saira Saeed Mirza, Andree-Ann Baril, Allison A. Dilliott, Andrew Frank, Anthony E. Lang, Ayman Hassan, Bruce G. Pollock, Christopher J. M. Scott, Connie Marras, Corinne E. Fischer, Dallas Seitz, Daniela Andriuta, Dar Dowlatshahi, David A. Grimes, David F. Tang-Wai, Demetrios J. Sahlas, Ekaterina A. Rogaeva, Elizabeth Finger, John F. Robinson, Kubra Tan, Malcolm A. Binns, Maria Carmela Tartaglia, Michael J. Borrie, Michael J. Strong, Miracle Ozzoude, Nuwan D. Nanayakkara, Rafaella A. Goncalves, Robert Bartha, Robert A. Hegele, Sali M. K. Farhan, Sandra E. Black, Sanjeev Kumar, Sean P. Symons, Seyyed M. H. Haddad, Stephen H. Pasternak, Stephen R. Arnott, Tarek K. Rajji, Thomas Steeves, Walter Swardfager, Nicholas J. Ashton, Hlin Kvartsberg, Henrik Zetterberg, Douglas P. Munoz, Mario Masellis
NEUROLOGY - 2025 -
Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple
sclerosis.
Igal Rosenstein, Lenka Nováková Nyrén, Hlin Kvartsberg, Anna Nordin, Sofia Rasch, Elzbieta Rembeza, Sofia Sandgren, Clas Malmeström, Stefanie Fruhwürth, Markus Axelsson, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Journal of Neuroinflammation - 2024 -
The detection of GRN mutation carriers by progranulin blood protein levels from finger-stick
collection
Hanna Huber, Valentina Cantoni, Daniele Altomare, Lana Grötschel, Laia Montoliu-Gaya, Francisco J Meda, Hlin Kvartsberg, Ilenia Libri, Maria Sofia Cotelli, Henrik Zetterberg, Kaj Blennow, Barbara Borroni, Nicholas J. Ashton
ALZHEIMERS & DEMENTIA - 2024 -
Neuronal plasma biomarkers in acute ischemic
stroke
Julia K. Gundersen, Fernando Gonzalez-Ortiz, Thomas Karikari, Bjorn-Eivind Kirsebom, Katrin Mertes, Henrik Zetterberg, Hlin Kvartsberg, Ole Morten Ronning, Berglind Gisladottir, Kaj Blennow, Tormod Fladby
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM - 2024 -
Novel ultrasensitive immunoassay for the selective quantification of tau oligomers and related soluble
aggregates
Tohidul Islam, Hlin Kvartsberg, Anuradha Sehrawat, Przemyslaw R. Kac, Bruno Becker, Maria Olsson, Eric E. Abrahamson, Henrik Zetterberg, Milos D. Ikonomovic, Kaj Blennow, Thomas Karikari
ALZHEIMERS & DEMENTIA - 2024 -
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease
neuropathology.
Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas Karikari
Nature communications - 2024 -
A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's
disease.
Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand González-Escalante, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R. Kac, Michael Turton, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Minguillon, Jose Contador, Marc Suárez-Calvet, Thomas Karikari, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2024 -
Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research
Initiative
Erlan Sanchez, Tim Wilkinson, Gillian Coughlan, Saira Mirza, Andrée Ann Baril, Joel Ramirez, Malcolm A. Binns, Sandra E. Black, Michael Borrie, Allison A. Dilliott, Roger A. Dixon, Dar Dowlatshahi, Sali Farhan, Elizabeth Finger, Corinne E. Fischer, Andrew Frank, Morris Freedman, Rafaella A. Goncalves, David A. Grimes, Ayman Hassan, Robert A. Hegele, Sanjeev Kumar, Anthony E. Lang, Connie Marras, Paula M. McLaughlin, Joseph B. Orange, Stephen H. Pasternak, Bruce G. Pollock, Tarek K. Rajji, Angela C. Roberts, John F. Robinson, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Michael J. Strong, Richard H. Swartz, David F. Tang-Wai, Maria Carmela Tartaglia, Angela K. Troyer, Hlin Kvartsberg, Henrik Zetterberg, Douglas P. Munoz, Mario Masellis
Alzheimer's and Dementia - 2024 -
Association of region-specific hippocampal reduction of neurogranin with inflammasome proteins in post mortem brains of Alzheimer's
disease
Regina T. Vontell, Ryan Gober, Julian Dallmeier, Daniel Brzostowicki, Ayled Barreda, Kaj Blennow, Henrik Zetterberg, Hlin Kvartsberg, Sakir Humayun Gultekin, Juan Pablo de Rivero Vaccari, Helen M. Bramlett, W. Dalton Dietrich, Robert W. Keane, David A. Davis, Tatjana Rundek, Xiaoyan Sun
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS - 2024 -
CSF p-tau205: a biomarker of tau pathology in Alzheimer's
disease.
Juan Lantero Rodriguez, Laia Montoliu-Gaya, Andréa Lessa Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner Scheeren Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2024 -
Analytical and clinical validation of a blood progranulin ELISA in frontotemporal
dementias
Francisco J Meda, Joel Simrén, B. Borroni, V. Cantoni, S. Archetti, G. Biasiotto, Ulf Andreasson, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg
Clinical Chemistry and Laboratory Medicine - 2023 -
A novel ultrasensitive assay for plasma p-tau217: performance in individuals with subjective cognitive decline and early Alzheimer's
disease.
Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand Gonzalez, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R. Kac, Michael Turton, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Miguillon, Jose Contador, Marc Suarez-Calvet, Thomas Karikari, Kaj Blennow
medRxiv : the preprint server for health sciences - 2023 -
Neurofilament light oligomers in neurodegenerative diseases: quantification by homogeneous immunoassay in cerebrospinal
fluid
Francisco J Meda, Kathryn Knowles, Imogen J. Swift, Aitana Sogorb-Esteve, Jonathan D. Rohrer, Anna Dittrich, Ingmar Skoog, Silke Kern, Bruno Becker, Kaj Blennow, Ulf Andreasson, Hlin Kvartsberg, Henrik Zetterberg
BMJ NEUROLOGY OPEN - 2023 -
Neurogranin in Alzheimer's disease and ageing: A human post-mortem
study
T. Saunders, C. Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, S. D. Shenkin, S. R. Cox, I. J. Deary, C. Smith, D. King, T. Spires-Jones
Neurobiology of Disease - 2023 -
Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive
Individuals.
Annika Öhrfelt, Andréa Lessa Benedet, Nicholas J. Ashton, Hlin Kvartsberg, Manu Vandijck, Michael W Weiner, John Q Trojanowski, Leslie M Shaw, Henrik Zetterberg, Kaj Blennow
Neurology - 2023 -
Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease
neuropathology.
Przemyslaw R. Kac, Fernándo González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas Karikari
medRxiv : the preprint server for health sciences - 2023 -
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired
individuals.
Joel Simrén, Wagner Scheeren Brum, Nicholas J. Ashton, Andréa Lessa Benedet, Thomas Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Alzheimer's research & therapy - 2022 -
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane
processing.
Tobias A Weber, Johan Lundkvist, Johanna Wanngren, Hlin Kvartsberg, ShaoBo Jin, Pia Larssen, Dan Wu, Daniel V Oliveira, Karolina Minta, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, Gunnar Nordvall, Bengt Winblad, Erik Portelius, Helena Karlström
Journal of cellular and molecular medicine - 2022 -
Molecular forms of neurogranin in cerebrospinal
fluid.
Faisal Hayat Nazir, Elena Camporesi, Gunnar Brinkmalm, Tammaryn Lashley, Christina E Toomey, Hlin Kvartsberg, Henrik Zetterberg, Kaj Blennow, Bruno Becker
Journal of neurochemistry - 2021 -
Amyloid pathology and synaptic loss in pathological
aging
Eleni Gkanatsiou, Johanna Nilsson, C. E. Toomey, A. Vrillon, Hlin Kvartsberg, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, T. Lashley, Gunnar Brinkmalm
Journal of Neurochemistry - 2021 -
Cerebrospinal fluid N-224 tau helps discriminate Alzheimer's disease from subjective cognitive decline and other
dementias
C. Cicognola, O. Hansson, P. Scheltens, Hlin Kvartsberg, Henrik Zetterberg, C. E. Teunissen, Kaj Blennow
Alzheimer's Research & Therapy - 2021 -
CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional
Study.
Marta Milà-Alomà, Ann Brinkmalm, Nicholas J. Ashton, Hlin Kvartsberg, Mahnaz Shekari, Grégory Operto, Gemma Salvadó, Carles Falcon, Juan Domingo Gispert, Natalia Vilor-Tejedor, Eider M Arenaza-Urquijo, Oriol Grau-Rivera, Aleix Sala-Vila, Gonzalo Sanchez-Benavides, José María González-de-Echávarri, Carolina Minguillon, Karine Fauria, Aida Niñerola-Baizán, Andrés Perissinotti, Gwendlyn Kollmorgen, Ivonne Suridjan, Henrik Zetterberg, José Luis Molinuevo, Kaj Blennow, Marc Suárez-Calvet
Neurology - 2021 -
Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer's
disease.
Joana B Pereira, Shorena Janelidze, Rik Ossenkoppele, Hlin Kvartsberg, Ann Brinkmalm, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Brain : a journal of neurology - 2021 -
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human
brain
I. Alic, P. A. Goh, A. Murray, Erik Portelius, Eleni Gkanatsiou, G. Gough, K. Y. Mok, D. Koschut, R. Brunmeir, Y. J. Yeap, N. L. O'Brien, J. Groet, X. W. Shao, S. Havlicek, N. R. Dunn, Hlin Kvartsberg, Gunnar Brinkmalm, R. Hithersay, C. Startin, S. Hamburg, M. Phillips, K. Pervushin, M. Turmaine, D. Wallon, A. Rovelet-Lecrux, H. Soininen, E. Volpi, J. E. Martin, J. N. Foo, D. L. Becker, A. Rostagno, J. Ghiso, Z. Krsnik, G. Simic, I. Kostovi, D. Mitrecic, P. T. Francis, Kaj Blennow, A. Strydom, J. Hardy, Henrik Zetterberg, D. Nizetic
Molecular Psychiatry - 2021 -
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging
Initiative.
Thomas Karikari, Andréa L Benedet, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Paramita Saha-Chaudhuri, Firoza Lussier, Hlin Kvartsberg, Alexis Moscoso Rial, Tharick A Pascoal, Ulf Andreasson, Michael Schöll, Michael W Weiner, Pedro Rosa-Neto, John Q Trojanowski, Leslie M Shaw, Kaj Blennow, Henrik Zetterberg
Molecular psychiatry - 2021 -
Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human
brain.
Ivan Alić, Pollyanna A Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Y Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh L O'Brien, Jürgen Groet, Xiaowei Shao, Steven Havlicek, N Ray Dunn, Hlin Kvartsberg, Gunnar Brinkmalm, Rosalyn Hithersay, Carla Startin, Sarah Hamburg, Margaret Phillips, Konstantin Pervushin, Mark Turmaine, David Wallon, Anne Rovelet-Lecrux, Hilkka Soininen, Emanuela Volpi, Joanne E Martin, Jia Nee Foo, David L Becker, Agueda Rostagno, Jorge Ghiso, Željka Krsnik, Goran Šimić, Ivica Kostović, Dinko Mitrečić, Paul T Francis, Kaj Blennow, Andre Strydom, John Hardy, Henrik Zetterberg, Dean Nižetić
Molecular psychiatry - 2021 -
Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle
pathology.
Kaj Blennow, Chun Chen, Claudia Cicognola, Kristin R Wildsmith, Paul T Manser, Sandra M Sanabria Bohorquez, Zhentao Zhang, Boer Xie, Junmin Peng, Oskar Hansson, Hlin Kvartsberg, Erik Portelius, Henrik Zetterberg, Tammaryn Lashley, Gunnar Brinkmalm, Geoffrey A Kerchner, Robby M Weimer, Keqiang Ye, Kina Höglund
Brain : a journal of neurology - 2020 -
Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic
degeneration.
Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Neurobiology of disease - 2020 -
Full-length and C-terminal neurogranin in Alzheimer's disease cerebrospinal fluid analyzed by novel ultrasensitive
immunoassays
Annika Öhrfelt, J. Dumurgier, Henrik Zetterberg, A. Vrillon, Nicholas J. Ashton, Hlin Kvartsberg, E. Bouaziz-Amar, J. Hugon, C. Paquet, Kaj Blennow
Alzheimers Research & Therapy - 2020 -
Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal
degeneration?
Henrik Zetterberg, Dag Aarsland, Patrizia Vannini, Hlin Kvartsberg, Bengt Winblad, Kaj Blennow, Yvonne Freund-Levi
Alzheimer's research & therapy - 2020 -
Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other
dementias.
Jozef Hanes, Andrej Kovac, Hlin Kvartsberg, Eva Kontsekova, Lubica Fialova, Stanislav Katina, Branislav Kovacech, Eva Stevens, Jakub Hort, Martin Vyhnalek, Lynn Boonkamp, Michal Novak, Henrik Zetterberg, Oskar Hansson, Philip Scheltens, Kaj Blennow, Charlotte E Teunissen, Norbert Zilka
Neurology - 2020 -
The postsynaptic protein neurogranin: a new item in the Alzheimer’s disease biomarker
toolbox
Hlin Kvartsberg
2019 -
The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's
disease.
Hlin Kvartsberg, Tammaryn Lashley, Christina E Murray, Gunnar Brinkmalm, Nicholas C Cullen, Kina Höglund, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Acta neuropathologica - 2019 -
Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl
endopeptidase
Bruno Becker, Faisal Hayat Nazir, Gunnar Brinkmalm, Elena Camporesi, Hlin Kvartsberg, Erik Portelius, Martina Boström, Marie Kalm, Kina Höglund, Maria Olsson, Henrik Zetterberg, Kaj Blennow
Molecular Neurodegeneration - 2018 -
Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and
neuropathology.
Erik Portelius, Bob Olsson, Kina Höglund, Nicholas C Cullen, Hlin Kvartsberg, Ulf Andreasson, Henrik Zetterberg, Åsa P Sandelius, Leslie M Shaw, Virginia M Y Lee, David J Irwin, Murray Grossman, Daniel Weintraub, Alice Chen-Plotkin, David A Wolk, Leo McCluskey, Lauren Elman, Jennifer McBride, Jon B Toledo, John Q Trojanowski, Kaj Blennow
Acta neuropathologica - 2018 -
Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's
Disease.
Philip W Brownjohn, James Smith, Erik Portelius, Lutgarde Serneels, Hlin Kvartsberg, Bart De Strooper, Kaj Blennow, Henrik Zetterberg, Frederick J Livesey
Stem cell reports - 2017 -
Amyloid precursor protein expression and processing are differentially regulated during cortical neuron
differentiation
Petra Bergström, Lotta Agholme, Faisal Hayat Nazir, Tugce Munise Satir, J. Toombs, H. Wellington, Joakim Strandberg, Thomas Olsson Bontell, Hlin Kvartsberg, Maria Holmström, Cecilia Boreström, Stina Simonsson, T. Kunath, Anders Lindahl, Kaj Blennow, Eric Hanse, Erik Portelius, S. Wray, Henrik Zetterberg
Scientific Reports - 2016 -
Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's
disease.
Hlin Kvartsberg, Flora H Duits, Martin Ingelsson, Niels Andreasen, Annika Öhrfelt, Kerstin Andersson, Gunnar Brinkmalm, Lars Lannfelt, Lennart Minthon, Oskar Hansson, Ulf Andreasson, Charlotte E Teunissen, Philip Scheltens, Wiesje M van der Flier, Henrik Zetterberg, Erik Portelius, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2015 -
Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's
disease
K. Hellwig, Hlin Kvartsberg, Erik Portelius, Ulf Andreasson, T. J. Oberstein, P. Lewczuk, Kaj Blennow, J. Kornhuber, J. M. Maler, Henrik Zetterberg, P. Spitzer
Alzheimers Research & Therapy - 2015 -
Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy
controls
Hlin Kvartsberg, Erik Portelius, Ulf Andreasson, Gunnar Brinkmalm, K. Hellwig, N. Lelental, J. Kornhuber, O. Hansson, L. Minthon, P. Spitzer, J. M. Maler, Henrik Zetterberg, Kaj Blennow, P. Lewczuk
Alzheimers Research & Therapy - 2015