Kristina Luthman
Professor Emerita
Department of Chemistry & Molecular-
Nature-Derived Epoxy Resin Monomers with Reduced Sensitizing Capacity-Isosorbide-Based
Bis-Epoxides
I. Karlsson, David J. Ponting, Miguel A. Ortega, Ida B Niklasson, L. Ndreu, E. Johanna L. Steen, Tina Seifert, Kristina Luthman, Ann-Therese Karlberg
Chemical Research in Toxicology - 2023 -
Nature-derived epoxy resins: Synthesis, allergenicity, and thermosetting properties of pinoresinol diglycidyl
ether
Niamh M O'Boyle, Ida B Niklasson, David J. Ponting, Miguel A. Ortega, Tina Seifert, A. Natsch, Kristina Luthman, Ann-Therese Karlberg
Toxicology and Industrial Health - 2022 -
A scaffold replacement approach towards new sirtuin 2
inhibitors
Tina Seifert, Marcus Malo, T. Kokkola, Johanna Stéen, K. Meinander, E. A. A. Wallen, E. M. Jarho, Kristina Luthman
Bioorganic & Medicinal Chemistry - 2020 -
Development of New Epoxy Resin Monomers - A Delicate Balance between Skin Allergy and Polymerization
Properties
David J. Ponting, Miguel A. Ortega, Ida B Niklasson, Isabella Karlsson, Tina Seifert, Johanna Stéen, Kristina Luthman, Ann-Therese Karlberg
Chemical Research in Toxicology - 2019 -
Can the epoxides of cinnamyl alcohol and cinnamal show new cases of contact
allergy?
Lina Hagvall, Ida B Niklasson, Kristina Luthman, Ann-Therese Karlberg
Contact dermatitis - 2018 -
Chroman-4-one and chromone based somatostatin beta-turn
mimetics
Maria Fridén-Saxin, Tina Seifert, Marcus Malo, Krystle da Silva Andersson, Nils Pemberton, Christine Dyrager, Annika Friberg, Kristian Dahlén, Erik A A Wallén, Morten Grøtli, Kristina Luthman
European Journal of Medicinal Chemistry - 2016 -
Identification of the Binding Site of Chroman-4-one Based Sirtuin 2 Selective Inhibitors using Photoaffinity Labeling in Combination with Tandem Mass
Spectrometry
Tina Seifert, Marcus Malo, Johan Lengqvist, Carina Sihlbom, Elina Jarho, Kristina Luthman
Journal of Medicinal Chemistry - 2016 -
Assessment of cross-reactivity of new less sensitizing epoxy resin monomers in epoxy resin-allergic
individuals
Lina Hagvall, Ida B Niklasson, Johanna Rudbäck, Niamh M O'Boyle, Eva Niklasson, Kristina Luthman, Ann-Therese Karlberg
Contact Dermatitis - 2016 -
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53
Interaction
Mariell Pettersson, Maria Quant, J. Min, L. Iconaru, R. W. Kriwacki, M. B. Waddell, R. K. Guy, Kristina Luthman, Morten Grøtli
PLoS ONE - 2015 -
Correction to skin sensitization of epoxyaldehydes: importance of
conjugation.
Tamara Delaine, Lina Hagvall, Johanna Rudbäck, Kristina Luthman, Ann-Therese Karlberg
Chemical research in toxicology - 2014 -
Chroman-4-one- and Chromone-based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer
Cells
Tina Seifert, Marcus Malo, Tarja Kokkola, Karin Engen, Maria Fridén-Saxin, Erik A A Wallén, Maija Lahtela-Kakkonen, Elina Jarho, Kristina Luthman
Journal of Medicinal Chemistry - 2014 -
Epoxyalcohols: bioactivation and conjugation required for skin
sensitization.
Tamara Delaine, David J. Ponting, Ida B Niklasson, Roger Emter, Lina Hagvall, Per-Ola Norrby, Andreas Natsch, Kristina Luthman, Ann-Therese Karlberg
Chemical research in toxicology - 2014 -
Epoxy Resin Monomers with Reduced Skin Sensitizing
Potency
Niamh M O'Boyle, Ida B Niklasson, Ali Reza Tehrani-Bagha, Tamara Delaine, Krister Holmberg, Kristina Luthman, Ann-Therese Karlberg
Chemical Research in Toxicology - 2014 -
Bioactivation of Cinnamic Alcohol Forms Several Strong Skin
Sensitizers
Ida B Niklasson, David J. Ponting, Kristina Luthman, Ann-Therese Karlberg
Chemical Research in Toxicology - 2014 -
Skin Sensitization of Epoxyaldehydes: Importance of
Conjugation.
Tamara Delaine, Lina Hagvall, Johanna Rudbäck, Kristina Luthman, Ann-Therese Karlberg
Chemical research in toxicology - 2013 -
Development of 7TM receptor-ligand complex models using ligand-biased, semi-empirical helix-bundle repacking in torsion space: application to the agonist interaction of the human dopamine D-2
receptor
Marcus Malo, Ronnie Persson, Peder Svensson, Kristina Luthman, Lars Brive
Journal of Computer-Aided Molecular Design - 2013 -
Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3
activity
K. Meinander, J. Weisell, M. Pakkala, A. C. Tadd, C. Hekim, R. Kallionpaa, K. Widell, U. H. Stenman, H. Koistinen, A. Narvanen, J. Vepsalainen, Kristina Luthman, Erik A A Wallén
Medchemcomm - 2013 -
Cinnamyl alcohol oxidizes rapidly upon air
exposure
Ida B Niklasson, Tamara Delaine, Islam Nurul, Roger Karlsson, Kristina Luthman, Ann-Therese Karlberg
Contact Dermatitis - 2013 -
Proline-mediated formation of novel chroman-4-one
tetrahydropyrimidines
Maria Fridén-Saxin, Tina Seifert, L. K. Hansen, Morten Grøtli, Mate Erdelyi, Kristina Luthman
Tetrahedron - 2012 -
A structure activity relationship study of geranial
derivatives
Tamara Delaine, Johanna Rudbäck, Ida B Niklasson, Lina Hagvall, Kristina Luthman, Ann-Therese Karlberg
Contact Dermatitis 11th congress of the European society of contact dermatitis (ESCD) 13-16 june 2012, Malmö, Sweden - 2012 -
Analogues of the epoxy resin monomer diglycidyl ether of Bisphenol F: effects on contact allergenic potency and
cytotoxicity
Niamh M O'Boyle, Tamara Delaine, Kristina Luthman, Andreas Natsch, Ann-Therese Karlberg
Chemical Research in Toxicology - 2012 -
Investigation of D1 receptor-agonist interactions and D1/D2 agonist selectivity using a combination of pharmacophore and receptor homology
modelling
Marcus Malo, Lars Brive, Kristina Luthman, Peder Svensson
ChemMedChem - 2012 -
Investigation of D2 receptor-agonist interactions using a combination of pharmacophore and receptor homology
modelling
Marcus Malo, Lars Brive, Kristina Luthman, Peder Svensson
ChemMedChem - 2012 -
3-Aminopiperidine Based Peptide Analogues as the First Selective Noncovalent Inhibitors of the Bacterial Cysteine Protease
IdeS
Kristina Berggren, Reine Vindebro, Claes Bergström, Christian Spoerry, Helen Persson, Tomas Fex, Jan Kihlberg, Ulrich von Pawel-Rammingen, Kristina Luthman
Journal of Medicinal Chemistry - 2012 -
Structure activity relationships of the epoxy resin
DGEBF
Niamh M O'Boyle, Ida B Niklasson, Tamara Delaine, Andreas Natsch, Kristina Luthman, Ann-Therese Karlberg
11th Congress of the European Society of Contact Dermatitis, 13-16 June 2012, Malmö, Sweden - 2012 -
Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective
Inhibitors
Maria Fridén-Saxin, Tina Seifert, M. R. Landergren, T. Suuronen, M. Lahtela-Kakkonen, E. M. Jarho, Kristina Luthman
Journal of Medicinal Chemistry - 2012 -
Synthesis of Orthogonally Protected Disulfide Bridge
Mimetics
AC Tadd, K Meinander, Kristina Luthman, EAA Wallen
Journal of organic chemistry - 2011 -
Structure-Activity Relationship between the in Vivo Skin Sensitizing Potency of Analogues of Phenyl Glycidyl Ether and the Induction of Nrf2-Dependent Luciferase Activity in the KeratinoSens in Vitro
Assay.
Tamara Delaine, Ida B Niklasson, Roger Emter, Kristina Luthman, Ann-Therese Karlberg, Andreas Natsch
Chemical research in toxicology - 2011 -
Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer
agents.
Christine Dyrager, Malin Wickström, Maria Fridén-Saxin, Annika Friberg, Kristian Dahlén, Erik A A Wallén, Joachim Gullbo, Morten Grøtli, Kristina Luthman
Bioorganic & medicinal chemistry - 2011 -
Impact of a Heteroatom in a Structure-Activity Relationship Study on Analogues of Phenyl Glycidyl Ether (PGE) from Epoxy Resin
Systems.
Ida B Niklasson, Tamara Delaine, Kristina Luthman, Ann-Therese Karlberg
Chemical research in toxicology - 2011 -
Optimization of isochromanone based urotensin II receptor
agonists.
Fredrik Lehmann, Erika A Currier, Roger Olsson, Jian-Nong Ma, Ethan S Burstein, Uli Hacksell, Kristina Luthman
Bioorganic & medicinal chemistry - 2010 -
Selective pharmacophore models of dopamine D(1) and D(2) full agonists based on extended pharmacophore
features.
Marcus Malo, Lars Brive, Kristina Luthman, Peder Svensson
ChemMedChem - 2010 -
KHMDS enhanced SmI(2)-mediated reformatsky type
alpha-cyanation.
Tobias Ankner, Maria Fridén-Saxin, Nils Pemberton, Tina Seifert, Morten Grøtli, Kristina Luthman, Göran Hilmersson
Organic letters - 2010 -
2,6,8-Trisubstituted 3-hydroxychromone derivatives as fluorophores for live-cell
imaging.
Christine Dyrager, Annika Friberg, Kristian Dahlén, Maria Fridén-Saxin, Karl Börjesson, Marcus Wilhelmsson, Maria Smedh, Morten Grøtli, Kristina Luthman
Chemistry (Weinheim an der Bergstrasse, Germany) - 2009 -
Novel and potent small-molecule urotensin II receptor
agonists
Fredrik Lehmann, Erika A. Currier, Bryan Clemons, Lars K. Hansen, Roger Olsson, Uli Hacksell, Kristina Luthman
Bioorganic & Medicinal Chemistry - 2009 -
Synthesis of 2-alkyl-substituted chromone derivatives using microwave
irradiation.
Maria Fridén-Saxin, Nils Pemberton, Krystle da Silva Andersson, Christine Dyrager, Annika Friberg, Morten Grøtli, Kristina Luthman
The Journal of organic chemistry - 2009 -
Reduced Sensitizing Capacity of Epoxy Resin Systems: A Structure-Activity Relationship
Study.
Ida Niklasson, Kerstin Broo, Charlotte A Jonsson, Kristina Luthman, Ann-Therese Karlberg
Chemical research in toxicology - 2009 -
Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence
determinant
Kristina Berggren, Björn Johansson, Tomas Fex, Jan Kihlberg, Lars Björck, Kristina Luthman
Bioorganic & Medicinal Chemistry - 2009 -
The Phospholipid Vesicle-Based Drug Permeability Assay: 5. Development Toward an Automated Procedure for High-Throughput Permeability
Screening
Gøril Eide Flaten, Opeyemi Awoyemi, Kristina Luthman, Martin Brandl, Ulrich Massing
Journal of the Association for Laboratory Automation - 2009 -
Oximes: Metabolic Activation and Structure−Allergenic Activity
Relationships
Moa Andresen Bergström, Sofia Andersson, Kerstin Broo, Kristina Luthman, Ann-Therese Karlberg
Journal of Medicinal Chemistry - 2008 -
Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin
Sensitizers
Ann-Therese Karlberg, Moa Andresen Bergström, Anna Börje, Kristina Luthman, J Lars G Nilsson
Chem. Res. Toxicol. - 2008 -
Drug permeability across a phospholipid vesicle-based barrier: 4. The effect of tensides, co-solvents and pH changes on barrier integrity and on drug
permeability
Goril Eide Flaten, Kristina Luthman, Terje Vasskog, Martin Brandl
European Journal of Pharmaceutical Sciences - 2008 -
Synthesis and evaluation of novel pyridine based PLG
tripeptidomimetics
Stina Saitton, Andria L Del Tredici, Maria Saxin, Tobias Stenström, Jan Kihlberg, Kristina Luthman
Org. Biomol. Chem. - 2008 -
Design, parallel synthesis and SAR of novel urotensin II receptor
agonists
Fredrik Lehmann, Lisa Lake, Erika A. Currier, Roger Olsson, Uli Hacksell, Kristina Luthman
European Journal of Medicinal Chemistry - 2007 -
Synthesis of functionalized, unsymmetrical 1,3,4,6-tetrasubstituted
2,5-diketopiperazines.
Marcus Tullberg, Morten Grøtli, Kristina Luthman
The Journal of organic chemistry - 2007 -
Synthesis of 3-aminomethyl-2-aryl-
8-bromo-6-chlorochromones.
Erik A A Wallén, Kristian Dahlén, Morten Grøtli, Kristina Luthman
Organic letters - 2007 -
Microwave assisted synthesis of
spiro-2,5-diketopiperazines
Fariba Jam, Marcus Tullberg, Kristina Luthman, Morten Grøtli
Tetrahedron - 2007 -
Metabolic epoxidation of an alpha,beta-unsaturated oxime generates sensitizers of extreme potency. Are nitroso intermediates
responsible?
Moa Andresen Bergström, Kristina Luthman, Ann-Therese Karlberg
Chemical Research in Toxicology - 2007 -
Drug permeability across a phospholipid vesicle based barrier: 3. Characterization of drug-membrane interactions and the effect of agitation on the barrier integrity and on the
permeability
G. E. Flaten, M. Skar, Kristina Luthman, M. Brandl
European Journal of Pharmaceutical Sciences - 2007 -
CYP2C9 structure-metabolism relationships: Optimizing the metabolic stability of COX-2
inhibitors
M. M. Ahlström, M. Ridderström, I. Zamora, Kristina Luthman
Journal of Medicinal Chemistry - 2007 -
beta- and -gammaDi- and Tripeptides as Potential Substrates for the Oligopeptide Transporter
hPepT1
Ina Hubatsch, Per I. Arvidsson, Dieter Seebach, Kristina Luthman, Per Artursson
Journal of medicinal chemistry - 2007 -
Taking control of P1, P1 ' and double bond stereochemistry in the synthesis of Phe-Phe (E)-alkene amide isostere
dipeptidomimetics
Daniel Wiktelius, Kristina Luthman
Organic & Biomolecular Chemistry - 2007 -
Novel potent and efficacious nonpeptidic urotensin II receptor
agonists
Fredrik Lehmann, Anna Pettersen, Erika A. Currier, Vladimir Sherbukhin, Roger Olsson, Uli Hacksell, Kristina Luthman
Journal of Medicinal Chemistry - 2006 -
Synthesis of 2,3,6,8-tetrasubstituted chromone
scaffolds.
Kristian Dahlén, Erik A A Wallén, Morten Grøtli, Kristina Luthman
The Journal of organic chemistry - 2006 -
Efficient synthesis of 2,5-diketopiperazines using microwave assisted
heating
Marcus Tullberg, Morten Grøtli, Kristina Luthman
Tetrahedron - 2006 -
Microwave-assisted solid-phase synthesis of 2,5-diketopiperazines: solvent and resin
dependence.
Marcus Tullberg, Kristina Luthman, Morten Grøtli
Journal of combinatorial chemistry - 2006 -
A scaffold approach to 3,6,8-trisubstituted
flavones
Kristian Dahlén, Morten Grøtli, Kristina Luthman
Synlett - 2006 -
Role of the subunit composition of central nicotinic acetylcholine receptors for the stimulatory and dopamine-enhancing effects of
ethanol.
Elisabeth Jerlhag, Morten Grøtli, Kristina Luthman, Lennart Svensson, Jörgen Engel
Alcohol and Alcoholism - 2006 -
Microwave-assisted synthesis of the Schollkopf chiral auxiliaries: (3S)- and
(3R)-3,6-dihydro-2,5-diethoxy-3-isopropyl-pyrazine
Anna-Carin Carlsson, Fariba Jam, Marcus Tullberg, Åke Pilotti, Panos Ioannidis, Kristina Luthman, Morten Grøtli
Tetrahedron Letters - 2006 -
Conjugated dienes as prohaptens in contact allergy: in vivo and in vitro studies of structure-activity relationships, sensitizing capacity, and metabolic
activation.
Moa Andresen Bergström, Kristina Luthman, J Lars G Nilsson, Ann-Therese Karlberg
Chemical research in toxicology - 2006 -
Peracid dependent stereoselectivity and functional group contribution to the stereocontrol of epoxidation of (E)-alkene dipeptide
isosteres
Daniel Wiktelius, W. Berts, A. J. Jensen, Joachim Gullbo, Stina Saitton, I. Csöregh, Kristina Luthman
Tetrahedron - 2006 -
Chemoenzymatic synthesis of enantiomerically enriched alpha-chiral 3-oxy-propionaldehydes by lipase-catalyzed kinetic resolution and
desymmetrization
Daniel Wiktelius, E. K. Larsson, Kristina Luthman
Tetrahedron-Asymmetry - 2006 -
Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive
diffusion.
Gøril Eide Flaten, Anand Babu Dhanikula, Kristina Luthman, Martin Brandl
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 2006 -
Drug permeability across a phospholipid vesicle-based barrier 2. Characterization of barrier structure, storage stability and stability towards pH
changes.
Gøril Eide Flaten, Heike Bunjes, Kristina Luthman, Martin Brandl
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 2006 -
Isochromanone-based urotensin-II receptor
agonists.
Fredrik Lehmann, Erika A Currier, Roger Olsson, Uli Hacksell, Kristina Luthman
Bioorganic & medicinal chemistry - 2005 -
A biocatalytic route to P-chirogenic compounds by lipase-catalyzed desymmetrization of a prochiral
phosphine-borane.
Daniel Wiktelius, Magnus Johansson, Kristina Luthman, Nina Kann
Organic Letters - 2005 -
An alpha,beta-unsaturated oxime identified as a strong contact allergen. Indications of antigen formation via several
pathways.
Anna-Malin Nilsson, Moa Andresen Bergström, Kristina Luthman, J Lars G Nilsson, Ann-Therese Karlberg
Food and chemical toxicology - 2005 -
Design and synthesis of novel chromone based
peptidomimetics
K Dahlén, Morten Grøtli, Kristina Luthman
Biopolymers - 2005 -
A conjugated diene identified as a prohapten: contact allergenic activity and chemical reactivity of proposed epoxide
metabolites.
Anna-Malin Nilsson, Moa Andresen Bergström, Kristina Luthman, J Lars G Nilsson, Ann-Therese Karlberg
Chemical research in toxicology - 2005 -
Benzyl-5-[N-(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoate
Jon Våbenø, T. Ingebrigtsen, T Lejon, Kristina Luthman, L. K Hansen
Acta Crystallographica Section E-Structure Reports Online - 2005 -
Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted
prodrugs.
Jon Våbenø, Carsten Uhd Nielsen, Bente Steffansen, Tore Lejon, Ingebrigt Sylte, Flemming Steen Jørgensen, Kristina Luthman
Bioorganic & medicinal chemistry - 2005 -
Virtual screening and scaffold hopping based on GRID molecular interaction
fields.
Marie M Ahlström, Marianne Ridderström, Kristina Luthman, Ismael Zamora
Journal of chemical information and modeling - 2005 -
Inhibition of the sensitizing effect of carvone by the addition of non-allergenic
compounds.
Anna-Malin Nilsson, Charlotte A Jonsson, Kristina Luthman, J Lars G Nilsson, Ann-Therese Karlberg
Acta dermato-venereologica - 2004 -
A synthetic approach to 2,3,4-substituted pyridines useful as scaffolds for
tripeptidomimetics
Stina Saitton, Jan Kihlberg, Kristina Luthman
Tetrahedron - 2004 -
Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological
investigations.
Jon Våbenø, Tore Lejon, Carsten Uhd Nielsen, Bente Steffansen, Weiqing Chen, Hui Ouyang, Ronald T Borchardt, Kristina Luthman
Journal of medicinal chemistry - 2004 -
Accuracy of calculated pH-dependent aqueous drug
solubility.
Christel A S Bergström, Kristina Luthman, Per Artursson
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 2004 -
Global and local computational models for aqueous solubility prediction of drug-like
molecules.
Christel A S Bergström, Carola M Wassvik, Ulf Norinder, Kristina Luthman, Per Artursson
Journal of chemical information and computer sciences - 2004 -
Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in
vivo.
Joachim Gullbo, Elin Lindhagen, Saadia Bashir-Hassan, Marcus Tullberg, Hans Ehrsson, Rolf Lewensohn, Peter Nygren, Manuel De La Torre, Kristina Luthman, Rolf Larsson
Investigational new drugs - 2004 -
Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: design, synthesis, stability, and biological
investigations.
Jon Våbenø, Carsten Uhd Nielsen, Truls Ingebrigtsen, Tore Lejon, Bente Steffansen, Kristina Luthman
Journal of medicinal chemistry - 2004 -
Design, synthesis and evaluation of a PLG tripeptidomimetic based on a pyridine
scaffold.
Stina Saitton, Andria L Del Tredici, Nina Mohell, Roeland C Vollinga, Dan Boström, Jan Kihlberg, Kristina Luthman
Journal of medicinal chemistry - 2004