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Clotilde Wiel
About Clotilde Wiel
Clotilde Wiel - Research on lung cancer metastasis, to determine how age and redox metabolism impact the metastatic process.
- Read more about her research - Group Clotilde Wiel
- SRC starting grant for research on lung cancer cell migration to new sites
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Monotherapy With Immune Checkpoint Blockade Improves Survival Outcomes in KRAS-Mutant but Not KRAS Wild-Type Metastatic Lung Adenocarcinoma: Validation From an Extended Swedish
Cohort
Ella Äng, Sama Sayin, Jonas Smith Jonsson, Hannes Nilsson van Renswoude, Jan Nyman, Andreas Hallqvist, Clotilde Wiel, Volkan Sayin
JTO CLINICAL AND RESEARCH REPORTS - 2025 -
Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new
inhibitors
Donika Klenja-Skudrinja, Kevin Ali, David Walker, Maureen Higgins, Angana Patel, Dorota Raj, Anna Creelman, Charlotte Mcdowall, Conor Taylor, Tomasz Wenta, Erik Larsson, Clotilde Wiel, Volkan Sayin, Laureano de la Vega
REDOX BIOLOGY - 2025 -
Nuclear AGO2 supports influenza A virus replication through type-I interferon
regulation.
Hsiang-Chi Huang, Michelle Fong, Iwona Nowak, Evgeniia Shcherbinina, Vivian Lobo, Danica F Besavilla, Hang Thuy Huynh, Karin Schön, Jakub O Westholm, Carola Fernandez, Angana A. H. Patel, Clotilde Wiel, Volkan I. Sayin, Dimitrios G Anastasakis, Davide Angeletti, Aishe A. Sarshad
Nucleic Acids Research - 2025 -
Comprehensive genetic variant analysis reveals combination of KRAS and LRP1B as a predictive biomarker of response to immunotherapy in patients with non-small cell lung
cancer.
Ella Äng Eklund, Johanna Svensson, Louise Stauber Näslund, Maria Yhr, Sama I Sayin, Clotilde Wiel, Levent Akyürek, Per Torstensson, Volkan I. Sayin, Andreas Hallqvist, Sukanya Raghavan, Anna Rohlin
Journal of Experimental & Clinical Cancer Research - 2025 -
Equalizing prognostic disparities in KRAS-mutated stage III NSCLC patients: addition of durvalumab to combined chemoradiotherapy improves
survival.
Ella A Eklund, Mathilda Orgard, Delice Wallin, Sama I Sayin, Henrik Fagman, Johan Isaksson, Sukanya Raghavan, Levent Akyürek, Jan Nyman, Clotilde Wiel, Andreas Hallqvist, Volkan I. Sayin
Lung Cancer - 2025 -
Distinct metastatic organotropism shapes prognosis in lung adenocarcinoma with brain
metastasis
Sama I Sayin, Ella M. Eklund, Kevin X. Ali, Jozefina J. Dzanan, Moe Xylander, Martin Dankis, Per Lindahl, Volkan I. Sayin, Andreas Hallqvist, Clotilde Wiel
FRONTIERS IN ONCOLOGY - 2025 -
Assessing the prognostic value of KRAS mutation combined with tumor size in stage I-II non-small cell lung cancer: a retrospective
analysis
Ella A Eklund, Ali Mourad, Clotilde Wiel, Sama I. Sayin, Henrik Fagman, Andreas Hallqvist, Volkan I. Sayin
Frontiers in Oncology - 2024 -
Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein
P.
Maria Schwarz, Caroline E Meyer, Alina Löser, Kristina Lossow, Julian Hackler, Christiane Ott, Susanne Jäger, Isabelle Mohr, Ella A Eklund, Angana A. H. Patel, Nadia Gul, Samantha Alvarez, Ilayda Altinonder, Clotilde Wiel, Maria Maares, Hajo Haase, Anetta Härtlova, Tilman Grune, Matthias B Schulze, Tanja Schwerdtle, Uta Merle, Hans Zischka, Volkan I. Sayin, Lutz Schomburg, Anna P Kipp
Nature communications - 2023 -
Tissue specificity of oncogenic BRAF targeted to lung and thyroid through a shared lineage
factor
Elin Schoultz, Shawn Liang, Therese Carlsson, Stefan Filges, Anders Ståhlberg, Henrik Fagman, Clotilde Wiel, Volkan I. Sayin, Mikael Nilsson
ISCIENCE - 2023 -
SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor
immunity
H. Zhong, W. Lu, Y. Tang, Clotilde Wiel, Y. Wei, J. Cao, G. Riedlinger, T. Papagiannakopoulos, J. Y. Guo, Martin O. Bergö, Y. B. Kang, S. Ganesan, H. E. Sabaawy, S. R. Pine
Oncogene - 2023 -
Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against
BACH1
R. Moreno, L. Casares, M. Higgins, Kevin X. Ali, T. Honda, Clotilde Wiel, Volkan I. Sayin, A. T. Dinkova-Kostova, L. de la Vega
Free Radical Biology and Medicine - 2022 -
Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes
arthritis
Eric Malmhäll-Bah, Karin Andersson, Malin Erlandsson, Murali K Akula, Mikael Brisslert, Clotilde Wiel, Ahmed E El Zowalaty, Volkan I. Sayin, Martin O. Bergö, Maria Bokarewa
Journal of Autoimmunity - 2022 -
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its
activity
L. Casares, R. Moreno, Kevin X. Ali, M. Higgins, S. D. Naidu, G. Neill, L. Cassin, A. E. Kiib, E. B. Svenningsen, A. Minassi, T. Honda, T. B. Poulsen, Clotilde Wiel, Volkan I. Sayin, A. T. Dinkova-Kostova, D. Olagnier, L. de la Vega
Redox Biology - 2022 -
KRAS mutations impact clinical outcome in metastatic non-small cell lung
cancer.
Ella A Eklund, Clotilde Wiel, Henrik Fagman, Levent Akyürek, Sukanya Raghavan, Jan Nyman, Andreas Hallqvist, Volkan I. Sayin
Cancers - 2022 -
Antioxidants promote intestinal tumor progression in
mice.
Zhiyuan V. Zou, Kristell Le Gal, Ahmed E El Zowalaty, Lara Pehlivanoglu, Viktor Garellick, Nadia Gul, Mohamed X Ibrahim, Per-Olof Bergh, Marcus Henricsson, Clotilde Wiel, Levent Akyürek, Martin Bergö, Volkan I. Sayin, Per Lindahl
Antioxidants - 2021 -
Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in
Mice
Kristell Le Gal, Clotilde Wiel, M. X. Ibrahim, Marcus Henricsson, Volkan I. Sayin, M. O. Bergo
Antioxidants - 2021 -
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer
Metastasis
Clotilde Wiel, Kristell Le Gal, M. X. Ibrahim, C. A. Jahangir, M. Kashif, H. D. Yao, Dorian V. Ziegler, X. F. Xu, Tanushree Ghosh, Tanmoy Mondal, Chandrasekhar Kanduri, Per Lindahl, Volkan I. Sayin, Martin O. Bergö
Cell - 2019 -
Antioxidants can increase melanoma metastasis in
mice.
Kristell Le Gal, Mohamed X Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K Akula, Christin Karlsson, Martin Dalin, Levent Akyürek, Per Lindahl, Jonas A Nilsson, Martin Bergö
Science Translational Medicine - 2015