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Giovanni Solinas
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Avd för molekylär och klinisk medicinOm Giovanni Solinas
Läs mer om Giovanni Solinas och hans forskning här (på engelska).
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Prevention of insulin-induced lipohypertrophy by coadministration of a low dose of high-affinity PI3K
inhibitors
Barbara Becattini, Andrea Usseglio Gaudi, Per-Anders Jansson, Giovanni Solinas
METABOLISM-CLINICAL AND EXPERIMENTAL - 2025 -
Harnessing insulin biology to treat diabetes and
cancer
Giovanni Solinas
Science - 2025 -
Ablation of PI3Ky in neurons protects mice from diet-induced obesity MASLD and insulin
resistance
Angela Molinaro, Arianna Mazzoli, Andrea Usseglio Gaudi, Amit Chand Gupta, Vagner Ramon Rodrigues Silva, Damien Ramel, Muriel Laffargue, Johan Ruud, Barbara Becattini, Giovanni Solinas
ISCIENCE - 2025 -
Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and
torpor.
Linda Engström Ruud, Ferran Font Gironès, Joanna Zajdel, Lara Kern, Júlia Teixidor Deulofeu, Louise Mannerås Holm, Alba Carreras, Barbara Becattini, Andreas Björefeldt, Eric Hanse, Henning Fenselau, Giovanni Solinas, Jens C Brüning, Thomas F Wunderlich, Fredrik Bäckhed, Johan Ruud
Cell reports - 2024 -
An adipoincretin effect links adipostasis with insulin
secretion.
Giovanni Solinas, Barbara Becattini
Trends in endocrinology and metabolism - 2024 -
Insulin Hypersecretion as Promoter of Body Fat Gain and
Hyperglycemia.
Bettina Mittendorfer, James D Johnson, Giovanni Solinas, Per-Anders Jansson
Diabetes - 2024 -
Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin
effect.
Barbara Becattini, Angela Molinaro, Marcus Henricsson, Jan Borén, Giovanni Solinas
Cell reports - 2024 -
PI3K and AKT at the Interface of Signaling and
Metabolism.
Giovanni Solinas, Barbara Becattini
Current topics in microbiology and immunology - 2022 -
Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue
Regeneration.
Eileen Dahlke, Toni Engmann, Yaman Anan, Robert Häsler, Giovanni Solinas, Franziska Theilig
International journal of molecular sciences - 2022 -
Somatic ablation of IKKβ in liver and leukocytes is not tolerated in obese mice but hepatic IKKβ deletion improves fatty liver and insulin
sensitivity.
Vagner Ramon Rodrigues Silva, Angela Molinaro, Andrea Usseglio Gaudi, Emanuel Fryk, Claudia Sardi, Maria Hammarlund, Filip Mjörnstedt, Maria E Johansson, Barbara Becattini, Per-Anders Jansson, Giovanni Solinas
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2022 -
JNK1 ablation improves pancreatic β-cell mass and function in db/db diabetic mice without affecting insulin sensitivity and adipose tissue
inflammation.
Arianna Mazzoli, Claudia Sardi, Ludovic Breasson, Franziska Theilig, Barbara Becattini, Giovanni Solinas
FASEB bioAdvances - 2021 -
Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort
study
Emanuel Fryk, Josefin Olausson, Karin Mossberg, Lena Strindberg, M. Schmelz, Helén Brogren, L. M. Gan, S. Piazza, A. Provenzani, Barbara Becattini, L. Lind, Giovanni Solinas, Per-Anders Jansson
Ebiomedicine - 2021 -
PI3K gamma promotes obesity-associated hepatocellular carcinoma by regulating metabolism and
inflammation
Barbara Becattini, Ludovic Breasson, Claudia Sardi, F. Zani, Giovanni Solinas
Jhep Reports - 2021 -
Insulin signaling and glucose metabolism in different hepatoma cell lines deviate from hepatocyte physiology toward a convergent aberrant
phenotype
Angela Molinaro, Barbara Becattini, Giovanni Solinas
Scientific Reports - 2020 -
MBOAT7 is anchored to endomembranes by six transmembrane
domains.
Andrea Caddeo, Oveis Jamialahmadi, Giovanni Solinas, Puija Arturo, Rosellina Margherita Mancina, Piero Pingitore, Stefano Romeo
Journal of structural biology - 2019 -
Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by
RAS.
Angela Molinaro, Barbara Becattini, Arianna Mazzoli, Augusto Bleve, Lucia Radici, Ingela Maxvall, Victoria Rotter Sopasakis, Antonio Molinaro, Fredrik Bäckhed, Giovanni Solinas
Cell Metabolism - 2019 -
Obesity promotes the expansion of metastasis-initiating cells in breast
cancer
M. Bousquenaud, F. Fico, Giovanni Solinas, C. Ruegg, A. Santamaria-Martinez
Breast Cancer Research - 2018 -
Genome-wide multi-omics profiling of the 8p11-p12 amplicon in breast
carcinoma.
Toshima Z Parris, Elisabeth Werner Rönnerman, Hanna Engqvist, Jana Biermann, Katarina Truvé, Szilard Nemes, Eva Forssell-Aronsson, Giovanni Solinas, Anikó Kovács, Per Karlsson, Khalil Helou
Oncotarget - 2018 -
PI3K gamma ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic beta-cell
apoptosis
Ludovic Breasson, Claudia Sardi, Barbara Becattini, Fabio Zani, Giovanni Solinas
Faseb Journal - 2018 -
PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during
obesity.
Ludovic Breasson, Barbara Becattini, Claudia Sardi, Angela Molinaro, Fabio Zani, Romina Marone, Fabrizio Botindari, Mélanie Bousquenaud, Curzio Ruegg, Matthias P Wymann, Giovanni Solinas
Science signaling - 2017 -
JNK at the crossroad of obesity, insulin resistance, and cell stress
response
Giovanni Solinas, Barbara Becattini
Molecular Metabolism - 2017 -
The role of PI3Kγ in metabolism and macrophage
activation.
Giovanni Solinas, Barbara Becattini
Oncotarget - 2017 -
JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative
damage.
Barbara Becattini, Fabio Zani, Ludovic Breasson, D'Agostino Vito, Claudia Sardi, Min-Kyung Choo, Alessandro Provenzani, Jin-Mo Park, Giovanni Solinas
The FASEB Journal - 2016 -
De novo lipogenesis in metabolic homeostasis: More friend than
foe?
Giovanni Solinas, Jan Borén, A. G. Dulloo
Molecular Metabolism - 2015 -
PER2 promotes glucose storage to hepatic glycogen during fasting and refeeding by inducing. Gys-2, PTG, and GL.
expression
Fabio Zani, Ludovic Breasson, Barbara Becattini, Jean-Pierre Montani, Alessandro Provenzani, Urs Albrecht, Juergen Ripperger, Giovanni Solinas
Molecular Metabolism - 2013 -
Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk
factors.
Matthias P Wymann, Giovanni Solinas
Annals of the New York Academy of Sciences - 2013 -
A role for adipose tissue de-novo lipogenesis in glucose homeostasis during catch-up growth: A Randle cycle favouring fat
storage.
Helena Marcelino, Christelle Veyrat-Durebex, Serge Summermatter, Delphine Sarafian, Jennifer Miles-Chan, Denis Arsenijevic, Fabio Zani, Jean-Pierre Montani, Josiane Seydoux, Giovanni Solinas, Abdul G. Dulloo
Diabetes - 2013 -
Molecular pathways linking metabolic inflammation and
thermogenesis.
Giovanni Solinas
Obesity reviews : an official journal of the International Association for the Study of Obesity - 2012 -
High identification rates of endogenous neuropeptides from mouse
brain.
Xiaozhe Zhang, Filomena Petruzziello, Fabio Zani, Laetitia Fouillen, Per E. Andren, Giovanni Solinas, Gregor Rainer
Journal of Proteome Research - 2012 -
Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK
Activation
Ryan G. Holzer, Eek-Joong Park, Ning Li, Helen Tran, Monica Chen, Crystal Choi, Giovanni Solinas, Michael Karin
Cell - 2011 -
PI3Kγ within a Nonhematopoietic Cell Type Negatively Regulates Diet-Induced Thermogenesis and Promotes Obesity and Insulin
Resistance.
Barbara Becattini, Romina Marone, Fabio Zan, Denis Arsenijevic, Josiane Seydoux, Jean-Pierre Montan, Abdul G. Dulloo, Bernard Thorens, Frédéric Preitner, Matthias P. Wymann, Giovanni Solinas
Proceedings of the National Academy of Science of the United States of America - 2011 -
JNK1 and IKKbeta: molecular links between obesity and metabolic
dysfunction.
Giovanni Solinas, Michael Karin
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2010 -
Body composition phenotypes in pathways to obesity and the metabolic
syndrome.
A G Dulloo, J Jacquet, Giovanni Solinas, J-P Montani, Y Schutz
International journal of obesity (2005) - 2010 -
Role of JNK activation in pancreatic β-cell death by
streptozotocin
Hwanju Cheon, Jae Min Cho, Sunshin Kim, Seung-Hoon Baek, Moon-Kyu Lee, Kwang-Won Kim, Seong-Woon Yu, Giovanni Solinas, Soung Soo Kim, Myung-Shik Lee
Molecular and Cellular Endocrinology - 2010 -
Adipose Tissue Plasticity During Catch-Up Fat Driven by Thrifty Metabolism Relevance for Muscle-Adipose Glucose Redistribution During Catch-Up
Growth
Serge Summermatter, Helena Marcelino, Denis Arsenijevic, Antony Buchala, Olivier Aprikian, Françoise Assimacopoulos-Jeannet, Josiane Seydoux, Jean-Pierre Montani, Giovanni Solinas, Abdul G. Dulloo
Diabetes - 2009 -
Identification of a new JNK inhibitor targeting the JNK-JIP interaction
site
John L. Stebbins, Surya K. De, Thomas Machleidt, Barbara Becattini, Jesus Vazquez, Christian Kuntzen, Li-Hsing Chen, Jason F. Cellitti, Megan Riel-Mehan, Aras Emdadi, Giovanni Solinas, Michael Karin, Maurizio Pellecchia
Proceedings of the National Academy of Science of the United States of America - 2008 -
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting
obesity
Giovanni Solinas, Cristian Vilcu, Jaap G Neels, Gautam K Bandyopadhyay, Jun-Li Luo, Willscott Naugler, Sergei Grivennikov, Anthony Wynshaw-Boris, Miriam Scadeng, Jerrold M Olefsky, Michael Karin
Cell Metabolism - 2007 -
Corticotropin-releasing hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid
oxidation
Giovanni Solinas, Serge Summermatter, Davide Mainieri, Marcel Gubler, Jean-Pierre Montani, Josiane Seydoux, SR Smith, Abdul G Dulloo
Endocrinology - 2006 -
The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP L
turnover
Lufen Chang, Hideaki Kamata, Giovanni Solinas, Jun-Li Luo, Shin Maeda, K Venuprasad, Yun-Cai Liu, Michael Karin
Cell - 2006 -
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor
substrates
Giovanni Solinas, Willscott Naugler, Francesco Galimi, Myung-Shik Lee, Michael Karin
Proceedings of the National Academy of Science of the United States of America - 2006 -
The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid
oxidation.
Giovanni Solinas, Serge Summermatter, Davide Mainieri, Marcel Gubler, Luciano Pirola, Matthias P Wymann, Sandro Rusconi, Jean-Pierre Montani, Josiane Seydoux, Abdul G Dulloo
FEBS letters - 2004 -
Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and
glucolipotoxicity.
A G Dulloo, M Gubler, J P Montani, J Seydoux, Giovanni Solinas
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 2004 -
Leptin directly stimulates thermogenesis in skeletal
muscle.
Abdul G Dulloo, Michael J Stock, Giovanni Solinas, Olivier Boss, Jean Pierre Montani, Josiane Seydoux
FEBS letters - 2002 -
Skeletal muscle mitochondrial efficiency and uncoupling protein 3 in overeating rats with increased
thermogenesis.
Susanna Iossa, Maria Pia Mollica, Lillà Lionetti, Raffaella Crescenzo, Monica Botta, Sonia Samec, Giovanni Solinas, Davide Mainieri, Abdul G Dulloo, Giovanna Liverini
Pflügers Archiv : European journal of physiology - 2002 -
Nonradioactive multi-sample protein-protein interaction assay using an epitope tagging
technique.
Giovanni Solinas, M Motto
BioTechniques - 1999 -
Maturation and translation mechanisms involved in the expression of a myb gene of
rice.
F Magaraggia, Giovanni Solinas, G Valle, G Giovinazzo, I Coraggio
Plant molecular biology - 1997