- Hem
- Om universitetet
- Hitta person
- Linda Engström Ruud
Linda Engström Ruud
Forskare
Sektionen för fysiologiOm Linda Engström Ruud
Forskare vid Sektionen för fysiologi
Forskningsprojekt
Anti-obesity treatment and the brain
Forskarporträtt
Linda Engström Ruud vill förstå hur läkemedel mot fetma verkar i hjärnan [27 april 2021]
I media
Viktminskning kopplas till nervceller i hjärnan [www.gu.se, 23 maj 2025]
LäkemedelsVärlden: ”Vill bidra till bättre fetmaläkemedel” [18 nov 2022]
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Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal
complex
Júlia Teixidor Deulofeu, Sebastian Blid Sköldheden, Ferran Font Gironès, Andrej Fejes, Johan Ruud, Linda Engström Ruud
Cell Metabolism - 2025 -
Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and
torpor.
Linda Engström Ruud, Ferran Font Gironès, Joanna Zajdel, Lara Kern, Júlia Teixidor Deulofeu, Louise Mannerås Holm, Alba Carreras, Barbara Becattini, Andreas Björefeldt, Eric Hanse, Henning Fenselau, Giovanni Solinas, Jens C Brüning, Thomas F Wunderlich, Fredrik Bäckhed, Johan Ruud
Cell reports - 2024 -
Melanocortin-4 receptors on neurons in the parabrachial nucleus mediate inflammation-induced suppression of food-seeking
behavior
K. Shionoya, A. Nilsson, Linda Engström Ruud, D. Engblom, A. Blomqvist
Brain, behavior, and immunity - 2023 -
RSPO3 is important for trabecular bone and fracture risk in mice and
humans
Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, T. L. Andersen, C. Ejersted, Jianyao Wu, Karin L. Gustafsson, A. Koskela, J. Tuukkanen, P. P. C. Souza, J. Tuckermann, Mattias Lorentzon, Linda Engström Ruud, T. Lehtimaki, J. H. Tobias, S. R. Zhou, Ulf H Lerner, J. B. Richards, Sofia Moverare-Skrtic, Claes Ohlsson
Nature Communications - 2021 -
NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP
neurons.
Linda Engström Ruud, Mafalda M A Pereira, Alain J de Solis, Henning Fenselau, Jens C Brüning
Nature communications - 2020 -
Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial
Nucleus
Fredrik Anesten, Devesh Mishra, Adria Dalmau Gasull, Linda Engström Ruud, Jakob Bellman, Vilborg Palsdottir, F Zhang, S. Trapp, Karolina P Skibicka, Matti Poutanen, John-Olov Jansson
Neuroendocrinology - 2019 -
The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny
Neurons
Johan Ruud, Jens Alber, Anna Tokarska, Linda Engström Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Änne Lautenschlager, Przemysław E. Cieślak, Łukasz Szumiec, Martin E. Hess, Hella S. Brönneke, Marcus Krüger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C. Brüning
Cell Reports - 2019 -
Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR
Activation.
Claus Brandt, Hendrik Nolte, Sinika Henschke, Linda Engström Ruud, Motoharu Awazawa, Donald A Morgan, Paula Gabel, Hans-Georg Sprenger, Martin E Hess, Stefan Günther, Thomas Langer, Kamal Rahmouni, Henning Fenselau, Marcus Krüger, Jens C Brüning
Cell - 2018 -
Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in
Obesity
Sophie Marie Steculorum, Katharina Timper, Linda Engström Ruud, Nadine Evers, Lars Paeger, Stephan Bremser, Peter Kloppenburg, Jens Claus Brüning
Cell Reports - 2017 -
IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6
trans-Signaling
Katharina Timper, Jesse Lee Denson, Sophie Marie Steculorum, Christian Heilinger, Linda Engström Ruud, Claudia Maria Wunderlich, Stefan Rose-John, F. Thomas Wunderlich, Jens Claus Brüning
Cell Reports - 2017 -
The Sense of Smell Impacts Metabolic Health and
Obesity
Celine E. Riera, Eva Tsaousidou, Jonathan Halloran, Patricia Follett, Oliver Hahn, Mafalda M.A. Pereira, Linda Engström Ruud, Jens Alber, Kevin Tharp, Courtney M. Anderson, Hella Brönneke, Brigitte Hampel, Carlos Daniel de Magalhaes Filho, Andreas Stahl, Jens C. Brüning, Andrew Dillin
Cell Metabolism - 2017 -
AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose
Tissue.
Sophie M Steculorum, Johan Ruud, Ismene Karakasilioti, Heiko Backes, Linda Engström Ruud, Katharina Timper, Martin E Hess, Eva Tsaousidou, Jan Mauer, Merly C Vogt, Lars Paeger, Stephan Bremser, Andreas C Klein, Donald A Morgan, Peter Frommolt, Paul T Brinkkötter, Philipp Hammerschmidt, Thomas Benzing, Kamal Rahmouni, F Thomas Wunderlich, Peter Kloppenburg, Jens C Brüning
Cell - 2016 -
Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting
cyclooxygenase-2
Linda Engström Ruud, Daniel Björk Wilhelms, Anna Eskilsson, Ana Maria Vasilache, Louise Elander, David Engblom, Anders Blomqvist
Neuropharmacology - 2013 -
Cancer-induced anorexia in tumor-bearing mice is dependent on
cyclooxygenase-1.
Johan Ruud, Anna Nilsson, Linda Engström Ruud, Wenhua Wang, Camilla Nilsberth, Britt-Marie Iresjö, Kent Lundholm, David Engblom, Anders Blomqvist
Brain, behavior, and immunity - 2013 -
Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial
cells
Linda Engström, Johan Ruud, Anna Eskilsson, Anders Larsson, Ludmila Mackerlova, Unn Kugelberg, Hong Qian, Ana Maria Vasilache, Peter Larsson, David Engblom, Mikael Sigvardsson, Jan Ingvar Jönsson, Anders Blomqvist
Endocrinology - 2012 -
The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin
e2
Camilla Nilsberth, Louise Elander, Namik Hamzic, Maria Norell, Johanna Lönn, Linda Engström, Anders Blomqvist
Endocrinology - 2009 -
Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune
challenge
Louise Elander, Linda Engström, Johan Ruud, Ludmila Mackerlova, Per Johan Jakobsson, David Engblom, Camilla Nilsberth, Anders Blomqvist
Journal of Neuroscience - 2009 -
Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal
gland
Linda Engström, Khadijah Rosén, Anna Angel, Anna Fyrberg, Ludmila Mackerlova, Jan Pieter Konsman, David Engblom, Anders Blomqvist
Endocrinology - 2008 -
IL-1β and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E
synthase-1
Louise Elander, Linda Engström, Martin Hallbeck, Anders Blomqvist
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - 2007 -
Lipopolysaccharide induces preproenkephalin transcription in hypophysiotropic neurons of the rat paraventricular hypothalamic nucleus suggesting a neuroendocrine role for enkephalins during immune
stress
Linda Engström, L. Mackerlova, A. Blomqvist
Neuroscience - 2006 -
Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E
synthase-1
Sipra Saha, Linda Engström, Ludmila Mackerlova, Per Johan Jakobsson, Anders Blomqvist
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - 2005 -
Systemic immune challenge induces preproenkephalin gene transcription in distinct autonomic structures of the rat
brain
Linda Engström, David Engblom, Anders Blomqvist
Journal of Comparative Neurology - 2003 -
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced
pyresis
David Engblom, Sipra Saha, Linda Engström, Marie Westman, Laurent P. Audoly, Per Johan Jakobsson, Anders Blomqvist
Nature Neuroscience - 2003 -
Preproenkephalin mRNA expression in rat parabrachial neurons: Relation to cells activated by systemic immune
challenge
Linda Engström, David Engblom, Unn Örtegren, Ludmila Mackerlova, Jakob Paues, Anders Blomqvist
Neuroscience Letters - 2001