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Kyong-Su Park
Researcher
Department of Internal Medicine and Clinical NutritionAbout Kyong-Su Park
About Kyong-Su Park
Kyong-Su Park is Associate Professor at Krefting Research Centre, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg, Sweden. His research interests involve the development of a comprehensive understanding of extracellular vesicles (EV) from mammalian and bacteria with over 18 years experiences in molecular biology, microbiology and immunology. Especially, he pursues to develop the technology to manipulate bio-mimetic EV such as synthetic eukaryotic vesicles (SyEV) and synthetic bacterial vesicles (SyBV), and then translate the SyEV/SyBV platform into specific therapeutics for inflammation and cancer.
He received his PhD in 2014 from Pohang University of Science and Technology (POSTECH), South Korea, under the supervision of Prof. Yong Song Gho. Following the completion of his doctoral studies, he worked at Hanmi Pharmaceutical Co., Ltd., South Korea (2014-2016), where he gained clinical experience and focused on clinical development strategies for anti-diabetic and anti-obesity drugs. He then returned to the EV field and worked as a postdoctoral fellow (2016-2021) in collaboration with Prof. Jan Lötvall at the Krefting Research Centre. Since 2022, he has been permanently employed in the same department.
His research has not only focused on the medical application of EV but also on understanding molecular mechanisms underlying disease pathogenesis. In particular, He has investigated the roles of EV in disease development and progression by identifying molecular pathways and functional biomolecules involved in EV-mediated intercellular communication. Furthermore, he has studied how engineered bio-mimetic EV (from mesenchymal stem cells or bacteria) can function as drug candidates by elucidating their molecular mechanisms of action, including their roles in inducing vaccine responses and therapeutic effects. These studies have resulted in multiple peer-reviewed scientific publications describing molecular mechanisms and functional properties of EV.
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Frozen melanoma tissues yield extracellular vesicles with preserved diagnostic and immunogenic
properties
Daniele DArrigo, Kyong-Su Park, Cecilia Lässer, Georgios Panagiotis Sigalas, Emma Symonds, Ornella Urzi, Camilla Locatelli, Roger Olofsson Bagge, Jan Lötvall, Rossella Crescitelli
BMC MEDICINE - 2026 -
Quantitative proteomic and functional comparison of extracellular vesicles from multiple adipose tissue mesenchymal stem cell
donors
Kyong-Su Park, Dae Hyun Ha, Jun Ho Lee, Negar Ordouzadeh, Markus Bergqvist, Hyun Ju Lee, Ella Shin, Byong Seung Cho, Jan Lötvall
Extracellular Vesicles and Circulating Nucleic Acids - 2026 -
Development of Anti-Inflammatory Extracellular Vesicles by Surface Expression of
Syndecan-4
Lijuan Yu, Markus Bergqvist, Kyong-Su Park, Cecilia Lässer, Jan Lötvall
Journal of Extracellular Vesicles - 2026 -
STING Agonist Drug Delivery by Bacterial Extracellular Vesicles Induces Synergistic Immuno-Oncology Responses and Efficient Inhibition of Tumour
Growth
Jan Lötvall, Negar Ordouzadeh, Rossella Crescitelli, Meghshree Deshmukh, Tao Jin, Kyong-Su Park
Journal of Extracellular Vesicles - 2025 -
Optimization of the Isolation Method for Large-Scale Production of Synthetic Bacterial Vesicles for Cancer
Immunotherapy
Negar Ordouzadeh, Rossella Crescitelli, Agnes Zimmer, Petra Tjarnlund, Cecilia Lässer, Jan Lötvall, Kyong-Su Park
ADVANCED THERAPEUTICS - 2025 -
A Non-Centrifugation Method to Concentrate and Purify Extracellular Vesicles Using Superabsorbent Polymer Followed by Size Exclusion
Chromatography
Markus Bergqvist, Cecilia Lässer, Rossella Crescitelli, Kyong-Su Park, Jan Lötvall
JOURNAL OF EXTRACELLULAR VESICLES - 2025 -
An Anti-Myd88 Peptide Synergistically Enhances the Anti-Inflammatory Effects of Extracellular Vesicles from Naïve Umbilical Cord MSC or HEK293F CD24 Overexpressing
Cells
Burcin Irem Abas, Markus Bergqvist, Lijuan Yu, Yi Wang, Mario Gimona, Kyong-Su Park, Jan Lötvall
ADVANCED MATERIALS INTERFACES - 2025 -
Extracellular vesicles and the lung: from disease pathogenesis to biomarkers and
treatments
Kyong-Su Park, Cecilia Lässer, Jan Lötvall
PHYSIOLOGICAL REVIEWS - 2025 -
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial
cells
Markus Bergqvist, Kyong-Su Park, Nasibeh Karimi, Lijuan Yu, Cecilia Lässer, Jan Lötvall
JOURNAL OF NANOBIOTECHNOLOGY - 2025 -
Effects of mesenchymal stem cell-derived nanovesicles in experimental allergic airway
inflammation
Elga Bandeira, Su Chul Jang, Cecilia Lässer, Kristina Johansson, Madeleine Rådinger, Kyong-Su Park
Respiratory Research - 2023 -
Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and
SARS-CoV-2
Kyong-Su Park, Kristina Svennerholm, Rossella Crescitelli, Cecilia Lässer, Inta Gribonika, Mickael Andersson, Jonas Boström, Hanna Alalam, Ali M Harandi, Anne Farewell, Jan Lötvall
Journal of Nanobiotechnology - 2023 -
Targeting Myd88 using peptide-loaded mesenchymal stem cell membrane-derived synthetic vesicles to treat systemic
inflammation
Kyong-Su Park, Markus Bergqvist, Cecilia Lässer, Jan Lötvall
Journal of Nanobiotechnology - 2022 -
Immune-Associated Proteins Are Enriched in Lung Tissue-Derived Extracellular Vesicles during Allergen-Induced Eosinophilic Airway
Inflammation
Cecilia Lässer, Yasunari Kishino, Kyong-Su Park, Ganesh V Shelke, Nasibeh Karimi, Shintaro Suzuki, Lilit Hovhannisyan, Madeleine Rådinger, Jan Lötvall
International Journal of Molecular Sciences - 2021 -
Synthetic bacterial vesicles combined with tumour extracellular vesicles as cancer
immunotherapy
Kyong-Su Park, Kristina Svennerholm, Rossella Crescitelli, Cecilia Lässer, Inta Gribonika, Jan Lötvall
Journal of Extracellular Vesicles - 2021 -
Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular
vesicles
Kyong-Su Park, Elga Bandeira, Ganesh V Shelke, Cecilia Lässer, Jan Lötvall
Stem Cell Research & Therapy - 2019 -
Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via
IL-10.
Kyong-Su Park, Kristina Svennerholm, Ganesh V Shelke, Elga Bandeira, Cecilia Lässer, Su Chul Jang, Rakesh Chandode, Inta Gribonika, Jan Lötvall
Stem cell research & therapy - 2019 -
Escherichia coli outer membrane vesicles can contribute to sepsis induced cardiac
dysfunction.
Kristina Svennerholm, Kyong-Su Park, Johannes Wikström, Cecilia Lässer, Rossella Crescitelli, Ganesh V Shelke, Su Chul Jang, Shintaro Suzuki, Elga Bandeira, Charlotta S Olofsson, Jan Lötvall
Scientific reports - 2017