- Hem
- Om universitetet
- Hitta person
- Helena Carén
Helena Carén
Professor
Avd för medicinsk kemi och cellbiologiOm Helena Carén
Helena Carén is Professor at the Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the University of Gothenburg. She obtained her PhD in 2009 working on the childhood tumour neuroblastoma. Following a postdoctoral stay at University College London between 2010-2012, exploring the concept of differentiation therapy for the brain tumour glioblastoma, she established her own lab at the Sahlgrenska Center for Cancer research in Gothenburg. Her research aims to improve current diagnostic methods and to decipher tumourigenic mechanisms of CNS tumours using patient-derived cell cancer stem cell models. Please visit https://www.gu.se/en/research/helena-caren for more info.
-
DNA methylation profiling for molecular classification of
neuroblastoma
Maja Löfgren, Anna Djos, Shiva Rezaei, Medha Suman, Per Kogner, Tommy Martinsson, Susanne Fransson, Helena Carén
CLINICAL EPIGENETICS - 2025 -
CDKN2A/B status versus morphology in diagnosing WHO grade 4 IDH-mutated astrocytomas: what is the clinical
relevance?
Anna Lipatnikova, Teresia Kling, Anna Dénes, Louise Carstam, Alba Corell, Malin Blomstrand, Sandra Ferreyra Vega, Dima Harba, Thomas Olsson Bontell, Helena Carén, Asgeir Store Jakola
JOURNAL OF NEURO-ONCOLOGY - 2025 -
Long-term clinical outcome of 103 patients with acromegaly after pituitary
surgery
Anna Pennlund, Daniela Esposito, Thomas Olsson Bontell, Thomas Skoglund, Tobias Hallén, Helena Carén, Gudmundur Johannsson, Daniel S Olsson
PITUITARY - 2025 -
A pilocytic astrocytoma with novel ATG16L1::NTRK2 fusion responsive to larotrectinib: a case report with genomic and functional
analysis
Lily Deland, Simon Keane, Thomas Olsson Bontell, Tomas Sjoberg Bexelius, Inga Gudinaviciene, Esther De La Cuesta, Francesca De Luca, Jonas A Nilsson, Helena Carén, Helena Morse, Frida Abel
ONCOLOGIST - 2024 -
Altered methylation of imprinted genes in neuroblastoma: implications for prognostic
refinement
Medha Suman, Maja Löfgren, Susanne Fransson, Jewahri Idris Yousuf, Johanna Svensson, Anna Djos, Tommy Martinsson, Per Kogner, Teresia Kling, Helena Carén
JOURNAL OF TRANSLATIONAL MEDICINE - 2024 -
Refinement of prognostication for IDH-mutant astrocytomas using DNA methylation-based
classification
Teresia Kling, Sandra Ferreyra Vega, Medha Suman, Anna Dénes, Anna Lipatnikova, Stina Lagerström, Thomas Olsson Bontell, Asgeir Store Jakola, Helena Carén
BRAIN PATHOLOGY - 2024 -
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor
morphology
Swenja Goedicke, Catena Kresbach, Max Ehlert, Denise Obrecht, Lea Altendorf, Karoline Hack, Katja von Hoff, Helena Carén, Viktoria Melcher, Kornelius Kerl, Bernhard Englinger, Mariella Filbin, Kristian W. Pajtler, Johannes Gojo, Torsten Pietsch, Stefan Rutkowski, Ulrich Schueller
ACTA NEUROPATHOLOGICA - 2024 -
Telomere Maintenance Mechanisms in a Cohort of High-Risk Neuroblastoma Tumors and Its Relation to Genomic Variants in the TERT and ATRX
Genes
Anna Djos, Ketan Thombare, Roshan Vaid, Jennie Gaarder, Ganesh Umapathy, Susanne E Reinsbach, Kleopatra Georgantzi, Jakob Stenman, Helena Carén, Torben Ek, Tanmoy Mondal, Per Kogner, Tommy Martinsson, Susanne Fransson
CANCERS - 2023 -
Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell
growth
A. Zisi, D. C. Kanellis, S. Moussaud, Ida Karlsson, Helena Carén, L. Braeutigam, J. Bartek, M. S. Lindstrom
Neuro-Oncology - 2023 -
The clinical value of proneural, classical and mesenchymal protein signatures in WHO 2021 adult-type diffuse lower-grade
gliomas.
Anna Dénes, Thomas Olsson , Hanna Barchéus, Sandra Ferreyra Vega, Helena Carén, Cecilia Lindskog, Asgeir Store Jakola, Anja Smits
PloS one - 2023 -
Stalled oligodendrocyte differentiation in IDH-mutant
gliomas.
Yanfei Wei, Guanzhang Li, Jing Feng, Fan Wu, Zheng Zhao, Zhaoshi Bao, Wei Zhang, Xiaodong Su, Jiuyi Li, Xueling Qi, Zejun Duan, Yunqiu Zhang, Sandra Ferreyra Vega, Asgeir Store Jakola, Yingyu Sun, Helena Carén, Tao Jiang, Xiaolong Fan
Genome medicine - 2023 -
Distinct Cholesterol Localization in Glioblastoma Multiforme Revealed by Mass Spectrometry
Imaging.
Mai H Philipsen, Ellinor Hansson, Auraya Manaprasertsak, Stefan Lange, Eva Jennische, Helena Carén, Kliment Gatzinsky, Asgeir Store Jakola, Emma U Hammarlund, Per Malmberg
ACS chemical neuroscience - 2023 -
Longitudinal DNA methylation analysis of adult-type IDH-mutant
gliomas.
Sandra Ferreyra Vega, Thomas Olsson Bontell, Teresia Kling, Asgeir Store Jakola, Helena Carén
Acta neuropathologica communications - 2023 -
CRISPR-Cas9 knockout screen identifies novel treatment targets in childhood high-grade
glioma
Anna Wenger, Ida Karlsson, Teresia Kling, Helena Carén
Clinical Epigenetics - 2023 -
Genome-Wide DNA Methylation Differences in Nonfunctioning Pituitary Adenomas With and Without Postsurgical
Progression
Tobias Hallén, Gudmundur Johannsson, Rahil Dahlén, Camilla A M Glad, C. Orndal, A. Engvall, Helena Carén, Thomas Skoglund, Daniel S Olsson
Journal of Clinical Endocrinology & Metabolism - 2022 -
Stemness and clinical features in relation to the subventricular zone in diffuse lower-grade glioma: an exploratory
study.
Alba Corell, Tomás Gomez Vecchio, Sandra Ferreyra Vega, Anna Dénes, Alice Neimantaite, Alexander Hagerius, Hanna Barcheus, Ole Solheim, Cecilia Lindskog, Thomas Olsson Bontell, Helena Carén, Asgeir Store Jakola, Anja Smits
Neuro-oncology advances - 2022 -
DNA methylation alterations across time and space in paediatric brain
tumours
Anna Wenger, Sandra Ferreyra Vega, Elizabeth Schepke, Maja Löfgren, Thomas Olsson Bontell, M. Tisell, Daniel Nilsson, Teresia Kling, Helena Carén
Acta Neuropathologica Communications - 2022 -
Spatial heterogeneity in DNA methylation and chromosomal alterations in diffuse gliomas and
meningiomas
Sandra Ferreyra Vega, Anna Wenger, Teresia Kling, Thomas Olsson Bontell, Asgeir Store Jakola, Helena Carén
Modern Pathology - 2022 -
Orthotopic Transplantation of Human Paediatric High-Grade Glioma in Zebrafish
Larvae
Susanna Larsson, Petronella Kettunen, Helena Carén
Brain Sciences - 2022 -
Methylation Profiling in Diffuse Gliomas: Diagnostic Value and
Considerations
Anna Wenger, Helena Carén
Cancers - 2022 -
WHO Grade Loses Its Prognostic Value in Molecularly Defined Diffuse Lower-Grade
Gliomas.
Louise Carstam, Alba Corell, Anja Smits, Anna Dénes, Hanna Barchéus, Klara Modin, Helene Sjögren, Sandra Ferreyra Vega, Thomas Olsson Bontell, Helena Carén, Asgeir Store Jakola
Frontiers in oncology - 2022 -
DNA methylation profiling for molecular classification of adult diffuse lower-grade
gliomas.
Sandra Ferreyra Vega, Thomas Olsson Bontell, Alba Corell, Anja Smits, Asgeir Store Jakola, Helena Carén
Clinical epigenetics - 2021 -
A randomized phase II trial of efficacy and safety of the immunotherapy ALECSAT as an adjunct to radiotherapy and temozolomide for newly diagnosed
glioblastoma.
Katja Werlenius, Giuseppe Stragliotto, Michael Strandeus, Malin Blomstrand, Helena Carén, Asgeir Store Jakola, Bertil Rydenhag, Dorte Dyregaard, Karine N Dzhandzhugazyan, Alexei F Kirkin, Martin K Raida, Anja Smits, Sara Kinhult
Neuro-oncology advances - 2021 -
Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver
Tissue.
Nidal Ghosheh, Barbara Küppers-Munther, Annika Asplund, Christian X Andersson, Petter Björquist, Tommy B Andersson, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren
ACS omega - 2020 -
DNA methylation-based age estimation in pediatric healthy tissues and brain
tumors.
Teresia Kling, Anna Wenger, Helena Carén
Aging - 2020 -
The clinical significance of the T2-FLAIR mismatch sign in grade II and III gliomas: a population-based
study.
Alba Corell, Sandra Ferreyra Vega, Nickoleta Hoefling, Louise Carstam, Anja Smits, Thomas Olsson Bontell, Isabella Björkman-Burtscher, Helena Carén, Asgeir Store Jakola
BMC cancer - 2020 -
Patterns of care and clinical outcome in assumed glioblastoma without tissue diagnosis: A population-based study of 131 consecutive
patients.
Katja Werlenius, Boglarka Fekete, Malin Blomstrand, Helena Carén, Asgeir Store Jakola, Bertil Rydenhag, Anja Smits
PloS one - 2020 -
Accumulation of DNA methylation alterations in paediatric glioma stem cells following fractionated dose
irradiation
Anna Danielsson, Kristell Barreau, Teresia Kling, Magnus Tisell, Helena Carén
Clinical Epigenetics - 2020 -
The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem
cells
G. Mazor, L. Levin, D. Picard, U. Ahmadov, Helena Carén, A. Borkhardt, G. Reifenberger, G. Leprivier, M. Remke, B. Rotblat
Cell Death & Disease - 2019 -
Intra-Tumor DNA Methylation Heterogeneity in Glioblastoma; Implications for DNA Methylation-Based
Classification.
Anna Wenger, Sandra Ferreyra Vega, Teresia Kling, Thomas Bontell, Asgeir Store Jakola, Helena Carén
Neuro-oncology - 2019 -
Methylation Analysis Using Microarrays: Analysis and
Interpretation.
Teresia Kling, Helena Carén
Methods in molecular biology (Clifton, N.J.), Tumor Profiling - 2019 -
The Gothenburg population-based glioblastoma research database: Methodological aspects and potential
impact
Boglarka Fekete, Katja Werlenius, Helena Carén, Anneli Ozanne, Lars Rosengren, Henrik Zetterberg, Magnus Tisell, Anja Smits, Fredrik Pontén, Cecilia Lindskog, Thomas Olsson Bontell, Asgeir Store Jakola, Bertil Rydenhag
Neurology and Neurosurgery - 2019 -
Individual Assignment of Adult Diffuse Gliomas into the EM/PM Molecular Subtypes Using a TaqMan Low-Density
Array.
Jiuyi Li, Yang Xue, Anna Wenger, Yingyu Sun, Zheng Wang, Chuan-Bao Zhang, Yunqiu Zhang, Boglarka Fekete, Bertil Rydenhag, Asgeir Store Jakola, Tao Jiang, Helena Carén, Xiaolong Fan
Clinical cancer research : an official journal of the American Association for Cancer Research - 2019 -
Cell line-based xenograft mouse model of paediatric glioma stem cells mirrors the clinical course of the
patient
Susanna Larsson, Anna Wenger, S. Dosa, Magnus Sabel, Teresia Kling, Helena Carén
Carcinogenesis - 2018 -
Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory
axis
Tanmoy Mondal, Prasanna Kumar Juvvuna, Agnete Kirkeby, Sanhita Mitra, Subazini Thankaswamy Kosalai, Larissa Traxler, Falk Hertwig, Sara Wernig-Zorc, Caroline Miranda, Lily Deland, Christoph Bartenhagen, Ruth Volland, Deniz Bartsch, Sashidar Bandaru, Anne Engesser, Santhilal Subhash, Tommy Martinsson, Helena Carén, Levent Akyürek, Leo Kurian, Meena Kanduri, Maite Huarte, Per Kogner, Matthias Fischer, Chandrasekhar Kanduri
Cancer Cell - 2018 -
Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem
Cells.
Anna Wenger, Katja Werlenius, Alexander Hallner, Fredrik Bergh Thorén, Dan Farahmand, Magnus Tisell, Anja Smits, Bertil Rydenhag, Asgeir Store Jakola, Helena Carén
Neoplasia - 2018 -
Stem cell cultures derived from pediatric brain tumors accurately model the originating
tumors.
Anna Wenger, Susanna Larsson, Anna Danielsson, Kirstine Juul Elbæk, Petronella Kettunen, Magnus Tisell, Magnus Sabel, Birgitta Lannering, Claes Nordborg, Elizabeth Schepke, Helena Carén
Oncotarget - 2017 -
High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor
response
O. Arrizabalaga, L. Moreno-Cugnon, J. Auzmendi-Iriarte, P. Aldaz, II de Caceres,, L. Garros-Regulez, V. Moncho-Amor, S. Torres-Bayona, O. Pernia, L. Pintado-Berninches, P. Carrasco-Ramirez, M. Cortes-Sempere, R. Rosas, P. Sanchez-Gomez, I. Ruiz, Helena Carén, S. Pollard, I. Garcia, A. A. Sacido, R. Lovell-Badge, C. Belda-Iniesta, N. Sampron, R. Perona, A. Matheu
Oncogenesis - 2017 -
Pediatric brain tumor cells release exosomes with a miRNA repertoire that differs from exosomes secreted by normal
cells
Ágota Tüzesi, Teresia Kling, Anna Wenger, Taral R Lunavat, Su Chul Jang, Bertil Rydenhag, Jan Lötvall, S. M. Pollard, Anna Danielsson, Helena Carén
Oncotarget - 2017 -
Validation of the MethylationEPIC BeadChip for fresh-frozen and formalin-fixed paraffin-embedded
tumours.
Teresia Kling, Anna Wenger, Stephan Beck, Helena Carén
Clinical epigenetics - 2017 -
Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver
tissue
Nidal Ghosheh, B. Kuppers-Munther, A. Asplund, J. Edsbagge, B. Ulfenborg, T. B. Andersson, P. Bjorquist, C. X. Andersson, Helena Carén, Stina Simonsson, P. Sartipy, J. Synnergren
Physiological Genomics - 2017 -
Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-beta delineate two distinct groups of children with brain
tumors
E. Sanden, J. E. Perez, E. Visse, M. Kool, Helena Carén, P. Siesjo, A. Darabi
Pediatr Blood Cancer - 2016 -
Differentiation therapy for glioblastoma - too many
obstacles?
Helena Carén, Stephan Beck, Steven M Pollard
Molecular & cellular oncology - 2016 -
Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma
tumors
Maja Olsson, S. Beck, P. Kogner, Tommy Martinsson, Helena Carén
Epigenetics - 2016 -
Alterations in Tumor DNA Are Related to Short Postoperative Survival in Patients Resected for Pancreatic Carcinoma Aimed at
Cure.
Annika Gustafsson Asting, David Ljungman, Helena Carén, Zilvinas Dambrauskas, Britt-Marie Iresjö, Anders Hyltander, Peter Naredi, Kent Lundholm
Pancreas - 2016 -
Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell
Lines
Nidal Ghosheh, B. Olsson, J. Edsbagge, B. Kuppers-Munther, M. Van Giezen, A. Asplund, T. B. Andersson, P. Bjorquist, Helena Carén, Stina Simonsson, P. Sartipy, J. Synnergren
Stem Cells International - 2016 -
Stability of patient-derived in vitro cultures of stem-like cells from high-grade paediatric brain
tumours.
Susanna Larsson, Anna Danielsson, Anna Wenger, Magnus Tisell, Magnus Sabel, Birgitta Lannering, Elizabeth Schepke, Helena Carén
Neuro-Oncology - 2016 -
MethPed: an R package for the identification of pediatric brain tumor
subtypes
MT Ahamed, Anna Danielsson, S. Nemes, Helena Carén
Bmc Bioinformatics - 2016 -
Rapid and specific hypomethylation of enhancers in endothelial cells during adaptation to cell
culturing.
Mia Magnusson, Pia Larsson, Emma Xuchun Lu, Niklas Bergh, Helena Carén, Sverker Jern
Epigenetics - 2016 -
Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric
medulloblastomas
E. Sanden, C. Dyberg, Cecilia Krona, E. Visse, Helena Carén, P. A. Northcott, M. Kool, N. Stahl, A. Persson, E. Englund, J. I. Johnsen, P. Siesjo, A. Darabi
Journal of Neuro-Oncology - 2015
Fler publikationer
Antalet publikationer som visas på denna sida är begränsat. Besök Göteborgs Universitets publikationsdatabas (GUP) för att söka efter fler publikationer.