Modelling neuroblastoma using human trunk neural crest cells
Tanmoy Mondal's group focuses on neuroblastoma (NB), a childhood cancer. NB is thought to be derived due to lack of differentiation of trunk neural crest cells (tNCC) during embryonic development. MYCN oncogene amplification is the most common genomic aberration in NB. 50 percent of NB patients with aggressive form of the disease, often do not respond to currently available therapy and better treatment strategies are required for these patients. Understanding how MYCN promotes tumor formation in NB can give us clues on how to treat NB patients who have aggressive disease with MYCN amplification.