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Mechanisms of toxicity - Chemical interactions in fish (CYP-lab)

Research project

Short description

We are interested in the physiology and the molecular mechanisms behind adverse chemical interactions in fish exposed to mixtures of chemicals. Our project focuses on key mechanisms in detoxification pathways and how chemicals alone and in mixtures interact with these pathways in cultured fish cells. We hypothesis that by describing “bottlenecks” in chemical elimination pathways new alternative models can be developed. These models can be used to assess and forecast unwanted synergistic mixture effect between different classes of substances including steroid hormones, pharmaceuticals and aromatic hydrocarbons. We have created a new conceptual toxicokinetic model, based on experimental data from our lab.

Members

Malin Celander (professor)

Charlotte Alvord (PhD-student)

Maja Edenius  (postdoc)

Ongoing collaborations

Torbjörn Lundh (professor) Department of Mathematical Sciences, Chalmers Technical University and University of Gothenburg

Anders Goksøyr (professor) dCod-project

John Stegeman (professor) Superfund Research Program at Boston University and Woods Hole Oceanographic Institution

Maria Granberg IVL

Publications

In October 2020 we published the first "CYPerModel" from the ongoing project. 

"New Conceptual Toxicokinetic Model to Assess Synergistic Mixture Effects between the Aromatic Hydrocarbon β‑Naphthoflavone and the Azole Nocodazole on the CYP1A Biomarker in a Fish Cell Line"

Fallahi S, Minariková M, Alvord C, Alendal G, Frøysa HG, Lundh T, Celander MC. Environ. Sci. Technol. 2020, 54, 21, 13748–13758

 

Find more of our publications on GUP

In May 2022 we are organizing the the 21st  International symposium on pollutant responses in marine organisms (PRIMO21)

To the symposium webpage PRIMO21

Malin Celander