Our areas of research
Clinical lung cancer
Lung cancer is the leading cause of cancer death worldwide. In clinical projects, we determine novel molecular mechanisms behind initiation of precancerous lesions and the biological relevance of different histomorphological phenotypes of lung cancers. We use human clinical samples, in vitro cell culture, organoid models and genetically modified animal models through established collaborations primarily between the Department of Oncology and Thoracic Surgery at the Sahlgrenska University Hospital and the Sahlgrenska Center for Cancer Research in Gothenburg.
Biology of filamins
Actin-binding cytoskeletal filamins are involved in both cardiovascular remodeling after atherosclerosis and myocardial infarction and tumor growth. In translational research projects, we discover novel mechanisms behind adaptive and oncogenic angiogenesis using vascular and cancer cells and murine lines lacking filamins. The biological importance of filamins in neuroblastoma is another focus. These projects are being performed in collaboration between the Sahlgrenska Center for Cancer Research in Gothenburg and the Karolinska Institute in Stockholm.
Volkan Sayin, Sahlgrenska Center for Cancer Research
Per Lindahl, Sahlgrenska Center for Cancer Research
Sukanya Raghavan, Department of Clinical Immunology and Transfusion Medicine, Sahlgrenska University Hospital
Andreas Hallqvist, Department of Oncology, Sahlgrenska University Hospital
Chandrasekhar Kanduri, Institute of Biomedicine, University of Gothenburg
Martin Bergö, Karolinska Institutet