Cholinergic anti-inflammatory pathway and its role in cardiovascular disease
Cardiovascular disease, manifested as myocardial infarction and/or stroke, is the leading cause of death in the world. The underlying factor for cardiovascular disease is usually atherosclerosis. Inflammation is central in cardiovascular disease, not only for the pathogenesis of atherosclerosis, but also in complications following atherosclerosis, for example during and after embolus/thrombus formation. The long-term goal of our research is to identify novel targets for the treatment and prevention of inflammation associated with cardiovascular disease. Our hypothesis is that the autonomic nervous system and the immune system interacts, and that nerve signalling can modulate inflammation. By combining experimental models with human material we can investigate these interactions from several different perspectives.