Unique Platform for Correlative imaging


The SECOM platform – an integrated solution for correlative light and electron microscopy (CLEM) – will be available at the Centre for Cellular Imaging (CCI) at Core Facilities. SciLifeLab recently granted an application where SEK 2 million was approved for investing in this technology, unique in Sweden.

“This upgrade to our scanning electron microscope will be the first of its kind in Sweden and will be at the very forefront of technological developments in the field of correlative imaging, allowing us to extend our professional technical and scientific support,” said Julia Fernández-Rodríguez, Head of the Centre for Cellular Imaging (CCI).

Clinical, biomedical, and pharmaceutical researcher, from Swedish and international institutions and industry will be among those who can benefit from the technology.

“With the cutting-edge capability of the equipment, combined with the 20 years of operational experience of the CCI team in Gothenburg, we expect positive impact on research output across multiple research areas,” Julia said.

The platform is planned to be installed and ready to use after the summer 2022.

Flagship of advanced imaging methods

Correlative Light and Electron Microscopy (CLEM) has during the past decade become the flagship of the development of advanced imaging methods. With the new system, an optical and an electron microscope are combined seamless into one instrument.

Traditionally, to acquire the results of CLEM, you need to use two separate instruments, at separate locations, using potentially different sample preparation methods. This would mean a time-consuming process where you also risk sample contamination. The Integrated CLEM will however produce an overlay of the two images quick and automatically, with reduced chance of changes in the sample during the process of data collection.

“This is a powerful technique that can be applied in several fields of the life sciences, such as neuroscience, cell and developmental biology, and tissue research, to name just a few,” Julia said.

Facts about CCI

The Centre for Cellular Imaging (CCI), a correlated multimodal imaging facility, has been in operation since 2002 and is one of the advanced open access technology platforms at the University of Gothenburg Core Facilities.

CCI is part of the SciLifeLab platform Cellular and Molecular Imaging (CMI), the National Microscopy Infrastructure (NMI), as well as the Swedish Node of the Euro-BioImaging infrastructure.